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| Number | Title | Issue Date |
| 8097618 | Pyridine derivatives and their use in the treatment of psychotic disorders A method of treatment of anxiety disorders which comprises administering to a host in need thereof an effective amount of a compound of formula (I): ... | 01/17/2012 |
| 8093242 | Crystalline forms of a pyridine derivative The invention relates to 4-methylbenzenesulfonate salt of the compound of formula (I) in a crystalline form or a solvate thereof, pharmaceutical formulations containing them, their use in therapy and processes for preparing... | 01/10/2012 |
| 8093239 | Imidazopyridine kinase inhibitors The present invention provides imidazopyridine compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents. ... | 01/10/2012 |
| 7994185 | Benzene sulfonamide thiazole and oxazole compounds The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents. ... | 08/09/2011 |
| 7981903 | 2-[2-{phenylamino}-1H-pyrrolo[2,3-D]pyrimidin-4-yl)amino] benzamide derivatives as IGF-1R inhibitors for the treatment of cancer Novel pyrrolopyrimidines as shown in formula (I): and pharmaceutically acceptable derivatives thereof. The compounds are useful in the inhibition of IGF-1R. ... | 07/19/2011 |
| 7960563 | Indazoles used to treat estrogen receptor beta mediated disorders The present invention relates to novel indazole derivatives having pharmacological activity, processes for their preparation, compositions containing them and uses of these compounds in the treatment of estrogen receptor beta mediated diseases. ... | 06/14/2011 |
| 7956083 | Compounds The present invention relates to novel indole derivatives having pharmacological activity, processes for their preparation, compositions containing them and the use of these compounds in the treatment of estrogen receptor beta mediated diseases. ... | 06/07/2011 |
| 7919491 | Pyridine derivatives and their use in the treatment of psychotic disorders A pyridine derivative novel compounds of formula (I) or a pharmaceutically acceptable salt thereof where all variables are defined herein. The compounds are useful in the treatment of psychotic disorders. ... | 04/05/2011 |
| 7829297 | Treatment of cancers expressing p95 ErbB2 The truncated ErbB2 receptor (p95ErbB2) is shown to differ from the full-length ErbB2 receptor in its association with other ErbB receptors. The truncated receptor preferentially associated with ErbB3, whereas full length ErbB2 heterodimerizes with either... | 11/09/2010 |
| 7812022 | 2-pyrimidinyl pyrazolopyridine ErbB kinase inhibitors The present invention provides 2-pyrimidinyl pyrazolopyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents. ... | 10/12/2010 |
| 7807673 | 2-pyrimidinyl pyrazolopyridine ErbB kinase inhibitors The present invention provides 2-pyrimidinyl pyrazolopyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents. ... | 10/05/2010 |
| 7799828 | Cycloalkylidene compounds as modulators of estrogen receptor The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation. ... | 09/21/2010 |
| 7794960 | Predictive biomarkers in cancer therapy The use of various biomarkers to assess a subject's suitability for treatment with a EGFR/ErbB2 kinase inhibitor for a solid tumor are described. The biomarkers include TGFalpha, pS6, IGF-1R and levels of apoptosis occurring in tumor tissue. ... | 09/14/2010 |
| 7723393 | Cycloalkylidene compounds as selective estrogen receptor modulators The present invention relates to compounds of formula (I) with a variety of therapeutic uses, more particularly the substituted cyclic alkylidene compounds are useful for selective estrogen receptor modulation. ... | 05/25/2010 |
| 7683056 | Pyridine derivatives and their use in the treatment of psychotic disorders There are provided according to the invention novel compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein all variables are defined herein. Also provided are pharmaceutical compositions ... | 03/23/2010 |
| 7652012 | 2-(R)-(4-fluoro-2-methyl-phenyl)-4-(S)-((8aS)-6-oxo-hexahydro-pyrrolo[1,2-]-pyrazin-2-yl)-piperidine-1-carboxylic acid [1-(R)-3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide maleate and pharmaceutical compositions thereof The present invention relates to piperidine derivatives of formula (I) specifically 2-(R)-(4-Fluoro-2-methyl-phenyl)-4-(S)-((8aS)-6-oxo-hexahydro-pyrrolo[1,2-a]-pyrazin-2-yl)-piperidine-1-carboxylic acid [1-(R)-(3,5-bis-tri... | 01/26/2010 |
| 7649093 | Naphthalene compounds as selective estrogen receptor modulators The present invention relates to cycloalkylidene compounds with a variety of therapeutic uses, more particularly novel naphthalene compounds that are particularly useful for selective estrogen receptor modulation. ... | 01/19/2010 |
| 7648990 | Chemical compounds The present invention provides a method for the treatment of emesis in a mammal being treated with an opiod analgesic. ... | 01/19/2010 |
| 7635701 | Pyrimidine derivatives and their use as CB2 modulators The present invention relates to novel pyrimidine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activi... | 12/22/2009 |
| 7589206 | Pyrrolopyridine derivatives The present invention relates to novel pyrrolopyridine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in a... | 09/15/2009 |
| 7572915 | Quinoline derivatives as phosphodiesterase inhibitors There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20, and R34 are as described in the specification, processes for preparing the... | 08/11/2009 |
| 7569601 | Cycloalkylidene compounds as modulators of estrogen receptor The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation. ... | 08/04/2009 |
| 7566786 | Quinoline derivatives as phosphodiesterase inhibitors There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20, and R34 are as described in the specifica... | 07/28/2009 |
| 7560589 | Cycloalkylidene compounds as modulators of estrogen receptor The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation. ... | 07/14/2009 |
| 7550498 | 1,2-Diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof The present invention relates to derivatives of 1,2-diaza-dibenzoazulene, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory actions, especially to the inhibition ... | 06/23/2009 |
| 7495004 | Purine derivatives as liver X receptor agonists The invention relates to methods for the treatment or prevention of an LXR mediated disease or condition, including cardiovascular disease and atherosclerosis, novel compounds of formula (I) for use in such methods and pharmaceutical compositions comprising compound... | 02/24/2009 |
| 7446117 | Cox-2 inhibiting pyridine derivatives Compounds of formula (I) or pharmaceutically acceptable salts thereof are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever and inflammation of a variety of conditions and diseases.... | 11/04/2008 |
| 7442833 | Triphenylethylene compounds as selective estrogen receptor modulators Compounds of formula (I): with a variety of therapeutic uses, more particularly novel prodrugs that are particularly useful for delivering a parent compound for selective estrogen receptor modulation. ... | 10/28/2008 |
| 7435834 | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof The present invention relates to compounds of 2-thia-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition... | 10/14/2008 |
| 7405303 | Substituted quinoline compounds for use as selective estrogen receptor modulator The present invention relates to novel compounds of formula (I) with a variety of therapeutic uses, more particularly novel substituted quinoline compounds particularly useful for selective estrogen receptor modulation. ... | 07/29/2008 |
| 7312203 | 1-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof The present invention relates to 1-aza-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumo... | 12/25/2007 |
| 7262309 | 1- or 3-thia-benzonaphthoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof The present invention relates to benzonaphthoazulene derivatives of tiophene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the i... | 08/28/2007 |
| 7262302 | 1-thia-3-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof The present invention relates to derivatives of 1-thia-3-aza-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the in... | 08/28/2007 |
| 7235560 | Pyrimidine derivative as selective COX-2 inhibitors The invention provides the compounds of formula (I) or a pharmaceutically acceptable salt thereof. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of ... | 06/26/2007 |
| 7232821 | (2-((2-alkoxy)-phenyl) -cyclopent-1enyl) aromatic carbo and heterocyclic acid and derivatives Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, R1, R2, Rx, R8, R9 and n are as defined in the specification, a proc... | 06/19/2007 |
| 7232815 | 1-oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof The present invention relates to derivatives of 1-oxa-3-aza-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory actions, especially to the inh... | 06/19/2007 |
| 7223772 | Pyrazolopyridine derivatives as selective cox-2 inhibitors The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof wherein: R0 and R1 are independently selected from the gr... | 05/29/2007 |
| 7166631 | Benzo[f]isoindole derivatives with affinity to the EP4 receptor The present invention relates to a compound of formula (I): corresponding pharmaceutical compositions, preparation processes, and/or methods of using the aforementioned compounds and/or compositions. ... | 01/23/2007 |
| 7084148 | Substituted pyrimidines as selective cyclooxygenase-2 inhibitors A compound of formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1 is H or C1-6alkyl; R2 is wherein ... | 08/01/2006 |
| 7074802 | Pyrimidine derivatives as selective inhibitors of cox-2 The invention thus provides the compounds of formula (I) and pharmaceutically acceptable salts thereof, in which: R1 and R2 are independently selected from the group consisting ... | 07/11/2006 |
