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| Application No. | Application Title | Issue Date |
| 20120129175 | METHOD FOR RENAL DISEASE DIAGNOSIS AND PROGNOSIS USING ANNEXIN A1 AND RAB23 AS MARKERS Use of Annexin A1 or Rab23 as a biomarker for diagnosing kidney disease or assessing efficacy of kidney disease treatment.... | 05/24/2012 |
| 20120108603 | AMINOCARBONYL-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE This invention comprises the novel compounds of formula (I) wherein n, R1, R2, R3, R4, L, Q, X, Y, Z and 05/03/2012 | |
| 20120107853 | Use of Genetically Modified Organisms to Generate Biomass Degrading Enzymes The present invention provides a method and compositions for high throughput screening of genetically modified photosynthetic organisms for plasmic state. The present invention provides methods of producing one or more proteins, including biomass degrading enzymes in a ... | 05/03/2012 |
| 20120083010 | METHOD FOR DIAGNOSING POMPE DISEASE Provided is a method for diagnosing Pompe disease in a patient by measuring acid α-glucosidase activity in a sample from the patient. The invention also provides a method for monitoring the treatment of Pompe disease with specific pharmacological chaperones by measurin... | 04/05/2012 |
| 20120070511 | MITOCHONDRIAL INHIBITORS AND USES THEREOF Compositions which modulate mitochondrial functions treat diseases associated with cells that are hyperactively using their endoplasmic reticulum. Screening assays identify agents which modulate mitochondrial functions.... | 03/22/2012 |
| 20120073003 | APOBEC3 MEDIATED DNA EDITING The present invention relates to methods and compositions for preventing the occurance or progression of a cancer or pre-cancerous condition associated with expression, or over-expression of human cytidine deaminases of the APOBEC3 family. The invention also relates to ... | 03/22/2012 |
| 20120052519 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY Methods for assaying α-L-iduronidase enzymatic activity and methods for screening newborns for Mucopolysaccharidosis Type-I.... | 03/01/2012 |
| 20120046639 | MICROFLUIDIC FREE INTERFACE DIFFUSION TECHNIQUES A static fluid and a second fluid are placed into contact along a microfluidic free interface and allowed to mix by diffusion without convective flow across the interface. In accordance with one embodiment of the present invention, the fluids are static and initially po... | 02/23/2012 |
| 20120046190 | HP1ALPHA AS A PROGNOSTIC MARKER IN HUMAN CANCER The present invention provides a prognostic marker in human cancer, HP1α, a high expression thereof being associated with a poor prognosis. The present invention further provides a method for diagnosing a cancer in a subject, HP1α a being specifically overexpressed in... | 02/23/2012 |
| 20120045784 | BIOTINIDASE ASSAY The present technology discloses biotinidase assay, biotinidase substrates (I) and a kit wherein the biotinidase substrate includes a label molecule separated from the biotin carbamoyl group by a linker X longer than about 4 Å but shorter than about 27 Å. | 02/23/2012 |
| 20120045785 | Hybrid Prokaryotic-Eukaryotic Tubulins and Use Thereof The present invention embraces hybrid Prosthecobacter-eukaryotic tubulin proteins and use thereof for identifying agents that modulate the activity of tubulin.... | 02/23/2012 |
| 20120040021 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER The invention relates to compositions comprising an acid ceramidase inhibitor and a choline kinase inhibitor as well as to the uses thereof for the treatment of cancer. The invention also relates to methods for the selection of an individualised therapy of a cancer pati... | 02/16/2012 |
| 20120041001 | CARBONYLAMINO-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y and | 02/16/2012 |
| 20120040858 | BIOMARKERS FOR STROKE Biomarkers for stroke and methods for their detection are disclosed. In one aspect, the present application discloses biomarkers for the diagnosis of stroke in a subject. In another aspect, the application discloses a method for the diagnosis of stroke in a subject. The... | 02/16/2012 |
| 20120040388 | CELLULASE-CONTAINING DISH DETERGENTS The present invention provides cellulase-containing dishwashing detergent compositions. The present invention also provides methods for the production of and use of such detergents. In addition, a spaghetti mix soil suitable for testing dishwashing detergents is also pr... | 02/16/2012 |
| 20120040380 | OPTICALLY-DETECTABLE ENZYME SUBSTRATES AND THEIR METHOD OF USE The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a β-lactamase... | 02/16/2012 |
| 20120034637 | DETECTION OF TRICHOMONAS AND CANDIDA The invention relates to a method and a kit for the detection of Trichomonas infection by detecting N-acetyl-β-D-hexosaminidase activity. The invention also relates to a method and a kit for selective detection of presence of Trichomonas or Candida | 02/09/2012 |
| 20120034632 | TWO-PHASE OPTICAL ASSAYS FOR ANALYTES OF NO INTRINSIC OPITCAL CONTRAST Methods and kits for performing a two-phase optical assay for one or more than one analyte without intrinsic optical contrast in a sample are disclosed. The method requires use of a functionalized microparticle immobilized with two or more than functional components and... | 02/09/2012 |
| 20120021924 | DETECTION AND MODULATION OF CYTOCHROME C ACETYLATION The invention relates to detection and modulation of cytochrome c acetylation. The invention has diagnostic and therapeutic applications for neurodegenerative disorders and cancer.... | 01/26/2012 |
| 20120021926 | FLUORESCENCE RESONANCE ENERGY TRANSFER ASSAYS FOR SARCO/ENDOPLASMIC RETICULUM CALCIUM ATPASE AND PHOSPHOLAMBAN Provided herein are methods for identifying molecules capable of modulating SERCA, the SERCA-PLB complex or the microenvironment of the complex. An exemplary assay provided herein is fluorescence resonance energy transfer (FRET). Also provided herein are FRET assays tha... | 01/26/2012 |
| 20120014927 | METHODS AND KITS FOR DETERMINING PREDISPOSITION TO CANCER Provided are methods and kits for determining predisposition to cancer by determining the presence or absence in a heterozygote form of the KLOTHO functional variant. Also provided are methods of designing treatment and treating cancer based on the increased predisposit... | 01/19/2012 |
| 20120003661 | METHODS AND DEVICES FOR THE SELECTIVE DETECTION OF MICROORGANISMS Methods and devices are provided for the rapid and specific detection of target microorganisms, cells, and the like. In one embodiment, the methods involve contacting a target microorganism (e.g., in a sample) with a permeabilization reagent that selectively permeabiliz... | 01/05/2012 |
| 20110318271 | Arginase Inhibitors for the Treatment of Depression The subjects of the current invention are compounds, which exhibit arginase inhibiting activity (including difluoromethylornithine (DFMO) and L-norvaline, but not limited to them), and which can be used as therapeutically active agents for the treatment and prevention o... | 12/29/2011 |
| 20110319398 | INHIBITION OF YOPS TRANSLOCATION The disclosure relates to compounds and methods of inhibiting type three secretion system effector molecules, to methods of detecting compounds that inhibit Yops translocation, and to methods of treating or preventing infections by administering compounds described here... | 12/29/2011 |
| 20110311505 | Photosensitive Aminoacid-Monomer Linkage and Bioconjugation Applications in Life Sciences and Biotechnology This invention is related to preparation of photosensitive ruthenium based aminoacid monomers and oligomers, aminoacid monomer-protein cross-linking using photo sensitat ion and conjugation on micro and nano-structures by ruthenium-chelate based monomers. Its vast range... | 12/22/2011 |
| 20110312505 | Rapid Isolation of Monoclonal Antibodies from Animals Methods and compositions for identification of candidate antigen-specific variable regions as well as generation of antibodies or antigen-binding fragments that could have desired antigen specificity are provided. For example, in certain aspects methods for determining ... | 12/22/2011 |
| 20110312007 | Detection of Histone Deacetylase Inhibition Provided are compositions and methods for intracellular detection of enzyme activity. One example of a composition is a histone deacetylase substrate comprising a compound of the following formula (I): One ex... | 12/22/2011 |
| 20110312006 | Enzymatic Assay for the Quantitative Determination of Phospholipase A1 or A2 Activity in a Sample The invention relates to a new method for measuring a calcium-dependent phospholipase A1 or A2 enzymatic activity in a sample, comprising the following steps: a) contacting said sample with a solid phase coated with a fluorochrome-labelled phospholipase A1 or A2 substra... | 12/22/2011 |
| 20110311508 | METHOD OF MODULATING HSF-1 The present invention is directed to methods of modulating HSF1 activity comprising modifying the acetylation of the DNA binding domain of the HSF1.... | 12/22/2011 |
| 20110306514 | RATIO BASED BIOMARKERS AND METHODS OF USE THEREOF Compositions, methods and kits are described for identifying biomolecules (e.g., proteins and nucleic acids) expressed in a biological sample that are associated with the presence, development, or progression of a disease (such as cancer), or more generally determinatio... | 12/15/2011 |
| 20110306035 | Methods and Compositions for Detection of a Pathogen, Disease, Medical Condition, or Biomarker Thereof Provided are methods for detecting the presence or absence of a pathogen, disease, or medical condition, or biomarker thereof, using an enzymatic activity assay. In one embodiment, the method provided utilizes competitive inhibition of an enzyme for detecting a pathogen... | 12/15/2011 |
| 20110306521 | SEPARATION OF PYROPHOSPHATE RELEASE AND PYROPHOSPHATE DETECTION The present technology relates to methods and systems for detection of pyrophosphate. As such, disclosed herein are methods and systems that permit improved pyrophosphate detection. Also disclosed herein are methods and systems which utilize improved pyrophosphate detec... | 12/15/2011 |
| 20110306075 | METHODS RELATED TO MODIFIED GLYCANS Among other things, the present disclosure provides methods for enriching, identifying, and/or quantifying unusually modified glycans (e.g., phosphorylated glycans, sulfated glycans, and/or multi-acetylated glycans). In many embodiments, methods comprise providing a gly... | 12/15/2011 |
| 20110300532 | CONTROL OF THE TOXICITY OF GOLD NANOPARTICLES The present invention relates to gold nanocluster compounds, especially gold nanoparticles, having a reduced toxicity, especially cytotoxicity, which are preferably appropriate for use in medical diagnostics such as medical imaging (e.g. X-ray, CT etc.), said gold nanoc... | 12/08/2011 |
| 20110301217 | Selective Glycosidase Inhibitors and Uses Thereof The application relates to an immoalditol compound for selectively inhibiting glycosidases, a prodrug thereof and a pharmaceutical composition comprising the compound or the prodrug The application also relates to the use of the immoalditol compound for treating disease... | 12/08/2011 |
| 20110300566 | METHODS FOR SCREENING FOR HISTONE DEACETYLASE ACTIVITY AND FOR IDENTIFYING HISTONE DEACETYLASE INHIBITORS The present invention relates to novel methods for screening for histone deacetylase enzyme activity in a test sample. The present invention further relates to novel methods for screening potential inhibitors of histone deacetylase enzymes.... | 12/08/2011 |
| 20110301148 | DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF The invention relates to compounds corresponding to formula (I), in the form of the base or of an acid-addition salt: in which n is equal to 0, 1, 2, 3 or 4; m is equal to 0, 1 or 2; o is equal to 0 or 1; X r... | 12/08/2011 |
| 20110294788 | DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF AS HIF ACTIVATORS The present invention relates to novel substituted dihydropyrazolone derivatives, to their preparation and to their therapeutic use as activators of the transcription factor HIF.... | 12/01/2011 |
| 20110287464 | Chromogenic plating media for the identification of Enterobacter sakazakii A plating medium for identification of Enterobacter sakazakii bacteria having a carbohydrate, but Enterobacter sakazakii bacteria being incapable of fermenting any carbohydrate in the medium. The medium also contains a pH indicator dye that changes the color of the medi... | 11/24/2011 |
| 20110288082 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are disclosed for inhibiting p97 ATPase and the degradation of a p97-dependent ... | 11/24/2011 |
