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| Application No. | Application Title | Issue Date |
| 20120039939 | COMPOSITIONS AND METHODS FOR VACCINE AND VIRUS PRODUCTION The present invention features methods of producing immunogenic compositions and viruses, methods of treating and preventing viral infection, and methods of producing an immune response using cells that express a polypeptide selected from the group consisting of: cdk13,... | 02/16/2012 |
| 20120003277 | NANOEMULSION VACCINES The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides nanoemulsion compositions harboring one or more immunogens within the oil phase of the nanoemulsion and methods of using the sam... | 01/05/2012 |
| 20110311536 | PREVENTION OF TYPE 1 DIABETES BY TREG VACCINATION WITH AN INSULIN MIMETOPE The invention involves methods and products for inducing Treg cells for immune suppression in connection with autoimmune disease and transplant rejection.... | 12/22/2011 |
| 20110293723 | SYNTHETIC NANOCARRIER COMBINATION VACCINES Disclosed are dosage forms and related methods, that include a first population of synthetic nanocarriers that have one or more first antigens coupled to them, one or more second antigens that are not coupled to the synthetic nanocarriers, and a pharmaceutically accepta... | 12/01/2011 |
| 20110287089 | USE OF A SACCHAROMYCES CEREVISIAE MITOCHONDRIAL NUCLEIC ACIDS FRACTION FOR IMMUNE STIMULATION The present invention relates to the use of a Saccharomyces cerevisiae mitochondrial nucleic acids fraction and an antigen for the preparation of a pharmaceutical composition intended to orient the immune response toward a Th1 type response directed against said ... | 11/24/2011 |
| 20110268762 | IMMUNIZATION OF AVIANS BY MUCOSAL ADMINISTRATION OF NON-REPLICATING VECTORED VACCINES The present invention relates generally to the fields of immunology and vaccine technology. More specifically, the invention relates to mucosal administration via aerosol spray to avians of immunogenic and vaccine compositions, including those comprising recombinant hum... | 11/03/2011 |
| 20110256166 | Multivalent vaccines comprising recombinant viral vectors The invention relates to vaccines comprising recombinant vectors, such as recombinant adenoviruses. The vectors comprise heterologous nucleic acids encoding for at least two antigens from one or more tuberculosis-causing bacilli. Also described is the use of specific pr... | 10/20/2011 |
| 20110243988 | Methods and Compositions for Stabilization of a Virus Vaccine This invention provides compositions and methods for stabilizing a live attenuated virus in dried formulations. In particular, compositions and methods of preparing a dried vaccine are provided that stabilize the viability of live vaccines such as measles and adenovirus... | 10/06/2011 |
| 20110236419 | RECOMBINANT CDV COMPOSITIONS AND USES THEREOF The present invention provides vectors that contain and express in vivo or in vitro CDV polypeptides or antigens that elicit an immune response in animal against CDV, compositions comprising said vectors and/or CDV polypeptides, and methods of vaccination against CDV. T... | 09/29/2011 |
| 20110217332 | Chimpanzee Adenovirus Vaccine Carriers The present invention provides recombinant replication-defective adenoviral vectors derived from chimpanzee adenoviruses and methods for generating recombinant adenoviruses in human E1-expressing cell lines. The invention also provides compositions and methods suitable ... | 09/08/2011 |
| 20110212123 | Immunogenic Substances Comprising a Polyinosinic Acid - Polycytidilic Acid Based Adjuvant The present invention provides a polynucleotide adjuvant (PICKCa) composition and methods of use in eliciting an immune response, in particular a mucosal immune response. The polynucleotide adjuvant comprises of a polyriboinosinic-polyribocytidylic acid (PIC), at least ... | 09/01/2011 |
| 20110189235 | Adipogenic Adenoviruses As A Biomarker For Disease A vaccine composition may be administered to a subject to increase immunity to an adipogenic adenovirus-related cancer. The vaccine composition stimulates the production of adipogenic adenovirus neutralizing antibodies in the subject, which may increase immunity to the ... | 08/04/2011 |
| 20110189234 | ADENOVIRUS PARTICLES HAVING A CHIMERIC ADENOVIRUS SPIKE PROTEIN, USE THEREOF AND METHODS FOR PRODUCING SUCH PARTICLES The present invention is concerned with means and methods for producing adenovirus particles comprising a chimeric adenovirus spike protein that essentially lacks a functional knob domain. One aspect of the invention is concerned with a method for producing adenovirus p... | 08/04/2011 |
| 20110171262 | PARVOVIRAL CAPSID WITH INCORPORATED GLY-ALA REPEAT REGION Parvoviral capsid with incorporated Gly-Ala repeat region The present invention provides a nucleic acid construct comprising a nucleic acid sequence encoding a parvoviral VP1, VP2 and VP3 capsid proteins comprising an immuno evasion repeat sequence. In addition, the pre... | 07/14/2011 |
| 20110165224 | VACCINES FOR INCLUSION BODY HEPATITIS A composition comprising an isolated fowl adenovirus (FAdV), wherein the FAdV is a strain selected from FAdV-2, FAdV-7, FAdv-8a, FAdV-8b, FAdV-8a/8b or FAdV-11 serotype strains; and a suitable carrier and methods for inducing protective immunity in a subject and/or its ... | 07/07/2011 |
| 20110150940 | DRY POWDER COMPOSITIONS AND SYSTEMS FOR POULTRY VACCINATION This invention provides a dry powder composition for poultry vaccination via inhalation comprising an effective amount of a poultry vaccine agent, and a supporting amount of carriers for said poultry vaccine agent, said carriers comprising a combination of a reducing or... | 06/23/2011 |
| 20110150930 | Recombinant viral-based malaria vaccines Described are vaccines against malarial infections, which are based on recombinant viral vectors, such as alpha viruses, adenoviruses, or vaccinia viruses. The recombinant viral-based vaccines can be used to immunize against different Plasmodium infections, such ... | 06/23/2011 |
| 20110135688 | Methods and Compositions for Increasing Titer of Recombinant Porcine Adenovirus-3 Vectors This invention relates to methods of increasing titer of recombinant PAdV-3 produced in porcine host cells by increasing PAdV-3 encapsidation efficiency and compositions comprising the same. More particularly, the invention describes optimized recombinant PAdV-3 vectors... | 06/09/2011 |
| 20110123569 | VACCINE DIRECTED AGAINST ADENOVIRUS SEROTYPE 14 The invention is directed to a live attenuated serotype 14 adenovirus, and a method of inducing an immune response against a serotype 14 adenovirus in a mammal using the live attenuated serotype 14 adenovirus.... | 05/26/2011 |
| 20110091502 | HUMAN PARVOVIRUS: HUMINK PARVOVIRUS Provided herein are sequences of the genomes and encoded proteins of a new human parvovirus, Humink parvovirus, and variants thereof. Also provided are methods of detecting the Humink parvovirus and diagnosing Humink parvovirus infection, methods of treating or preventi... | 04/21/2011 |
| 20110091496 | METHODS AND COMPOSITIONS FOR THE DELIVERY OF VACCINES TO DISRUPTED EPITHELIUM The invention features immunogenic compositions and methods useful for eliciting an immune response. In preferred embodiments, papillomavirus or adenovirus vectors are used to elicit exceptionally potent antibody and T cells responses in disrupted epithelium. The method... | 04/21/2011 |
| 20110086063 | VACCINES FOR PREVENTION AND TREATMENT OF ADDICTION The invention provides an adenovirus-antigen conjugate comprising an adenovirus with a coat protein and an antigen of an addictive drug conjugated to the coat protein of the adenovirus. The invention also provides an adenoviral vector comprising a nucleic acid sequence ... | 04/14/2011 |
| 20110081377 | AEROSOLIZED GENETIC VACCINES AND METHODS OF USE The present invention generally features methods for the mucosal delivery of immunogenic compositions and methods for treating or preventing diseases featuring such immunogenic compositions. In particular embodiments, the immunogenic compositions are genetic vaccines fo... | 04/07/2011 |
| 20110064768 | Immunogenic Compositions An immunogenic composition comprising a viral vector, said vector comprising a nucleic acid sequence encoding a C4bp domain or variant or fragment thereof and a nucleic acid sequence encoding an antigen of interest.... | 03/17/2011 |
| 20110059135 | Capsid-Incorporated Antigen for Novel Adenovirus Vaccine This invention pertains to tropism-modified adenoviral vectors optimized for antigen delivery that induced both humoral and cellular immune responses, as well as a method of constructing and using such vectors. The vectors of the present invention may incorporate an epi... | 03/10/2011 |
| 20110002961 | Interleukin 12 paracrine gene delivery enhanced CTL immunotherapy A method of treating a patient with a disease wherein the patient contains diseased cells which cells contain antigens for identification and which cells are capable of presenting at least part of said antigen on their surface by an HLA class I (or equivalent) molecule,... | 01/06/2011 |
| 20100322896 | MOLECULAR ADJUVANT This invention relates to the use of a molecular adjuvant to generate an immune response in a host. In particular, the molecular adjuvant may be a TLR signalling pathway component, a co-stimulatory molecule, an NKG2D ligand, IL- or IL-15.... | 12/23/2010 |
| 20100310602 | SYNTHETIC GLUCOPYRANOSYL LIPID ADJUVANTS Compounds, particularly, glucopyranosyl lipid adjuvant (GLA) compounds, having the following structure (I) are provided: or a pharmaceutically acceptable salt thereof, wherein L1, L2, L<... | 12/09/2010 |
| 20100303859 | VECTORS AND METHOD FOR GENETIC IMMUNIZATION Improved DNA vaccine plasmids are disclosed that contain novel immunostimulatory RNA compositions. The improved plasmids eliminate all extraneous sequences, incorporate a novel antibiotic free short RNA based selectable marker, increase eukaryotic expression using a nov... | 12/02/2010 |
| 20100297177 | MUTATED PARVOVIRUS STRUCTURAL PROTEINS AS VACCINES The present invention is related to a method for identifying a parvovirus mutated structural protein capable of specifically binding to a binder for an antigen, a parvovirus mutated structural protein which comprises at least one B-cell epitope heterologous to the parvo... | 11/25/2010 |
| 20100272753 | Recombinant Adenovirus Vaccines Recombinant adenovirus vaccines comprising recombinant adenoviruses whose hexon, fiber or protein IX capsid proteins are engineered to include exogenous peptide segments, e.g. vaccines for human papillomavirus (HPV) and malaria.... | 10/28/2010 |
| 20100260800 | AVV Vectors and Methods The invention relates to Adeno-associated virus vectors. In particular, it relates to Adeno-associated virus vectors with modified capsid proteins and materials and methods for their preparation and use.... | 10/14/2010 |
| 20100260799 | SIMIAN SUBFAMILY C ADENOVIRUSES SAdV-40, -31, AND -34 AND USES THEREOF A recombinant vector comprises simian adenovirus SAdV-31 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-31 gene(s) is also disclosed. Methods of using the vectors and cell lines are provide... | 10/14/2010 |
| 20100247621 | CODON MODIFIED IMMUNOGENIC COMPOSITIONS AND METHODS OF USE The present invention features immunogenic compositions comprising codon modified genes that encode viral proteins and/or glycoproteins or fragments. The immunogenic compositions of the invention are useful in various methods of treatment, such as preventing or treating... | 09/30/2010 |
| 20100209451 | Compositions and Methods Related to Adenovirus Based Delivery of Antigens Embodiments of the present invention include the construction and generation of a multi-use adenoviral vaccine platform applicable to biodefense, and emerging and re-emerging infectious diseases. Adenoviral vaccines of the invention will elicit an immune response agains... | 08/19/2010 |
| 20100203083 | MUTATED STRUCTURAL PROTEIN OF A PARVOVIRUS The present invention is related to a structural protein of a parvovirus with an amino acid insertion at the insertion site I-453, a library comprising the protein, a multimeric structure comprising the protein, a nucleic acid encoding the protein, a vector, virus or ce... | 08/12/2010 |
| 20100196408 | METASTATIC COLORECTAL CANCER VACCINE The invention relates to prophylactic and therapeutic vaccines for protecting individuals against metastatic colorectal cancer and for treating individuals who are suffering from metastatic colorectal cancer.... | 08/05/2010 |
| 20100183673 | METHODS AND COMPOSITIONS FOR PRODUCING AN ADENOVIRUS VECTOR FOR USE WITH MULTIPLE VACCINATIONS Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.... | 07/22/2010 |
| 20100166799 | ADENOVIRAL VECTORS AND METHODS AND USES RELATED THERETO The present invention relates to the fields of life sciences and medicine. Specifically, the invention relates to cancer therapies. More specifically, the present invention relates to oncolytic adenoviral vectors and cells and pharmaceutical compositions comprising said... | 07/01/2010 |
| 20100158939 | VACCINE AGAINST PANDEMIC STRAINS OF INFLUENZA VIRUSES The present disclosure provides compositions and methods for eliciting an immune response against avian or pandemic influenza. The compositions include adenovirus vectors comprising avian influenza antigens, recombinant adenovirus and immunogenic compositions comprising... | 06/24/2010 |
