Famous Patents
The ice cream cone was invented at the St. Louis Worlds Fair by Ernest Hamwi in 1904. His waffle booth was next to an ice cream vendor who ran short of dishes. Hamwi rolled a waffle to hold ice cream and the cone was born.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Application No. | Application Title | Issue Date |
| 20120128594 | SELECTIVE INFARCTED-TISSUE-TARGETING BACTERIA AND USE THEREOF The present invention relates to bacteria which specifically target infracted tissue and use thereof. The present invention provides a selective infracted tissue-targeting bacterium for the first time, and can be used in selectively delivering drugs to the infracted tis... | 05/24/2012 |
| 20120128593 | USE OF A MAGNETIC RESONANCE IMAGING MEDIUM COMPRISING HYPERPOLARIZED 13C PYRUVATE FOR THE DETECTION OF INFLAMMATION OR INFECTION The invention relates to a method of 13C-MR imaging, 13C-MR spectroscopy and/or 13C-MR spectroscopic imaging of inflammation or infection using an imaging medium which comprises a hyperpolarized 13C-substance.... | 05/24/2012 |
| 20120128581 | Sincalide Formulations The invention features sincalide formulations that include an effective amount of sincalide, a bulking agent/tonicity adjuster, a stabilizer, a surfactant, a chelator, and a buffer. The invention also features kits and methods for preparing improved sincalide formulatio... | 05/24/2012 |
| 20120107229 | NOVEL NANO-PROBES FOR MOLECULAR IMAGING AND TARGETED THERAPY OF DISEASES The present inventions relate to compositions and methods for imaging and treating atherosclerotic diseases, pathogen infections, and tumors by administering actively targeting magnetic nanoparticles. In particular, the present inventions provide new types of targeting ... | 05/03/2012 |
| 20120082616 | Aptamer Conjugates for Targeting of Therapeutic and/or Diagnostic Nanocarriers The present invention provides targeted delivery compositions and their methods of use in treating and diagnosing a disease state in a subject.... | 04/05/2012 |
| 20120070383 | POLYMERIC NANO-CARRIERS WITH A LINEAR DUAL RESPONSE MECHANISM AND USES THEREOF The present invention features compositions in which nano-carriers are synthesized with polymers that respond to lower pH and/or ROS by being degraded. The compositions may be utilized to selectively deliver payloads within patients by responding to lower pH and/or ROS ... | 03/22/2012 |
| 20120052015 | END-CAPPED POLYMERS Polymers that can include an end-cap selected from Formula (I) and/or Formula (II) and a recurring unit of the Formulae (III), and/or (IV). The polymers can include various substituents such as drug, targeting agents, stabilizing agents, imaging agent and polydentate li... | 03/01/2012 |
| 20120052014 | FERRITIN BIOSENSOR AND METHODS OF USING THE SAME Disclosed herein are methods of diagnosing, monitoring and treating iron disorders using assays of serum ferritin. Some embodiments relate to detection and management of iron and iron-containing proteins in the body. For instance, the level of ferritin may be determined... | 03/01/2012 |
| 20120052003 | MICROORGANISMS FOR PREVENTING AND TREATING NEOPLASMS ACCOMPANYING CELLULAR THERAPY Provided are methods for using cellular compositions in combination with oncolytic viruses. The methods include administering oncolytic viruses for the inhibition and treatment of tumors caused by administration of cellular therapies, such as stem cell therapies. The me... | 03/01/2012 |
| 20120045398 | Method For The Manufacture Of Nanoparticle Complexes And Triblock Polymer Ligands And Products Thereof The present invention relates to the manufacture of triblock polymer ligands (30) and nanoparticle complexes (80). The nanoparticle complexes (80) comprise a capped nanoparticle (10) and the triblock polymer ligand (30). The triblock p... | 02/23/2012 |
| 20120045397 | ULTRASONICALLY-TRIGGERED DRUG VEHICLE WITH MAGNETIC RESONANCE IMAGING FUNCTION Present invention relates to an ultrasonically-triggered drug vehicle with magnetic resonance imaging function. In the delivery system of the invention, tracks the of drug vehicle carrying a certain drug (or drugs) is detectable by magnetic resonance imaging, and the re... | 02/23/2012 |
| 20120039803 | PRETARGETING KIT, METHOD AND AGENTS USED THEREIN Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse ele... | 02/16/2012 |
| 20120042398 | COMPOSITIONS FOR LABELING AND IDENTIFYING AUTOPHAGOSOMES AND METHODS FOR MAKING AND USING THEM The invention provides methods and compositions for detecting and measuring the amount of autophagosomes in cells or tissues, including biopsy samples, in vitro, in situ and/or in vivo. By detecting and measuring the amount of autophagosomes in cells or tissues, the met... | 02/16/2012 |
| 20120030780 | TARGETING OF SALL4 FOR THE TREATMENT AND DIAGNOSIS OF PROLIFERATIVE DISORDERS ASSOCIATED WITH MYELODYSPLASTIC SYNDROME (MDS) The present invention discloses nucleic acids, proteins, and antibodies for SALL4 (including isoforms SALL4A, SALL4B, and SALL4C), a zinc finger transcriptional factor. Further, methods are disclosed which demonstrate that constitutive expression of SALL4 increases leuk... | 02/02/2012 |
| 20120027686 | HK1-BINDING PROTEINS The invention features hK1 binding polypeptides as well as compositions comprising such polypeptides and methods of making and using such polypeptides.... | 02/02/2012 |
| 20120014868 | METHODS TO DIAGNOSE DEGENERATIVE DISC DISEASE Methods are provided that better describe, and localize the pain generator or suspected pain generator in and around spinal discs in relation to neck or back pain so as to improve the diagnosis of degenerative disc disease. In some embodiments, there are methods for dia... | 01/19/2012 |
| 20120003160 | Macrophage-Enhanced MRI (MEMRI) in a Single Imaging Session Methods for performing macrophage-enhanced MRI, utilizing a macrophage imaging agent, in a single imaging session are provided. The macrophage imaging agent may be an ultrasmall superparamagnetic iron oxide particle. One embodiment includes administering a macrophage im... | 01/05/2012 |
| 20110311444 | IMAGING DIAGNOSTIC AGENT AND EXTRACORPOREAL DIAGNOSTIC AGENT FOR INCURABLE NEUROLOGICAL DISEASES Disclosed are a curcumin derivative or a salt thereof, which contains a fluorine atom, represented by formula (I): (wherein R1a and R1b are each independently a hydrogen atom, alkyl, ace... | 12/22/2011 |
| 20110313677 | METHOD FOR DETERMINING THE LIVER PERFORMANCE OF A LIVING ORGANISM BY THE MEANS OF QUANTITATIVE MEASURING THE METABOLIZATION OF SUBSTRATES A method for determining the liver performance of a living organism, in particular a human, comprising administering at least one 13C labelled substrate, which is converted by the liver by releasing at least one 13C labelled metabolization product,... | 12/22/2011 |
| 20110311455 | ENCAPSULATED AGENT GUIDED IMAGING AND THERAPIES A nano-capsule construct for imaging and therapeutic uses and method for production are provided. One nano-probe embodiment based on genome-depleted plant brome mosaic virus (BMV) whose interior is doped with indocyanine green (ICG), an FDA-approved near infrared fluore... | 12/22/2011 |
| 20110300072 | Benzimidazole-derived compounds use as markers in the case of neurodegenerative diseases Use of benzimidazole-derived compounds of formula (I) according to the following structure, wherein x is a heteroatom selected from N, S, O, P, SO, SO2 and SO3, preferably from N, S and SO3 and most preferably from N and SO3; ... | 12/08/2011 |
| 20110293531 | Porphyrazine Optical and Dual Optical/MR Contrast and Therapeutic Agents Porphyrazines capable of localizing in a tumor of a mammal are disclosed. The porphyrazines are used in methods of imaging a tumor and in methods of treating tumors, either alone or in combination with a chemotherapeutic agent and/or radiation.... | 12/01/2011 |
| 20110293528 | ENEMA PREPARATIONS AND THEIR USE This invention relates to improved methods of photodynamic treatment and diagnosis of cancer and non-cancerous conditions, and in particular to improved enema preparations for use in such methods, said enema preparations comprising a photosensitiser which is 5-aminolevu... | 12/01/2011 |
| 20110293527 | Modified vaccinia virus strains for use in diagnostic and therapeutic methods Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tum... | 12/01/2011 |
| 20110287262 | NANOPARTICLES, NANOCAPSULES AND NANOGELS Acid-labile poly(N-vinyl formamide) (“PNVF”) nanocapsules were synthesized by free radical polymerization of N-vinyl formamide with optional active ingredients on the surface of silica nanoparticles. Polymerization in the presence of a novel cross-linker that contai... | 11/24/2011 |
| 20110280800 | IL-1 BINDING PROTEINS Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.... | 11/17/2011 |
| 20110274624 | CONTRAST AGENTS IN POROUS PARTICLES MRI imaging compositions are disclosed comprising non-chelated MRI contrast agents in the pores of at least one porous microparticle or nanoparticle. The compositions of the invention have been found to exhibit increased relaxivity and therefore, enhanced MRI imaging. T... | 11/10/2011 |
| 20110268654 | COMPOSITIONS AND METHODS FOR DELIVERING A SUBSTANCE TO A BIOLOGICAL TARGET The present application provides compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reaction for rapid and specific covalent delivery of a “payload” to a ligand bound to a biological target.... | 11/03/2011 |
| 20110268659 | HIGH SHEAR APPLICATION IN DRUG DELIVERY In this disclosure, methods and systems for drug delivery utilizing high shear are disclosed. In an embodiment, a method comprises (1) subjecting a therapeutic fluid containing a drug to high shear; and (2) obtaining a processed therapeutic fluid, wherein ... | 11/03/2011 |
| 20110256067 | Contrast agents endowed with high relaxivity The present invention relates to a novel class of paramagnetic ion-based contrast agents of formula (I), wherein a chelating backbone moiety is highly functionalized by the presence of one or more polyhydroxylated chain, that show a pharmacokinetic profile analogous to ... | 10/20/2011 |
| 20110250143 | PROCESS FOR PREPARING CHLORINS AND THEIR PHARMACEUTICAL USES The disclosed subject matter includes methods of preparation, properties, pharmaceutical compositions and methods of therapy of sulfonated chlorins and bacterioclorins designed for the photodynamic therapy (PDT) of hyperproliferative tissues such as tumors, hyperprolife... | 10/13/2011 |
| 20110250135 | Piperazine Derivatives for Binding and Imaging Amyloid Plaques and Their Use The invention relates to compounds of formula I, their synthesis and their use, in particular for detecting amyloid deposits in a patient.... | 10/13/2011 |
| 20110243855 | METHOD AND IMAGING MEDIUM FOR USE IN THE METHOD The invention relates to a method of 13C-MR detection using an imaging medium comprising hyperpolarised 13C acetate and to an imaging medium comprising hyperpolarised 13C-acetate.... | 10/06/2011 |
| 20110236307 | IN VIVO IMAGING METHOD The present invention provides an in vivo imaging method that facilitates the diagnosis of Parkinson's disease (PD) at an early stage. Early diagnosis is particularly advantageous as neuroprotective treatment can be applied to healthy neural cells to delay or even preve... | 09/29/2011 |
| 20110229414 | Contrast Agents For Detecting Protease Activity By Means Of Hyperpolarization And For Stratifying Patients A contrast agent is disclosed for imaging methods. In at least one embodiment the contrast agent includes a construct including i) at least two copies of a substrate for at least one tumor-specific protease, and ii) at least one linker having at least one recognition si... | 09/22/2011 |
| 20110223103 | Multimodal Imaging of Atherosclerotic Plaque Targeted to LOX-1 The present invention provides multiple modalities for detecting LOX-1. More particularly, an imaging composition is provided that allows for the in vivo imaging of atherosclerotic plaque.... | 09/15/2011 |
| 20110224608 | Compound for Local Deletion of Tumors A compound for injecting locally into an intratumoral space of a body made of a mixture of a biocompatible wax, admixed with biocompatible oil. The compound is liquid at a temperature above body temperature but compatible with the life of healthy cells. It exhibits an i... | 09/15/2011 |
| 20110217241 | CONJUGATES OF 19F MR IMAGING TRACERS FOR USE IN MULTI-CHROMIC MRI IMAGING Compositions for producing multi-chromic (“color”) magnetic resonance images (MRI). The compositions for use as MRI imaging agents include a magnetic resonance imaging tracer having a signal emitter, such as a 19F imaging tracer (19FIT), conjug... | 09/08/2011 |
| 20110213293 | LIGANDS TO RADIATION-INDUCED MOLECULES A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecu... | 09/01/2011 |
| 20110200534 | T1-T2 Dual Modal MRI Contrast Agents The present invention relates a T1-T2 dual-modal MRI (magnetic resonance imaging) contrast agent, comprising (a) a first layer consisting of T1 contrast material; (b) a second layer consisting of T2 contrast material; and (c) a separating layer which is present in a spa... | 08/18/2011 |
