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"I watched his countenance closely, to see if he was not deranged ... and I was assured by other senators after he left the room that they had no confidence in it."
U.S. Senator Smith of Indiana ; After seeing Samuel Morse demonstrate the telegraph.
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| Application No. | Application Title | Issue Date |
| 20120070403 | USE OF G-CSF FOR THE EXTENSION OF THE THERAPEUTIC TIME-WINDOW OF THROMBOLYTIC STROKE THERAPY The present invention relates to the use of G-CSF and derivatives thereof for extending the therapeutic window of subsequent thrombolytic treatment of acute stroke, and thereby, allowing the diagnostic examinations which are necessary prior to the thrombolytic treatment... | 03/22/2012 |
| 20100317056 | FERMENTATION MEDIAS AND PROCESSES THEREOF The present invention demonstrates the utility of carbonic acid amides such as urea or its derivatives, carbamates, carbodiimides & thiocarbamides as nitrogenous supplements in fermentation media for production of recombinant proteins to achieve enhanced bioconversi... | 12/16/2010 |
| 20100254943 | AMINO ACID SUBSTITUTED MOLECULES The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety ... | 10/07/2010 |
| 20100034804 | MUTANTS OF STREPTOKINASE AND THEIR COVALENTLY MODIFIED FORMS The present invention relates to novel mutants of Streptokinase, its functional fragments and covalently modified forms. Methods are provided for the preparation of the bacterial plasminogen activator protein, Streptokinase its muteins, species variants and their covale... | 02/11/2010 |
| 20100015123 | NOVEL THROMBOLYTIC MOLECULES AND A PROCESS THEREFOR New thrombolytic protein molecules such as recombinant staphylokinase or streptokinase, urokinase, tissue plasminogen activator and the like, and suitable variants thereof, for targeting to brain tissue or any other tissue by either fusing to, or by synthesizing the can... | 01/21/2010 |
| 20090098049 | Targeting transducible molecules to specific cell types The disclosure provides fusion polypeptides and constructs useful in targeting molecules including diagnostics and therapeutics to a cell type of interest. The fusion constructs include a protein transduction domain, a ligand domain and a cargo domain. Also provided are... | 04/16/2009 |
| 20060127389 | Fused protein with the function of both hemolysis and anticoagulation and use of it This application relates to a fusion protein, which is composed of a thrombolytic protein, an anticoagulant protein, and a linker peptide. In particular, the fusion protein is composed of an anticoagulant protein and a protein molecule having plasminogen-activating acti... | 06/15/2006 |
| 20050260598 | Novel clot-specific streptokinase proteins possessing altered plasminogen activation characteristics and a process for the preparation of said protein Clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or l... | 11/24/2005 |
| 20050136045 | Identification, production and use of staphylokinase derivatives with reduced immunogenicity and/or reduced clearance Methods for the identification, production and use of staphylokinase derivatives characterized by a reduced immunogenicity after administration in patients and that can be administered by a single bolus injection. The derivatives of the invention are obtained by prepari... | 06/23/2005 |
| 20050019862 | Method for oxygen regulated production of recombinant staphylokinase The present invention relates to a nucleotide sequence of expression cassette OXY-1 of SEQ ID No. 1, a modified staphylokinase SAK-2 gene of SEQ ID No. 2, a peptide sequence of modified staphylokinase SAK-2 gene, of SEQ ID No. 3... | 01/27/2005 |
