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Patent No. 5285430

Behavior Modification Wristwatch

A wristwatch including a watch band and a watch body having an octagon shaped perimeter and being red in color and having the word STOP thereon to resemble a stop sign.

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Class 424/450 - Liposomes


Subclass of Class 424 - Drug, bio-affecting and body treating compositions
Definition: Subject matter in which the special physical form is a pharmaceutical
No. of applications: 2359
Last issue date: 05/24/2012


1                      
Application No.Application TitleIssue Date
20120128761Lipophilic Polynucleotide Conjugates
Disclosed are lipophilic polynucleotide conjugates including polynucleotide-cholesterol conjugates and methods of delivering therapeutic polynucleotides to a mammalian cell or patient in need of treatment using said conjugates. The disclosure further provides methods of...
05/24/2012
20120128758FORMULATION FOR INDUCING BROADLY REACTIVE NEUTRALIZING ANTI-HIV ANTIBODIES
The present invention relates in general, to a formulation suitable for use in inducing anti-HIV-1 antibodies, and, in particular, to a formulation comprising Toll Like Receptor (TLR) agonists with HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome con...
05/24/2012
20120128760LIPID COMPOSITIONS
Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is (F). Also disclosed are methods of producing the cationic lipid of formula (I)....
05/24/2012
20120128762Sphingomyelin Liposomes for the Treatment of Hyperactive Bladder Disorders
The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to prevent, manage, ameliorate and/or treat disorders involving neuropathic pain an...
05/24/2012
20120128757Method of Manufacture of Liposome Composition
The present invention provides a method of manufacture of a liposome composition including a step in which: a liposome dispersion liquid containing a liposome, and further containing cyclodextrin in the liposome internal phase is provided and a step in which an active c...
05/24/2012
20120128587FOLATE-TARGETED DIAGNOSTICS AND TREATMENT
Methods of detecting and assessing functionally active folate receptors on tumors and treatment associated with those tumors are described. Also described are methods of selecting ovarian and lung cancer patients for therapy with a folate-vinca conjugate by identifying ...
05/24/2012
20120128756Skin Permeating And Cell Entering (SPACE) Peptides and Methods of Use Thereof
The present disclosure provides peptides and peptide compositions, which facilitate the delivery of an active agent or an active agent carrier wherein the compositions are capable of penetrating the stratum corneum (SC) and/or the cellular membranes of viable cells....
05/24/2012
20120128582METHODS AND COMPOSITIONS OF [32P]-LABELED ADENINE NUCLEOTIDES FOR THE TREATMENT OF ATHEROSCLEROSIS, VASCULAR ARTERIAL DISEASES AND CORONARY ARTERY DISEASES
A method for the treatment of atherosclerosis. The method includes the administration of a 32P-labeled agent as a beta emitter, such as 32P-labeled ATP or other 32P-labeled adenine nucleotides, whereby the 32P-labeled agent seeks and then permeates the atherosclerotic p...
05/24/2012
20120128759METHOD TO INHIBIT AIRWAY HYPERRESPONSIVENESS USING AEROSOLIZED T CELL RECEPTOR ANTIBODIES
Disclosed is a method to reduce airway hyperresponsivesness in an animal by the direct delivery to the lungs of aerosolized antibodies against T cell receptors. The method is particularly useful for treating airway hyperresponsiveness associated with allergic inflammati...
05/24/2012
20120128755Personal Care Composition Containing Yeast Extract And Hexapeptide
A personal care composition comprising (a) a yeast extract, (b) Hexapeptide-11 (Phe-Val-Ala-Pro-Phe-Pro) (SEQ ID NO:1), and (c) a determatologically-acceptable carrier, wherein the total amount of components (a) and (b) is from about 2 wt % to about 6 wt %, preferably f...
05/24/2012
20120128763LUBRICANT FOR THE OCULAR SURFACE
A formulation has been developed for treatment of the symptoms of dry eye which incorporates the natural product jojoba wax, or components thereof, to enhance the spreading of the artificial tear and eyedrop as well as stabilize the eyedrop. The improved performance of ...
05/24/2012
20120108880CHROMOSOME 3p21.3 GENES ARE TUMOR SUPPRESSORS
Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) ar...
05/03/2012
20120107390FELINE INFECTIOUS PERITONITIS VACCINE
FIP vaccines were provided that use an N protein with a specific structure, or a fragment thereof, as an antigen. Preferred antigens of this invention are N proteins derived from a specific type I virus strain (KU-2). Vaccines comprising such an N protein confer prevent...
05/03/2012
20120107389AMPHOTERIC LIPOSOMAL COMPOSITIONS FOR CELLULAR DELIVERY OF SMALL RNA MOLECULES FOR USE IN RNA INTERFERENCE
The present invention provides method and pharmaceutical composition for efficient delivery of siRNA (small interfering ribonucleic acids) into cultured mammalian cells. In addition, the present invention provides methods and compositions for knocking down the expressio...
05/03/2012
20120107392USE OF HUPERZINE FOR DISORDERS
Methods and compositions containing huperzine are used to prevent and alleviate seizures. The invention is also directed to methods and compositions for using huperzine for the prevention and/or treatment of orthostatic hypotension....
05/03/2012
20120107391THERAPY OF PLATINUM-RESISTANT CANCER
The present invention concerns a method for treating platinum-resistant, ovarian cancer, primary peritoneal carcinoma or fallopian tube carcinoma with the combination of a HER2 antibody that effectively inhibits HER dimerization as well as gemcitabine....
05/03/2012
20120082716Cytotoxic agents
A method of killing a cell that is lacking in effective p53 protein activity, particularly as compared to wild type, is provided characterised in that it comprises delivering to the cell a single stranded DNA including a portion with at least one base, internally locate...
04/05/2012
20120082616Aptamer Conjugates for Targeting of Therapeutic and/or Diagnostic Nanocarriers
The present invention provides targeted delivery compositions and their methods of use in treating and diagnosing a disease state in a subject....
04/05/2012
20120082717COMPLEX, MULTILAYER USING THE SAME, AND DEVICE COATED WITH THE MULTILAYER
Disclosed herein is a complex, wherein micelles and/or liposomes dispersed in hyaluronic acids and/or hyaluronic acid derivatives, with a drug and/or functional material loaded in the micelles and/or the liposomes. The complex can release the drug and/or functional mate...
04/05/2012
20120070490ANTI-TRYPANOSOMAL PEPTIDES AND USES THEREOF
The present invention provides methods of killing, inhibiting the growth, and/or inhibiting the reproduction of kinetoplastid protozoan with hydrophobic signal sequence peptides and compositions including such hydrophobic signal sequence peptides....
03/22/2012
20120070488METHOD OF INDUCING NEUTRALIZING ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS
The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions suitable for use in such a method....
03/22/2012
20120070487ALKYLSACCHARIDE COMPOSITIONS WITH NUTRACEUTICALS
The present invention provides nutraceutical compositions with enhanced oral bioavailability. The compositions of the present invention include one or more alkylsaccharides admixed with one or more nutraceutical....
03/22/2012
20120070486METHODS AND COMPOSITIONS RELATED TO PREFOLDIN AND ITS REGULATION
The present invention relates to the fields of molecular biology and drug delivery. In certain embodiments, the present invention provides methods for the delivery of a siNA (e.g., a siRNA) to a cell to modulate expression of a PFDN 1-6. These methods may be used to tre...
03/22/2012
20120070489COMBINATION THERAPY FOR TREATMENT OF FIV INFECTION
The present invention pertains to methods for therapeutic and prophylactic treatment of cats against FIV infection. Methods of the present invention utilize a combination of antiretroviral compounds to treat or prevent FIV infection in a feline animal. In one embodiment...
03/22/2012
20120070491CASB7439 CONSTRUCTS
The present disclosure relates to compounds and methods for increasing the recombinant production of CASB7439 polypeptides, and for methods of utilizing the same....
03/22/2012
20120052115NANOCARRIER THERAPY FOR TREATING INVASIVE TUMORS
Liposomes of a size of less than 200 nanometers target tumors and preferentially deliver imipramine blue to tumors, including brain tumors such as gliomas. The imipramine blue decreases the invasiveness of the tumors, and inhibits tumor metastasis. The liposomes include...
03/01/2012
20120052007PERIPHERAL BLOOD SPARC BINDING ANTIBODIES AND USES THEREOF
The invention provides SPARC binding antibodies that have high affinity to SPARC, particularly plasma SPARC, and methods of using such antibodies in treating conditions including cancer....
03/01/2012
20120052116IMMUNOGENIC EPITOPES OF NGEP ANTIGEN
The invention provides a peptide comprising a human cytolytic T lymphocyte (CTL) epitope from the human tumor-associated antigen (TAA) New Gene Expressed in Prostate (NGEP), which can be used in vaccine prevention or therapy of prostate cancer, as well as a nucleic acid...
03/01/2012
20120052114APPARATUS AND METHODS FOR MAKING NANOSOMES LOADED WITH NUCLEIC ACID
Embodiments of the present invention are directed to an apparatus and methods for making nucleic acid loaded nanosomes. One embodiment of the present invention directed to an apparatus comprises a first containment means for containing a mixture of an aqueous solution o...
03/01/2012
20120045394HUMAN AND MOUSE TARGETING PEPTIDES IDENTIFIED BY PHAGE DISPLAY
The present invention concerns methods and compositions for in vivo and in vitro targeting. A large number of targeting peptides directed towards human organs, tissues or cell types are disclosed. The peptides are of use for targeted delivery of therapeutic agents, incl...
02/23/2012
20120045503Compositions And Methods For Wound Healing
The present invention is related to the field of wound healing or tissue regeneration due to disease (i.e., for example, cardiovascular diseases, osteoarthritic diseases, or diabetes). In particular, the present invention provides compositions and methods comprising mol...
02/23/2012
20120045463Methods and compositions comprising supramolecular constructs
The present invention comprises novel compositions and methods for eliciting high immune responses, of great specifity yielding conformationally sensitive antibodies. These antibodies recognize specific epitopes on a wide variety of antigens including but not limited to...
02/23/2012
20120045500NOVEL DIOXO-IMIDAZOLIDINE DERIVATIVES, WHICH INHIBIT THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM
Compounds of general formula (I):

and cosmetic and pharmaceutical compositions including such a compound are described....

02/23/2012
20120045501CONNEXIN ENHANCES CHEMOTHERAPY-INCLUDED APOPTOSIS IN HUMAN CANCER CELLS INHIBITING TUMOR CELL PROLIFERATION
The present invention provides methods and compositions for the inhibition of proliferation rate of target cells, for example tumor cells. In particular, a nucleic acid encoding a connexin protein, fragment, derivative or analog thereof can be incorporated into a target...
02/23/2012
20120045502ANTAGONISTS OF MUC1
The present invention is directed to improved compositions for cellular delivery of peptides. Using segments of only 3-5 positively-charged residues, one can effectively transfer peptides, including therapeutic peptides, into cells. Also provided are modified peptides s...
02/23/2012
20120039989ERYTHROCYTE-BINDING THERAPEUTICS
Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fu...
02/16/2012
20120039990Liposome Compositions and Methods of Use Thereof
The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the pHLIP polypeptide....
02/16/2012
20120039994VACCINE COMPOSITION CONTAINING SYNTHETIC ADJUVANT
Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provide...
02/16/2012
20120039991USE OF APOPTOSIS INHIBITING COMPOUNDS IN DEGENERATIVE NEUROLOGICAL DISORDERS
The invention provides methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain associated with a neurodegenerative diseases that is characterized by an excess buildup of buildup of intracellular protei...
02/16/2012
20120039988CANCER-TARGETING PEPTIDES AND USES THEREOF IN CANCER THERAPY
Cancer-targeting peptides and uses thereof in cancer therapy....
02/16/2012
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