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| Application No. | Application Title | Issue Date |
| 20130058995 | Composition and method for weight reduction Disclosed is a composition and method for facilitating weight loss in individuals. The composition is a physiologically effective amount of the herbal substance Bauhinia in a suitable carrier. The carrier can be water, alcohol, mixtures thereof, capsules powders,... | 03/07/2013 |
| 20130058996 | LIPOSOME CONTAINING shRNA MOLECULE TARGETING A THYMIDYLATE SYNTHASE AND USE THEREOF This method provides a method for delivering shRNA targeting TS in vivo. In addition, the following is provided: an antitumor agent, which comprises short hairpin RNA (shRNA) capable of inhibiting expression of thymidylate synthase by RNAi action and a PEG-modified cati... | 03/07/2013 |
| 20130058997 | VACCINE COMPOSITION CONTAINING SYNTHETIC ADJUVANT Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provide... | 03/07/2013 |
| 20130058998 | ENCAPSULATED N-ACETYLMANNOSAMINE OR N-ACETYLNEURAMINIC ACID TO INCREASE SIALYLATION A method for treating a disorder characterized by hyposialylation in a subject that includes administering to the subject an effective amount of (i) a composition comprising N-acetylmannosamine, or a derivative thereof, encapsulated within a liposome, or (ii) a composit... | 03/07/2013 |
| 20130052245 | COSMETIC AND DERMATOLOGICAL FORMULATIONS OF MNTF PEPTIDES The disclosure is directed to methods and compositions that include MNTF peptides and their analogs for cosmetic and dermatological purposes.... | 02/28/2013 |
| 20130052259 | LIPOSOMES COMPRISING AMPHIPATHIC DRUGS AND METHOD FOR THEIR PREPARATION The present invention provides a liposome having co-encapsulated in its intraliposomal aqueous core at least two amphipathic drugs, the liposomes being characterized by one of the following: the amphipathic drugs are co-encapsulated at a pre-determined ratio; the liposo... | 02/28/2013 |
| 20130052260 | LIPID-BASED COMPOSITIONS OF ANTIINFECTIVES FOR TREATING PULMONARY INFECTIONS AND METHODS OF USE THEREOF A system for treating or providing prophylaxus against a pulmonary infection is disclosed comprising: a) a pharmaceutical formulation comprising a mixture of free antiinfective and antiinfective encapsulated in a lipid-based composition, and b) an inhalation delivery de... | 02/28/2013 |
| 20130045271 | STEROID HORMONE DELIVERY SYSTEMS AND METHODS OF PREPARING THE SAME The present invention is directed to steroid hormone delivery systems and methods of preparing the same. In particular, the steroid hormone delivery systems provided include a primary construct having one or more hydrophobic steroid hormone esters in the form of a lipos... | 02/21/2013 |
| 20130045272 | AGENT FOR TREATING MYELOFIBROSIS Disclosed is a substance delivery carrier for an extracellular-matrix-producing cell in the bone marrow, which comprises a retinoid. Also disclosed in an agent for treating myelofibrosis by utilizing a substance capable of regulating the activity or proliferation of an ... | 02/21/2013 |
| 20130045270 | METHOD OF USE OF STABILIZED GROWTH FACTOR IN SKIN CARE Dermatologic compositions for therapeutic use, containing a growth factor, or a growth factor purified from transgenic plants, or animal, bacterial, yeast or insect cells, or a mixture of growth factors in purified form, for treatment of various dermatological condition... | 02/21/2013 |
| 20130039976 | Sodium channel blocker for treatment of loss of superficial sensitivity The invention concerns a sodium channel blocker for the treatment of a reduction or loss of superficial sensitivity or sense of touch of a human being or another mammal.... | 02/14/2013 |
| 20130039847 | LIPOSOMES FOR PULMONARY ADMINISTRATION The invention relates to liposomes for pulmonary application, advantageously comprising at least one first and at least one second phospholipid, cholesterol, and at least one active substance and/or colorant, wherein the first phospholipid is a phosphatidylcholine, pref... | 02/14/2013 |
| 20130039972 | COMPOSITIONS AND METHODS OF USE OF TARGETING PEPTIDES AGAINST PLACENTA AND ADIPOSE TISSUES The present invention concerns compositions comprising and methods of identification and use of targeting peptides for placenta or adipose tissue. In certain embodiments, the targeting peptides comprise part or all of SEQ ID NO:5-11, SEQ ID NO:13-22 or SEQ ID NO:144. Th... | 02/14/2013 |
| 20130039971 | COMPOSITIONS AND METHODS FOR INHIBITION OF VEGF Disclosed herein are siRNA compositions and methods useful for inhibiting expression of vascular endothelial growth factor (VEGF) isoforms. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degene... | 02/14/2013 |
| 20130039851 | Stabilizing Alkylglycoside Compositions and Methods Thereof The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity, increasing the biological activity, and reducing or preventing fibrillar formation of a peptide, polypeptide, o... | 02/14/2013 |
| 20130039977 | PHARMACEUTICAL COMPOSITION, A METHOD OF PREPARING IT AND A METHOD OF TREATMENT BY USE THEREOF Pharmaceutically acceptable liposome-encapsulated busulphan formulations for parenteral administration are provided, as well as such formulations furthermore comprising glutathione and/or at least one glutathione precursor and a process for manufacture of the preparatio... | 02/14/2013 |
| 20130039973 | Viral Immunogenic Compositions Disclosed herein are immunogenic compositions for producing immediate and sustained immunity to infectious viral and bacteriological pathogens. A univalent immunogenic composition is disclosed comprising an isolated antigen and a polynucleotide formulated into a nanopar... | 02/14/2013 |
| 20130041307 | APPLICATION OF BETA-FUNCTIONALIZED DIHYDROXY-CHLORINS FOR PDT The present invention provides methods to obtain biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and ... | 02/14/2013 |
| 20130039969 | Method And Composition For Treating Rhinitis There is provided pharmaceutical compositions for the treatment of rhinitis by, for example, nasal or ocular administration comprising zwitterionic cetirizine, a polar lipid liposome and a pharmaceutical acceptable aqueous carrier. The compositions are preferably homoge... | 02/14/2013 |
| 20130039970 | Processes and Compositions for Liposomal and Efficient Delivery of Gene Silencing Therapeutics Processes and compositions for liposomal delivery of therapeuticals prepared by contacting an aqueous solution of an active agent with a solution of liposome-forming components containing one or more DILA2 amino acid compounds or lipids in organic solvent to form an imp... | 02/14/2013 |
| 20130039975 | Liposomes Containing Prostaglandin E1 (PGE1), Formulations Containing Them and Their Use Unilamellar liposomes comprising PGE1 and/or PGE1-α-cyclodextrin combined with carnitine, in which there are hydrophilic polymers on the external surface of the liposomes are described.... | 02/14/2013 |
| 20130039974 | ANTI-MUC1 ANTIBODIES FOR CANCER DIAGNOSTICS The present invention is directed to antibodies binding to the MUC1 cytoplasmic domain and methods of using such antibodies to treat, diagnose, detect and monitor cancers that express the MUC1 antigen.... | 02/14/2013 |
| 20130034597 | ORALLY BIOAVAILABLE PEPTIDE DRUG COMPOSITIONS AND METHODS THEREOF The present invention provides orally bioavailable peptide drug compositions including a cyclic peptide and an orally compatible absorption enhancer, as well as methods for providing increased oral bioavailability of peptide drugs.... | 02/07/2013 |
| 20130034598 | INHIBITORS OF AKT/PKB WITH ANTI-TUMOR ACTIVITY The subject invention concerns materials and methods for inhibiting the Akt/PKB pathway. In one embodiment, a compound of the invention inhibits kinase activity and/or phosphorylation levels of Akt proteins. The subject invention also concerns methods for inhibiting or ... | 02/07/2013 |
| 20130034493 | METHODS AND COMPOSITIONS FOR MODULATION OF OLFML3 MEDIATED ANGIOGENESIS The present invention relates to antibodies against specific domains of Olfml3 and the use of such in angiogenesis. In particular aspects, angiogenesis-related conditions, such as cancer, can be treated by the composition comprising the Olfml3 antagonists.... | 02/07/2013 |
| 20130034599 | SYNTHETIC NANOSTRUCTURES INCLUDING NUCLEIC ACIDS AND/OR OTHER ENTITIES Articles, compositions, kits, and methods relating to nanostructures, including synthetic nanostructures, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanostructure core may be surrounded by ... | 02/07/2013 |
| 20130028964 | NOVEL RNAi THERAPEUTIC FOR TREATMENT OF HEPATITIS C INFECTION Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that target human cyclophilin A (CyPA) to inhibit Hepatitis C (HCV) infection. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nuc... | 01/31/2013 |
| 20130028951 | Polymer-Liposome Nanocomposite Composition for Percutaneous Absorption, and Method for Preparing Same Provided are a polymer/liposome nanocomposite composition comprising lipids and poly(amino acids), and a method for preparing same. The polymer/liposome nanocomposite composition has excellent formation stability with respect to surfactants and salts, and can be used in... | 01/31/2013 |
| 20130028955 | SUSTAINED RELEASE ORAL MATRIX AND METHODS OF MAKING THEREOF A solid dosage form suitable for forming a tablet for the containment and delivery of medicament is provided wherein the matrix forming material is a pressure sensitive adhesive, present in the amount from about 0.1 to about 40 weight %, based on the total weight of the... | 01/31/2013 |
| 20130028965 | NOVEL RNAi THERAPEUTIC FOR TREATMENT OF HEPATITIS C INFECTION Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C (HCV) infection in a cell. Such siRNA and shRNAs may have a length of from ... | 01/31/2013 |
| 20130028956 | METHOD FOR PREVENTING OR TREATING MEMORY IMPAIRMENT AND PHARMACEUTICAL COMPOSITIONS USEFUL THEREFORE In a first aspect, the present invention relates to a method for prevention or treating memory impairment and/or a neurodegenerative condition, disorder or disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount o... | 01/31/2013 |
| 20130028957 | PHARMACEUTICAL COMPOSITION FOR TREATING CANCER The present invention provides a pharmaceutical composition for treating cancer, comprising at least one selected from deoxyribonucleic acids (DNA) for encoding small interfering RNA (siRNA) which complementarily binds to the base sequence of the transcript (mRNA transc... | 01/31/2013 |
| 20130028963 | Forming an Artificial Cell with controlled membrane composition, asymmetry, and contents The present invention provides a vesicle having a unilamellar bilayer including a lipid and a second bilayer component selected from a membrane protein or a functionalized lipid. The vesicle also includes a component encapsulated by the unilamellar bilayer, wherein the ... | 01/31/2013 |
| 20130028966 | Broad Spectrum Antiviral and Antiparasitic Agents The invention provides compounds represented by the formulae: (I) and (II) where the compounds are useful in treating, for example, viral and/or parasitic infections. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using t... | 01/31/2013 |
| 20130028961 | PHARMACEUTICAL COMPOSITIONS, COMPRISING A COMBINATION OF SELECT CARRIERS, VITAMINS, TANNINS AND FLAVONOIDS AS ANTIGEN-SPECIFIC IMMUNO-MODULATORS The present invention provides adjuvant compositions that are capable of modulating the immune response in a subject, including enhancing or suppressing the immune response. These adjuvant compositions may also be used to enhance or suppress the immunogenicity of antige... | 01/31/2013 |
| 20130028958 | BETA-CARBOLINES FOR USE IN THE TREATMENT OF HEARING LOSS AND VERTIGO The present invention is directed at β-carbolines, preferred 9-alkyl-β-carbolines (9-alkyl-β-BC), their manufacture as well as their use in prophylaxis and treatment of hearing damages, tinnitus, acute acoustic trauma, vertigo and vestibular disorder as well a... | 01/31/2013 |
| 20130028962 | Triggered Cargo Release from Nanoparticle Stabilized Liposomes Control of the fusion activity of liposomes by adsorbing biocompatible nanoparticles to the outer surface of phospholipid liposomes is disclosed. The biocompatible nanoparticles effectively prevent liposomes from fusing with one another. Release of cargo from the liposo... | 01/31/2013 |
| 20130028959 | Liposomes for Preventing the Spread of HIV Formulations for preventing the sexual transmission of the HIV virus are provided. In one embodiment, the formulations contain un-conjugated liposomes whose physicochemical properties allow binding to the HIV virus. The liposomes are made up of natural or synthetic lipi... | 01/31/2013 |
| 20130028960 | LIPID-BASED COMPOSITIONS OF ANTIINFECTIVES FOR TREATING PULMONARY INFECTIONS AND METHODS OF USE THEREOF A system for treating or providing prophylaxus against a pulmonary infection is disclosed comprising: a) a pharmaceutical formulation comprising a mixture of free antiinfective and antiinfective encapsulated in a lipid-based composition, and b) an inhalation delivery de... | 01/31/2013 |
| 20130028967 | THERAPEUTIC AGENT FOR PULMONARY FIBROSIS Disclosed are: a substance transfer carrier to an extracellular matrix-producing cell in the lung, which comprises a retinoid; a therapeutic agent for pulmonary fibrosis, which utilized the carrier; and a preparation kit of the therapeutic agent.... | 01/31/2013 |
