Class 424/283.1 - Lipid or oil

Subclass of Class 424 - Drug, bio-affecting and body treating compositions
Definition: Subject matter involving a lipid or an oil.
No. of applications: 36
Last issue date: 02/23/2012

Application No.	Application Title	Issue Date
20120045389	METHODS AND REAGENTS FOR EFFICIENT AND TARGETED GENE TRANSFER TO MONOCYTES AND MACROPHAGES The present invention provides a biosafe and useful vector to transfer genetic material to CD14+ mononuclear cells (monocytes and monocyte-derived macrophages) in an efficient and specific manner. The embodiment of the invention makes use of the chimeric human adenoviru...	02/23/2012
20120027803	BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for del...	02/02/2012
20120021043	Nucleic Acids Comprising formula (NuGlXmGnNv)a and Derivatives Thereof as Immunostimulating Agent/Adjuvant The present invention relates to nucleic acids of the general formula (I): (N_uG_lX_mG_nN_v)_aand derivatives thereof as an immunostimulating agent/adjuvant and to compositions containing same, optionally comp...	01/26/2012
20120014976	COMPOSITIONS AND METHODS FOR ENHANCING IMMUNE RESPONSES TO VACCINES The disclosure provides adjuvants, immunogenic compositions, and methods useful for vaccination and immune response. In particular, the disclosure provides a class of adjuvants comprising cationic lipid:co-lipid mixtures and methods for delivering formulated composition...	01/19/2012
20120009222	MODULATION OF THE IMMUNE RESPONSE The present invention provides lipidoids that can be used to modulate the immune response in a subject. Lipidoids are prepared by the conjugate addition of an amine to an acrylate to acrylamide. The lipidoids form complexes or particles with an immunostimulatory polynuc...	01/12/2012
20120003277	NANOEMULSION VACCINES The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides nanoemulsion compositions harboring one or more immunogens within the oil phase of the nanoemulsion and methods of using the sam...	01/05/2012
20110311583	NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS (A1) Translate this text The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure (I) wherein R1 and R2 are ...	12/22/2011
20110311562	Glycolipid Mixture with Anti-Inflammatory Activity Obtained from Oscillatoria Planktothrix It was observed that a highly purified preparation of polar glycolipids extracted from cells of the cyanobacterium Oscillatoria Planktothrix is characterized by the presence of at least one species of high molecular weight glycolipid comprising one or more units ...	12/22/2011
20110287087	MODIFIED CATIONIC LIPOSOME ADJUVANS The present invention relates to the use of vaccines with adjuvants comprising cationic liposomes where neutral lipids has been incorporated into the liposomes to change the gel-liquid phase transition and thereby modifying the IgG sub-type response and enhancing the CD...	11/24/2011
20110280893	SYNTHETIC LIPID A DERIVATIVE The invention provides functionalized monosaccharides and disaccharides suitable for use in synthesizing a lipid A derivative, as well as methods for synthesizing and using a synthetic lipid A derivative....	11/17/2011
20110262488	Novel HIV-1 Envelope Glycoprotein The present application relates to a novel HIV-1 envelope glycoprotein which may be utilized as an HIV-1 vaccine immunogen, antigens for crystallization and for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and pu...	10/27/2011
20110256175	AMINO LIPIDS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of t...	10/20/2011
20110243969	PRODUCTION OF SQUALENE FROM HYPER-PRODUCING YEASTS A method for preparing purified yeast is disclosed, where the squalene source is a yeast that hyper-produces squalene. The squalene is useful for pharmaceutical purposes. For instance, it can be used to prepare an oil-in-water emulsion, and the emulsion is particularly ...	10/06/2011
20110162982	Methods for producing vaccine adjuvants An improved method for the manufacture of an oil-in-water emulsion involves three procedures: (i) preparation of a preliminary emulsion; (ii) microfluidization of the preliminary emulsion to reduce its droplet size; and (iii) filtration of the microfluidized emulsion th...	07/07/2011
20110165193	Methods for producing vaccine adjuvants An improved method for the manufacture of an oil-in-water emulsion involves three procedures: (i) preparation of a preliminary emulsion; (ii) microfluidization of the preliminary emulsion to reduce its droplet size; and (iii) filtration of the microfluidized emulsion th...	07/07/2011
20110142914	INHALABLE COMPOSITIONS HAVING ENHANCED BIOAVAILABILITY The present disclosure provides methods and compositions suitable for delivering lipophilic bioactive agents. The compositions may be utilized to treat numerous diseases and conditions that would benefit from the application of a lipophilic bioactive agent. In embodimen...	06/16/2011
20110110972	STIMULATION OF AN IMMUNE RESPONSE BY ENANTIOMERS OF CATIONIC LIPIDS Compositions and methods for treating immune cells and activating immune responses are disclosed. The compositions comprise one or more optically active chiral cationic lipids....	05/12/2011
20110111016	NON-DNA BASE-CONTAINING POLYNUCLEOTIDE COMPOSITIONS AND THEIR USE FOR THE MODULATION OF IMMUNE RESPONSES The present invention provides compositions comprising synthetic non-DNA base-containing polynucleotide sequences of 3 to 30 bases in length comprising one or more non-DNA bases wherein the bases are nebularine, hypoxanthine, or uracil, or combinations of nebularine, hy...	05/12/2011
20110033485	ANALOGUES OF GLYCOLIPIDS USEFUL AS IMMUNOADJUVANTS The invention provides analogs of alpha-galactosyl ceramide that increase the immune response elicited by various antigens. It also provides methods of using such compounds to increase the effectiveness of vaccines....	02/10/2011
20110033484	LprG AS A CHAPERONE OF IMMUNE ADJUVANTS An adjuvant combination that stimulates immune activation or response includes a hydrophobic immune adjuvant and a pathogen derived lipoprotein that chaperones the hydrophobic immune adjuvant to an immune receptor....	02/10/2011
20110002983	COMPOUND The invention provides a compound (which can act as an adjuvant) of Formula I or Formula (II), wherein R₁R₄R₅R₆and R₇are each independently selected from hydrogen, acetyl, hydrocarbyl, a lipid moiety and a lipi...	01/06/2011
20100316657	Synthetic Archaeal Glycolipid Adjuvants Archaeal lipid adjuvants are synthesized by chemically coupling various carbohydrates or anionic polar groups to the free hydroxyl(s) of archaeal lipid cores. Chemically stable lipid cores such as saturated archaeol and caldarchaeol are obtained from appropriate Archaea...	12/16/2010
20100278875	PROSTAGLANDIN E2 (PGE2) AS AN ADJUVANT IN MONOCLONAL ANTIBODY GENERATION The present invention provides PGE2 as a novel adjuvant for enhancing the immune response in a host, as well as methods of using PGE2 to enhance B cell response and thereby increasing antibody titer against a given immunogen are also disclosed and antibodies produced by...	11/04/2010
20100247537	ADJUVANT COMBINATIONS OF NKT ACTIVATOR, CD40 AGONIST, AND OPTIONAL ANTIGEN, THE USE THROUGH INDUCING SYNERGISTIC CELLULAR IMMUNITY Adjuvant combinations comprising at least one NKT activator, such as alpha-galactosylceramide (α-Gal-Cer) or iGb3, a CD40 agonist and optionally an antigen are disclosed. The use of these immune adjuvants for treatment of various chronic diseases such as cancers is als...	09/30/2010
20100233207	C-GLYCOLIPIDS WITH ENHANCED TH-1 PROFILE The invention is directed to novel synthetic C-glycolipids that selectively induce a ThI-type immune response characterized by enhanced IL-12 secretion and increased activation of dendritic cells. The compounds of the invention are thereby useful in treating infections,...	09/16/2010
20100221269	SYNTHETIC LIPID A DERIVATIVE The invention provides functionalized monosaccharides and disaccharides suitable for use in synthesizing a lipid A derivative, as well as methods for synthesizing and using a synthetic lipid A derivative....	09/02/2010
20100172941	Adjuvant Compositions and Methods of Use This disclosure provides adjuvant compositions that are capable of modulating the immune response in a subject. These adjuvant compositions may also be used enhance the immunogenicity of antigens. Also provided are methods of making the adjuvant compositions as well as ...	07/08/2010
20100015215	Use of Glycolipids as Adjuvants The present invention relates to adjuvants of the glycolipid type and their uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new uses of compounds useful as adjuvants for prophylactic and/or therapeutic vaccination in ...	01/21/2010
20090291103	QUALITY CONTROL METHODS FOR OIL-IN-WATER EMULSIONS CONTAINING SQUALENE Measurements of the squalene content in oil-in-water emulsions can be used as a way of checking for problems during production. In particular, it has been found that a drop in squalene content can indicate that filtration problems occurred. Testing the squalene content ...	11/26/2009
20090214592	Adjuvant composition comprising aluminium phosphate and 3D-MPL An immunogenic composition comprising: (i) an antigen; (ii) an aluminum phosphate adjuvant; and (iii) a 3-O-deacylated monophosphoryl lipid A adjuvant. Components (ii) and (iii) can also be used as a separate adjuvant system. Various features of the compositions are dis...	08/27/2009
20090191227	Compositions and Methods for Enhancing Immune Responses to Vaccines The disclosure provides adjuvants, immunogenic compositions, and methods useful for vaccination and immune response. In particular, the disclosure provides a class of adjuvants comprising cationic lipid:co-lipid mixtures and methods for delivering formulated composition...	07/30/2009
20090169636	Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions Immunogenic compositions are described herein which comprise microparticles that further comprise a biodegradable polymer. The microparticle compositions also comprise a cationic polysaccharide and an immunological species selected from an antigen, an immunological adju...	07/02/2009
20090047306	ADJUVANT COMPOSITIONS An adjuvant composition comprises a Th1-activating alkaloid, optionally further comprising an auxiliary adjuvant selected from a type 2 adjuvant (e.g. alum and/or MF59), a type 1 adjuvant and/or a balanced adjuvant. Vaccines comprising the adjuvant composition include n...	02/19/2009
20080187553	Immunstimulating lipid formulation A pharmaceutical formulation for parenteral or mucosal administration of antigens and/or vaccines to humans and animals, comprising monglyceride preparations having at least 80% monoglyceride content and where the acyl group contains from 6 to 24 carbon atoms, together ...	08/07/2008
20080145387	Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of cytofectin:co-lipid mixture wherein cytofectin is GAP-DMORIE....	06/19/2008
20080124350	Nanoparticle-based vaccine delivery system containing adjuvant A vaccine delivery system comprising adjuvant and nanoparticles comprising an immunogenic agent is provided. A method of immunizing an animal comprising administering a nanoparticle-based vaccine delivery system is also provided....	05/29/2008

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Class 424/283.1 - Lipid or oil