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3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Application No. | Application Title | Issue Date |
| 20120052479 | METHODS, COMPOSITIONS AND DEVICES FOR INDUCING STASIS IN TISSUES AND ORGANS The present invention concerns the use of oxygen antagonists for inducing stasis in tissue, including all or part of organs. It includes methods and apparatuses for achieving stasis in tissue, so as to preserve and/or protect them. In specific embodiments, preservation ... | 03/01/2012 |
| 20120045460 | METHODS AND COMPOSITIONS FOR TREATMENT OF GRAFT REJECTION AND PROMOTION OF GRAFT SURVIVAL Embodiments of the present invention illustrate methods of treating and preventing transplantation and side effects associated with transplantation. In certain embodiments, compositions and methods relate to inhibition of graft rejection and promotion of graft survival.... | 02/23/2012 |
| 20120045449 | COMPOSITIONS, METHODS AND USES OF ALPHA 1-ANTITRYPSIN FOR EARLY INTERVENTION IN BONE MARROW TRANSPLANTATION AND TREATMENT OF GRAFT VERSUS HOST DISEASE Embodiments of the present invention relate to compositions and methods for treatment of subjects in need of or having a bone marrow transplant. Certain embodiments describe compositions and methods for treatment of conditions associated with bone marrow transplantation... | 02/23/2012 |
| 20120034593 | CYCLIC PEPTIDES WITH AN ANTI-PARASITIC ACTIVITY The present invention relates to a method for preparing a cyclic peptide with antiparasite activity and anticancer activity. The invention also relates to this peptide as an antiparasite agent, for example in the treatment of toxoplasmosis and as an anticancer agent. Th... | 02/09/2012 |
| 20120028234 | TISSUE AND ORGAN GRAFT BIOREACTOR AND METHOD OF OPERATION A single-use, single or multiple tissue, organ, and graft bioreactor and environmental control system is designed to replicate the necessary conditions for growth of tissues, organs, or grafts, while addressing problems in scaling up the tissue growth; adaptation to a s... | 02/02/2012 |
| 20120003194 | IN VITRO MICRO-ORGANS, AND USES RELATED THERETO Micro-organ cultures which include isolated populations of cells having specific characteristics are described. Salient features of the subject micro-organ cultures include the ability to be maintained in culture for relatively long periods of time, as well as the prese... | 01/05/2012 |
| 20120003195 | IN VITRO MICRO-ORGANS, AND USES RELATED THERETO Micro-organ cultures which include isolated populations of cells having specific characteristics are described. Salient features of the subject micro-organ cultures include the ability to be maintained in culture for relatively long periods of time, as well as the prese... | 01/05/2012 |
| 20110311959 | SOLUTION FOR PRESERVING LIVER The present invention provides a liver preservation solution containing trehalose and dibutyryl-cAMP. The content of nitroglycerin in the preservation solution is preferably lower than 0.44 mM. In the liver preservation solution of the present invention, since the toxic... | 12/22/2011 |
| 20110307967 | TetO-p16 Transgenic Mice Mice comprising a human p16 transgene operably linked to an inducible promoter and capable of controlled expression of p16 are provided. Also provided are cells, tissues, and organs obtainable from such mice, and methods for producing p16 transgenic mice.... | 12/15/2011 |
| 20110300237 | Protective solutions for organs Described is a protective solution for avoiding ischemic, storage or ischemia/reperfusion to organs, or to isolated cell systems, or to tissue components after perfusion, surgery, transplantation, or cryopreservation and subsequent reperfusion, which contains alkali ion... | 12/08/2011 |
| 20110287403 | Graft Tensioning Device A graft tensioning device comprising a basin capable of containing a fluid, a heating element capable of heating the fluid to an appropriate temperature, a tray disposed within the basin, and a graft holding fixture for maintaining a tissue graft in tension, permanently... | 11/24/2011 |
| 20110287404 | Stationary Bubble Reactors Reactors that allow mixing and gasification by converting the entire floor of the reactor vessel to a sparge filter is described.... | 11/24/2011 |
| 20110236874 | METHOD FOR FORMATION OF RENAL TUBULES There is provided a method of making a renal tubule. The method comprises seeding renal tubule cells onto a solid surface; culturing the renal tubule cells in a liquid growth medium to form a monolayer on the solid surface; and continuing culturing the renal tubule cell... | 09/29/2011 |
| 20110224779 | THIN COLLAGEN TISSUE FOR MEDICAL DEVICE APPLICATIONS This invention relates to processes of preparing heterogeneous graft material from animal tissue. Specifically, the invention relates to the preparation of animal tissue, in which the tissue is cleaned and chemically cross-linked using both vaporized and liquid cross-li... | 09/15/2011 |
| 20110200981 | Polymerized Hemoglobin Media And Its Use In Isolation And Transplantation of Islet Cells Solutions and suspensions comprising polymerized hemoglobin derived from human blood are disclosed. The solutions and suspensions may comprise cell culture medium, an enzyme (such as a protease), and/or a buffer. Processes of preparing the solutions and suspensions are ... | 08/18/2011 |
| 20110189252 | PHARMACEUTICAL COMPOSITIONS COMPRISING LIGNANS AND THEIR DERIVATIVES FOR TREATING HYPERPLASTIC DISEASES The present invention relates to a pharmaceutical composition comprising specific compounds which may be obtained from Leontopodium alpinum Cass. (Edelweiss). A preferred compound is leoligin (=(2S,3R,4R)-4-(3,4-dimethoxybenzyl)-2-(3,4-dimethoxyphenyl)tetrahydrof... | 08/04/2011 |
| 20110190572 | Methods and Compositions for Vein Harvest and Autografting The leading cause of graft failure is the subsequent development of intimal hyperplasia, which represents a response to injury that is thought to involve smooth muscle proliferation, migration, phenotypic modulation, and extracellular matrix (ECM) deposition. Surgical t... | 08/04/2011 |
| 20110178152 | COMPOSITION COMPRISING S-ALLYLMERCAPTO-N-ACETYLCYSTEINE (ASSNAC) FOR UP-REGULATION OF CELLULAR GLUTATHIONE LEVEL The present invention relates to S-allylmercapto-N-acetylcysteine (ASSNAC) and its pharmaceutically acceptable salts and solvates, which are useful for up-regulation of cellular glutathione levels and expression of phase II detoxifying enzymes. The invention further pro... | 07/21/2011 |
| 20110171625 | Media solutions and methods for cryopreservation and thawing of in vitro fertilization specimens A medium solution which will increase the growth, survival and ultimately the live birth rate of oocytes and embryos which have been or will be subjected to cryopreservation. The solution contains varied amounts of glucose, pyruvates, amino acids, vitamins K5 and C, ant... | 07/14/2011 |
| 20110171624 | Media solutions and methods for cryopreservation and thawing of in vitro fertilization specimens A medium solution which will increase the growth, survival and ultimately the live birth rate of oocytes and embryos which have been or will be subjected to cryopreservation. The solution contains varied amounts of glucose, pyruvates, amino acids, vitamins K5 and C, ant... | 07/14/2011 |
| 20110165553 | VITRIFIED COMPOSITION WHICH PRESERVES BIOLOGICAL MATERIALS The present invention relates to a method for preserving biological material comprising the steps of: providing a vitrification solution comprised of the biological material and a vitrification agent where the solution has a temperature in the range from 0.1° C. to 17.... | 07/07/2011 |
| 20110166650 | NEW TECHNIQUE FOR PREPARING, STORING AND TRANSPLANTING ENDOTHELIAL GRAFTS The present invention relates to a new isolated cornea wherein the Descemet's membrane is separated from the overlying corneal stroma by an air cushion. For “DMEK” surgery a spatula (1) is provided, comprising a rounded glide (2) suitable for receiving... | 07/07/2011 |
| 20110144074 | CASPASE INHIBITORS AND USES THEREOF This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R1 is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; | |
| 20110143331 | Methods and Compositions for the Preservation of Cells and Tissues Disclosed are methods for the preservation and storage of living biological tissues, organs, and populations of isolated cells. Also disclosed are compositions and methods to permit biological samples (including e.g., cells, cell cultures, tissues, and organs) to be har... | 06/16/2011 |
| 20110136095 | BIOREACTOR FOR PRODUCING A TISSUE PROSTHESIS, PARTICULARLY A HEART VALVE The invention relates to a bioreactor for producing a tissue prosthesis, particularly a heart valve, comprising a reactor chamber for holding a fluid nutrient medium and a prosthesis support, a device for placing the prosthesis support in the area of the reaction chambe... | 06/09/2011 |
| 20110129809 | METHODS FOR THE ANTI-INFLAMMATORY AND ANTI-EDEMATOUS PROTECTION OF EXPLANTED BIOLOGICAL MATERIAL UNTIL THE TRANSPLANTATION THEREOF IN PATIENTS The invention relates to a method for protecting transplants, as well as organs and individual blood vessels, against inflammatory reactions that are caused by the operative procedure linked to the explantation and storage until transplantation. This can be achieved by ... | 06/02/2011 |
| 20110110900 | NOVEL ADULT PROGENITOR CELL The invention relates to the isolation and use of a novel progenitor cell population from the lamina propria of the oral mucosa. The novel progenitor cell population is highly proliferative and can be differentiated into a range of cell lineages. Further, these novel pr... | 05/12/2011 |
| 20110111030 | Method of Producing Progenitor Cells from Differentiated Cells The present invention provides a method of producing progenitor cells, such as cells capable of being differentiated into a plurality of different cell types, from differentiated cells. Methods of using progenitor cells in differentiation and/or tissue or organ repair a... | 05/12/2011 |
| 20110110901 | METHODS OF LONG-TERM CULTURE OF EUKARYOTIC CELLS AND USES THEREOF An immortalizing protein complex, comprises an internalizing molecule, a transforming polypeptide and an endosome releasing molecule; all molecule and/or polypeptides being operatively linked to one or more of the other polypeptides, and optionally one or more of a nucl... | 05/12/2011 |
| 20110104656 | ARTIFICIAL KIDNEY PRECURSOR AND PROCESS FOR PRODUCTION THEREOF The present invention provides an artificial kidney precursor containing a non-human mammalian metanephros separated out from a living body, wherein the metanephros has been subjected to freezing and thawing treatments outside a living body, and contains mammalian mesen... | 05/05/2011 |
| 20110105835 | METHOD FOR PRESERVING SPERM AND APPLICATIONS THEREOF The invention relates to a sperm dilution medium that comprises a base medium to which are added yolk or yolk plasma, glycerol and native phosphocaseinate. The medium can particularly be used for the freeze-preservation of mammal sperm in order to enhance the fertilizat... | 05/05/2011 |
| 20110097700 | Methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in the blood Devices, systems, and methods reduce levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood by selective adsorption. The devices, systems, and methods are useful in situations where abnormal levels of or unregulated or excessive interaction am... | 04/28/2011 |
| 20110091862 | GENERATION OF AN HLA-NEGATIVE OSTEOGENIC PRECURSOR CELL LINE The present disclosure provides methods for producing human osteogenic cell lines in which HLA Class I expression is absent or reduced. The resulting osteogenic cells can then be used, for example, to form mineralized three-dimensional bone constructs which can be used,... | 04/21/2011 |
| 20110082199 | USE OF NON-TOXIC CROSSLINKING REAGENTS TO IMPROVE FATIGUE RESISTANCE AND REDUCE MECHANICAL DEGRADATION OF INTERVERTEBRAL DISC AND OTHER COLLAGENOUS TISSUES A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous tissue with an effective amount of a crosslinking reagent. The crosslinking... | 04/07/2011 |
| 20110076665 | ELECTROMAGNETIC CONTROLLED BIOFABRICATION FOR MANUFACTURING OF MIMETIC BIOCOMPATIBLE MATERIALS The precise application of an electromagnetic field controls cell motion to guide extrusion and deposition of biopolymers produced by the cells. This controlled biofabrication process is used to fabricate two- and three-dimensional networks of biocompatible nanofibrils ... | 03/31/2011 |
| 20110065083 | Compositions and Methods for Enhancing the Viability of Animal Cells, Tissues, and Organ Explants Disclosed are compositions and methods for the preservation, storage, and transport of living biological tissues, organs, and populations of isolated cells. In particular, the disclosed compositions and processes permit mammalian cells, tissues, and organs to be harvest... | 03/17/2011 |
| 20110059069 | Gapr-1 Methods Methods of treatment, diagnosis and screening related to GAPR-1 are disclosed.... | 03/10/2011 |
| 20110039253 | APPARATUS AND METHOD FOR MAINTAINING AND/OR RESTORING VIABILITY OF ORGANS An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing th... | 02/17/2011 |
| 20110027380 | CARBON DIOXIDE REMOVAL FROM WHOLE BLOOD BY PHOTOLYTIC ACTIVATION Apparatus and methods for removing carbon dioxide from whole blood. Hydrogen ions are generated from water in the blood, resulting in the formation and release of carbon dioxide from the blood.... | 02/03/2011 |
| 20110020295 | PRE-TRANSPLANT ACCOMMODATED ORGANS RESISTANT TO ANTI-DONOR IMMUNITY This invention includes the composition of organ grafts accommodated prior to transplantation and therefore resistant to rejection by preformed antibodies. Accommodation is achieved within the donor animal by administration of sub-lethal levels of accommodation inducing... | 01/27/2011 |
