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Attorney: Zhou; Wei


Number of patents: 13
Last date: April 29, 2008

NumberTitleIssue Date
7364895Bioarray chip reaction apparatus and its manufacture
A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets
04/29/2008
7117095Methods for selecting nucleic acid probes
Methods and computer software products are provided for selecting nucleic acid probes. In one embodiment, dynamic programming is employed to select a set of k probes from n probes so that the selected probes have a maximum aggregate adjusted quality score. ...
10/03/2006
7053198Functionated photoacid generator and functionated polymer system for biological microarray synthesis
In some embodiment of the invention, methods are provided for the synthesis of polymer arrays. In one embodiment, a reactive polymer and a photo acid generator is used for the photodirected polymer array synthesis. ...
05/30/2006
6996475Computer software products for nucleic acid hybridization analysis
Methods and computer software products are provided for analyzing gene expression data. In one embodiment, multiple probes are used to detect a single transcript. The hybridization intensities of each probe is adjusted by dividing the intensities by the affinities o...
02/07/2006
6985655Compositions and methods involving direct write optical lithography
In one embodiment, fiber optic arrays or bundles are used as a light guide to transmit ultraviolet light to the substrate surface for photo-directed polymer synthesis. Digital Micromirror Array (DMA) is used as a switching device to reflect light onto the entry side...
01/10/2006
6957149Computer-aided probability base calling for arrays of nucleic acid probes on chips
A computer system for analyzing nucleic acid sequences is provided. The computer system is used to calculate probabilities for determining unknown bases by analyzing the fluorescence intensities of hybridized nucleic acid probes on biological chips. Additionally, in...
10/18/2005
6907146Methods, systems and computer software for detecting pixel stutter
Embodiments of the invention provide methods, computer software products and systems for detecting pixel stutter of a scanner. In one embodiment, a numeric count of stuttered pixels in both the x (row) and y (column) directions and a graphic display of the stuttered...
06/14/2005
6884578Genes differentially expressed in secretory versus proliferative endometrium
The present invention compares expression profiles from matched samples to identify differential gene expression. Samples are matched according to physiological, pharmacological and/or disease state. Comparison of matched samples eliminates gene expression differenc...
04/26/2005
6850846Computer software for genotyping analysis using pattern recognition
Methods, systems and computer software products are provided for determining genotype of a sample using a plurality of probes. In one preferred embodiment, a tentative genotype call is made based upon the relative allele signals. Pattern recognition is then used to ...
02/01/2005
6828104Nucleic acid affinity columns
This invention provides nucleic acid affinity matrices that bear a large number of different nucleic acid affinity ligands allowing the simultaneous selection and removal of a large number of preselected nucleic acids from the sample. Methods of producing such affin...
12/07/2004
6694321System, method, and product for development and maintenance of database-related software applications
A schema-isolated system is disclosed for developing, modifying, or maintaining client applications that accesses target databases. The system includes a middleware-table inserter that inserts middleware tables into the target database. The middleware tab...
02/17/2004
6687692Method and apparatus for providing an expression data mining database
According to the invention, a system and method for organizing expression information in a way that facilitates data mining. A database model is provided which may organize information relating to, e.g., sample preparation, expression analysis of experime...
02/03/2004
6670122Method for detecting transcription templates
Methods are provided for detecting the sense and antisense transcripts and for determining template strand of a genomic DNA. Exemplary methods include reverse transcribing transcripts without second strand synthesis. The resulting single stranded DNA is l...
12/30/2003
 
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