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| Number | Title | Issue Date |
| 7838237 | Screening methods and sequences relating thereto A screening method for identifying an individual having a pre-disposition towards having a cancer is disclosed, which screening method comprises the steps of: (a) obtaining a test sample comprising a nucleotide sequence comprised in the MYH gene of the ... | 11/23/2010 |
| 7794933 | Depression-related gene The invention relate to the discovery of a depression associated AKAP9 predisposing variant. The invention provides for detecting the variant. The invention also provides methods for screening for antidepressants based on modulating AKAP9 mediated signaling. ... | 09/14/2010 |
| 7732576 | Tumor suppressor designated TS10Q23.3 A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region ... | 06/08/2010 |
| 7670776 | MYH gene variants and use thereof Variants in MYH gene are disclosed which can result in abnormal synthesis of MYH proteins and alteration of MYH activities. The invention provides methods for detecting the newly discovered genetic variants. Use of MYH genetic variants as biomarkers in diagnosing ca... | 03/02/2010 |
| 7662566 | Gene copy number profiling The invention relates to copy number profile analysis. Specifically, copy number profile analysis is used to determine whether two or more separate tumors in a single individual are derived from a common source. ... | 02/16/2010 |
| 7622258 | Screening methods and sequences relating thereto A screening method for identifying an individual having a pre-disposition towards having a cancer is disclosed, which screening method comprises the steps of: (a) obtaining a test sample comprising a nucleotide sequence comprised i... | 11/24/2009 |
| 7598253 | Reverse-turn mimetics and methods relating thereto Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility in the treatment of cell adhesion-indicated diseases, such as multi... | 10/06/2009 |
| 7595401 | Therapeutic compounds and their use in cancer The invention relates to compounds of Formula I and their therapeutic uses, wherein substituent A is chosen from a substituted or unsubstituted aryl, heteroaryl, heterocyclic, or carboxylic group, B is chosen from a substit... | 09/29/2009 |
| 7572905 | Depression gene The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human depression predisposing gene, specifically the apoptotic protease activating factor 1 (APA... | 08/11/2009 |
| 7563571 | MYH gene variants and use thereof Variants in MYH gene are disclosed which can result in abnormal synthesis of MYH proteins and alteration of MYH activities. The invention provides methods for detecting the newly discovered genetic variants. Use of MYH genetic variants as biomarkers in diagnosing ca... | 07/21/2009 |
| 7547804 | Compounds, compositions, and methods employing same Compounds and pharmaceutical compositions containing the same are provided, which are useful in therapeutic treatment or prevention of various diseases. ... | 06/16/2009 |
| 7511039 | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins There are disclosed β-sheet mimetics and methods relating to the same for imparting or stabilizing the β-sheet structure of a peptide, protein or molecule. In one aspect, β-sheet mimetics are disclosed having utility as protease inhibitors in general and, more sp... | 03/31/2009 |
| 7470510 | Methods for diagnosing cancer and determining a susceptibility for developing cancer A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with ... | 12/30/2008 |
| 7422853 | RNA interference using a universal target The present invention provides novel methods for manipulating levels of expression of gene products using RNA interference (RNAi). The methods disclosed can be used to investigate gene function, to create disease-resistant organisms, and to treat disease. ... | 09/09/2008 |
| 7410944 | Depression gene The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human depression predisposing gene, specifically the apoptotic protease activating factor 1 (APA... | 08/12/2008 |
| 7407952 | Reverse-turn mimetics and compositions and methods related thereto Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: wherein A, R1, R2 | 08/05/2008 |
| 7405283 | Screening methods and sequences relating thereto A screening method for identifying an individual having a pre-disposition towards having a cancer is disclosed, which screening method comprises the steps of: (a) obtaining a test sample comprising a nucleotide sequence comprised in a gene in a gene in a base excisi... | 07/29/2008 |
| 7405212 | Helix mimetics and composition and methods related thereto Compounds which mimic the secondary structure of helical regions of biologically active peptides and proteins having the following structure: including pharmaceutically acceptable salts and stereoisomers thereof, wherein Y,... | 07/29/2008 |
| 7393940 | Screening methods and sequences relating thereto A screening method for identifying an individual having a pre-disposition towards having a cancer is disclosed, which screening method comprises the steps of: (a) obtaining a test sample comprising a nucleotide sequence comprised in the MYH gene of the ... | 07/01/2008 |
| 7374884 | Diabetes gene The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect human diabetes mellitus predisposing gene, specifically the angiotensinogen (AGT) gene, some mutan... | 05/20/2008 |
| 7371850 | Method and composition for reducing expression of ROCK-II Methods and pharmaceutical compositions for treating, and delaying the onset of, viral infection, are provided. ... | 05/13/2008 |
| 7345040 | Reverse-turn mimetics and compositions and methods relating thereto Reverse-turn mimetics and methods relating to the same having the following structure are disclosed: including pharmaceutically acceptable salts and stereoisomers thereof, wherein R1, R2, R3 | 03/18/2008 |
| 7338775 | Enzyme assay and use thereof An assay and kit for determining the activity of an enzyme such as kinase, ATPase and GTPase is disclosed. The assay and kit are useful in drug screening to select modulators of such an enzyme. ... | 03/04/2008 |
| 7335468 | TSG101-GAG interaction and use thereof Isolated protein complexes are provided comprising Tsg101 and HIV GAG or GAGp6. The protein complexes are useful in screening assays for selecting compounds effective in modulating the Tsg101-HIV GAG or GAGp6 interaction within the protein complexes. ... | 02/26/2008 |
| 7314713 | Obesity gene and use thereof The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human obesity and diabetes predisposing gene, specifically the TBC1D1 gene, some mutant alleles ... | 01/01/2008 |
| 7297515 | Zinc finger proteins Novel zinc finger proteins and nucleic acids encoding the proteins are provided. The zinc finger proteins interact with ZNF202, a zinc finger protein that regulates the expression of a variety of genes involved in lipid metabolism and transportation. Modulation of t... | 11/20/2007 |
| 7286941 | Method for haplotype analysis The invention relates to a method for determining haplotypes. The method is capable of providing phase information from a set of unphased genotype observations in an efficient robust manner. The method is capable of handling large datasets that include missing data.... | 10/23/2007 |
| 7250497 | Large deletions in human BRCA1 gene and use thereof Large deletions have been identified in the BRCA1 gene in patients. The large deletions predispose the patients to breast cancer and ovarian cancer. Thus, methods for detecting the genetic variants are provided which can be used in detecting a predisposition to canc... | 07/31/2007 |
| 7217795 | Tumor suppressor designated TS10q23.3 A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region ... | 05/15/2007 |
| 7202329 | Tsg101-GAGp6 interaction and use thereof Isolated protein complexes are provided comprising Tsg101 and HIV GAGp6. The protein complexes are useful in screening assays for selecting compounds effective in modulating the Tsg101-HIV GAGp6 interaction within the protein complexes. ... | 04/10/2007 |
| 7195873 | Drug response marker in beta-1 adrenergic receptor gene Methods of using a genetic polymorphic variation in the human beta-1 adrenergic receptor gene as a drug response marker are presented. Determining the presence or absence of the A145G genetic variation in the human beta-1 adrenergic receptor gene is useful in predic... | 03/27/2007 |
| 7141401 | COX1-interacting proteins and use thereof Protein complexes are provided comprising COX1 and one or more proteins selected from the group consisting of THR S14 and Opa1. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes and in treati... | 11/28/2006 |
| 7129040 | Tumor suppressor designated TS10q23.3 A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region ... | 10/31/2006 |
| 7125872 | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins There are disclosed β-sheet mimetics and methods relating to the same for imparting or stabilizing the β-sheet structure of a peptide, protein or molecule. In one aspect, β-sheet mimetics are disclosed having utility as protease inhibitors in general and, more sp... | 10/24/2006 |
| 7097998 | Aβlowering agents The invention provides a method of preventing, delaying, or reversing the progression of Alzheimer's disease by administering an Aβ42 lowering agent to a mammal under conditions in which levels of Aβ42 are selectively reduced, levels of Aβ | 08/29/2006 |
| 7091173 | FAP48-interacting proteins and use thereof Protein complexes are provided comprising FAP48 and one or more FAP48-interacting proteins. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes and in treating and/or preventing diseases and di... | 08/15/2006 |
| 7052853 | Depression gene The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human depression predisposing gene, specifically the apoptotic protease activating factor 1 (APA... | 05/30/2006 |
| 7053214 | β-sheet mimetics and composition and methods relating thereto Compounds having the following structure: including pharmaceutically acceptable salts and stereoisomers thereof, wherein A, A′, B, X, Y, R2, R3, R4 and R5 are as defi... | 05/30/2006 |
| 7008941 | Reverse-turn mimetics and methods relating thereto Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: wherein A, B, X, R1 | 03/07/2006 |
| 6960431 | Therapeutic compositions and methods for treating viral infection Methods for inhibiting viral propagation and treating viral infection are provided which include administering to cells infected with viruses a therapeutic peptide or a derivative thereof. ... | 11/01/2005 |
