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| Application No. | Application Title | Issue Date |
| 20120129178 | GENOMIC POLYMORPHISM FOR PREDICTING THERAPEUTIC RESPONSE The present invention relates to the use of genomic polymorphism to provide individualized therapeutic regimens to treat patients suffering from diseases such as cancer. The invention discloses methods for determining the efficacy or choice of chemotherapeutic drugs and... | 05/24/2012 |
| 20120125783 | REAL SPACE MAPPING OF IONIC DIFFUSION AND ELECTROCHEMICAL ACTIVITY IN ENERGY STORAGE AND CONVERSION MATERIALS A method and system for probing mobile ion diffusivity and electrochemical reactivity on a nanometer length scale of a free electrochemically active surface includes a control module that biases the surface of the material. An electrical excitation signal is applied to ... | 05/24/2012 |
| 20120103809 | METHOD FOR SEPARATING NANOCARBON MATERIAL, SEPARATION DEVICE, AND SEPARATED NANOCARBON DISPERSION SOLUTION A method for separating a nanocarbon material includes a step in which a dispersion solution of the nanocarbon material which is dispersed into nanocarbon micelle groups having a plurality of different electric charges, and a retaining solution having a different specif... | 05/03/2012 |
| 20120070843 | DBC1, A NOVEL NATIVE INHIBITOR OF THE ANTI-AGING PROTEIN SIRT1 A novel complex is identified between the NAD-dependent deacetylase, SIRT1 and its novel inhibitor, DBC1. Provided herein are methods to indentify a compound that inhibits the complexation between SIRT1 and DBC1. Exemplary methods comprise contacting either the complexa... | 03/22/2012 |
| 20120043206 | Device and Method for Improving Sample Injection and Stacking The invention provides devices and methods for isolating one or more sample components of a sample material following separation of the sample material into a plurality of sample components. A device includes a separation channel having a sample loading well. A low-cond... | 02/23/2012 |
| 20120046184 | METHOD FOR THE SELECTIVE CONCENTRATION OF A SPECIFIC LOW ABUNDANCE BIOMOLECULE Provided herein is a method for the isolation or removal of a cellular component from a cell that comprises the steps of applying a pulse of nanoparticles to the cell, allowing the nanoparticles to traffic through the cell for a period of time sufficient to allow the na... | 02/23/2012 |
| 20120046191 | AUTOMATED DETECTION AND COUNTING OF BIOMOLECULES USING NANOPARTICLE PROBES An apparatus and method for counting nanoparticle probes is disclosed. In one embodiment, quantum dot-tagged proteins on optically transparent membranes or slides are counted. The transparent membranes or slides are loaded onto a stage (e.g., an X-Y stage or X-Y-Z stage... | 02/23/2012 |
| 20120043210 | Apparatus for Purifying Molecules The invention provides devices for trapping and collecting separated biomolecules following a separation step. The invention also provides methods of using the devices to trap and collect separated biomolecules.... | 02/23/2012 |
| 20120040466 | Analytical Method of Hemoglobin A method for analyzing hemoglobin in a sample by separation analysis while suppressing the denaturation of the hemoglobin includes separating hemoglobin in the presence of at least one of a sulfurous acid compound and a dithionous acid compound.... | 02/16/2012 |
| 20120037507 | METHOD AND MARKER FOR DIAGNOSIS OF TUBULAR KIDNEY DAMAGE AND ILLNESSES A method for the diagnosis of tubular kidney diseases comprising the step of determining the presence or absence or amplitude of at least three polypeptide markers in a urine sample, the polypeptide marker being selected from the markers characterized in Table 1 by valu... | 02/16/2012 |
| 20120040363 | METHOD FOR ENRICHING A PROKARYOTIC DNA A method is described for enriching procaryotic DNA, said method including the steps of contacting at least one procaryotic DNA with at least one protein or polypeptide which is capable of specifically binding to non-methylated CpG motifs, and separating the protein/pol... | 02/16/2012 |
| 20120031757 | SELECTIVE ION TRANSPORT DEVICE A device for controlled transport of ions comprising a first source element arranged to receive ions of a first class from an ion source, a first target element arranged to release ions of said first class to an ion target, wherein each of said first source element and ... | 02/09/2012 |
| 20120024702 | CHARGED PARTICLE MOTION INDUCING APPARATUS Apparatus for inducing motion of charged particles in a liquid or gel using an electric field includes a region in which the motion is to be induced, first and second electrodes for generating the electric field in the region whereby a current passes between the electro... | 02/02/2012 |
| 20120018306 | Sample Processing Droplet Actuator, System and Method Sample processing droplet actuators, systems and methods are provided. According to one embodiment, a stamping device including a droplet microactuator is provided and includes: (a) a first plate including a path or network of control electrodes for transporting droplet... | 01/26/2012 |
| 20120015376 | Free Solution Measurement Of Molecular Interactions By Backscattering Interferometry Disclosed are methods, systems, and apparatuses for the free solution measurement of molecular interactions by backscattering interferometry (BSI). Molecular interaction can be detected between analytes in free-solution wherein at least one of the analytes is label-free... | 01/19/2012 |
| 20120000779 | SURFACE ACOUSTIC WAVE SENSOR DEVICE INCLUDING TARGET BIOMOLECULE ISOLATION COMPONENT Provided herein is a surface acoustic wave (“SAW”) sensor device including an isolation component of a target biomolecule. A sample containing the target biomolecule is separated by its size using electrophoresis, and sequentially reacts with a SAW sensor. In other ... | 01/05/2012 |
| 20110315552 | Systems and Methods for Discovery and Analysis of Markers A business method for use in classifying patient samples. The method includes steps of collecting case samples representing a clinical phenotypic state and control samples representing patients without said clinical phenotypic state. Preferably the system uses a mass sp... | 12/29/2011 |
| 20110308968 | METHOD FOR SEPARATING NANOMATERIALS A method for dispersing nanomaterial comprising an electrochemical process, a solution of dispersed nanomaterial, comprising individual charged nanomaterial at a concentration of about O.1 mgm−1 or more and a solvent and an electrochemical cell are describe... | 12/22/2011 |
| 20110308948 | DEVICE FOR CRYSTALLIZING BIOPOLYMER, CELL OF SOLUTION FOR CRYSTALLIZING BIOPOLYMER, METHOD FOR CONTROLLING ALIGNMENT OF BIOPOLYMER, METHOD FOR CRYSTALLIZING BIOPOLYMER AND BIOPOLYMER CRYSTAL The subject is providing a crystallizing device of a biopolymer, which made to form biopolymer crystal efficiently in crystallization solution of a small amount of biopolymers by applying a low voltage and not to make an electrode disturb but observable a state of cryst... | 12/22/2011 |
| 20110311493 | METHODS FOR STABILIZING A BIOPROSTHETIC TISSUE BY CHEMICAL MODIFICATION OF ANTIGENIC CARBOHYDRATES Methods are provided herein for modifying antigenic carbohydrate epitopes within a xenographic bioprosthetic tissue by oxidation of vicinal diols to form aldehydes or acids and subsequence reductive amination of aldehydes to form stable secondary amines, or amidation or... | 12/22/2011 |
| 20110303542 | Use of Additives for Enhancing Droplet Operations The invention relates to a droplet actuator with a substrate comprising electrodes arranged for conducting droplet operations on a droplet operations surface of the substrate; a filler fluid phase in contact with the droplet operations surface at least partially surroun... | 12/15/2011 |
| 20110303541 | CONTROLLED FLOW OF A THIN LIQUID FILM BY ELECTROWETTING Apparatus and methods for controllably wetting a microstructured surface.... | 12/15/2011 |
| 20110290647 | SYSTEM AND INSTRUMENT FOR PROCESSING BIOLOGICAL SAMPLES AND MANIPULATING LIQUIDS HAVING BIOLOGICAL SAMPLES A biological sample processing system comprises a container for large volume processing, a flat polymer film having a lower surface and a hydrophobic upper surface, which is kept at a distance d to the base side of the container by the protrusions. The distance d define... | 12/01/2011 |
| 20110272282 | SYSTEMS AND METHODS FOR ENHANCED SCODA Methods and apparatus for concentrating particles may be applied, for example, to concentrating DNA, RNA, proteins and the like. Proteins may be pre-treated to facilitate concentration by scodaphoresis. The pre-treatment may comprise, for example, heating or chemical tr... | 11/10/2011 |
| 20110275542 | SIGNATURES AND DETERMINANTS FOR DISTINGUISHING BETWEEN A BACTERIAL AND VIRAL INFECTION AND METHODS OF USE THEREOF The present invention provides methods of detecting infection using biomarkers.... | 11/10/2011 |
| 20110269139 | BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO EPIDERMAL GROWTH FACTOR RECEPTOR MODULATORS The present invention provides methods useful for predicting the likelihood that a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, and diagnostic methods and kits thereof.... | 11/03/2011 |
| 20110256536 | Two stage nucleic acid amplification using an amplification oligomer This invention provides methods, compositions and systems to detect a nucleic acid of interest in a two-stage amplification. The two-stage amplification begins with a first non-enzymatic accumulation of an amplification oligomer that is the target substrate for a second... | 10/20/2011 |
| 20110252489 | METHOD OF IDENTIFYING PROLIFICACY IN MAMMALS The present invention refers to a method of predicting prolificacy in mammals, by means of analyzing a specific molecular marker for a novel mutation correlated to the increase of the ovulation rate. The correct and simple identification of the presence of the mutation,... | 10/13/2011 |
| 20110250699 | Fluorescent Dye Compounds, Conjugates and Uses Thereof The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.... | 10/13/2011 |
| 20110247934 | MICROELECTRODE ARRAY ARCHITECTURE Disclosed herein is a device A device of the microelectrode array architecture, comprising: (a) a bottom plate comprising an array of multiple microelectrodes disposed on a top surface of a substrate covered by a dielectric layer; wherein each of the microelectrode is c... | 10/13/2011 |
| 20110250641 | ZWITTERIONIC ACID-LABILE SURFACTANTS AND METHODS OF USE A compound of the formula: wherein R1 is independently selected from C1-C10 alkyl or substituted alkyl, R2 is independently selected from the group consisting of ... | 10/13/2011 |
| 20110245482 | NON-INVASIVE DETECTION OF FETAL GENETIC TRAITS Blood plasma of pregnant women contains fetal and (generally>90%) maternal circulatory extracellular DNA. Most of said fetal DNA contains ≦500 base pairs, said maternal DNA having a greater size. Separation of circulatory extracellular DNA of <500 base pairs res... | 10/06/2011 |
| 20110244468 | PARALLEL EXTRACTION OF DIFFERENT BIOMOLECULES FROM FORMALIN-FIXED TISSUE The present invention relates to a method of isolating/extracting in parallel various biomolecules, in particular nucleic acids and proteins, from the same fixed biological samples, to the quantification and analysis of the biomolecules isolated by the method of the inv... | 10/06/2011 |
| 20110236878 | Rapid Characterization of Proteins in Complex Biological Fluids Disclosed herein are compositions and methods for the rapid screening of candidate protein therapeutics. In particular, the instant invention provides compositions and methods for assaying the behavior of candidate protein therapeutics in complex biological fluids and f... | 09/29/2011 |
| 20110226620 | Highly Homogeneous Molecular Markers for Electrophoresis The invention relates to marker molecules for identifying physical properties of molecular species separated by the use of electrophoretic systems. The invention further relates to methods for preparing and using marker molecules.... | 09/22/2011 |
| 20110226622 | NOVEL CLEAR NATIVE ELECTROPHORESIS METHOD UTILIZING AROMATIC SULFONIC ACID COMPOUND This invention provides a reagent for protein electrophoresis, an electrophoresis gel or buffer composition containing the reagent, and a protein separation method and an electrophoresis kit using the reagent and the composition.... | 09/22/2011 |
| 20110229872 | Microfabricated Cell Sorter The invention provides a microfabricated device for sorting cells based on a desired characteristic, for example, reporter-labeled cells can be sorted by the presence or level of reporter on the cells. The device includes a chip having a substrate into which is microfab... | 09/22/2011 |
| 20110229878 | HUMAN CONSENSUS SODIUM-IODIDE SYMPORTER REPRESSOR (NIS-REPRESSOR) BINDING SITE The present disclosure relates to a Sodium-Iodide Symporter-repressor (NIS-repressor) binding site (NRBS) consensus sequence consisting of a DNA molecule having the sequence: 5′-T/C(G/A)GCCT(T/C)A(G/A)TTTCCCCA(T/C)CTGT-3.′ The disclosure further relates to methods o... | 09/22/2011 |
| 20110220502 | Unitary Biochip Providing Sample-in to Results-out Processing and Methods of Manufacture A biochip for the integration of all steps in a complex process from the insertion of a sample to the generation of a result, performed without operator intervention includes microfluidic and macrofluidic features that are acted on by instrument subsystems in a series o... | 09/15/2011 |
| 20110209998 | Droplet Actuator and Methods A series of microactuators for manipulating small quantities of liquids, and methods of using these for manipulating liquids, are disclosed. The microactuators are based on the phenomenon of electrowetting and contain no moving parts. The force acting on the liquid is a... | 09/01/2011 |
