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| Application No. | Application Title | Issue Date |
| 20120129218 | COFILIN KNOCKDOWN HOST CELLS AND USES THEREOF The present invention relates to a host cell comprising a cofilin-specific small interfering RNA (siRNA) sequence. The host cell may further comprise a nucleic acid encoding a recombinant protein. The present invention also relates to a method for producing a recombinan... | 05/24/2012 |
| 20120129237 | POLYNUCLEOTIDES ENCODING NOVEL PCSK9 VARIANTS The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention furthe... | 05/24/2012 |
| 20120053080 | PROTEIN MARKERS IDENTIFICATION FOR GASTRIC CANCER DIAGNOSIS Methods for detecting cancer as well as methods of diagnosis of cancer by detecting proteins secreted into biological fluids are disclosed The invention was first applied to detecting proteins secreted into serum and urine However, it is understood that the methods have... | 03/01/2012 |
| 20120045777 | NOVEL GENES ENCODING PROTEINS HAVING PROGNOSTIC, DIAGNOSTIC, PREVENTIVE, THERAPEUTIC, AND OTHER USES The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The inv... | 02/23/2012 |
| 20120040905 | MEANS FOR PURIFYING A COAGULATION PROTEIN, AND METHODS FOR IMPLEMENTING SAME An affinity substrate for selectively binding a coagulation protein, includes a substrate solid on which nucleic aptamers binding specifically to the coagulation protein are immobilized.... | 02/16/2012 |
| 20120041056 | NUCLEIC ACIDS SPECIFICALLY BINDING WITH HUMAN FACTOR VII/VIIA AND USES THEREOF A nucleic acid includes at least 15 nucleotides with a length specifically binding with the human factor VII/VIIa.... | 02/16/2012 |
| 20120034674 | METHOD OF PRODUCING RECOMBINANT ADAMTS13 IN CELL CULTURE Among other aspects, the present invention relates to cell culture conditions for producing high molecular weight vWF, in particular, highly multimericWF with a high specific activity and ADAMTS13 with a high specific activity. The cell culture conditions of the present... | 02/09/2012 |
| 20120010557 | Drug Delivery System for Use in the Treatment of Vascular and Vessel-Related Pathologies The present invention relates to a drug delivery system for use in the treatment of vascular and vessel-related pathologies, comprising a drug delivery platform that comprises at least one compound capable of exerting an effect on the formation and/or maintenance of a t... | 01/12/2012 |
| 20120003695 | METABOLIC ENGINEERING OF A GALACTOSE ASSIMILATION PATHWAY IN THE GLYCOENGINEERED YEAST PICHIA PASTORIS Lower eukaryotic cells such as Pichia pastoris that normally cannot use galactose as a carbon source but which have been genetically engineered according to the methods herein to use galactose as a sole source of carbon are described. The cells are genetically en... | 01/05/2012 |
| 20110312059 | TAU PROTEASE COMPOSITIONS AND METHODS Tau protein has a causative role in Alzheimer's disease and multiple other neurodegenerative disorders exhibiting tau histopathology collectively termed tauopathies. The primary function of tau protein is to facilitate assembly and maintenance of microtubules in neurona... | 12/22/2011 |
| 20110311509 | TREATMENT OF OCULAR DISEASES The present invention relates to the use of at least one protease for the manufacture of a medicament for the treatment and/or prevention of ocular diseases related to neoangiogenesis selected from the group consisting of age related macular degeneration (AMD), choroida... | 12/22/2011 |
| 20110306507 | METHOD AND TOOLS FOR PROGNOSIS OF CANCER IN HER2+PARTIENTS A gene or protein set includes at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, and possibly 40, 45, 50, 55, 60, 65 genes or proteins, antibodies or hypervariable portion thereof ... | 12/15/2011 |
| 20110300122 | METHOD FOR TREATING A PATIENT Intra-arterial administering at least one blood coagulation to a bleeding patient is provided, together with a pharmaceutical composition therefor.... | 12/08/2011 |
| 20110294149 | Alzheimer's Disease Secretase, APP Substrates Therefor, and Uses Therefor The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein a... | 12/01/2011 |
| 20110294141 | METHOD FOR ANALYZING PSA AND METHOD FOR DISTINGUISHING PROSTATE CANCER FROM PROSTATIC HYPERTROPHY USING THAT METHOD FOR ANALYZING PSA A method for distinguishing prostate cancer from prostatic hypertrophy using the method for analyzing PSA and an analysis kit of PSA are provided. An object of the present invention can be solved by being brought into contact a lectin havin... | 12/01/2011 |
| 20110287518 | Polypeptide Purification The invention relates to the purification of different gamma carboxylated forms of a polypeptide using ion exchange chromatography. In particular, the invention provides a method for purifying a polypeptide having a desired content of gamma-carboxyglutamic acid from a s... | 11/24/2011 |
| 20110265197 | Signatures and PCDeterminants Associated with Prostate Cancer and Methods of Use Thereof The present invention provides methods of detecting cancer using biomarkers.... | 10/27/2011 |
| 20110263499 | IFBM'S TO PROMOTE THE SPECIFIC ATTACHMENT OF TARGET ANALYTES TO THE SURFACE OF ORTHOPEDIC IMPLANTS The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (... | 10/27/2011 |
| 20110263000 | A THROMBIN-LIKE ENZYME OF AGKISTRODON ACUTUS A thrombin-like enzyme isolated from Agkistrodon acutus venom, comprising an alpha subunit having the sequence of SEQ ID No. 1 and a beta subunit having the sequence of SEQ ID No. 2, which are linked by seven disulfide bonds, is provided. The hemocoagulase of Agkistr... | 10/27/2011 |
| 20110256120 | Methods and Compositions for Reducing Amyloid Beta Levels The present invention provides a method of increasing cathepsin B-induced cleavage of amyloid-β (Aβ) peptide in a cell or tissue, the method generally involving contacting the cell or tissue with an agent that increases the level of cathepsin B in the cell or tissue. ... | 10/20/2011 |
| 20110236397 | LIMITED PROTEOLYSIS OF CD2AP AND PROGRESSION OF RENAL DISEASE Compositions which specifically block cathepsin L function in podocytes, compositions which protect cytoskeletal adaptor protein (CD2AP) for degradation, compositions which modulate expression or function of cytoskeletal adaptor protein (CD2AP), protect against renal di... | 09/29/2011 |
| 20110206704 | Methods and compositions for modulating hepatocyte growth factor activator The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention concerns modulators of hepatocyte growth factor activator function, and the identification and uses of said modulators.... | 08/25/2011 |
| 20110189182 | PROTEOLYTICALLY CLEAVABLE FUSION PROTEINS WITH HIGH MOLAR SPECIFIC ACTIVITY The invention relates to therapeutic fusion proteins in which a coagulation factor is fused to a half-life enhancing polypeptide, and in which both are connected by a linker peptide that is proteolytically cleavable. The cleavage of such linkers liberates the coagulatio... | 08/04/2011 |
| 20110165648 | Co-crystal structure of factor D and anti-factor D antibody The present invention is directed towards the co-crystal structure of Factor D and an anti-Factor D antibody or an antigen binding fragment thereof.... | 07/07/2011 |
| 20110162094 | MODIFIED HUMAN FACTOR VII/VIIA AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME Modified factors VII/VIIa with a high stability, nucleic acids encoding such modified factors VII/VIIa, and methods of preparing the same.... | 06/30/2011 |
| 20110151536 | THROMBIN ACTIVATOR COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME Disclosed are compositions for activating thrombin precursors to thrombin. The compositions provided include polypeptide compositions wherein the pre-pro-sequence comprises a thrombin cleavage site. The compositions provided also include polynucleotides encoding said po... | 06/23/2011 |
| 20110151470 | BIOMARKERS FOR ASSESSING RESPONSE TO C-MET TREATMENT Biomarkers that correlate to treatment with drugs that inhibit c-met are disclosed. These biomarkers have been shown to have utility in assessing response to the compounds. The expression level of the biomarkers is reduced upon treatment with c-met inhibitor compounds, ... | 06/23/2011 |
| 20110126303 | Modified Blood Clotting Factors And Methods Of Use The invention provides compositions including modified blood clotting factors that have a non-native proteolytic cleavage site engineered into them allowing intracellular cleavage and secretion of an active form. The compositions are useful in the methods for treating a... | 05/26/2011 |
| 20110112990 | Efficient Production of Peptides The present invention relates to processes for the production of peptides, and the peptides produced accordingly. Peptides produced according to the invention may be produced more efficiently than peptides produced according to prior art processes. The production proces... | 05/12/2011 |
| 20110081700 | Methods of Purifying Recombinant Adamts13 and Other Proteins and Compositions Thereof Provided herein are methods for purifying recombinant A Disintegrin-like and Metallopeptidase with Thrombospondin Type 1 Motif 13 (ADAMTS13) protein from a sample. The method comprises enriching for ADAMTS13 protein by chromatographically contacting the sample with hydr... | 04/07/2011 |
| 20110070607 | GLYCOPROTEIN SYNTHESIS AND REMODELING BY ENZYMATIC TRANSGLYCOSYLATION A chemoenzymatic method for the preparation of a homogeneous glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group consisting of GlcNAc-protein and GlcNAc-peptide; and (b) reacting the acceptor with a donor substrate including an acti... | 03/24/2011 |
| 20110059065 | FUNCTION AND REGULATION OF ADAMTS-1 The present invention relates to ADAMTS-1 and uses thereof. The present invention also relates to fragments of ADAMTS-1 and methods of inhibiting cell growth and metastasis. The present invention also provide methods of identifying inhibitors and activators relating to ... | 03/10/2011 |
| 20110045535 | Activator for Blood Coagulation Factor VII Promoter and Utilization of the Same It is intended to provide an activator for blood coagulation factor VII. Ribavirin or its derivative is used as an activator for blood coagulation factor VII promoter.... | 02/24/2011 |
| 20110038895 | MULTI-EPITOPE PEPTIDE-LOADED DENDRITIC CELL IMMUNOTHERAPY FOR CANCER The invention involves peptides of from about 7 to about 50 amino acid residues in length that have epitopes that bind to more than one HLA class II protein and stimulate CD4+ T cells for treatment of cancer from one of three serine proteases overexpressed in ovarian ca... | 02/17/2011 |
| 20100254972 | METHODS FOR SELECTING PROTEASE RESISTANT POLYPEPTIDES The invention relates to a method for selecting, isolating and/or recovering a peptide or polypeptide from a library or a repertoire of peptides and polypeptides (e.g., a display system) that is resistant to degradation by a protease such as a protease found in the GI t... | 10/07/2010 |
| 20100239554 | EXTENDED RECOMBINANT POLYPEPTIDES AND COMPOSITIONS COMPRISING SAME The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositio... | 09/23/2010 |
| 20100144013 | OVER EXPRESSION OF FOLDASES AND CHAPERONES IMPROVES PROTEIN PRODUCTION The present teachings provide methods for increasing protein secretion, e.g., chymosin in filamentous fungi by co-expressing certain chaperone(s) and/or foldase(s). The present teachings also provide filamentous fungi containing certain chaperone(s) and/or foldase(s) an... | 06/10/2010 |
| 20100104554 | PEPTIDE AND USES THEREOF A method of inhibiting activity of a cathepsin L-like protease in cells or tissue and the use of the method in the treatment of disease such as cancer and inflammatory diseases is described. The method comprises administration of a cathepsin propeptide or a nucleic acid... | 04/29/2010 |
| 20100021987 | Compositions, Methods, and Kits for Enhancing Protein Expression The inventive subject matter relates to novel compositions, methods, and kits for enhancing the expression, solubility, and isolation of heterologous proteins. Further, the inventive subject matter relates to methods for generating proteins with novel N-terminal amino a... | 01/28/2010 |
| 20090221016 | MODIFIED TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME AND METHODS OF USE THEREOF The present invention discloses a modified tumor necrosis factor-alpha converting enzyme (TACE) catalytic domain, that unlike the native TACE catalytic domain, is stable at high protein concentrations. The present invention further discloses methods for generating cryst... | 09/03/2009 |
