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Attorney: millen, White, Zelano, Branigan, P.C.


Number of patents: 203
Last date: May 10, 2011

1            
NumberTitleIssue Date
7939296Method for production of recombinant human FSH
Disclosed is a method for production of recombinant human FSH in high yield and a high purity. The method comprises the steps of: (a) culturing recombinant human FSH-producing mammalian cells in a serum-free medium, (b) collecting culture supernatant, (c) subjecting...
05/10/2011
7935347DNA sequence, and recombinant preparation of group 4 major allergens from cereals
The invention relates to the preparation of DNA sequences of group 4 major allergens from cereals. The invention also includes fragments, novel combinations of partial sequences and point mutations with hypoallergenic effects. The recombinant DNA molecules and the d...
05/03/2011
7935339Inhibition of the CD95 ligand/receptor system for the treatment of neurological disorders and injuries
The present invention relates to the use of inhibitors of the CD95 ligand/receptor system for the manufacture of a medicament for the treatment of neurological disorders or injuries in a mammal, particularly for the treatment of spinal cord injury, more particularly...
05/03/2011
7902223Phenyl derivatives as factor XA inhibitors
Novel compounds of the formula (I), in which D, W, X, Y, T and R1 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of t...
03/08/2011
7893272Reagents and kits for detection of influenza virus and the like
The present invention relates to reagents and methods for influenza virus detection. These reagents and methods disclosed in the present invention enable simple, rapid, specific and sensitive detection of influenza virus types A and B. These reagents are N-acetylneu...
02/22/2011
7893253Solid-phase oligosaccharide tagging: a technique for manipulation of immobilized carbohydrates
The invention relates to methods of manipulating immobilised carbohydrates by derivatisation. Depending on the nature of the derivatisation, the carbohydrate may thereby be more easily detected and/or identified or handled. In particular, the invention relates to me...
02/22/2011
7893185Polycarbonate copolymer, method for producing the same, molded body, optical material, and electrophotographic photosensitive body
A polycarbonate copolymer contains: 0.1 to 50 mol % of a monomer unit represented by the following formula (1); and a monomer unit represented by the following formula (2). In the polycarbonate copolymer, the content of biphenols having a structure represented by th...
02/22/2011
7892540B7-H1 and methods of diagnosis, prognosis, and treatment of cancer
The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects...
02/22/2011
7888357Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death
A novel class of pyridazine compositions and related methods of use. ...
02/15/2011
7846928Substituted pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
The invention relates to substituted pyrazolopyridines according to the general formula (I): in which A, B, D, E, Ra, R1, R2, R3, R4, R5 and q are as defined...
12/07/2010
7879357Pharmaceutical composition in the form of a hydrogel for transdermal administration of active ingredients
The invention relates to a pharmaceutical composition in the form of a hydrogel that comprises a carboxylic acid diester, a C2-C4 alkyl alcohol, an active ingredient and a polymer matrix. The invention also relates to the use of a carboxylic ac...
02/01/2011
7858329Antibody tools for the diagnostic use in the medical therapy with inhibitors of histone deacetylases
The invention relates to a method for determining whether a treatment of a disorder with an HDAC inhibitor is to be started/continued or not comprising determining the level of histone acetylation in the sample by use of an antibody capable of binding to acetylated ...
12/28/2010
7858153Powder primer composition and method for forming coating film
A powder primer composition comprising as essential components (A) a carboxyl group-containing thermosetting polyester resin, (B1) a bisphenol A-type epoxy resin with an epoxy equivalent of 400-2000 g/eq or (B2) a bisphenol-type epoxy resin with an epoxy equivalent ...
12/28/2010
7851599Combination of an anti-ED—B fibronectin domain antibody—IL-2 fusion protein and gemcitabine
The invention refers to the use of L19IL2 for treatment of pancreatic cancer. In another embodiment, the invention relates to a combination (i) of a fusion protein, comprising an Interleukin 2 part and an antibody part, specifically recognizing the extra domain B of...
12/14/2010
7851320Mesostructured aluminosilicate material
A mesostructured aluminosilicate material is described, constituted by at least two spherical elementary particles, each of said spherical particles being constituted by a matrix based on silicon oxide and aluminum oxide, having a pore size in the range 1.5 to 30 nm...
12/14/2010
7838211Method for determining endoglycosidase enzyme activity
The invention relates to a method for determining endoglycosidase enzyme activity, and in particular of the heparanase type, in a sample, and also to a method for detecting a compound capable of modulating the activity of an endoglycosidase, and in particular of an ...
11/23/2010
7834020Polymorphic forms of 1-′4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl) piperazine hydrochloride
The invention relates to new crystalline modifications of the hydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine, crystalline modification of the dihydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl...
11/16/2010
7829721Specific caspase-10 inhibitors
The invention relates to compounds of the general formula (I), and to their use as caspase-10 inhibitors, especially for the treatment of diabetic retinopathy. ...
11/09/2010
7829565Indole derivatives as serotonin reuptake inhibitors
Compounds of the formula (I), the use thereof for the preparation of a medicament for the treatment of diseases associated with the serotonin receptor and/or serotonin reuptake, in particular for the preparation of a medicament as anxiolytic, antidepressant, neurole...
11/09/2010
7825128Sulfoximine-substituted pyrimidines, processes for production thereof and use thereof as drugs
The invention relates to sulfoximine-substituted pyrimidines of the general formula I processes for the preparation thereof and their use as drugs. ...
11/02/2010
7824745Benzochromene derivatives
The present invention relates to benzochromene derivatives of the formula I where the various parameters have the meaning indicated in the text, and to liquid-crystal media which comprise these compounds, and to the use of ...
11/02/2010
7820847Butenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them and use for the treatment of dyslipidaemia, atherosclerosis and diabetes
The present invention relates to butenoic acid derivatives of the formula I: in which R, R1, R2 and R3 are as defined in the description, and also to processes for the preparation ...
10/26/2010
RE41858Pearlescent pigment for water-borne surface-coating systems
A pearlescent pigment based on a metal oxide-coated, platelet-shaped substrate and a top layer on the metal oxide layer, where the top layer comprises silicon dioxide, at least one further metal hydroxide or metal oxide hydrate and at least one organic coupling reag...
10/26/2010
7816369Mediators of hedgehog signaling pathways, compositions and uses related thereto
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small ...
10/19/2010
7807598Mesostructured material with a high aluminum content
A mesostructured material that consists of at least two elementary spherical particles, each of said particles comprising a mesostructured matrix based on aluminum oxide and having a pore size of between 1.5 and 30 nm, an aluminum oxide content that represents more ...
10/05/2010
7807236Liquid-crystalline medium
The invention relates to a liquid-crystalline medium, characterised in that it comprises one or more compounds of the formula I in which R0, L1, n, A and B have the meanings indicated in Claim 1...
10/05/2010
7807121Lithium metal phosphates, method for producing the same and use thereof as electrode material
The invention describes a process for producing a compound of the formula LiMPO4, in which M represents at least one metal from the first transition series, comprising the following steps: a) production of a precursor mixture, containing at least one Li
10/05/2010
7807068Polymerizable compounds
The present invention relates to novel polymerizable compounds, to processes and intermediates for the preparation thereof, and to the use thereof for optical, electro-optical and electronic purposes, in particular in liquid-crystal (LC) media and LC displays, espec...
10/05/2010
7803917Breast cancer resistance protein (BCRP) and antibodies thereto
The present invention provides a breast cancer resistance polynucleotide and protein of Macaca mulata (rhesus monkey) and uses thereof. The present invention also provides anti-BCRP antibodies and uses thereof, particularly as a hematopoietic stem cell marker...
09/28/2010
7803903Protein-binding doxorubicin peptide derivatives
The invention relates to low-molecular doxorubicin peptide derivatives containing MMP-2 or MMP-9 divisible peptide sequences and a protein-binding group. ...
09/28/2010
7803570Method for determining the concentration of thrombin inhibitors
The invention relates to a method for determining the concentration of thrombin inhibitors in a non-turbid body liquid or a non-turbid extract from a body liquid. It comprises the following steps. The body liquid is taken from a living body, and the body liquid is s...
09/28/2010
7803434Liquid-crystalline medium
Disclosed is a liquid-crystalline medium based on a mixture of polar compounds having negative dielectric anisotropy, which contains at least one compound of formula I and at least one compound of formula I*,
09/28/2010
7803266Doped spherically-shaped supported catalyst and process for hydrotreating and hydroconverting metal-containing oil fractions
A catalyst and process for hydrotreating and/or hydroconverting heavy metal-containing hydrocarbon feeds, said catalyst comprising a support in the form of beads based on alumina, at least one catalytic metal or a compound of a catalytic metal from group VIB (column...
09/28/2010
7799770Solid body forms of mesoprogestin 11β-{4E-(hydroxyiminomethyl)-phenyl}-17α methoxymethyl-17β-methoxy-estra-4,9-dien-3-one
The invention relates to novel solid body forms of mesoprogestin 11β-[4E-(hydroxyiminomethyl)-phenyl]-17α-methoxymethyl-17β-methoxy-estra-4,9-dien-3-one (oxime J 867), particularly a highly pure and stable amorphous or highly crystalline form (ansolvate/anhydrate...
09/21/2010
7795264Substituted arylpyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
The invention relates to substituted arylpyrazolopyridines according to the general formula (I): in which A, B, D, E, Ra, R1, R2, R3, R4, R5 and q are as def...
09/14/2010
7794952Biomarker isolation and use thereof to characterize physiological state
The present invention relates to compositions and methods for characterizing the physiological state of a living system, including cells, tissues, organs, and whole organisms. The methods involve capturing biomarkers from the living system, and correlating their pre...
09/14/2010
7794621Liquid crystal system and liquid crystal display
The instant invention relates to mesogenic systems comprising a) a polymeric component, component A, obtained or obtainable from polymerisation of a precursor comprising one or more mesogenic mono-reactive compounds, one or more di-reactive compounds, which optional...
09/14/2010
7790821Dispersions of acrylic polymer latex as additives for the inhibition of the deposition of paraffins in crude oils and compositions that contain them
This invention relates to latex dispersions that are based on (co)polymers with one or more n-alkyl(meth)acrylate monomers with n a varying from 6 to 40, and optionally one or more monomers that are not very water-soluble of the (meth)acrylic and/or vinyl type, opti...
09/07/2010
7790723Thiazole derivatives as phosphodiesterase IV inhibitors
Thiazole derivatives of the formula I in which R1, R2, R3, V, W, X and B are as defined in claim 1, act as phosphodiesterase IV inhibitors and can be employed for the treatment of ost...
09/07/2010
7790722Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof
The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of ...
09/07/2010
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