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| Application No. | Application Title | Issue Date |
| 20100239595 | EQUINE ANTIBODIES AGAINST BACILLUS ANTHRACIS FOR PASSIVE IMMUNIZATION AND TREATMENT Disclosed are compositions and methods for treating a subject infected with Bacillus anthracis or at risk for infection with B. anthracis. The compositions include and the methods utilize isolated or purified equine antisera against B. anthracis. ... | 09/23/2010 |
| 20100226941 | METHOD OF PREVENTING INFECTIONS FROM BIOTERRORISM AGENTS WITH IMMUNOSTIMULATORY CPG OLIGONUCLEOTIDES The present disclosure relates to a method of preventing or treating an infection caused by a bioterrorism agent, specifically to a method of increasing an immune response to a bioterrorism agent using an oligodeoxynucleotide including a CpG motif, and a method of enhan... | 09/09/2010 |
| 20100183675 | Stable vaccine compositions and methods of use A stable lyophilized protein formulation containing recombinant Protective Antigen (rPA) is described that can be reconstituted with a suitable diluent to generate a high potency protein concentration reconstituted formulation which is suitable for use as a vaccine agai... | 07/22/2010 |
| 20100178303 | STABLE ORGANIC-CARRIER-BASED MICROBIAL INOCULANTS AND METHOD FOR PRODUCING THE SAME The present invention relates to methods for producing microbial preparations for crop production and microbial preparations produced through such methods. The formulations contain microbial inoculants like Azospirillum spp. which are grown in a complex medium, l... | 07/15/2010 |
| 20100172926 | ANTHRAX COMPOSITIONS AND METHODS OF USE AND PRODUCTION Compositions and methods effective for eliciting an immune response for preventing or reducing infection or improving clinical outcomes caused by Bacillus anthracis are provided. The compositions include a naturally occurring or synthetic protein, peptide, or pro... | 07/08/2010 |
| 20100150965 | DNA PROMOTERS AND ANTHRAX VACCINES The invention is related to intracellularly induced bacterial DNA promoters and vaccines against Bacillus anthracis. ... | 06/17/2010 |
| 20100143416 | Alpha-defensins as anthrax immunotherapeutis The present invention relates to the use of an alpha-defensin in the manufacture of a medicament for the treatment, amelioration or prevention of a disease caused by Bacillus anthracis (B anthracis) infection. Furthermore, methods for the treatment of an <... | 06/10/2010 |
| 20100143417 | Compositions and methods for controlling diseases in animals Disclosed herein are compositions for the treatment of a disease in an animal including yeast extract of Saccharomyces cerevisiae, Bacillus licheniformis or Bacillus subtilis spores, and a carrier. Also included are animal feed compositions including the c... | 06/10/2010 |
| 20100136058 | DNA vaccines against tumor growth and methods of use thereof A DNA vaccine suitable for eliciting an immune response against cancer cells comprises a polynucleotide construct operably encoding an a Fra-1 protein, such as a polyubiquitinated human Fra-1 protein, and IL-18, such as human IL-18, in a pharmaceutically acceptable carr... | 06/03/2010 |
| 20100098728 | Immunostimulating composition containing Lactic Acid bacteria Producing an immunostimulating composition containing lactic acid bacteria having IL-12 production-inducing activity, by culturing lactic acid bacteria belonging to the genus Lactobacillus, immediately killing the bacteria at the point of time at which the pH of the cul... | 04/22/2010 |
| 20100068177 | METHODS OF ORGAN REGENERATION The invention features methods for increasing or maintaining the number of functional cells of a predetermined type in a mammal (e.g., a human patient), for example, the insulin producing cells of the pancreas, liver cells, spleen cells, or bone cells, that has injured ... | 03/18/2010 |
| 20100028448 | IMMUNOGENIC COMPOSITIONS AND METHODS OF USE Disclosed herein are immunogenic compositions comprising a multilayer film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A first layer polyelectrolyte comprises an antigenic polypeptide comprisin... | 02/04/2010 |
| 20100015181 | Vaccine formulation Spore coat-associated proteins from members of Bacillus genera, and in particular spore-coat associated protein N (CotN), have utilisation as adjuvants in vaccine formulations. The vaccine formulations most likely contain a virulence factor of bacterial origin, w... | 01/21/2010 |
| 20100008950 | COMPOSITION AND METHOD FOR THE INDUCTION OF IMMUNITY AGAINST BACILLUS CEREUS GROUP BACTERIA A composition comprised of one or more bacterial proteins that are conserved among members of Bacillus cereus that is capable of inducing an immune response against members of Bacillus cereus group bacteria. The invention also relates to a method of utiliz... | 01/14/2010 |
| 20090324639 | COMPOSITIONS AND METHODS FOR ACTIVATING INNATE AND ALLERGIC IMMUNITY Methods for making and using therapeutic formulations of Proteosome-based immunoactive compositions are provided. The immunogenic compositions, which include Proteosomes and liposaccharides, may be used to elicit or enhance a nonspecific innate immune response to, for e... | 12/31/2009 |
| 20090317427 | Zwitterionic Polysaccharides for Promotion of Immune System Maturation and Health Certain zwitterionic polysaccharides, including those naturally expressed by commensal B. fragilis in the gut, interact with cells of the immune system and affect the TH1/TH2 balance so as to promote health. Nutritional formulas and nutritio... | 12/24/2009 |
| 20090304741 | Yeast-Dendritic Cell Vaccines and Uses Thereof Disclosed is a vaccine that includes a dendritic cell loaded with a yeast vehicle and antigen. Also disclosed are methods of making the vaccine and using the vaccine to elicit cellular and humoral immune responses in a mammal. Additionally, a method to elicit an immune ... | 12/10/2009 |
| 20090297559 | USE OF TIGHT JUNCTION AGONISTS TO FACILITATE PULMONARY DELIVERY OF THERAPEUTIC AGENTS The present invention provides materials and methods to facilitate the pulmonary delivery of therapeutic agents. In some embodiments, agonists of tight junctions (e.g., zonulin agonists) are used in compositions to facilitate the uptake of therapeutic agents from the pu... | 12/03/2009 |
| 20090175911 | Bacterial Production of Carotenoids The present invention is based on a Bacillus the spores and vegetative cells forms of which are a different colour because of differential presence of at least one carotenoid in the spore and vegetative cell forms of the Bacillus. The Bacillus may t... | 07/09/2009 |
| 20090155330 | Vaccine Delivery via Microneedle Arrays A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another ... | 06/18/2009 |
| 20090142372 | Therapeutic composition for use in the prevention and treatment of bone metastases The invention is relates to drugs on the basis of antibodies against non-cellular bone matrix proteins, especially BSP, for use in the prevention and treatment of bone metastases. According to the invention, the antibodies are induced in the patient by recombinantly exp... | 06/04/2009 |
| 20090136623 | GROWTH INHIBITORY COMPOSITION AGAINST PATHOGENIC BACTERIA OF MEAT BASED FOOD STUFF COMPRISING IGY The present invention relates to growth-inhibitory composition against pathogenic bacteria of meat based food stuff comprising IgY, a specific immunoglobulin derived from yolk of egg. The 12 representative bacteria and other microbes deteriorating quality of process mea... | 05/28/2009 |
| 20090130144 | Direct vaccination of the bone marrow The present invention provides methods for eliciting an effective immune response against a weakly immunogenic disease or for priming T cells to become memory T cells against a weakly immunogenic disease by directly vaccinating into the bone marrow of the patient an ant... | 05/21/2009 |
| 20090110700 | ACELLULAR IMMUNOGENIC COMPOSITIONS AND ACELLULAR VACCINE COMPOSITIONS AGAINST BACILLUS ANTHRACIS The invention concerns an acellular immunogenic or vaccine composition for producing antibodies against Bacillus anthracis comprising a protective antigen (PA) and killed and optionally purified spores, obtained from mutating strains of Bacillus anthracis ... | 04/30/2009 |
| 20090098164 | Spore associated display The present invention concerns spore display methods. More specifically, the invention concerns display of heterologous molecules, such as peptides and polypeptides, on spores of bacilli, such as, for example, Bacillus thuringiensis (Bt) or Bacillus cereus | 04/16/2009 |
| 20090092652 | Method for the inhibition of angiogenesis or cancer using protective antigen related molecules The present invention is based on the discovery that protective antigen related molecules (PARMs) without anthrax lethal factor have antiangiogenic or anticancer properties. The invention is directed to a method of inhibiting an angiogenic disease/disorder or cancer. Ad... | 04/09/2009 |
| 20090074816 | TISSUE TARGETED ANTIGENIC ACTIVATION OF THE IMMUNE RESPONSE TO CANCERS The invention provides in part methods of treating cancers of a specific organ or tissue by administering a composition that is antigenically specific for one or more microbes that are pathogenic in the specific organ or tissue in which the cancer is situated. The formu... | 03/19/2009 |
| 20090010964 | Lipid and Nitrous Oxide Combination as Adjuvant for the Enhancement of the Efficacy of Vaccines The invention provides for a method of enhancing immunological responses to an antigen in a vaccine formulation, and for a vaccine formulation that provides for an enhanced immunological response to an antigen. In the method and formulation the antigen is administered w... | 01/08/2009 |
| 20080317784 | Immunogenic Compositions Containing Anthrax Antigen, Biodegradable Polymer Microparticles, And Polynucleotide-Containing Immunological Adjuvant Immunogenic compositions and kits, as well as methods of stimulating immune responses and methods of immunization using the same. The compositions and kits comprise: (a) an antigen derived from Bacillus anthracis; (b) polymer microparticles comprising a biodegrad... | 12/25/2008 |
| 20080311147 | Rhabdoviral N-Fusion Proteins as Carrier for Foreign Antigens Rabies virus (RV) nucleoprotein (N) tightly encapsidates the genomic and antigenomic RNA thereby forming the ribonucleoprotein (RNP) complex. Antigens presented in a rigid and repetitive organization are sufficient to activate B cells to proliferate. In addition to the ... | 12/18/2008 |
| 20080299153 | B. ANTHRACIS PREVENTION AND TREATMENT: MUTANT B. ANTHRACIS LACKING LUXS ACTIVITY AND FURANONE INHIBITION OF GROWTH, AI-2 QUORUM SENSING, AND TOXIN PRODUCTION The present invention pertains to the discovery that B. anthracis possesses a luxS gene that encodes a functional LuxS polypeptide, and that B. anthracis synthesizes a functional AI-2 quorum-sensing molecule. The invention provides mutant B. anthracis <... | 12/04/2008 |
| 20080233181 | NANOPARTICLE ADJUVANTS FOR SUB-UNIT VACCINES The present invention relates to nanoparticle vaccine adjuvants comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed on the carrier. Such antigen-displaying nanoparticles may also d... | 09/25/2008 |
| 20080226729 | STABLE POWDER FORMULATIONS OF ALUM-ADSORBED VACCINES The present invention is directed to methods for preparing a stable powder formulation of an alum-adsorbed vaccine. The methods comprise atomizing a liquid formulation comprising an immunogen adsorbed onto an aluminum adjuvant to produce an atomized formulation, freezin... | 09/18/2008 |
| 20080213316 | Destruction of spores through glycoconjugate enhanced phagocytosis Methods for enhancing destruction and killing of bacterial spores via phagocytosis, where phagocytosis of bacterial spores is enhanced by using a glycoconjugate. In one embodiment, the method includes the steps of modifying a surface of a bacterial spore to increase adh... | 09/04/2008 |
| 20080171066 | Listeriolysin-Containing Bacillus Spores as Antigen Delivery Agents The present invention is based on the provision of non-pathogenic Bacillus spores comprising: (i) a polynucleotide sequence encoding a phagosome membrane-rupturing agent; and (ii) a polynucleotide sequence encoding at least one further heterologous polypeptide. T... | 07/17/2008 |
| 20080159984 | Compositions Capable of Facilitating Penetration Across a Biological Barrier This invention relates to novel penetrating compositions including one or more effectors included within a water soluble composition, immersed in a hydrophobic medium The invention also relates to methods of treating or preventing diseases by administering such penetrat... | 07/03/2008 |
| 20080138431 | Pharmaceutical Composition A microparticle composition comprising a biodegradable polymer, an immunogenic single-stranded ribonucleic acid (ss-RNA) material, a biologically active macromolecule and a stabilising agent wherein the outer surface of the resulting microparticle is free from adsorbed ... | 06/12/2008 |
| 20080131462 | LACTIC ACID BACTERIA STRAINS USEFUL AGAINST GASTROINTESTINAL PATHOGENS AND COMPOSITIONS CONTAINING SAME The invention relates to a method for preventing or treating gastrointestinal infections in humans, which comprises administering a pharmaceutical preparation comprising, in combination with a pharmaceutically acceptable or food grade carrier, a therapeutically effectiv... | 06/05/2008 |
| 20080124362 | Domain II Mutants Of Anthrax Lethal Factor A series of mutants of Anthrax lethal factor (LF) are disclosed which define a conformational epitope or region of the molecule that interacts with the LF target, the MEK enzyme. Such mutants or variants, and nucleic acids encoding them are disclosed. The knowledge of s... | 05/29/2008 |
