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| Application No. | Application Title | Issue Date |
| 20120128637 | Cellular Seeding and Co-Culture of a Three Dimensional Fibroblast Construct The present invention provides methods for cellular seeding onto three-dimensional fibroblast constructs, three-dimensional fibroblast constructs seeded with muscle cells, and uses therefore.... | 05/24/2012 |
| 20120128636 | Gingiva Derived Stem Cell And Its Application In Immunodulation And Reconstruction The present invention relates to gingiva derived messenchymal stem cells (GMSCs). More specifically, the invention provides compositions and methods of using GMSCs to regulate inflammatory response in the setting of normal versus pathological wound healing and to treat ... | 05/24/2012 |
| 20120128641 | METHODS AND COMPOSITIONS FOR IMPROVING THE VIABILITY OF CRYOPRESERVED CELLS The present invention provides polymers and methods for increasing the viability of cryopreserved cells after thawing. Thawing cryopreserved cells in the presence of a polymer such as poloxymer P1 88 or other non-ionic polymers is thought to stabilize the membranes of t... | 05/24/2012 |
| 20120128640 | HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various disorders is provided. 05/24/2012 | |
| 20120128635 | METHODS AND COMPOSITIONS FOR TREATING HEMOPHILIA B Disclosed herein are methods and compositions for insertion of Factor IX (FIX) sequences into the genome of a cell for treating hemophilia B.... | 05/24/2012 |
| 20120128638 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF HEART DISEASES The present invention is related to a pharmaceutical composition comprising cells committed to the generation of heart tissue and at least one pharmaceutically acceptable excipient produced according to internationally recognized standards for pharmaceutical product man... | 05/24/2012 |
| 20120128642 | POTENCY MARKERS Methods for identifying trichogenic dermal cells, including dermal papilla cells and dermal sheath cells, capable of inducing hair follicle formation when injected into skin are provided. Biomarkers have been discovered that can be used to detect, identify, and distingu... | 05/24/2012 |
| 20120128739 | THREE-DIMENSIONAL NANOSTRUCTURED HYBRID SCAFFOLD AND MANUFACTURE THEREOF A method of making a three-dimensional biocompatible scaffold capable of supporting cell activities such as growth and differentiation, the method includes providing a supporting grid that forms an open network and provides mechanical support of a second biocompatible m... | 05/24/2012 |
| 20120128741 | MODIFIED HYALURONIC ACID POLYMER COMPOSITIONS AND RELATED METHODS The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled reaction of such lightly modified hyaluronic acid with suitable difunctional or multi-functional crosslinkers, and ... | 05/24/2012 |
| 20120128782 | Multicomponent Degradable Cationic Polymers Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a c... | 05/24/2012 |
| 20120128639 | In Vitro Production Of Oligodendrocytes From Human Umbilical Cord Stem Cells The invention provides a method of producing oligodendrocytes by in vitro differentiation of human multi-potent progenitor cells (MLPCs). The method comprises culturing isolated MLPCs on a first surface in a serum-free defined culture medium; replacing the culture mediu... | 05/24/2012 |
| 20120107318 | METHODS OF ADMINISTERING PIF AGONIST PEPTIDES AND USES THEREOF A novel class of embryo derived peptides are described (Preimplantation factor) that were generated synthetically and were tested on peripheral blood immune cells and shown to block activated but not basal immunity, inhibiting cell proliferation and creating a TH 05/03/2012 | |
| 20120107281 | COMPOSITIONS AND METHODS FOR MODIFYING CELL SURFACE GLYCANS Methods and compositions for modifying glycans (e.g., glycans expressed on the surface of live cells or cell particles) are provided herein.... | 05/03/2012 |
| 20120107282 | NEURAL STEM CELL COMPOSITION CAPABLE OF TREATING CANCER AND METHOD OF TREATMENT Disclosed is a method of treatment of an individual suffering from primary brain tumors (glioma and medulloblastoma) and brain metastases of extracranial cancers using human stem cells encoding therapeutic genes. The method includes giving the individual a clinically ac... | 05/03/2012 |
| 20120107384 | APPARATUS FOR FORMING AN IMPLANT Implants for repairing tissue defects, such as cartilage tissue defects, and methods of their preparation and use are disclosed. A mold of a tissue defect is prepared by pressing upon the defect a substrate having shape memory, such as aluminum foil. The mold, which has... | 05/03/2012 |
| 20120107403 | BLADDER RECONSTRUCTION The invention is directed to methods and devices for the reconstruction, repair, augmentation or replacement of laminarily organized luminal organs or tissue structures in a patient in need of such treatment. The device comprises a biocompatible synthetic or natural pol... | 05/03/2012 |
| 20120107283 | HUMAN SKIN EQUIVALENTS EXPRESSING EXOGENOUS POLYPEPTIDES The present invention relates generally to compositions for wound closure. More specifically, the present invention provides human skin equivalents engineered to express exogenous polypeptides (e.g., antimicrobial polypeptides and keratinocyte growth factor 2) and compo... | 05/03/2012 |
| 20120109107 | Muscle Derived Cells for the Treatment of Urinary Tract Pathologies and Methods of Making and Using the Same The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft ti... | 05/03/2012 |
| 20120082649 | PERIVASCULAR MESENCHYMAL PRECURSOR CELLS Mesenchymal precursors cells have been isolated from perivascular niches from a range of tissues utilizing a perivascular marker. A new mesenchymal precursor cell phenotype is described characterized by the presence of the perivascular marker 3G5, and preferably also al... | 04/05/2012 |
| 20120082642 | Reversal of Adult Onset Disorders with Granulocyte-Colony Stimulating Factors A method for treating adult onset neurodegenerative diseases and diabetes by administering an effective dose of Granulocyte-Colony Stimulating Factors.... | 04/05/2012 |
| 20120082704 | Oxygenated demineralized bone matrix for use in bone growth An improved composition for inducing bone growth is provided that is a combination of at least DBM and an oxygen carrier. Injection/implantation of a composition of DBM and an oxygen carrier (e.g. a perfluorocarbon) results in enhancement of bone formation compared to D... | 04/05/2012 |
| 20120070450 | LEUKEMIA STEM CELL MARKERS The invention provides a test method for predicting the initial onset or a recurrence of acute myeloid leukemia (AML) comprising (1) measuring the expression level of human leukemic stem cell (LSC) marker genes in a biological sample collected from a subject for a trans... | 03/22/2012 |
| 20120071855 | COMPOSITIONS AND METHODS OF VASCULAR INJURY REPAIR The present invention relates to pharmaceutical compositions comprising a chemotactic hematopoietic stem cell product comprising an enriched population of CD34+ cells containing a subpopulation of CD34+/CXCR-4+ cells having CXCR-4-mediated chemotactic activity, methods ... | 03/22/2012 |
| 20120070419 | METHOD OF ALTERING THE DIFFERENTIATIVE STATE OF A CELL AND COMPOSITIONS THEREOF The present invention provides a method of altering the differentiative state of cells utilizing innovative protein expression constructs encoding transcription factors. The methods and compositions described herein may be used to generate induced pluripotent stem (iPS)... | 03/22/2012 |
| 20120070427 | VORTEX-INDUCED SILK FIBROIN GELATION FOR ENCAPSULATION AND DELIVERY The present invention provided for a novel process of forming silk fibroin gels, and controlling the rate of β-sheet formation and resulting hydrogelation kinetics, by vortex treatment of silk fibroin solution. In addition, the vortex treatment of the present invention... | 03/22/2012 |
| 20120070418 | STEM CELLS FOR MUSCULOSKELETAL TISSUE REPAIR The stem cells that can be propagated and maintained for extended periods of time in culture in the absence of a feeder layer, and can be used to repair tissue damage. These cells are derived from fetal tissues and are able to repair different types of damage in musculo... | 03/22/2012 |
| 20120052012 | HIGHLY BIOCOMPATIBLE DUAL THERMOGELLING CHITOSAN/GLUCOSAMINE SALT COMPOSITIONS The present disclosure relates to a chitosan solution neutralized with amino-sugar carbonate buffering solution or amino-sugar phosphate buffering solution or phosphorylated aminosugar buffering solution. The resulting thermogelling chitosan composition is highly biocom... | 03/01/2012 |
| 20120052045 | Compositions and methods for modulating ischemic injury The invention is directed to methods of modulating ischemic injury in tissues and organs. The invention is further directed to methods of increasing time to ischemic injury in tissues and organs. Such methods utilize compositions comprising cells capable of modulating i... | 03/01/2012 |
| 20120052061 | THERAPIES FOR TREATING CANCER USING COMBINATIONS OF COX-2 INHIBITORS AND ANTI-HER2(ERBB2) ANTIBODIES OR COMBINATIONS OF COX-2 INHIBITORS AND HER2(ERBB2) RECEPTOR TYROSINE KINASE INHIBITORS Described herein are compositions and methods for using these compositions in the treatment of cancer, tumors, and tumor-related disorders in a subject.... | 03/01/2012 |
| 20120053558 | TISSUE REPAIR WITH MULTIPOTENT CELLS The invention relates to the field of medical science, in particular to technology directed at repairing defects in living, preferably human, tissue. The present invention provides a method for inducing differentiation of multipotent cells to a desired cell type, as wel... | 03/01/2012 |
| 20120052049 | Systemic, Allogenic Stem Cell Therapies For Treatment of Diseases in Animals A method for treating preselected diseases comprising the steps of providing a therapeutic dose of a mesenchymal stem cell composition, the mesenchymal stem cell composition comprising mesenchymal stem cells harvested from at least one tissue selected from the group con... | 03/01/2012 |
| 20120045460 | METHODS AND COMPOSITIONS FOR TREATMENT OF GRAFT REJECTION AND PROMOTION OF GRAFT SURVIVAL Embodiments of the present invention illustrate methods of treating and preventing transplantation and side effects associated with transplantation. In certain embodiments, compositions and methods relate to inhibition of graft rejection and promotion of graft survival.... | 02/23/2012 |
| 20120045512 | METHODS AND SUBSTRATES FOR DIFFERENTIATION OF NEURAL STEM CELLS The present invention is directed to methods and substrates for promoting the differentiation of neural stem cells to neurons.... | 02/23/2012 |
| 20120045394 | HUMAN AND MOUSE TARGETING PEPTIDES IDENTIFIED BY PHAGE DISPLAY The present invention concerns methods and compositions for in vivo and in vitro targeting. A large number of targeting peptides directed towards human organs, tissues or cell types are disclosed. The peptides are of use for targeted delivery of therapeutic agents, incl... | 02/23/2012 |
| 20120045419 | METHODS AND USES OF HYPOXIC COMPARTMENT CELLS The disclosure relates to methods of maintaining and/or expanding an in vitro population of hypoxia compartment cells comprising culturing said population of cells optionally in an oxygen controlled environment, wherein the population of hypoxia compartment cells is exp... | 02/23/2012 |
| 20120045420 | COMPOSITIONS AND IMPROVED SOFT TISSUE REPLACEMENT METHODS The present specification discloses compositions and methods of transplanting tissue useful for treating a soft tissue condition of an individual.... | 02/23/2012 |
| 20120045421 | METHODS FOR THE ISOLATION OF CARDIAC STEM CELLS Method for the isolation, expansion and preservation of cardiac stem cells from human or animal tissue biopsy samples to be employed in cell transplantation and functional repair of the myocardium or other organs. Cells may also be used in gene therapy for treating card... | 02/23/2012 |
| 20120045418 | PHARMACEUTICAL PREPARATION COMPRISING SUPERNATANT OF BLOOD MONONUCLEAR CELL CULTURE The present invention relates to a topical pharmaceutical preparation for treating an inflammatory skin condition, preferably a condition associated with ischemia, comprising a supernatant of a physiological solution obtainable by cultivating peripheral blood mononuclea... | 02/23/2012 |
| 20120045435 | COMPOSITIONS AND METHODS TO INHIBIT STEM CELL AND PROGENITOR CELL BINDING TO LYMPHOID TISSUE AND FOR REGENERATING GERMINAL CENTERS IN LYMPHATIC TISSUES The present invention relates to compositions and methods of inhibiting stem cell binding to organs and tissues, including the blocking of stem cell binding to germinal centers present in lymph tissue. Disclosed are compositions and methods for regenerating germinal cen... | 02/23/2012 |
| 20120045411 | SHORT BETA-DEFENSIN-DERIVED PEPTIDES The invention is directed to beta-defensin-derived peptides and their use in modulating the activity of hematopoietic cells and other CXCR4-expressing cells. Specifically, the invention provides compositions and methods useful in the treatment of cancer. The invention f... | 02/23/2012 |
