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| Application No. | Application Title | Issue Date |
| 20130129841 | THERAPEUTIC COMBINATION COMPRISING A PARP-1 INHIBITOR AND AN ANTI-NEOPLASTIC AGENT The present invention provides a therapeutic combination comprising (a) a compound of formula (I) as set forth in the specification and (b) one or more antineoplastic agents selected from the group consisting of an alkylating or alkylating-like agent, an antimetabolite ... | 05/23/2013 |
| 20130129618 | EGCG STABILIZED GOLD NANOPARTICLES AND METHOD FOR MAKING SAME The invention provides stabilized, biocompatible gold nanoparticles that are stabilized with material from epigallocatechin Gallate (EGCg), which is a polyphenols- or flavanoids-rich plant material that can be obtained from green tea. The EGCg is an an antioxidant reduc... | 05/23/2013 |
| 20130129840 | COMBINATION THERAPY USING A RUTHENIUM COMPLEX A combination therapy is disclosed for treating cancer. The method comprises administering to a cancer patient a therapeutically effective amount of trans-[tetrachlorobis(1H-indazole)ruthenate(III)] or a pharmaceutically acceptable salt thereof, and administering to the... | 05/23/2013 |
| 20130121986 | NITROGENATED DERIVATIVES OF PANCRATISTATIN The present invention concerns nitrogenated derivatives of narciclasine and pancratistatin of the following general formula (I) as well as their pharmaceutically acceptable salts. The present invention also concerns the use of these compounds in cancer therapy as well a... | 05/16/2013 |
| 20130122110 | ANTI-HUMAN UROTHELIAL CARCINOMA OF SUPERCRITICAL CARBON DIOXIDE EXTRACT OF CINNAMOMUM SUBAVENIUM, AND THE PREPARATION PROCESS AND USES What is disclosed in the invention is a preparation method of a supercritical Cinnamomum subavenium extract, which is made from the material, the dried stem of C. subavenium. The extract is obtained by extracting C. subavenium which is pulverized as... | 05/16/2013 |
| 20130121994 | TRIAZOLOPYRIDINE DERIVATIVES The present invention relates to triazolopyridine compounds of general formula (I) which are Monopolar Spindle 1 kinase (Mps-1 or TTK) inhibitors in which R1, R2, R3, R4, and R5 are as given in the description and i... | 05/16/2013 |
| 20130121963 | N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVES This disclosure relates to novel N-phenyl-2-pyrimidineamines and pharmaceutically acceptable salts thereof. This disclosure also provides compositions comprising a compound of this disclosure and the use of such compositions in methods of treating diseases and condition... | 05/16/2013 |
| 20130122112 | Derivatized Hyperbranched Polyglycerols Herein are provided derivatized hyperbranched polyglycerols (“dHPGs”). The dHPG comprises a core comprising a hyperbranched polyglycerol derivatized with C1C20 alkyl chains and a shell comprising at least one hydrophilic substituent bound to hy... | 05/16/2013 |
| 20130122111 | METHOD FOR TREATMENT OF ADVANCED SOLID TUMORS The present invention relates to the use of Volasertib or a salt thereof or a hydrate thereof in combination with Cisplatin or Carboplatin or a salt thereof or a hydrate thereof for treating patients suffering from advanced and/or metastatic solid tumours.... | 05/16/2013 |
| 20130122063 | Nanotubes as Mitochondrial Uncouplers A method of uncoupling mitochondria in a subject including administering nanotubes to the subject in a therapeutically effective amount, wherein the nanotubes are self-rectifying is provided. A method of decreasing reactive oxygen species and decreasing detrimental load... | 05/16/2013 |
| 20130122113 | ANTITUMORAL COMBINATION COMPRISING OMBRABULIN, A TAXANE DERIVATIVE AND A PLATINUM DERIVATIVE The invention concerns an antitumoral combination comprising ombrabulin, a taxane derivative and a platinum derivative and its use in the treatment of advanced solid tumors.... | 05/16/2013 |
| 20130121912 | MICRORNA-198 AS A TUMOR SUPPRESSOR IN PANCREATIC CANCER A novel network of tumorigenic prognostic factors is identified that plays a critical role in advanced pancreatic cancer (PC) pathogenesis. This interactome is interconnected through a central tumor suppressive microRNA, miR-198, which is able to both directly and indir... | 05/16/2013 |
| 20130122114 | METHODS AND COMPOSITIONS FOR INHIBITING THE NUCLEAR FACTOR KAPPAB PATHWAY The current invention provides therapeutic methods which include inhibition of nuclear factor κb pathway in a cell based on the discovery of an active fraction of a plant extract termed NUP or a composition which includes NUP. NUP is used in treating and managing diffe... | 05/16/2013 |
| 20130115210 | Peptide for Use in the Treatment of Breast Cancer and/or Bone Metastases The invention relates to the use of the Peptide of the formula Cyclo-(Arg-Gly-Asp-DPhe-NMe-Val) and/or the pharmaceutically acceptable dervatives, solvates and/or salts thereof, for the manufacture of a medicament for the treatment of breast cancer and/or bone metastase... | 05/09/2013 |
| 20130115309 | METHODS FOR IDENTIFYING AND USING INHIBITORS OF CASEIN KINASE 1 EPSILON ISOFORM FOR INHIBITING THE GROWTH AND/OR PROLIFERATION OF MYC-DRIVEN TUMOR CELLS In one aspect, the invention provides a method for inhibiting the growth and/or proliferation of a myc-driven tumor cell comprising the step of contacting the tumor cells with a CSNK1ε inhibitor. In another aspect, the invention provides a method of treating a subject ... | 05/09/2013 |
| 20130115310 | Compounds Useful as Inhibitors of ATR Kinase The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions u... | 05/09/2013 |
| 20130115273 | Combinational Liposome Compositions for Cancer Therapy The present invention provides methods for delivery of therapeutic agents to a subject using multi-component liposomal systems. The methods include administration of a therapeutic liposome containing an active agent, followed by a administration of an attacking liposome... | 05/09/2013 |
| 20130115311 | Compounds Useful as Inhibitors of ATR Kinase The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions u... | 05/09/2013 |
| 20130115313 | Compounds Useful as Inhibitors of ATR Kinase The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions u... | 05/09/2013 |
| 20130115312 | Compounds Useful as Inhibitors of ATR Kinase The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions u... | 05/09/2013 |
| 20130115314 | Compounds Useful as Inhibitors of ATR Kinase The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions u... | 05/09/2013 |
| 20130108711 | METHODS FOR TREATING DISEASES OF THE LUNG Provided herein are methods of treating diseases of the lung in a mammal, including cancer of the lung, mesothelioma, emphysema, and bronchopleural fistula. The methods comprise delivering a biocompatible hydrogel polymer optionally comprising a therapeutic agent direct... | 05/02/2013 |
| 20130101679 | CHOLESTANOL DERIVATIVE FOR COMBINED USE The invention provides a cancer chemotherapeutic agent which has fewer side effects and excellent efficacy. The cancer chemotherapeutic agent of the invention includes a cholestanol derivative represented by formula (1): 04/25/2013 | |
| 20130101680 | RADIOTHERAPY ENHANCER The present invention relates to a method of treating pancreatic cancer in a subject in need thereof by administering an effective amount of a composition containing (A) tegafur and (B) gimeracil in conjunction with radiotherapy.... | 04/25/2013 |
| 20130101514 | COMPOSITIONS AND METHODS FOR TREATING NEPHROPATHY Activated fatty acids, pharmaceutical composition compositions including activated fatty acids, methods for using activated fatty acids to treat nephropathy, and methods for preparing activated fatty acids are provided herein.... | 04/25/2013 |
| 20130101552 | METHODS AND COMPOSITIONS FOR CONTRIBUTING TO THE TREATMENT OF CANCERS Methods and compositions for contributing to the treatment of cancers, especially ovarian tumors, are disclosed. The methods and compositions utilize an endothelin B agonist (ETB) to enhance the delivery and resulting efficacy of chemotherapeutic agent(s) (e.... | 04/25/2013 |
| 20130095193 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions u... | 04/18/2013 |
| 20130095170 | METHODS AND SYSTEMS FOR IDENTIFYING AND TREATING ANTI-PROGESTIN SENSITIVE TUMORS Methods and systems for identifying and treating a patient suspected of having a tumor susceptible to growth inhibition by anti-progestins are provided. The degree of focal distribution of the progesterone receptor can be used to identify tumors susceptible to treatment... | 04/18/2013 |
| 20130089624 | Compounds Useful as Inhibitors of ATR Kinase The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions u... | 04/11/2013 |
| 20130089625 | Compounds Useful as Inhibitors of ATR Kinase The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions u... | 04/11/2013 |
| 20130089597 | MicroRNA-130a,b as a Tumor Suppressor and Sensitizing Agent for Chemotherapy The present invention provides a method of improving a therapeutic response to a cancer treatment, in a subject, the method comprising administering an effective amount of an agent that enhances the expression of microRNA-130 or an agent that mimics the effects of micro... | 04/11/2013 |
| 20130089626 | Treating Cancer with ATR Inhibitors This invention relates to methods and compositions for treating pancreatic cancer. More specifically, this invention relates to treating pancreatic cancer with certain ATR inhibitors in combination with gemcitabine and/or radiation therapy. This invention also relates t... | 04/11/2013 |
| 20130089627 | METHOD FOR TREATING A CANCER CAUSED BY CANCER STEM CELLS This invention provides a method for treating a cancer caused by cancer stem cells in a subject in need thereof, comprising administering to the subject an effective amount of Antrodia camphorata extracts. The invention also provides a method for treating a cance... | 04/11/2013 |
| 20130084319 | BROAD-SPECTRUM ANTIMICROBIAL COMPOSITIONS BASED ON COMBINATIONS OF TAUROLIDINE AND PROTAMINE AND MEDICAL DEVICES CONTAINING SUCH COMPOSITIONS Novel antimicrobial compositions and coatings are disclosed. The antimicrobial compositions consist of mixtures of taurolidine and protamine, including protamine salts. The antimicrobial compositions are particularly useful in coatings for implantable medical devices. T... | 04/04/2013 |
| 20130084345 | INDIBULIN THERAPY The invention provides combination therapy, wherein one or more other therapeutic agents are administered with indibulin or a pharmaceutically acceptable salt thereof and the combination is synergistic. Another aspect of the invention relates to the treatment of cancer ... | 04/04/2013 |
| 20130084242 | COMBINATORIAL THERAPIES FOR THE TREATMENT OF NEOPLASIAS USING THE OPIOID GROWTH FACTOR RECEPTOR The present invention relates to pharmaceutical compositions for treating neoplasias in an animal or human comprised of a carrier and therapeutically effective amounts of at least one chemotherapeutic agent along with the biotherapeutic endogenous pentapeptide Met-enkep... | 04/04/2013 |
| 20130078288 | Method of Treating Cancer A method and composition for administering a therapeutic composition to a lesion comprising about 20% to about 50% ethanol and other novel therapeutic agents.... | 03/28/2013 |
| 20130078319 | DETECTION OF OVARIAN CANCER Among other things, the present disclosure provides a method including the steps of: obtaining a uterine sample; and detecting and/or characterizing in the uterine sample an ovarian cancer biomarker (e.g., CA125).... | 03/28/2013 |
| 20130071323 | THERAPIES FOR HEMATOLOGIC MALIGNANCIES The invention provides methods that relate to a novel therapeutic strategy for the treatment of hematological malignancies and inflammatory diseases. In particular, the method comprises administering a compound of formula A,
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| 20130064902 | PHOSPHAPLATINS AND THEIR USE FOR TREATMENT OF CANCERS Stable monomeric phosphaplatins, namely, (pyrophosphato)platinum(II) or platinum(IV) complexes containing a cis-cyclohexanediamine ligand or enantiomerically enriched or enantiopure trans-cyclohexanediamine ligands, and synthesis of these complexes, are provided. Effica... | 03/14/2013 |
