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| Number | Title | Issue Date |
| 7871786 | GEF-H1b: biomarkers, complexes, assays and therapeutic uses thereof The present invention relates to diagnosing abnormal cell proliferation in biological samples and screening for drugs which inhibit, reduce or abolish cell growth, especially tumorigenic cell growth, by detecting a phosphovariant isoform of a guanine nucleotide exch... | 01/18/2011 |
| 7645786 | Substituted arylpyrazoles This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthes... | 01/12/2010 |
| 7618626 | Combination treatment for non-hematologic malignancies The present invention relates to a therapeutic method for the treatment of non-hematologic malignancies comprising administering anti-IGF-1R antibodies, particularly human anti-IGF-1R antibodies, to a patient, in conjunction with the administration of at least one o... | 11/17/2009 |
| 7592362 | Substituted imidazoles This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides. ... | 09/22/2009 |
| 7575746 | Modified human IGF-IR antibodies The present invention relates to antibodies, which are directed to the human IGF-1 receptor (IGF-1R) and are to be administered for the treatment of cancer. The antibodies of the present invention have been altered to comprise antibodies with one or more selected ge... | 08/18/2009 |
| 7371378 | Modified human IGF-IR antibodies The present invention relates to antibodies, which are directed to the human IGF-1 receptor (IGF-1R) and are to be administered for the treatment of cancer. The antibodies of the present invention have been altered to comprise antibodies with one or more selected ge... | 05/13/2008 |
| 7160888 | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia This invention relates to compounds of the formula 1 wherein G, D, A, Z, Q, X, Y, R1, and R4 through R7 are defined as in the specification, processes for preparing the same and i... | 01/09/2007 |
| 7119201 | Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione; metalloproteinase inhibitors of the formula wherein X, A, Y, B, G, W, and R1 are as defined in the specification, and to pharmace... | 10/10/2006 |
| 7037695 | Methods of assessing wolframin protein activity The present invention relates to a method of assaying modulators of the interaction between Wolframin protein and its identified cellular binding partner. ... | 05/02/2006 |
| 6998249 | Toxicity screening method The present invention provides materials and methods for predicting the in vivo toxicity of a given compound. For example, the invention comprises conducting at least three distinct assays in parallel to provide information about three distinct parameters of cytotox... | 02/14/2006 |
| 6979545 | Method for determining chemical reactivity A method for screening chemical compounds for electrophilic properties comprising the steps of: (a) providing an assay having one or more reaction vessels; (b) adding a predetermined amount of separate chemical compounds for screening to ea... | 12/27/2005 |
| 6962973 | Porcine α2δ-1 calcium channel subunit cDNA and soluble secreted α2δ-1 subunit polypeptides Soluble α2δ-1 subtype polypeptides. Methods for cloning, expression and purification of freely soluble α2δ-1 subtype polypeptides. ... | 11/08/2005 |
| 6939560 | Pharmaceutical composition having two coating layers The present invention provides a pharmaceutical composition which is substantially free of unpleasant tastes and orally administrable which comprises: (a) an active medicament, (b) an inner coating layer comprising... | 09/06/2005 |
| 6919332 | N-substituted-heteroaryloxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to N-substituted-heteroaryloxy-aryloxy-2,4,6-trione metalloproteinase inhibitors of the formula wherein X, A, Y, B, G, and R1 are as defined in the specification, and to pharmac... | 07/19/2005 |
| 6916807 | Triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein said ring X is a 5-7 membered heterocyclic ring, and wherein A, Y, B, G, and W are as ... | 07/12/2005 |
| 6908917 | Chromone derivatives as matrix metalloproteinase inhibitors This invention provides compounds defined by Formula I or a pharmaceutically acceptable salt thereof, wherein R1, Q, Y2, Y3, Y4, U5, U6, U | 06/21/2005 |
| 6740652 | Oxazolidinones to treat eye infections The present invention involves a method of treating an ophthalmic infection in a useful warm blooded mammal who is in need of such treatment which comprises topical administration of an ophthalmologically effective amount of an OXAZOLIDINONE. ... | 05/25/2004 |
| 6602868 | Treatments for restless legs syndrome The invention provides methods and use of heterocyclic amines, and phenylazacycloalkane compounds, and their pharmacologically acceptable salts for the treatment of Restless Legs Syndrome (RLS).... | 08/05/2003 |
| 6562820 | Method for treatment and prevention of mastitis The invention is directed to a method of treatment or prevention of mastitis in mammals with known oxazolidinone anti-bacterial agents, either alone or in combination with exogenous lactoferrins.... | 05/13/2003 |
| 6555548 | Compounds for treating fibromyalgia and chronic fatigue syndrome The present invention provides for methods for the treatment of fibromyalgia syndrome or chronic fatigue syndrome by the administration of cabergoline-type compounds or a salt of said compound.... | 04/29/2003 |
| 6538035 | Use of tolterodine to treat asthma The present invention is a method of treating an mammal selected from the group consisting of humans and horses who has asthma, COPD or allergic rhinitis and is in need of such treatment by inhaling an anti-asthma, anti-COPD anti-allergic rhinitis effecti... | 03/25/2003 |
| 6503920 | Cabergoline and pramipexole: new uses and combinations This invention discloses new uses and treatments involving cabergoline, pramipexole and new combinations of cabergoline plus pramipexole used to treat patients. Here we disclose the use of cabergoline or pramipexole to treat PSP and MSA. Also disclosed is... | 01/07/2003 |
| 6448258 | Treating fibromyalgia and chronic fatigue syndrome The present invention provides for methods for the treatment of fibromyalgia syndrome or chronic fatigue syndrome by the administration of heterocyclic amine-type compounds or a salt of any said compound.... | 09/10/2002 |
