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| Application No. | Application Title | Issue Date |
| 20120129788 | PHOSPHODIESTERASE 4D7 AS MARKER FOR MALIGNANT, HORMONE-SENSITIVE PROSTATE CANCER The present invention relates to phosphodiesterase 4D7 (PDE4D7) for use as a marker for malignant, hormone-sensitive prostate cancer, wherein the expression of the marker is increased when comparing the expression in malignant, hormone-sensitive prostate cancer tissue, ... | 05/24/2012 |
| 20120128635 | METHODS AND COMPOSITIONS FOR TREATING HEMOPHILIA B Disclosed herein are methods and compositions for insertion of Factor IX (FIX) sequences into the genome of a cell for treating hemophilia B.... | 05/24/2012 |
| 20120129239 | HOMOLOGOUS RECOMBINATION-BASED DNA CLONING COMPOSITIONS Methods and compositions for cloning a donor DNA molecule into an acceptor vector at a predetermined location are described. The methods are based on homologous recombination mediated by in vitro treatment of the donor DNA and the acceptor vector with an enzyme cocktail... | 05/24/2012 |
| 20120129218 | COFILIN KNOCKDOWN HOST CELLS AND USES THEREOF The present invention relates to a host cell comprising a cofilin-specific small interfering RNA (siRNA) sequence. The host cell may further comprise a nucleic acid encoding a recombinant protein. The present invention also relates to a method for producing a recombinan... | 05/24/2012 |
| 20120108493 | Polypeptide Fragments Comprising Endonuclease Activity and Their Use The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase or variants thereof possessing endonuclease activity, wherein said PA subunit is from a virus belonging to the Orthomyx... | 05/03/2012 |
| 20120107906 | NOVEL LIPOLYTIC ENZYME LIP1 The present invention provides a novel nucleic acid sequence, designated LIP1, encoding a lipolytic enzyme and the corresponding encoded amino acid sequences. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding at le... | 05/03/2012 |
| 20120052533 | 4S-IOTA-CARRAGEENAN SULFATASE AND USE THEREOF TO OBTAIN ALPHA-CARRAGEENAN The present invention relates to 4S-iota-carrageenan sulfatase and to the use thereof for partially or totally converting the iota-carrageenan into iota-/alpha-carrageenan or alpha-carrageenan. The invention also relates to the method for extracting said enzyme from a <... | 03/01/2012 |
| 20120045816 | Novel Glycosylated Polypeptides Provided herein are glycosylated polypeptide compositions with substantially reduced Neu5Gc content. The glycosylated polypeptides compositions with substantially reduced Neu5Gc content can be obtained from cell sources cultured with Neu5Gc competitor or from non-human ... | 02/23/2012 |
| 20120040434 | Protein exhibiting activity of pyrethrin biosynthetic enzyme, gene encoding the protein, and vector bearing the gene The present invention relates to an enzyme determining amino acid sequences of an enzyme involved in pyrethrin biosynthesis and a base sequence of the gene thereof; constructing vectors bearing the gene and transformants; and extractable from plant bodies producing pyre... | 02/16/2012 |
| 20120040345 | 2-Nitrobenzyl-Modified Ribonucleotides This disclosure provides novel reversibly terminated ribonucleotides which can be used as a reagent for DNA sequencing reactions. Methods of sequencing nucleic acids using the disclosed nucleotides are also provided.... | 02/16/2012 |
| 20120034650 | Nucleic acid molecule of a biosynthetic cluster encoding non ribosomal peptide synthases and uses thereof The present invention relates to the provision of a polynucleotide comprising one or more functional fragments of a biosynthetic gene cluster involved in the production of a compound of formula (I) or (I′). The present invention also provides a method of preparing a c... | 02/09/2012 |
| 20120028911 | Mucin Derived Polypeptides The present technology relates to isolated MUC17, Muc3 or MUC3 derived polypeptides and polynucleotides encoding the same. The MUC17, Muc3 or MUC3 derived polypeptides and polynucleotides can be used to treat gastrointestinal tract diseases and disorders. Also described... | 02/02/2012 |
| 20120030783 | RATIONALLY DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of l... | 02/02/2012 |
| 20120021488 | THERMOTOLERANT NON-K12 ESCHERICHIA COLI PHYTASE AND ITS PRODUCTION This invention relates to cloning and sequencing of thermotolerant phytase gene from Non-K12 Escherichia coli strain, ATCC 9637, phytase gene expression in Escherichia coli expression system, codon usage optimized and expression in Pichia pastoris, Pich... | 01/26/2012 |
| 20120023599 | GENOME EDITING OF CYTOCHROME P450 IN ANIMALS The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding cytochrome P450 (CYP) proteins. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. The invention ... | 01/26/2012 |
| 20120014964 | ALPHA SYNUCLEIN TOXICITY Present inventions demonstrates that alpha synuclein toxicity such as α-synuclein mediated cell death, alpha synuclein induced reactive oxygen species (ROS) in a cell requires the proapoptotic endonuclease G and that the deletion of the endonuclease G or suppressing of... | 01/19/2012 |
| 20120015421 | RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of l... | 01/19/2012 |
| 20120003695 | METABOLIC ENGINEERING OF A GALACTOSE ASSIMILATION PATHWAY IN THE GLYCOENGINEERED YEAST PICHIA PASTORIS Lower eukaryotic cells such as Pichia pastoris that normally cannot use galactose as a carbon source but which have been genetically engineered according to the methods herein to use galactose as a sole source of carbon are described. The cells are genetically en... | 01/05/2012 |
| 20120003715 | Process for Producing Recombinant Lyosomal Using Insect Larvae A method for expressing and industrial scale production of recombinant lysosomal enzymes utilizing insect larva including the steps of infecting an insect larva population of the species Spodoptera littoralis via a recombinant baculovirus liquid suspension which ... | 01/05/2012 |
| 20110321197 | Plants with Increased Yield (NUE) A method for producing a plant with increased yield as compared to a corresponding wild type plant whereby the method comprises at least the following step: increasing or generating in a plant or a part thereof one or more activities selected from the group consisting o... | 12/29/2011 |
| 20110311679 | PREGASTRIC ESTERASE AND DERIVATIVES THEREOF The present invention relates to novel lipase polynucleotide sequences, their corresponding proteins as well as ways of manufacturing said sequences and said proteins and use of the proteins in the preparation of food compositions. The invention further relates to metho... | 12/22/2011 |
| 20110312043 | EXTRACTION SOLVENTS DERIVED FROM OIL FOR ALCOHOL REMOVAL IN EXTRACTIVE FERMENTATION In an alcohol fermentation process, oil derived from biomass is hydrolyzed into an extractant available for in situ removal of a product alcohol such as butanol from a fermentation broth. The glycerides in the oil can be catalytically (e.g., enzymatically) hydrolyzed in... | 12/22/2011 |
| 20110306098 | COMPOSITIONS AND METHODS FOR USE IN ISOLATION OF NUCLEIC ACID MOLECULES The present invention relates generally to recombinant genetic technology. More particularly, the present invention relates to compositions and methods for use in selection and isolation of nucleic acid molecules. The invention further relates to methods for the prepara... | 12/15/2011 |
| 20110305688 | NEW VIRULENCE FACTORS OF STREPTOCOCCUS PNEUMONIAE The present invention provides proteins/genes, which are essential for survival, and consequently, for virulence of Streptococcus pneumoniae in vivo, and thus are ideal vaccine candidates for a vaccine preparation against pneumococcal infection. Further, also ant... | 12/15/2011 |
| 20110300143 | PRENATAL ENZYME REPLACEMENT THERAPY The invention contemplates transplacental enzyme replacement therapy (ERT) for deficiency of a polypeptide such as a tissue-nonspecific alkaline phosphatase (TNSALP) by administering a before-described pharmaceutical composition to a pregnant animal whose fetus or embry... | 12/08/2011 |
| 20110301073 | Novel DNA-binding proteins and uses thereof Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomi... | 12/08/2011 |
| 20110294164 | VARIANT HUMICOLA GRISEA CBH1.1 Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrol... | 12/01/2011 |
| 20110294165 | VARIANT HUMICOLA GRISEA CBH1.1 Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrol... | 12/01/2011 |
| 20110294674 | MODIFIED RNASE H AND DETECTION OF NUCLEIC ACID AMPLIFICATION A reversibly modified ‘hot start’ RNAse H enzyme composition is described for the improved CATACLEAVE™ probe detection of nucleic acid sequences in a test sample. A key feature of the enzyme composition is the ability to regulate the catalytic activity of the RNAs... | 12/01/2011 |
| 20110294217 | DNA NICKING ENZYME FROM A HOMING ENDONUCLEASE THAT STIMULATES SITE-SPECIFIC GENE CONVERSION An engineered highly specific DNA-cleavage enzyme delivers a site-specific nick in a double stranded DNA, to cleave one DNA strand within its target site while leaving the opposing DNA strand intact. The engineered enzyme provides the ability to induce a gene conversion... | 12/01/2011 |
| 20110286977 | G6PC2-Encoded Beta Cell Surface Tags The invention relates to G6PC2-encoded beta cell surface markers, methods of identifying and obtaining a culture cells comprising fully differentiated beta cells. Also contemplated is a method of sorting such cells, isolated cells and compositions thereof.... | 11/24/2011 |
| 20110286952 | DERMOCOSMETIC COMPOSITION, AESTHETIC TREATMENT METHOD USING THE COMPOSITION, AND USE OF THE COMPOSITION FOR LIGHTENING THE PIGMENTATION OF THE SKIN The invention relates to a dermocosmetic composition essentially characterized in that it comprises at least one hydrolase selected from acid phosphatases. The invention also relates to a method of aesthetic treatment of the skin aimed in p... | 11/24/2011 |
| 20110287513 | USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF A single chain homing endonuclease, comprising a first variant of I-CreI having the amino acid sequence of accession number pdb 1g9y and a second variant of I-CreI variant having the amino acid sequence of accession number pdb 1g9y in a single polypeptide.... | 11/24/2011 |
| 20110287512 | Compositions for linking zinc finger modules Disclosed herein are compositions for linking DNA binding modules to allow for specific and selective binding to module subsites separated by 1 or more base pairs. Also described are methods of making and using compositions comprising these linkers.... | 11/24/2011 |
| 20110289632 | METHYLKETONE SYNTHASE, PRODUCTION OF METHYLKETONES IN PLANTS AND BACTERIA Isolated genes and amino acid sequences encode methylketone synthase 2 (MKS2) enzymes from tomato plants, including, ShMKS2 and SlMKS2. When expressed recombinantly in bacteria and other host cells, the MKS2 enzymes produce methylketones of various carbon chain lengths ... | 11/24/2011 |
| 20110281276 | NUCLEIC ACID-FREE THERMOSTABLE ENZYMES AND METHODS OF PRODUCTION THEREOF The present invention provides thermostable enzymes, such as DNA polymerases and restriction endonucleases, that are substantially free from contamination with nucleic acids. The invention also provides methods for the production of these enzymes, and kits comprising th... | 11/17/2011 |
| 20110281306 | Novel Zinc Finger Nuclease and Uses Thereof The present invention relates to methods and compositions useful for targeted cleavage and alteration of a genomic sequence, targeted cleavage followed by homologous recombination between an exogenous polynucleotide and a genomic sequence, or targeted cleavage followed ... | 11/17/2011 |
| 20110275135 | Genetic elements, proteins, and associated methods including application of additional genetic information to gram (+) thermoacidophiles Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering recombination inside or outside of a cell using isolated and/or purif... | 11/10/2011 |
| 20110274673 | Bacillus amyloliquefaciens Strain The present disclosure relates to a strain of Bacillus amyloliquefaciens bacteria that hyperproduces amylase enzyme and protease enzyme. The strain is also suitable for producing lipase for the degradation of oleaginous materials such as fats, greases and cooking... | 11/10/2011 |
| 20110269198 | METHODS FOR CONTROL OF FLUX IN METABOLIC PATHWAYS The invention pertains to a method for preparing cells that can be used as biocatalysts by inducing in them a growth-decoupled state, in which interferase inhibits the expression of genes except the ones that code for the pathway enzymes of interest. mRNAs that code for... | 11/03/2011 |
