Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Application No. | Application Title | Issue Date |
| 20120128580 | PRESELECTION OF SUBJECTS FOR THERAPEUTIC TREATMENT WITH ELESCLOMOL BASED ON HYPOXIC STATUS The present invention provides methods for the preselection of a subject for therapeutic treatment with elesclomol based on modulated levels of hypoxia in the subject. In one embodiment, the invention provides methods for the preselection of a subject for therapeutic tr... | 05/24/2012 |
| 20120107852 | METHOD FOR PREPARING MODIFIED POLYPEPTIDES Methods for producing polypeptide with altered immunogenicity or improved stability properties are disclosed. The methods involve
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| 20120107836 | DEVELOPMENT OF FLUORESCENTLY P-LOOP LABELLED KINASES FOR SCREENING OF INHIBITORS The present invention relates to a kinase labelled at an amino acid naturally present or introduced in the P-loop of said kinase, wherein said labelling is effected at a free thiol or amino group of said amino acid and said label is (a) a thiol- or amino-reactive fluoro... | 05/03/2012 |
| 20120107814 | Method for Determining the Predisposition of a Patient to Changed Biotransformation and to the Development of Undesired Drug Effects in a Treatment of the Patient with Atrovastatin A method for determining a predisposition of a patient to the development of muscular diseases and/or to changed biotransformation in a treatment of the patient with atorvastatin is disclosed. The presence of at least one single nucleotide polymorphism (SNP) in the UGT1... | 05/03/2012 |
| 20120108449 | CRYSTAL STRUCTURE OF ISOGLUTAMINYL CYCLASE A crystal comprising human isoglutaminyl cyclase having a characterised space group of P1211 and unit cell dimensions of +/−5% of a=126.51 Å, b=109.68 Å, c=159.53 Å, α=90.0°, β=104.9° and γ=90.0°.... | 05/03/2012 |
| 20120108500 | Compositions and Methods for Modulating Immunodeficiency Virus Transcription The present disclosure provides methods of modulating immunodeficiency virus transcription, involving modulating enzymatic activity and/or levels of a lysine-specific demethylase-1 (LSD1) polypeptide and/or LSD1-mediated demethylation of methylated Tat. The present disc... | 05/03/2012 |
| 20120108464 | TEST SYSTEMS, METHODS AND USES INVOLVING AS160 PROTEIN The present invention relates to a method of identifying a substance altering glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell comprising contacting a test system comprising AKT substrate 160 kDa-protein (AS160-protein) with a test substance, a... | 05/03/2012 |
| 20120083427 | KINASE AND PHOSPHATASE ASSAYS Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptid... | 04/05/2012 |
| 20120070848 | TUMOR CELL-DERIVED MICROVESICLES The present invention relates to a method for diagnosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anti-cancer treatment in a sample of a subject by detecting oncogenic proteins in microvesicles, and to the use of an age... | 03/22/2012 |
| 20120071339 | BIOMARKERS The invention relates to a method of diagnosing or monitoring multiple sclerosis.... | 03/22/2012 |
| 20120052518 | FLUORESCENT PROBE FOR MEASURING PROTEASE A compound represented by the formula (I) or a salt thereof (R1 represents hydrogen atom, or a substituent; R2 to R7 represent hydrogen atom, hydroxyl group, an alkyl group, or a halogen atom; R8 and R9 represent hy... | 03/01/2012 |
| 20120052506 | CYANINE DYES The invention provides a novel class of cyanine dyes that are functionalized with sulfonic acid groups and a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties... | 03/01/2012 |
| 20120053225 | AKT TYROSINE 176 PHOSPHORYLATION CANCER BIOMARKER AKT/PKB kinase is a key signaling component of one of the most frequently activated pathways in cancer and is a major target of cancer drug development. The present study uncovered that growth factors binding to RTKs lead to activation of a non-receptor tyrosine kinase,... | 03/01/2012 |
| 20120053208 | Curcumin Analogs as Dual JAK2/STAT3 Inhibitors and Methods of Making and Using the Same Curcumin analogues and methods of making and using the same are disclosed.... | 03/01/2012 |
| 20120053185 | METHOD TO TREAT MELANOMA IN BRAF INHIBITOR-RESISTANT SUBJECTS Methods to treat cancer patients, especially melanoma patients, who have BRAF mutations and have become resistant to BRAF mutant kinase inhibitors employ inhibitors of multiple receptor tyrosine kinases. In addition, methods are described for identifying pharmaceutical ... | 03/01/2012 |
| 20120045775 | PHOSPHOSPECIFIC PAK ANTIBODIES AND DIAGNOSTIC KITS The present invention relates to the use of phosphorylated p21-activated protein kinases (PAK), especially PAK4, as biomarkers of tumorogenesis. The present invention contemplates the use of phosphospecific antibodies for detecting phosphorylated PAK from mammalian biop... | 02/23/2012 |
| 20120045451 | Mnk KINASE HOMOLOGOUS PROTEINS INVOLVED IN THE REGULATION OF ENERGY HOMEOSTASIS AND ORGANELLE METABOLISM This invention relates to the use of nucleic acid sequences of the MAP kinase-interacting kinase (Mnk) gene family and amino acid sequences encoded thereby, and to using these sequences or effectors of Mnk nucleic acids or polypeptides, particularly Mnk kinase inhibitor... | 02/23/2012 |
| 20120046199 | METHOD FOR DETERMINING THE ESTROGEN RECEPTOR STATUS OF BREAST CANCER The present invention relates to a method for determining the estrogen receptor status of patients suffering from breast cancer. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with breast cancer to specif... | 02/23/2012 |
| 20120045452 | Mnk KINASE HOMOLOGOUS PROTEINS INVOLVED IN THE REGULATION OF ENERGY HOMEOSTASIS AND ORGANELLE METABOLISM This invention relates to the use of nucleic acid sequences of the MAP kinase-interacting kinase (Mnk) gene family and amino acid sequences encoded thereby, and to using these sequences or effectors of Mnk nucleic acids or polypeptides, particularly Mnk kinase inhibitor... | 02/23/2012 |
| 20120040387 | METHOD AND REAGENT FOR MEASURING MEVALONIC ACID, 3-HYDROXYMETHYLGLUTARYL COENZYME A, AND COENZYME A The present invention provides a method for measuring the concentration of an analyte in a test solution wherein the analyte is mevalonic acid and/or 3-hydroxymethylglutaryl coenzyme A, comprising the following steps (p) and (q): (p) a step of allowing an enzyme that ca... | 02/16/2012 |
| 20120040858 | BIOMARKERS FOR STROKE Biomarkers for stroke and methods for their detection are disclosed. In one aspect, the present application discloses biomarkers for the diagnosis of stroke in a subject. In another aspect, the application discloses a method for the diagnosis of stroke in a subject. The... | 02/16/2012 |
| 20120040976 | SMALL MOLECULE IMMUNOMODULATORS FOR ALZHEIMER'S DISEASE Disclosed are methods for identifying individuals suffering from a CNS disorder (including Alzheimer's Disease, ALS, behavioral disorders, and the like) that could be treated with a CNS drug with greater therapeutic efficacy and lower side effects and the compounds usef... | 02/16/2012 |
| 20120040361 | METHODS AND COMPOSITIONS FOR DETECTION OF LETHAL SYSTEM AND USES THEREOF Provided herein is a method for detecting the presence of lethal system in a patient using the expression of nuclear factor A (NFA) in marker cell. In another aspect, provided herein is a method for predicting if a patient has metastatic potential and is at risk of deve... | 02/16/2012 |
| 20120041017 | PYRIDOCARBAZOLE TYPE COMPOUNDS AND APPLICATIONS THEREOF Pyridocarbazole-type compounds of formula (I): are provided as a medicament, and more particularly for application in anticancer chemotherapy. Also provided is a pharmaceutical composition with the compound a... | 02/16/2012 |
| 20120034619 | METHOD OF DETERMINING THE OLIGOMERIC STATE OF A PROTEIN COMPLEX A method of counting protein subunits to determine the oligomeric state of an oligomeric protein complex includes tagging and expressing the protein subunits with a mass/charge tag and selectively removing each mass/charge tag. The number of protein subunits of the olig... | 02/09/2012 |
| 20120035076 | IRAK KINASE FAMILY AS NOVEL TARGET AND BIOMARKER FOR ALZHEIMER The present invention relates to methods and devices for the diagnosis or drug response prediction of neurological disorders by measuring kinase activity and studying the phosphorylation levels and profiles in samples of said patients. Furthermore the present invention ... | 02/09/2012 |
| 20120034614 | EARLY DETECTION OF PATHOGENS IN BLOOD The present invention is a method of extracting infectious pathogens from a volume of blood including the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expose the pathogens for analysis. The fibrin lysis reagent i... | 02/09/2012 |
| 20120028284 | TRAPPING COMPOUNDS AND METHOD FOR IDENTIFYING REACTIVE METABOLITES A compound of formula (I) is useful to identify reactive metabolites. [X is CH2, and p, q and r are each independently 0 or 1 with a proviso that the compound wherein p is 0, q is 0 and r is 1 is e... | 02/02/2012 |
| 20120030776 | NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, P... | 02/02/2012 |
| 20120022065 | C-Met Modulators and Method of Use The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazoline... | 01/26/2012 |
| 20120021929 | USE OF DPPIV/SEPRASE AS A MARKER FOR CANCER Described is a method aiding in the assessment of the presence of cancer. The method uses the soluble DPPIV/seprase protein complex (DPPIV/seprase) as a universal marker of different cancer types. Measurement of DPPIV/seprase complex can, e.g., be used in the early dete... | 01/26/2012 |
| 20120020953 | DIAGNOSIS AND TREATMENT OF CANCER Provided herein are methods for diagnosing cancer by determining the level of expression of SETDB1 in a biological sample. Also provided herein are methods for treating cancer by administering an inhibitor of SETDB1 to a subject in need thereof.... | 01/26/2012 |
| 20120014974 | METHODS OF MODULATING CELL DEATH BASED ON THE BIT1/AES REGULATORY PATHWAY The present invention provides a method of identifying an effective agent that alters the association of a Bit1 polypeptide with an AES polypeptide. The method is practiced by contacting a Bit1 polypeptide, or active fragment thereof, and an AES polypeptide, or active f... | 01/19/2012 |
| 20120015364 | METHOD FOR THE SELECTION OF ENDOTHELIAL CELLS DEATH INDUCERS VIA NETRIN-1 AND ITS APPLICATIONS The present invention relates to an in vitro method for selecting a compound capable to induce the death of endothelial cells, preferably endothelial cells from vessels or neovessels. The invention further comprises the use of netrin-1 function inhibitors as compounds c... | 01/19/2012 |
| 20120014937 | Human Beta-Adrenergic receptor kinase polypeptide and methods Various embodiments of the invention provide human kinases and phosphatases (KPP) polypeptides and polynucleotides which identify and encode KPP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embod... | 01/19/2012 |
| 20120014949 | Serum Biomarkers For Early Detection Of Acute Cellular Rejection The present invention provides an improved method of diagnosing a subject having received an organ transplant with Acute Cellular Rejection (ACR). The method comprises obtaining a biological sample from the subject, detecting an amount of at least one protein indicative... | 01/19/2012 |
| 20120009588 | LIVE BIOLOAD DETECTION USING MICROPARTICLES The present invention provides methods to concentrate cells onto microparticles, to concentrate the microparticles, and to detect the cells. The present invention also includes unitary sample preparation and detection devices to be used in accordance with the methods.... | 01/12/2012 |
| 20120010095 | METHODS FOR DIAGNOSIS AND PROGNOSIS OF PULMONARY HYPERTENSION The invention relates to diagnostic and prognostic assays and kits for pulmonary hypertension (PH) and types thereof. The invention includes detecting the expression level of markers associated with pulmonary hypertension for diagnosis, prognosis, or treatment of pulmon... | 01/12/2012 |
| 20120010100 | PLANT FARNESYLTRANSFERASES This invention relates to an isolated nucleic acid fragment encoding a farnesyltransferase subunit. The invention also relates to the construction of a chimeric gene encoding all or a portion of the farnesyltransferase subunit, in sense or antisense orientation, wherein... | 01/12/2012 |
| 20120010230 | METHODS AND COMPOSITIONS FOR IDENTIFICATION, ASSESSMENT AND TREATMENT OF CANCERS ASSOCIATED WITH HEDGEHOG SIGNALING Provided herein are methods, assays and kits for evaluating a sample, e.g., a sample obtained from a cancer patient, to detect one or more hedgehog biomarkers and/or one or more cilium markers. Thus, the invention can be used, inter alia, as a means to identify patients... | 01/12/2012 |
