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| Application No. | Application Title | Issue Date |
| 20120128684 | Conserved Hemagglutinin Epitope, Antibodies to the Epitope and Methods of Use Disclosed are antibodies that bind to the stem region of influenza hemagglutinin in the neutral pH conformation, hemagglutinin epitopes in the stem region, and methods of making and using both.... | 05/24/2012 |
| 20120107355 | METHOD OF RAPIDLY PRODUCING IMPROVED VACCINES FOR ANIMALS A method of quickly producing a vaccine for a biotype of pathogenic microorganism is described, where a nucleic acid molecule or fragment thereof is obtained from a biological sample from an animal exposed to the microorganism, a protective molecule is prepared based on... | 05/03/2012 |
| 20120082697 | METHOD FOR PROPHYLAXIS OF INFLUENZA USING VACCINE FOR INTRANASAL ADMINISTRATION The present invention provides a vaccine composition for transnasal mucous membrane administration, which contains an influenza virus antigen, polyriboinosinic polyribocytidylic acid (poly (I:C)) or a derivative thereof and a carboxyvinyl polymer. The present invention ... | 04/05/2012 |
| 20120045473 | Biomolecule Surface Display and Uses Thereof A vaccine for the treatment or prevention of a disease in a subject, wherein said disease is associated with an avian influenza virus, and wherein said vaccine comprises an expression vector comprising a nucleic acid encoding a hemagglutinin peptide, such that in use sa... | 02/23/2012 |
| 20120039934 | ADJUVANT-SPARING MULTI-DOSE INFLUENZA VACCINATION REGIMEN An influenza vaccine is administered by a multi-dose regimen, in which (i) a first dose is administered with an adjuvant and (ii) a later dose is administered either without an adjuvant or with a different adjuvant. Thus the invention provides the benefits of a two-dose... | 02/16/2012 |
| 20120027813 | ADJUVANTED INFLUENZA VACCINES FOR PEDIATRIC USE An influenza vaccine adjuvanted with a sub-micron oil-in-water emulsion elicits significantly higher immune responses in human pediatric populations. Compared to an existing unadjuvanted pediatric influenza vaccine, the adjuvanted vaccines provided herein can induce in ... | 02/02/2012 |
| 20120014972 | INFLUENZA VIRUS COMPOSITIONS AND METHODS FOR UNIVERSAL VACCINES The disclosure relates at least in part to embodiments of compositions and methods including vaccines for protection against multiple serologically distinct strains of influenza virus. This disclosure provides significant advances and addresses important needs in the in... | 01/19/2012 |
| 20110311586 | Materials and methods for respiratory disease control in canines The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and methods for inducing an immune response against an influenza virus of the... | 12/22/2011 |
| 20110305748 | Vaccines for Pandemic Influenza Pharmaceutical and vaccine compositions comprise recombinant hemagglutinin from a pre-pandemic or pandemic influenza virus and an adjuvant comprising GLA. A particularly relevant pre-pandemic influenza virus is H5N1. Kits and methods of using the compositions are also p... | 12/15/2011 |
| 20110250237 | IMMUNOGENIC AMPHIPATHIC PEPTIDE COMPOSITIONS The present application pertains to a composition, comprising (a) amphipathic peptides; (b) lipids and (c) at least one immunogenic species. Respective compositions are suitable for immunogenic species transport and delivery, for example for systemic or local delivery t... | 10/13/2011 |
| 20110229519 | VACCINE COMPOSITION FOR USE AGAINST INFLUENZA The present invention relates to a vaccine composition comprising: —at least one prophylactically active agent against influenza, and —at least one adjuvant, said adjuvant being a derivative of a galactosylceramide, for use in the treatment of influenza.... | 09/22/2011 |
| 20110191915 | INFLUENZA VIRUS IMMUNIZING EPITOPE A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of a novel influenza HA protein in plants and its purification The invention is also directed towards a VLP comprising infl... | 08/04/2011 |
| 20110182940 | METHOD FOR PRODUCING PURIFIED INFLUENZA VIRUS ANTIGEN The present invention aims to provide a method which enables efficient removal of impurities such as the host proteins from an influenza virus culture liquid by a simple operation, allowing separation and purification of an influenza virus antigen. | 07/28/2011 |
| 20110151015 | IMMUNOMODULATOR PARTICLES AND METHODS OF TREATING A method of stimulating an immune response in a subject including administering a micrometer-sized particle coupled with an antigen to the subject, wherein increasing the aspect ratio of the micrometer-sized particle increases the immune response. A method of stimulatin... | 06/23/2011 |
| 20110129438 | IMMUNOGENIC PROTEIN CONSTRUCTS Bacterial immunity proteins are utilized to increase immune response to an antigen of interest.... | 06/02/2011 |
| 20110123568 | NOVEL USE The present invention relates to influenza vaccine formulations and vaccination regimes for immunizing against influenza disease. In particular the invention relates to vaccine formulations comprising an oil-in-water emulsion adjuvant and optionally 3D-MPL, their use in... | 05/26/2011 |
| 20110117128 | Compositions that Include Hemagglutinin, Methods of Making and Methods of Use Thereof Compositions comprise a flagellin component that is at least a portion of a flagellin, wherein the flagellin component includes at least one cysteine residue and whereby the flagellin component activates a Toll-like Receptor 5. Compositions can further include an antige... | 05/19/2011 |
| 20110104293 | SYNERGISTIC INDUCTION OF HUMORAL AND CELLULAR IMMUNITY BY COMBINATORIAL ACTIVATION OF TOLL-LIKE RECEPTORS Described herein are compositions that include a selected antigen, a TLR4 ligand and a TLR7/TLR8 ligand, wherein the antigen and TLR ligands are encapsulated in nanoparticles. Co-administration of both a TLR4 ligand and a TLR7/TLR8 ligand results in the synergistic indu... | 05/05/2011 |
| 20110104202 | Modified Influenza Virus For Monitoring And Improving Vaccine Efficiency The immunogenicity of the influenza virus hemagglutinin (HA) molecule may be increased by substitutions of amino acids in the HA sequence. The substitution of specific HA residues, such as asparagine at position 223 of H5 HA, increase the sensitivity of the hemagglutini... | 05/05/2011 |
| 20110070298 | Compositions Comprising Liposomes, An Antigen, A Polynucleotide and A Carrier Comprising a Continuous Phase of a Hydrophobic Substance The invention provides a composition comprising: an antigen; liposomes; a polyI:C polynucleotide; and a carrier comprising a continuous phase of a hydrophobic substance. Methods for making and using the compositions are also provided.... | 03/24/2011 |
| 20110059130 | PROPHYLACTIC AND THERAPEUTIC INFLUENZA VACCINES, ANTIGENS, COMPOSITIONS AND METHODS The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and vaccines useful in prevention of infection by influenza virus. Provided are recombinant protein antigens, compositions, and methods fo... | 03/10/2011 |
| 20110045057 | Virosomes Comprising Hemagglutinin Derived from an Influenza Virus Produced in a Cell Line, Compositions, Methods of Manufacturing, Use Thereof The present invention relates to virosomes comprising hemagglutinin (HA) with improved fusion activity. Preferably, the HA comprised in said virosomes was derived from influenza virus produced in a cell line. The present invention also relates to compositions and a kit ... | 02/24/2011 |
| 20110038935 | ANTIBODIES AGAINST INFLUENZA VIRUS AND METHODS OF USE THEREOF The invention provides human scFv antibodies and monoclonal antibodies that neutralize influenza virus. Also provided are methods of treating and/or preventing a influenza related disease or disorder such bird flu The invention also provides methods of vaccinating a pat... | 02/17/2011 |
| 20110027315 | PROTEIN CAGES AND THEIR USES The present disclosure provides compositions comprising a protein cage and methods for using the protein cage compositions to induce an immune protection response, or to prevent or ameliorate a viral or a bacterial infection.... | 02/03/2011 |
| 20110014230 | PREPARATION OF INFLUENZA VIRUS VACCINE ANTIGENS A number of improvements for preparing vaccine antigens from disintegrated influenza viruses are disclosed. A splitting step can be followed by detergent exchange. Splitting can take place in the presence of a buffer with a higher ionic strength and/or in the presence o... | 01/20/2011 |
| 20100310604 | RECOMBINANT INFLUENZA VIRUS-LIKE PARTICLES (VLPS) PRODUCED IN TRANSGENIC PLANTS EXPRESSING HEMAGGLUTININ A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a V... | 12/09/2010 |
| 20100297174 | INFLUENZA VIRUS VACCINES AND USES THEREOF Provided herein are influenza hemagglutinin stem domain polypeptides, compositions comprising the same, vaccines comprising the same and methods of their use.... | 11/25/2010 |
| 20100297170 | VACCINES The invention refers an improved vaccine against infections with pathogens, especially viral pathogens, comprising an antigen, a peptide of the formula R1—XZSZN—XZX—R2 and an immunostimulatory deoxynucleic acid containing deoxyinos... | 11/25/2010 |
| 20100278861 | METHODS AND COMPOSITIONS FOR PREDICTING EMERGENCE AND EXPANSION OF DRUG RESISTANT STRAINS OF INFLUENZA VIRUS The instant invention provides methods for determining, predicting and characterizing the genetic variability, emergence and expansion of viruses, in particular, influenza. Accordingly, the invention provides methods for identifying virulent pathogens, genetic mutations... | 11/04/2010 |
| 20100247571 | METHODS AND COMPOSITIONS FOR IMMUNIZATION AGAINST VIRUS Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection ag... | 09/30/2010 |
| 20100239610 | INFLUENZA VIRUS-LIKE PARTICLES (VLPS) COMPRISING HEMAGGLUTININ PRODUCED WITHIN A PLANT A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a V... | 09/23/2010 |
| 20100221284 | NOVEL VACCINE COMPOSITION An inactivated influenza virus preparation is described which comprises a haemagglutinin antigen stabilised in the absence of thiomersal, or at low levels of thiomersal, wherein the haemagglutinin is detectable by a SRD assay. The influenza virus preparation may compris... | 09/02/2010 |
| 20100189731 | RECOMBINANT AVIAN INFLUENZA VACCINE AND USES THEREOF The present invention encompasses influenza vaccines, in particular avian influenza vaccines. The vaccine may be a subunit vaccine based on the hemagglutinin of influenza. The hemagglutinin may be expressed in plants including duckweed. The invention also encompasses re... | 07/29/2010 |
| 20100183671 | LOW-ADDITIVE INFLUENZA VACCINES An influenza vaccine that lacks at least three of a mercurial preservative; an antibiotic; formaldehyde; and egg-derived materials. In some embodiments, the vaccine includes none of these four components.... | 07/22/2010 |
| 20100129401 | Functional Influenza Virus Like Particles (VLPs) The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector cons... | 05/27/2010 |
| 20090304744 | METHODS OF ENHANCING IMMUNE RESPONSE IN THE INTRADERMAL COMPARTMENT AND COMPOUNDS USEFUL THEREOF The present invention relates to immunogenic compositions for intradermal delivery of an antigenic or immunogenic agent in combination with one or more excipients. The immunogenic compositions of the invention comprise an antigenic or immunogenic agent and at least one ... | 12/10/2009 |
| 20090285851 | VACCINE COMPRISING MONOCYTE OR IMMATURE MYELOID CELLS (IMC) WHICH WERE LOADED WITH THE LIGAND OF NATURAL KILLER T CELL AND ANTIGEN The present invention relates to an immuno-therapeutic and prophylactic vaccine comprising monocytes or immature myeloid cells (IMCs) loaded with the ligand of natural killer T cell and an antigen for the prevention and treatment of infectious disease or cancer, more pr... | 11/19/2009 |
| 20090162400 | Compositions of influenza viral proteins and methods of use thereof Compositions, fusion proteins and polypeptides comprise at least one pathogen-associated molecular pattern and at least a portion of at least one integral membrane protein of an influenza viral antigen. The compositions, fusion proteins and polypeptides are used to stim... | 06/25/2009 |
| 20090104147 | Sialoadhesin-Related Compositions and Methods Methods of delivering a cargo moiety to a cell is provided according to embodiments of the present invention which includes contacting a cell expressing sialoadhesin with a conjugate including a sialoadhesin binding moiety and a cargo moiety. The sialoadhesin binding mo... | 04/23/2009 |
| 20090081255 | Method for Producing the Flu Virus The invention relates to a method for producing flu virus according to which:
| 03/26/2009 |
