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| Number | Title | Issue Date |
| 6129788 | Method of producing saccharide preparations The present invention relates to a method for the production of saccharide preparations, i.e., syrups, by saccharifying a liquefied starch solution, which method comprises a saccharification step during which step one or more enzymatic saccharification st... | 10/10/2000 |
| 6020349 | Constrained somatostatin agonists and antagonists The present invention relates to a compound of general formula I ##STR1## for treating medical disorders related to binding to human somatostatin receptor subtypes.... | 02/01/2000 |
| 5965384 | Methods for producing Humicola lipases in aspergillus A process for expression of a protein product in Aspergillus oryzae is disclosed. The process comprises transforming Aspergillus oryzae with a vector system comprising DNA sequences encoding functions facilitating gene expression, a suitable marker for se... | 10/12/1999 |
| 5958747 | Aspergillus oryzae 5-aminolevulinic acid synthases and nucleic acids encoding same The present invention relates to Aspergillus oryzae 5-aminolevulinic acid synthases and isolated nucleic acid fragments comprising nucleic acid sequences encoding the 5-aminolevulinic acid synthases as well as nucleic acid constructs, vectors, and recombi... | 09/28/1999 |
| 5914306 | Stabilized enzymes This invention relates to novel stabilized enzymes. More specifically the invention relates to novel stabilized enzymes, in which a naturally occurring amino acid residue (other than proline) has been substituted with a proline residue at one or more posi... | 06/22/1999 |
| 5883118 | Prostatic carcinoma The present invention provides novel uses of compounds of general formula I ##STR1## wherein R1, R4 and R5 are individually hydrogen, hydroxy, halogen, trifluoromethyl, lower alkyl lower alkoxy or (tertiary amino)(low... | 03/16/1999 |
| 5871991 | Aspergillus oryzae 5-aminolevulinic acid synthases and nucleic acids encoding same The present invention relates to Aspergillus oryzae 5-aminolevulinic acid synthases and isolated nucleic acid fragments comprising nucleic acid sequences encoding the 5-aminolevulinic acid synthases as well as nucleic acid constructs, vectors, and recombi... | 02/16/1999 |
| 5866393 | Haloperoxidases from curvularia verruculosa and nucleic acids encoding same The present invention relates to Curvularia verruculosa haloperoxidases and isolated nucleic acid fragments comprising nucleic acid sequences encoding the haloperoxidases as well as nucleic acid constructs, vectors, and recombinant host cells comprising t... | 02/02/1999 |
| 5863759 | Process for the production of protein products in aspergillus A process for expression of a protein product in Aspergillus oryzae is disclosed. The process comprises transforming Aspergillus oryzae with a vector system comprising DNA-sequences encoding functions facilitating gene expression, a suitable marker for se... | 01/26/1999 |
| 5859045 | Crystalline-! 3R 4R-trans-7 methoxy 2,2-dimethyl1-3-phenyl 1-4 4-12 pyrrolidin-1 -Y1!ethoxyl 1!chromane hydrogen fumarate The present invention provides novel crystalline (-)-3R,4R-trans-7-methoxy-2,2-dimethyl-3-phenyl-4-{4-2-(pyrrolidin-1-yl)e thoxy!phenyl}chromane, hydrogen fumarate useful for reducing or preventing bone loss as well as pharmaceutical compositions contain... | 01/12/1999 |
| 5846801 | Thermostable lipase isolated from Pseudomonas solanacearum A thermostable lipase has been isolated from Pseudomonas solanacearum SD709 (FERM BP-5358) which has a mass of 32 kD by SDS-PAGE, enzymatic activity in a pH range of about 4-12, a pH optimum of 6.5-9.5 and a temperature optimum of 80°-90° C.... | 12/08/1998 |
| 5847150 | Solid phase and combinatorial synthesis of substituted 2-methylene-2, 3-dihydrothiazoles and of arrays of substituted 2-methylene-2, 3-dihydrothiazoles A solid phase method for the synthesis of a plurality of differently substituted 2-methylenethiazoles with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The 2-methylenethiazoles are prepared by acylation of a su... | 12/08/1998 |
| 5846968 | N-substituted azaheterocyclic carboxylic acids and esters The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them... | 12/08/1998 |
| 5843720 | Introduction of DNA into bacillus strains by conjugation The present invention relates to methods of constructing recombinant Bacillus strains encoding a polypeptide of interest, in which method a DNA construct comprising a DNA sequence encoding the polypeptide of interest is introduced into a recipient Bacillu... | 12/01/1998 |
| 5840677 | Boronic acid or borinic acid derivatives as enzyme stabilizers The invention relates to a detergent composition comprising an enzyme and a boronic acid or borinic acid derivative which acts as a stabilizer for the enzyme in detergent compositions. Specific boronic acid inhibiters include benzofuran substituted boroni... | 11/24/1998 |
| 5837517 | Protease variants and compositions The present invention relates to enzymes produced by mutating the genes for a number of subtilases and expressing the mutated genes in suitable hosts are presented. The enzymes exhibit improved stability and/or improved wash performance in any detergent i... | 11/17/1998 |
| 5834495 | Crystalline xamoneline tartrate The invention provides crystalline 3-(4-hexyloxy-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine (+) L-hydrogentartrate, its preparation and use as a therapeutic agent.... | 11/10/1998 |
| 5827856 | Method of treating insulin resistance The present invention provides a novel method for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.... | 10/27/1998 |
| 5821104 | Tripeptidyl aminopeptidase The present invention relates to a tripeptidyl aminopeptidase, a DNA construct encoding the tripeptidyl aminopeptidase, a method of producing tripeptidyl aminopeptidase and methods of reducing the tripeptidyl aminopeptidase production in cells in which tr... | 10/13/1998 |
| 5817654 | N-substituted naphthofused lactams The present invention relates to novel N-substituted naphthofused lactams and salts thereof of the formula ##STR1## Compounds of the general formula I possess the ability to stimulate the release of endogenous growth hormone. Thus, these compounds ma... | 10/06/1998 |
| 5811382 | Detergent compositions The invention relates to a detergent additive and a detergent composition which comprises a protease enzyme derived from Nocardiopsis, a surfactant, and either/or an enzyme which exhibits peroxidase activity and hydrogen peroxide or precursor thereof or a... | 09/22/1998 |
| 5801035 | L-amino acid oxidase An L-amino oxidase isolated from Trichoderma harzianumi is disclosed. The enzyme exhibits activity on L-arginine, L-lysine, L-methionine, L-asparagine, L phenylalanine, and L-leucine. The pH optimium of the enzyme is alkaline.... | 09/01/1998 |
| 5795746 | Synthetic leader peptide sequences The present invention relates to a DNA expression cassette comprising the following sequence: 5'-P-SP-LS-PS-*gene*-(T)i -3' wherein P is a promoter sequence, SP is a DNA sequence encoding a signal peptide, LS is a DNA sequence encoding a leader peptide o... | 08/18/1998 |
| 5795888 | N-substituted azaheterocyclic carboxlic acids and esters thereof The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to th... | 08/18/1998 |
| 5783575 | Antagonists, their preparation and use The present invention relates to therapeutically active non competitive antagonists, acting selectively at the metabotropic glutamate receptor. The novel compounds are useful in treating diseases in the central nervous system by modulating synaptic transm... | 07/21/1998 |
| 5780486 | Heterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them... | 07/14/1998 |
| 5776757 | Fungal cellulase composition containing alkaline CMC-endoglucanase and essentially no cellobiohydrolase and method of making thereof A cellulase preparation useful for reducing the harshness of cotton-containing fabrics and for reducing the rate at which such fabrics become harsh comprises about 40% or more (based on the total protein content) of an endoglucanase component with a pH op... | 07/07/1998 |
| 5773452 | Heterocyclic compounds and their use The present invention relates to therapeutically active azabicyclic compounds of formula (1), wherein Z1 is oxygen or sulphur, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as st... | 06/30/1998 |
| 5770418 | Purified polyporus laccases and nucleic acids encoding same The present invention relates to isolated nucleic acid constructs containing a sequence encoding a Polyporus laccase, and the laccase proteins encoded thereby.... | 06/23/1998 |
| 5766912 | Humicola lipase produced in aspergillus A process for expression of a protein product in Aspergillus oryzae is disclosed. The process comprises transforming Aspergillus oryzae with a vector system comprising DNA sequences encoding functions facilitating gene expression, a suitable marker for se... | 06/16/1998 |
| 5766896 | Method of producing iodine by use of a copper containing oxidase enzyme The present invention relates to a method for oxidation of iodide which comprises contacting, in an aqueous solution, a copper-containing oxidaze enzyme and a source of ionic iodide(I-), for a time and under conditions sufficient to permit the ... | 06/16/1998 |
| 5767085 | Compounds with growth hormone releasing properties Compounds of the formula A--B--C--D(--E)p are used to stimulate the release of growth hormone from the pituitary.... | 06/16/1998 |
| 5763383 | Alkaline lipases A highly alkaline, positionally non-specific lipase can be obtained from the strains of streptomyces, cluster 1. Strains of cluster 1 of Streptomyces were not previously known to produce lipase. The lipase preparation has more than 50% of its optimum acti... | 06/09/1998 |
| 5753643 | Heterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them... | 05/19/1998 |
| 5753683 | Antipsychotic method The present invention relates to a novel method for treating a mammal suffering from or susceptible to schizophrenia and schizophreniform diseases.... | 05/19/1998 |
| 5753678 | Heterocyclic compounds The present invention relates to novel N-substituted amino alcohols, amino acids and acid derivatives thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing... | 05/19/1998 |
| 5750518 | Heterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them... | 05/12/1998 |
| 5750497 | Acylated insulin The present invention relates to human insulin derivatives having a protracted profile of action in which the A21 and B3 amino acid residues are, independently, any amino acid residue which can be coded for by the genetic code except Lys, Arg and Cys; Phe... | 05/12/1998 |
| 5750140 | Transdermal delivery of tiagabine A transdermal delivery system containing tiagabine or its pharmaceutically acceptable salts or esters is disclosed. The delivery system is useful in the treatment of epilepsy.... | 05/12/1998 |
| 5750541 | Method of treating schizophrenia The present invention relates to a novel method for treating a mammal suffering from or susceptible to schizophrenia and schizophreniform diseases by administering thiadiazole or oxadiazole compounds.... | 05/12/1998 |
