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| Number | Title | Issue Date |
| 6297243 | Methods of treating hot flashes, estrogen deficiencies and deferring menopause by the administration of a luteinizing hormone antagonist A pharmaceutical composition comprising a LH antagonist or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier is useful for deferring the onset of menopause.... | 10/02/2001 |
| 6169087 | Modulators of protein tyrosine phosphatases (PTPases) The present invention provides novel compounds of Formula 1 or Formula 2 and compositions thereof, methods of their use, and methods of their manufacture, ##STR1## wherein X, Y, Z, W, R1, R2 and R3 are defined more fully i... | 01/02/2001 |
| 6159941 | Use of somatostatin agonists and antagonists for treating diseases related to the eye The invention relates to the use of a somatostatin receptor ligand of nonpeptide origin, e.g. of the general formula Ia or Ib ##STR1## or a pharmaceutically acceptable salt thereof, which has high and/or selective affinity to the somatostatin recepto... | 12/12/2000 |
| 6147098 | Substituted guanidines and diaminonitroethenes, their preparation and use Guanidine and diaminonitroethene derivatives represented by the formula ##STR1## wherein X, R1, R2, R3 and R4 are defined in the description, compositions thereof and methods for preparing the compounds are... | 11/14/2000 |
| 6133268 | 1,4-disubstituted piperazines The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their ... | 10/17/2000 |
| 6127354 | Compounds with growth hormone releasing properties Novel peptide derivatives, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone are disclosed. The peptides have the formula (I): ##STR1## wherein a, b, A, R1, L1 | 10/03/2000 |
| 6127391 | Compounds with growth hormone releasing properties Compounds of peptide mimetic nature having the general formula I ##STR1## wherein a and b are independently 1 or 2, R1 and R2 are independently H or C1-6 alkyl, G and J are independently, inter alia, aromats, and D an... | 10/03/2000 |
| 6127341 | Compounds with growth hormone releasing properties Compounds of the general formula I ##STR1## compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone are described.... | 10/03/2000 |
| 6117996 | Triazine based ligands and use thereof The present invention relates to novel affinity ligand-matrix conjugates comprising a ligand with the general formula (a) ##STR1## which ligand is attached to a support matrix in position (A), optionally through a spacer arm interposed between the ma... | 09/12/2000 |
| 6114354 | N-substituted azaheterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description, or salts thereof, to me... | 09/05/2000 |
| 6110913 | N-substituted azaheterocyclic carboxylic acids and esters thereof The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them... | 08/29/2000 |
| 6100253 | Tricycle substituted with azaheterocyclic carboxylic acids The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description, or salts thereof, to me... | 08/08/2000 |
| 6090797 | 4,5,6,7-tetrahydro-thieno(2,3-C)pyridine derivatives Disclosed are compounds of formula (I) ##STR1## wherein R1 is C1-8 -alkyl, C2-8 -alkenyl, C3-8 -cycloalkyl, C5-8 -cycloalkenyl, Q or aryl; R2 is C1-8 -alkyl, C2-8 -alkenyl, C3-8 ... | 07/18/2000 |
| 6080754 | Pyrrolo[2,1,5-cd]indolizine derivatives useful in the prevention or treatment of estrogen related diseases or syndromes The present invention relates to therapeutically active compounds of formula I ##STR1## a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in the prevention or treatment of ... | 06/27/2000 |
| 6080770 | Modulators of molecules with phosphotyrosine recognition units The present invention relates to novel organic compounds, to methods for their preparation, to compositions containing them, to their use for treatment of human and animal disorders, to their use for purification of proteins or glycoproteins, and to their... | 06/27/2000 |
| 6075036 | Pyrrolo [2,1,5-cd] indolizine derivatives useful in the prevention or treatment of estrogen related diseases or syndromes The present invention relates to therapeutically active compounds of formula I ##STR1## a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in the prevention or treatment of ... | 06/13/2000 |
| 6071901 | Substituted dibenz[b,f]azepines and uses thereof The present invention relates to novel N-substituted azaheterocyclic carboxylic acids andy esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing the... | 06/06/2000 |
| 6066632 | Heterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description, or salts thereof, to me... | 05/23/2000 |
| 6054458 | Heterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R1, R2 and m are as defined in the detailed part of the present description, or salts thereof, to me... | 04/25/2000 |
| 6048856 | Heterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic compounds of the formula ##STR1## wherein X, Y, R1, R1a, R2, R2a, R12, R13, A, r and s are as defined in the detail... | 04/11/2000 |
| 6043239 | Heterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them... | 03/28/2000 |
| 6040318 | Tricycle substituted with azaheterocyclic carboxylic acids The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description, or salts thereof, to methods for thei... | 03/21/2000 |
| 6040302 | 1,4-disubstituted piperazines The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their ... | 03/21/2000 |
| 6022868 | Substituted azacyclic or azabicyclic compounds Disclosed are compounds of formula (I) selected from the following ##STR1## wherein Y is ##STR2## and wherein A, B, C, D, R, k, m, n, o, p, s, t and u are as defined in the specification. These compounds are useful in treating diseases in the ... | 02/08/2000 |
| 6017915 | Heterocyclic compounds The present invention relates to novel N-substituted amino alcohols, amino acids and acid derivatives thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing... | 01/25/2000 |
| 6015813 | Heterocyclic compounds and their preparation and use The present invention relates to therapeutically active azabicyclic compounds of formula I ##STR1## wherein X, R1, R2, R3, Ar, m and n are defined in the description, a method of preparing the same and to pharmaceutic... | 01/18/2000 |
| 6011006 | Method of treating hot flushes with hexapeptides The present invention relates to a method of treating migraine, non-insulin dependent diabetes mellitus (type II diabetes), sepsis, inflammation and/or vasomotor disturbances. This method utilizes a hexapeptide of formula (I) A1 -A2 ... | 01/04/2000 |
| 6004961 | 1,4-disubstituted piperazines The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their ... | 12/21/1999 |
| 6001832 | [1,2,4]triazolo[4,3-a]quinoxalinone derivatives, their preparation and use The present invention relates to [1,2,4]triazolo[4,3-a]quinoxalinone compounds of the formula ##STR1## wherein R1 is POX'X" or alkyl substituted with COX' or POX'X", and X' and X" independently are hydroxy or alkoxy, and R7 is ... | 12/14/1999 |
| 5994373 | Substituted azacyclic compounds The present invention relates to therapeutically active heterocyclic compounds, to methods for their preparation and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system... | 11/30/1999 |
| 5990084 | Compounds with growth hormone releasing properties The present invention related to truncated GHRs of the general formula I K-(M)x -A-B-(C)w -D-E-(F)z -G-(N)y -L (I) which have the ability to stimulate release of endogenous growth hormone.... | 11/23/1999 |
| 5977158 | Pharmaceutical formulations comprising levormeloxifene compounds The present invention relates to a pharmaceutical formulation for oral administration which comprises a compound of formula I ##STR1## wherein R is C1-6 alkyl; or a pharmaceutically acceptable salt thereof, in combination with a hydrophili... | 11/02/1999 |
| 5972873 | 4-substituted-phenyl-boronic acids as enzyme stabilizers The present invention relates to a liquid composition comprising an enzyme and a phenyl boronic acid derivative enzyme stabilizer of the following formula: ##STR1## wherein R is selected from the group consisting of hydrogen, hydroxy, C1 | 10/26/1999 |
| 5972978 | Modulators of molecules with phosphotyrosine recognition units The present invention relates to novel organic compounds, to methods for their preparation, to compositions containing them, to their use for treatment of human and animal disorders, to their use for purification of proteins or glycoproteins, and to their... | 10/26/1999 |
| 5968887 | Boronic acid or borinic acid derivatives as enzyme stabilizers The invention relates to a liquid composition which comprises an enzyme and a enzyme stabilizing component. The enzyme stabilizing component is a boronic acid derivative.... | 10/19/1999 |
| 5962449 | Tricyclic compounds in treating hyperalgesic conditions and NIDDM The present invention relates to novel N-substituted amino acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use fo... | 10/05/1999 |
| 5958967 | Cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes The present invention relates to therapeutically active compounds of formula I a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in the prevention or treatment of estrogen related di... | 09/28/1999 |
| 5958951 | Modified form of the R(-)-N-(4,4-di(3-methylthien-2-yl)but-3-enyl)-nipecotic acid hydrochloride The present invention provides R(-)-N-(4,4-di(3-methylthien-2-yl)but-3-enyl)-nipecotic acid hydrochloride in its pure and stable anhydrous form.... | 09/28/1999 |
| 5955548 | Substituted 3, 3-diamino-2-propenenitriles, their preparation and use Substituted cyanoenamines of the formula I ##STR1## wherein Z, R1, R2 and R3 are defined in the description, compositions thereof and methods for preparing the compounds are disclosed. The compounds are useful in the ... | 09/21/1999 |
| 5952352 | Heterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them... | 09/14/1999 |
