...that when IBM conducted a market study of Chester Carlson's invention in 1959, the company concluded that it would take only 5000 units of his new product to saturate the market? IBM therefore declined to be part of the new product introduction. Too bad for IBM. Carlson's invention was the xerography process, and his new product was the beginning of the Xerox Corporation. It is estimated that every day, worldwide, 3,000,000,000 copies are made!!
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| Number | Title | Issue Date |
| 7914999 | Non-denaturing lysis reagent The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent inc... | 03/29/2011 |
| 7776605 | Assay for cardiac troponin autoantibodies The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, a... | 08/17/2010 |
| 7517876 | Anti-infective agents Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermedia... | 04/14/2009 |
| 6827208 | Packaging system for separately storing and dispensing together separate medication components The present invention relates to a packaging system intended to simplify the usage of multiple medications stored separately and used together, thereby minimize the non-compliant use of the multiple medications. Generally, the separate medication components are cont... | 12/07/2004 |
| 6720004 | Controlled release formulation of divalproex sodium A new oral polymeric controlled release formulation suitable for the once-a-day administration of valproate compounds, such as divalproex sodium, has been discovered. This formulation exhibits significant advantages over the sustained release valproate formulations ... | 04/13/2004 |
| 6713086 | Controlled release formulation of divalproex sodium A new oral polymeric controlled release formulation suitable for the once-a-day administration of valproate compounds, such as divalproex sodium, has been discovered. This formulation exhibits significant advantages over the sustained release valproate formulations ... | 03/30/2004 |
| 6528091 | Controlled release formulation of divalproex sodium A controlled release tablet formulation which permits once daily dosing in the treatment of epilepsy comprises from about 50 weight percent to about 55 weight percent of an active ingredient selected from the group consisting of valproic acid, a pharmaceu... | 03/04/2003 |
| 6528090 | Controlled release formulation of divalproex sodium A new oral polymeric controlled release formulation suitable for the once-a-day administration of valproate compounds, such as divalproex sodium, has been discovered. This formulation exhibits significant advantages over the sustained release valproate fo... | 03/04/2003 |
| 6521790 | Alkynyl amides and their therapeutic applications Compounds of formula (I) ##STR1## are novel and useful for treating seizure, migraine and psychiatric disorders.... | 02/18/2003 |
| 6511678 | Controlled release formulation of divalproex sodium A new oral polymeric controlled release formulation suitable for the once-a-day administration of valproate compounds, such as divalproex sodium, has been discovered. This formulation exhibits significant advantages over the sustained release valproate fo... | 01/28/2003 |
| 6294326 | Analyte detection process using dual labeled probes Provided herein is a method for detecting the presence of a target nucleic acid sequence in a sample. The present method uses a combination of dual labeled probes and heterogeneous detection methods.... | 09/25/2001 |
| 6232455 | Nucleic acid primers and probes for detecting HIV-1 and HIV-2 Provided herein are primer/probe sets useful for detecting HIV (i.e. either or both HIV 1 or HIV 2) in a test sample. The primer/probe sets are can be employed according to nucleic acid amplification procedures including PCR or RT PCR. The primer/probe se... | 05/15/2001 |
| 6210876 | Nucleic acid primers and probes for detecting Chlamydia pneumoniae Nucleic acid sequences that are useful for detecting Chlamydia pneumoniae are herein provided. These sequences can be used in hybridization assays or amplification based assays designed to detect the presence of Chlamydia pneumoniae in a test sample. Addi... | 04/03/2001 |
| 6210898 | Method of performing immunochromatography The invention relates to multiplex ligase chain reaction (LCR). Two or more putative target sequences are selected. For each one, a set of four probes is used simultaneously to amplify the putative sequence if it is present in the sample. Preferably, all ... | 04/03/2001 |
| 6203992 | Nucleic acid primers and probes for detecting tumor cells Nucleic acid sequences are provided that are useful as amplification primers and hybridization probes for detecting CK19 target sequence in a test sample. The primers and probes can be employed in amplification based methods for detecting the presence of ... | 03/20/2001 |
| 6100099 | Test strip having a diagonal array of capture spots The invention relates to multiplex ligase chain reaction (LCR). Two or more putative target sequences are selected. For each one, a set of four probes is used simultaneously to amplify the putative sequence if it is present in the sample. Preferably, all ... | 08/08/2000 |
| 6071480 | Method for generating a standing sonic wave, methods of sonication with a standing sonic wave, and a standing sonic wave sonicator The present invention provides a standing sonic wave sonicator, methods of generating a standing sonic wave and a method of sonication which employs a standing sonic wave to disrupt particulate material.... | 06/06/2000 |
| 6068978 | Apparatus and method for transfer of a fluid sample Methods, devices, apparatus and kits for amplifying and detecting nucleic acid are provided. The apparatus is a one or two-tier thermal cycling device that operates in conjunction with a reaction/detection unit. A sample is loaded into a reaction chamber ... | 05/30/2000 |
| 6010857 | Detection of cervical chlamydia trachomatis infection The present invention provides methods for detecting Chlamydia trachomatis infections using a female urine sample.... | 01/04/2000 |
| 5998593 | Fluorescent enzyme substrates Fluorescent enzyme substrates are provided. The substrates are derivatives of coumarin having an enzyme cleavable group at position 7 and a hydrophilic amide group at position 4. The compounds are highly water soluble, stable at ambient and reduced temper... | 12/07/1999 |
| 5976824 | Method and apparatus for collecting a cell sample from a liquid specimen A method and apparatus for collecting a binding member of interest from a liquid specimen utilizes a collection receptacle in which the specimen is deposited, with an affinity-filter media being place in communication with a discharge port in the collecti... | 11/02/1999 |
| 5968739 | Nucleic acid primers and probes for detecting Legionella pneumophila Nucleic acid sequences that are useful for detecting Legionella pneumophila are herein provided. These sequences can be used in hybridization assays or amplification based assays designed to detect the presence of Legionella pneumophila in a test sample. ... | 10/19/1999 |
| 5962665 | Nucleic acid primers and probes for detecting HIV-1 and HIV-2 Provided herein are primer/probe sets useful for detecting HIV (i.e. either or both HIV 1 or HIV 2) in a test sample. The primer/probe sets are can be employed according to nucleic acid amplification procedures including PCR or RT PCR. The primer/probe se... | 10/05/1999 |
| 5955268 | Method and reagent for detecting multiple nucleic acid sequences in a test sample Provided herein are methods for detecting multiple target nucleic acid sequences in a test sample. Also provided is a hybridization platform useful for detecting multiple target sequences in a test sample. The hybridization platform comprises a solid supp... | 09/21/1999 |
| 5858732 | Wide dynamic range nucleic acid detection using an aggregate primer series The present invention provides a method of detecting the amount of a target sequence which may be present in a test sample. The method uses an aggregate primer series, which comprises at least two primer sets, in an amplification reaction to detect the re... | 01/12/1999 |
| 5846785 | Oligonucleotides specific for the MOMP gene sequence and methods for the detection of Chlamydia trachomatis The present invention relates to oligonucleotide probes useful in detecting, e.g. by hybridization or the ligase chain reaction, Chlamydia trachomatis DNA in the presence of other related DNA. The present invention is also directed to methods of detecting... | 12/08/1998 |
| 5817798 | Rapid RNA isolation procedure in the presence of a transition metal ion Provided herein is a rapid method for isolating total RNA from test samples and further for isolating mRNA from test samples.... | 10/06/1998 |
| 5817463 | Nucleic acid primers and probes for detecting Mycoplasma pneumoniae Nucleic acid sequences that are useful for detecting Mycoplasma pneumoniae are herein provided. These sequences can be used in hybridization assays or amplification based assays designed to detect the presence of Mycoplasma pneumoniae in a test sample. Ad... | 10/06/1998 |
| 5616505 | Haptens tracers, immunogens and antibodies for 3-phenyl-1-adamantaneacetic acids Novel tethered hapten intermediates and related conjugates based on 3-phenyl-1-adamantaneacetic acid, as well as methods for making and using such conjugates. Haptens based on the above core structure may be substituted at any position on the phenyl ring,... | 04/01/1997 |