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Class 424/491 - Containing proteins and derivatives


Subclass of Class 424 - Drug, bio-affecting and body treating compositions
Definition: Subject matter in which the particle is coated with a protein
No. of applications: 132
Last issue date: 05/24/2012


1        
Application No.Application TitleIssue Date
20120128779PROCESS FOR PRODUCING PROTEIN MICROPARTICLES
The present invention relates to a process for producing protein microparticles in dilute organic acid solutions and in the absence of an alcohol such as ethanol. The microparticles are formed by dissolving a cereal prolamin protein in a concentrated organic acid soluti...
05/24/2012
20120128592SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) COMPOUNDS AND METHODS OF THEIR PREPARATION
A compound for detecting an analyte using Surface Enhanced Raman Spectroscopy (SERS) and a method of forming the compound is provided. The compound has Formula I:

wherein W is selected from the group consisti...

05/24/2012
20120128780NANOPARTICULATE BISPHOSPHONATE COMPOSITIONS
Nanoparticulate bisphosphonate compositions, having an effective average particle size of less than 2000 nm, are described. The compositions are useful in treating bone resorption in a mammal....
05/24/2012
20120107407BONE GRAFT AND BIOCOMPOSITE FOR PROSTHETIC DENTISTRY
A bone graft or biocomposite for treating osseous defects and neogenesis of bone which is a composite of a biodegradable polymer and granules of beta-tricalciumphosphate, further comprising as active ingredient and embedded in the biodegradable polymer a physiologically...
05/03/2012
20120082728MULTIFUNCTIONAL STEALTH NANOPARTICULES FOR BIOMEDICAL USE
The present invention relates to the field of drug delivery nanosystems. More precisely, the present invention concerns a copolymer with advantageous properties for the outer coating of various nanoparticles. Said copolymer comprises at least three types of monomers wit...
04/05/2012
20120070502METHODS OF TREATING CANCER
The present invention provides methods and compositions for treating non-small-cell lung cancer (NSCLC) by administering a) a composition comprising nanoparticles that comprise paclitaxel and an albumin and b) a platinum-based agent (e.g., carboplatin). The present appl...
03/22/2012
20120052127EXPANDED POLYSTYRENE PARTICLES HAVING SKIN LAYER WITH SUPERIOR MOLDABILITY, METHOD FOR PREPARING THE SAME AND EXPANDED POLYSTYRENE MOLDED ARTICLE USING THE SAME
Disclosed are an expanded polystyrene particle having a skin layer with superior moldability, a method for preparing the same, and an expanded polystyrene molded article using the same. Provided is an expanded polystyrene particle provided on the surface thereof with a ...
03/01/2012
20120021058PROCESS FOR MAKING DRY AND STABLE HEMOSTATIC COMPOSITIONS
Described is a process for making a dry and stable hemostatic composition, said process comprising
    • a) providing a dry g...
01/26/2012
20120015037FUNCTIONALIZED NANOPARTICLE, METHOD FOR PREPARING THE SAME AND APPLICATION THEREOF
The present invention relates to a new type of functionalized nanoparticles for drug delivery, comprising a type of polymer nanoparticles, a polymer stabilizer coating, and a drug, wherein said polymer stabilizer coating is coated on the surface of said type of polymer ...
01/19/2012
20110318423Methods and Apparatus for Creating Particle Derivatives of HDL with Reduced Lipid Content
The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. The...
12/29/2011
20110311616TARGETING TUMOR ASSOCIATED MACROPHAGES USING BISPHOSPHONATE-LOADED PARTICLES
Provided herein are compositions including particles that comprise a bisphosphonate compound and a tumor specific targeting peptide or peptidomimetic. Also provided herein are methods of reducing tumor associated macrophages and methods of treating cancer with said comp...
12/22/2011
20110305765PREPARATION AND METHODOLOGY OF SILK FIBROIN NANOPARTICLES
Disclosed are nanoparticles for delivery of drugs and/or nutraceuticals that include a fibroin polypeptide and a drug or nutraceutical, wherein the nanoparticle has a diameter of about 1 nm to about 500 nm, and compositions of the nanoparticles. The nanoparticles may fu...
12/15/2011
20110293728PHOTOSENSITIZER-METAL NANOPARTICLE COMPLEX AND COMPOSITION CONTAINING THE COMPLEX FOR PHOTODYNAMIC THERAPY OR DIAGNOSIS
Provided are a photosensitizer-metal nanoparticle complex and a composition for photodynamic therapy or diagnosis having the same. The complex includes a photosensitizer, a metal nanoparticle, and a backbone linking the photosensitizer with the metal nanoparticle. The b...
12/01/2011
20110280944FIBROUS MICROCAPSULES AND METHODS OF ASSEMBLY AND USE THEREOF
The present invention relates to assembly of peptide amphiphiles and biopolymers into fibrous microcapsules, and uses thereof. In particular, the present invention provides devices, compositions, and methods for interfacial self-assembly of peptide amphiphiles and biopo...
11/17/2011
20110274761POLYMER CARRIER
Compositions and methods for delivering bioactive agents, such as vitamins, hormones, nutrients and drugs, by stabilizing and or solubilizing these agents in a polymer matrix. The carrier polymers can be used in drug delivery and are useful for delivery of small molecul...
11/10/2011
20110268792SURFACE ACTIVE PROTEINS AS EXCIPIENTS IN SOLID PHARMACEUTICAL FORMULATIONS
The invention relates to a use of surface active hydrophobins for applications in pharmaceutical technology, in particular as excipients for galenic use. Provided is a method for either admixture of hydrophobins to galenic compositions or for treating the surface of pha...
11/03/2011
20110268807Biodegradable Microspheres and Methods of Use Thereof
The present invention provides biodegradable microspheres, compositions comprising a subject biodegradable microsphere, and methods of using a subject biodegradable microsphere for delivery of an agent to a site in an individual....
11/03/2011
20110262546GOLD NANOPARTICLES COATED WITH POLYELECTROLYTES AND ALBUMIN
It is described a gold nanoparticle coated with from two to five layers of a combination of a polyelectrolyte having amino functionality and a polyelectrolyte having sulfonic functionality, or with one single layer of said polyelectrolyte having amino functionality, pre...
10/27/2011
20110256228Solid Forms for Tissue Repair Background of the Invention
This invention provides coral-based scaffolds for cartilage repair, and instruments for insertion and utilization of same within a site of cartilage repair....
10/20/2011
20110236466CHEMO VECTOR THERAPY TO DELIVER CHEMOTHERAPY MOLECULES TO SPECIFIC CELLS TO MANAGE BREAST CANCER, OTHER CANCERS AND INFLAMMATORY DISORDERS
The innovative treatment strategy described here utilizes configurable microscopic medical payload delivery devices to act as a transport means to deliver chemotherapy molecules to specific cell types in the body. Utilizing probes present on the exterior of the transpor...
09/29/2011
20110236493POROUS MATERIALS
A consumer care composition or a food composition comprising a mesoporous microparticulate material wherein at least some of the pores of the material are loaded with at least one ingredient and the loaded mesoporous microparticulate material is encapsulated by a cappin...
09/29/2011
20110206771Encapsulated functional fine particle composition capable of spraying and preparation method thereof
Provided is an encapsulated functional fine particle composition capable of spraying that is useful for hemostasis and wound protection and allows a patient to treat the wound by oneself. Additionally, the composition can be rapidly applied on a large wound during an op...
08/25/2011
20110195126PEPTIDE-COATED NANOPARTICLES WITH GRADED SHELL COMPOSITIONS
A peptide-coated nanoparticle that includes a nanocrystal surrounded by a graded shell that is composed of at least two different semiconductor molecules. At least one peptide is attached to the surface of the graded shell to render the nanoparticle biocompatible. The n...
08/11/2011
20110189299PHARMACEUTICAL COMPOSITION CONTAINING SURFACE-COATED MICROPARTICLES
The invention provides a pharmaceutical composition that can be used for efficient administration of low-molecular weight drugs and polymeric compounds such as peptides and proteins by methods other than injection, as well as a method for producing the composition. The ...
08/04/2011
20110177153 TARGETED NANOPARTICLE DRUG FOR MAGNETIC HYPERTHERMIA TREATMENT ON MALIGNANT TUMORS
The present invention relates to a targeted magnetic nanoparticle drug and the preparation method thereof. The targeted magnetic nanoparticle drug comprises an effector molecule and a guidance molecule in a weight ratio of 1:0.0001-0.20. The aforesaid effector molecule ...
07/21/2011
20110165255MALIGNANT TUMOR HEAT THERAPY KIT COMPRISING ANTI-REGULATORY T CELL ANTIBODY AND MAGNETIC FINE PARTICLES AND HEAT THERAPY METHOD THEREOF
The present invention discloses a heat therapy kit for malignant tumor treatment that comprises a pharmaceutical agent containing anti-regulatory T cell antibody and a pharmaceutical agent containing magnetic fine particles, and a heat therapy method that uses that kit....
07/07/2011
20110165256COMPOSITIONS AND METHODS FOR TREATMENT OF HYPERPLASIA
In accordance with the present invention, there are provided methods for treating hyperplasia in a subject in need thereof. In another aspect of the invention, there are provided methods for reducing neointimal hyperplasia associated with vascular interventional procedu...
07/07/2011
20110159103Novel Preparation of an Enteric Release System
Hydrophobic liquids are microencapsulated by an enteric matrix in an environment substantially free of organic solvents. The process includes forming an emulsion of the enteric material and hydrophobic liquid in water, titrating the emulsion with an acid to form a parti...
06/30/2011
20110151012COMPOSITIONS COMPRISING POORLY WATER SOLUBLE PHARMACEUTICAL AGENTS AND ANTIMICROBIAL AGENTS
The present invention provides compositions comprising a poorly water soluble pharmaceutical agent, a carrier protein, and an antimicrobial agent, wherein significant microbial growth is inhibited in the composition. The amount of the antimicrobial agent in the composit...
06/23/2011
20110123632Nanoscale Adjuvants and Related Pharmaceutical Compositions and Methods
Described herein are nanoscale adjuvants for use in pharmaceutical compositions. In one embodiment, a pharmaceutical composition includes: (a) a vaccine; and (b) a nanoscale adjuvant including an aluminum compound in the form of clusters having a peak size in the sub-mi...
05/26/2011
20110123438UNIVERSAL ANCHOR PEPTIDE FOR NANOPARTICLES
The present invention provides a substantially non-lytic, non-cytotoxic anchor peptide that is capable of stably inserting into lipid membranes. In particular, the invention provides nanoparticles comprising stably inserted anchor peptides, which may be conjugated to a ...
05/26/2011
20110117204IMMUNOLOGICALLY ACTIVE COMPOSITIONS
This invention provides a microparticle carrier system comprising of one or more proteins, peptides, nucleic acids, carbohydrates, lipids or other bioactive substances with or without targeting molecules attached. In addition, the invention also provides immune modulato...
05/19/2011
20110111040POLYELECTROLYTE-ENCAPSULATED GOLD NANOPARTICLES CAPABLE OF CROSSING BLOOD-BRAIN BARRIER
A gold-creatine nanoparticle is described, preferably covered with albumin, together with a process for its preparation and its use as medicament, in particular for the treatment of stroke. Said gold nanoparticle is capable of crossing the blood-brain barrier....
05/12/2011
20110111021PHARMACEUTICAL PREPARATION
The present invention provides a pharmaceutical preparation including a compartment containing a renin inhibitor as a pharmacologically active ingredient, and a compartment containing an HMG-CoA reductase inhibitor as a pharmacologically active ingredient, wherein one c...
05/12/2011
20110104069MULTI-FUNCTIONAL BIODEGRADABLE PARTICLES FOR SELECTABLE TARGETING, IMAGING, AND THERAPEUTIC DELIVERY AND USE THEREOF FOR TREATING OCULAR DISORDERS
In various embodiments, provided are multi-functional biodegradable particles for selectable targeting, imaging, and delivery of therapeutic agents. Also provided are methods of using the provided particles for treatment of ocular disorders, such as for the treatment of...
05/05/2011
20110091562NANOGELS FOR CELLULAR DELIVERY OF THERAPEUTICS
The various embodiments of the present disclosure relate generally to nanogels for the cellular delivery of therapeutics and methods of using the same. More particularly, the various embodiments of the present invention are directed to systems and methods for the target...
04/21/2011
20110059181METHODS FOR DRUG DELIVERY COMPRISING UNFOLDING AND FOLDING PROTEINS AND PEPTIDE NANOPARTICLES
The present invention provides preparation methods of protein nanoparticles for in vivo delivery of pharmacologically active agents, wherein said methods are to encase pharmaceutically active agents into proteins or peptides to form nanoparticles by unfolding the protei...
03/10/2011
20110052709NOVEL NANOPARTICLES FOR DELIVERY OF ACTIVE AGENTS
Milled nanoparticles comprising a biologically active agent, at least one biopolymer and a coating containing at least one coating which is a polymer or ligand are produced using milling and coating techniques which have not previously been used for these applications....
03/03/2011
20110052708METHODS AND FORMULATIONS FOR THE DELIVERY OF PHARMACOLOGICALLY ACTIVE AGENTS
In accordance with the present invention, novel formulations have been developed which are much more effective for the delivery of hydrophobic drugs to patients in need thereof than are prior art formulations. Invention formulations are capable of delivering more drug i...
03/03/2011
20110054442Cell Membrane Translocation of Regulated Snare Inhibitors, Compositions Therefor, and Methods for Treatment of Disease
Compositions and methods of modulating cellular function and treatment of disease in mammals comprising locally administering a regulated SNARE inhibitor and a translocating agent to the mammal. Regulated SNARE inhibitors include clostridial neurotoxins, tetanus neuroto...
03/03/2011
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