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| Number | Title | Issue Date |
| 8183276 | Therapeutic agents The invention encompasses 2-[4-(imidazolyl)-phenyl]vinyl-heterocycle derivatives which selectively attenuate production of Abeta(1-42) and are useful in the treatment of Alzheimer's disease. Pharmaceutical compositions and methods of use are also encompassed. ... | 05/22/2012 |
| 8114879 | Piperazine derivatives useful as CCR5 antagonists The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R | 02/14/2012 |
| 8080544 | Prodrugs of CGRP receptor antagonists Disclosed are prodrug compounds of formula (I) (wherein variables R1 and R2 are as described herein) which are analogues of an antagonist of CGRP receptors and which are useful in the treatment or prevention of diseases in which CGRP is involve... | 12/20/2011 |
| 8071772 | Spirolactam bicyclic CGRP receptor antagonists Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B, E1, E2, E3, E4, E5 | 12/06/2011 |
| 8071771 | Bicyclic spirohydantoin CGRP receptor antagonists Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B, E1, E2, E3, E4, E5 | 12/06/2011 |
| 8071770 | Spirohydantoin aryl CGRP receptor antagonists Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B, E1, E2, E3, E4, E5 | 12/06/2011 |
| 8039460 | CGRP receptor antagonists Compounds of Formula (I): and Formula (II): (where variables R2, R4, A, B, D, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such... | 10/18/2011 |
| 8003792 | Bicyclic anilide spirolactam CGRP receptor antagonists The present invention is directed to compounds of Formula I: (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as an... | 08/23/2011 |
| 7994325 | CGRP receptor antagonists Compounds of Formula I: (where variables R1, A, B, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved,... | 08/09/2011 |
| 7989624 | Aryl spirolactam CGRP receptor antagonists The present invention is directed to compounds of Formula (I): where variables A1, A2, B, J, K, m, n, R4, R5a, R5b, R5c and X are as defined herein useful as antagonists of CGRP receptors and useful i... | 08/02/2011 |
| 7968540 | Spirohydantoin tricyclic CGRP receptor antagonists Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B1, B2, B3, B4, D1, ... | 06/28/2011 |
| 7960417 | Benzazole potentiators of metabotropic glutamate receptors The present invention is directed to benzazole compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamat... | 06/14/2011 |
| 7951795 | Constrained spirocyclic compounds as CGRP receptor antagonists Compounds of formula I: (wherein variables A1, A2, A3, G1, G2, G3, J, m, n, p, R1, R2, R3, R4 and Y are as descri... | 05/31/2011 |
| 7947714 | Piperidine glycine transporter inhibitors The present invention is directed to piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunction and diseas... | 05/24/2011 |
| 7947678 | Heterocyclic benzodiazepine CGRP receptor antagonists Compounds of formula I: (where variables R2, R7, D, W, X, Y and Z are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in whi... | 05/24/2011 |
| 7947677 | Spirolactam tricyclic CGRP receptor antagonists Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B1, B2, B3, B4, D1, ... | 05/24/2011 |
| 7893079 | Substituted monocyclic CGRP receptor antagonists Compounds of formula I: (wherein variables A1, A2, A3, A4, m, n, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, R | 02/22/2011 |
| 7893052 | CGRP receptor antagonists The present invention is directed to compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W... | 02/22/2011 |
| 7851638 | Cyclohexanesulfonyl derivatives as GLYT1 inhibitors to treat schizophrenia The present invention provides compounds of formula I: wherein R1 is an alkyl, phenyl, heterocyclyl, cycloalkyl, alkoxy, ester, amino or amide group; R2 is a phenyl, ... | 12/14/2010 |
| 7851464 | Spirolactam aryl CGRP receptor antagonists Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, E1, E2, E3, E4, E5, ... | 12/14/2010 |
| 7834031 | Radiolabeled glycine transporter inhibitors The present invention is directed to radiolabeled glycine transporter inhibitors which are useful for the labeling and diagnostic imaging of glycine transporters in mammals. ... | 11/16/2010 |
| 7829699 | Process for the preparation of CGRP antagonist An efficient synthesis for the preparation of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1 -carboxamide, by coupling (3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifl... | 11/09/2010 |
| 7776886 | Cyclopropyl piperidine glycine transporter inhibitors The present invention is directed to cyclopropyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neuro-transmission dysfuncti... | 08/17/2010 |
| 7772224 | CGRP receptor antagonists The present invention is directed to compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W... | 08/10/2010 |
| 7759492 | Enantioselective synthesis of 13-oxotricyclo[8.2.1.0.] trideca-3(8),4,6-triene-5-carboxylates An enantioselective route to compounds of formula I is disclosed: The compounds of formula I are key intermediates in the synthesis of compounds useful in treatment of Alzheimer's disease. ... | 07/20/2010 |
| 7750010 | Tricyclic anilide spirohydantion CGRP receptor antagonists The present invention is directed to compounds of Formula I: I (where A1, A2, B1, B2, B3, B4, D1, D2, T, U, V, W, X, Y, Z, R4, R5a?, R5b, R5... | 07/06/2010 |
| 7745427 | CGRP receptor antagonists The present invention is directed to compounds of Formula (I) and Formula (II) (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in... | 06/29/2010 |
| 7732438 | CGRP receptor antagonists Compounds of Formula (I) and Formula (II) (where variables R1, R2, R4, A, B, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is invo... | 06/08/2010 |
| 7728022 | (4, 5, 6, 7-tetrahydro-1-H-indol-7-yl) acetic acid derivatives for treatment of Alzheimer's disease Compounds of formula I: are disclosed. The compounds are useful in treating or preventing diseases associated with deposition of Aβ in the brain. ... | 06/01/2010 |
| 7655675 | Gamma-secretase inhibitors Compounds of formula I: inhibit the processing of APP by gamma-secretase and hence find use in treatment of Alzheimer's disease. ... | 02/02/2010 |
| 7655644 | Piperidine and azetidine derivatives as GlyT1 inhibitors The present invention provides compounds of formula (I), wherein both p's are one or two, R1 is generally heteroaryl or cycloalkyl, R2 is C3-6cycloalkyl or phenyl and R3 is heteroaryl, and pharmaceutically acceptable salts... | 02/02/2010 |
| 7645790 | Hydroisoindoline tachykinin receptor antagonists The present invention is directed to certain hydroisoindoline compounds of formula I which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formula... | 01/12/2010 |
| 7638629 | Piperidines and related compounds for treatment of alzheimer's disease Compounds of formula I: selectively inhibit production of Aβ(1-42) and hence are useful in treatment or prevention of disease associated with deposition of β-amyloid in the brain. ... | 12/29/2009 |
| 7629338 | Substituted monocyclic CGRP receptor antagonists Compounds of formula I: (wherein variables A1, A2, A3, A4, m, n, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, R | 12/08/2009 |
| 7626056 | Cyclohexanesulfonyl derivatives as GlyT1 inhibitors to treat schizophrenia The present invention provides compounds of formula I: wherein R1 is an alkyl, phenyl, heterocyclyl, cycloalkyl, alkoxy, ester, amino or amide group; R2 is a phenyl, heterocycly... | 12/01/2009 |
| 7625901 | Substituted monocyclic CGRP receptor antagonists Compounds of formula I: (wherein variables A1, A2, A3, A4, m, n, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, R | 12/01/2009 |
| 7598386 | Sulphones which modulate the action of gamma-secretase Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of γ-secretase and are therefore useful in the treatment or... | 10/06/2009 |
| 7595344 | Sulphones which modulate the action of gamma secretase Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease. ... | 09/29/2009 |
| 7576083 | Morpholinyl piperidine glycine transporter inhibitors The present invention is directed to morpholinyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunctio... | 08/18/2009 |
| 7572792 | Azetidine glycine transporter inhibitors The present invention is directed to azetidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunction and disease... | 08/11/2009 |
