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| Number | Title | Issue Date |
| 8178092 | Methods of treating psoriasis by administration of antibodies to the p40 subunit of IL-12 and/or IL-23 The invention provides a method of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23. ... | 05/15/2012 |
| 8168760 | Crystalline anti-human IL-12 antibodies The invention relates to batch crystallization methods for crystallizing an anti-hIL-12 antibody that allows the production of the antibody on an industrial scale, antibody crystals obtained according to the methods, compositions containing the crystals, and methods... | 05/01/2012 |
| 8158594 | CYP1B1 nucleic acids and methods of use The present invention provides nucleic acids containing transcriptional units that encode CYP1B1 polypeptides or portions thereof, wherein the transcriptional units lack sequences found in the untranslated region (UTR) of naturally occurring forms of the CYP1B1 tran... | 04/17/2012 |
| 8084419 | Pharmaceutical compositions for sustained drug delivery Sustained delivery formulations comprising a water-insoluble complex of a peptide and a plurality of ligands are disclosed. The formulations of the invention allow for loading of high concentrations of peptide in a small volume and for delivery of a pharmaceutically... | 12/27/2011 |
| 8062892 | Genes, compositions, kits, and methods for identification, assessment, prevention and therapy of cervical cancer The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical... | 11/22/2011 |
| 8017726 | Anti-inflammatory compounds and uses thereof The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inh... | 09/13/2011 |
| 7972994 | Methods for synthesis of encoded libraries The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide, wherein the encoding oligonucleotide comprises a capping sequence containing degenerate nucleotid... | 07/05/2011 |
| 7972992 | Methods for synthesis of encoded libraries The present invention provides methods of synthesizing a molecule comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods include providing an initiator compound comprising an initial functional moiety comprising n buil... | 07/05/2011 |
| 7968684 | IL-18 binding proteins The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or... | 06/28/2011 |
| 7935658 | Methods for synthesis of encoded libraries The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods generally include providing a solution comprising initiator compounds comprising an i... | 05/03/2011 |
| 7927491 | Integrated bio-digestion facility Methods and systems for processing organic waste material are provided. These methods and systems include integrating an anaerobic bio-digester and nutrient recovery module with a bio-production facility, which can locally provide feedstock for the bio-production fa... | 04/19/2011 |
| 7883704 | Methods for inhibiting the activity of the P40 subunit of human IL-12 Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12 ) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention ca... | 02/08/2011 |
| 7846737 | Genes, compositions, kits, and methods for identification, assessment, prevention and therapy of cervical cancer The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical... | 12/07/2010 |
| 7872094 | Anti-inflammatory compounds and uses thereof The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inh... | 01/18/2011 |
| 7871775 | Compositions and methods for the identification, assessment, prevention and therapy of human cancers The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention feat... | 01/18/2011 |
| 7871610 | Antibodies to Tie1 ectodomain Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial c... | 01/18/2011 |
| 7812118 | Anti-inflammatory compounds and uses thereof The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inh... | 10/12/2010 |
| 7803774 | Modulators of β-amyloid peptide aggregation Compounds that modulate natural β amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a β amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3-5 D-amino acid... | 09/28/2010 |
| 7799518 | Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer The invention relates to newly discovered nucleic acid molecules and proteins associated with ovarian cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human ovarian cancers are provided. ... | 09/21/2010 |
| 7785812 | Multidrug resistance-associated polypeptide Compositions and methods are disclosed for improving the effectiveness of a chemotherapeutic regimen to eradicate multidrug-resistant transformed cells from the body of a mammal, preferably from the body of a human. The present disclosure capitalizes on the discover... | 08/31/2010 |
| 7776331 | Methods of treating plaque psoriasis The invention provides a method of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23. ... | 08/17/2010 |
| 7771598 | Apparatus, methods and systems for handling and processing waste material Apparatus, methods and systems for processing waste are provided. For example, a system for processing waste, wherein the waste comprises hard particulates embedded therein, can be provided. The system can comprise a waste disruptor, wherein the waste disrupter disr... | 08/10/2010 |
| 7767207 | Antibodies that bind IL-18 and methods of inhibiting IL-18 activity Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have ... | 08/03/2010 |
| 7705120 | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided. ... | 04/27/2010 |
| 7658917 | Modulators of amyloid aggregation Compounds that modulate the aggregation of amyloidogenic proteins or peptides are disclosed. The modulators of the invention can promote amyloid aggregation or, more preferably, can inhibit natural amyloid aggregation. In a preferred embodiment, the compounds modula... | 02/09/2010 |
| 7601505 | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer The invention relates to nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided. ... | 10/13/2009 |
| 7538089 | Anti-inflammatory compounds and uses thereof The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inh... | 05/26/2009 |
| 7534858 | Anti-inflammatory compounds and uses thereof The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inh... | 05/19/2009 |
| 7510854 | genes encoding metabolic pathway proteins Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP nuc... | 03/31/2009 |
| 7504485 | Human antibodies that bind human IL-12 Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can... | 03/17/2009 |
| 7504222 | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers. A variety of newly identified markers are provided, wherein changes in the levels of expression of one or more of the markers is co... | 03/17/2009 |
| 7494775 | Compositions, kits, and methods for identification, assessment, prevention and therapy of breast and ovarian cancer The invention relates to newly discovered nucleic acid molecules and proteins associated with breast or ovarian cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast or ovarian cancers are provided. ... | 02/24/2009 |
| 7485297 | Method of inhibition of vascular development using an antibody Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial c... | 02/03/2009 |
| 7446089 | Methods of inhibiting and treating bacterial biofilms by metal chelators The invention presented herein provides methods and compositions for the prevention and treatment of bacterial infections. The methods are based on the discovery that depletion of bioavailable iron stimulates surface motility in bacteria thus inhibiting the ability ... | 11/04/2008 |
| 7439050 | genes encoding diaminopimelate epimerase Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP nuc... | 10/21/2008 |
| 7425435 | genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS ... | 09/16/2008 |
| 7393675 | genes encoding proteins involved in carbon metabolism and energy production Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP ... | 07/01/2008 |
| 7361511 | Compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer The invention relates to nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are also... | 04/22/2008 |
| 7357915 | Method of imaging cell death in vivo A method of imaging apoptosis in vivo, using radiolabeled annexin, is described. ... | 04/15/2008 |
| 7355028 | Genes encoding genetic stability, gene expression and folding proteins The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms. ... | 04/08/2008 |
