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| Number | Title | Issue Date |
| 8178651 | Somatostatin-dopamine chimeric analogs Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is: 6-n-propyl-8β-ergolinglmethylthioacetyl-D-Phe-c(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH2. ... | 05/15/2012 |
| 8138218 | Growth hormone secretagogues A family of peptides and peptidomimetic compounds useful as GHS analogs according to either formula (I) or (II) as depicted below: or a pharmaceutically acceptable salts thereof, wherein the variables are as defined in the specification. | 03/20/2012 |
| 8076281 | Use of a ghrelin agonist to improve the catabolic effects of glucocorticoid treatment A method and pharmaceutical composition for inhibiting the effect of glucocorticoids, particularly dexamethasone, which suppress growth hormone secretion, by administering ghrelin or a ghrelin analogue, for example, [Aib2, Glu3(NH-hexyl)]hGhrel... | 12/13/2011 |
| 8039435 | Melanocortin receptor ligands The present invention is directed to compounds according to formula, (R2R3)-A1-c(A2-A3-A4-A5-A6-A7-A8-A9)-A10-R1... | 10/18/2011 |
| 7932231 | Compositions and methods for stimulating gastrointestinal motility The present invention relates to a method of treating a transient impairment of the motility of the gastrointestinal system resulting from postoperative ileus in a patient wherein said method includes the step of administering a therapeutically effective amount of a... | 04/26/2011 |
| 7897566 | Analogues of GLP-1 Disclosed are peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, methods of using such analogues to treat mammals and pharmaceutical compositions useful therefor comprising said analogues. ... | 03/01/2011 |
| 7811989 | Peptide YY analogs The invention provides analogs of PYY. The invention also provides compositions and methods useful for controlling biological activities such as cell proliferation, nutrient transport, lipolysis, and intestinal water and electrolyte secretion. ... | 10/12/2010 |
| 7589058 | Ghrelin analogs The invention comprises peptidyl analogs that possess agonist or antagonist ghrelin activity, along with therapeutic and non-therapeutic uses thereof. ... | 09/15/2009 |
| 7579435 | Somatostatin-dopamine chimeric analogs Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is: 6-n-propyl-8β-ergolinglmethylthioacetyl-D-Phe-c-(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH2. ... | 08/25/2009 |
| 7572883 | Somatostatin-dopamine chimeric analogs Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is: 6-n-propyl-8β-ergolinglmethylthioacetyl-D-Phe-c(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH2 ... | 08/11/2009 |
| 7517853 | Somatostatin-dopamine chimeric analogs The invention features somatostatin-dopamine chimeric analogs and methods relating to their therapeutic use for the treatment of neoplasia, acromegaly, and other conditions. ... | 04/14/2009 |
| 7456253 | Growth hormone releasing peptides Disclosed are peptide and peptidomimetic compounds generally according to formula (I), and pharmaceutically acceptable salts thereof, that are useful as GHRP analogs: R1-A2-A3-A4-A5-R2 (I) or a pharma... | 11/25/2008 |
| 7321034 | Process for the physical depolymerization of glycosaminogylcanes and products obtained thereform The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of electron beam radiation, optionally in the presence of an organic compound selected from the group consisting of ethers, alcohols, aldehydes, amides and fo... | 01/22/2008 |
| 7312304 | Somatostatin agonists Claimed are a series of somatostatin agonists and uses thereof, according to formula (I), A1-cyclo[Cys-A2-D-Trp-A3-A4-Cys]-A5-Y1, (I) wherein A1, A2, A | 12/25/2007 |
| 7241737 | Urotensin-II agonists and antagonists The present invention is directed to a novel class of cyclic polypeptides of the formula: (R1)a-AA1-cyclo[AA2-AA3-AA4-AA5-AA6-Cys]-AA7-R2, pharmaceutically ... | 07/10/2007 |
| 7144859 | Somatostatin agonists The present invention is directed to cyclic peptides of formula (I): X-A1-cyclo(D-Cys-A3-A4-Lys-A6-A7)-A8-Y, or a pharmaceutically acceptable salt thereof. The peptides bind selectively to the somatos... | 12/05/2006 |
| 7122628 | Process for the synthesis of a peptide having a Trp residue A process for the solid phase synthesis of a peptide having at least one thyptophan residue, wherein said method comprises temporarily protecting the indole ring of said tryptophan residue with a side chain protecting group which is labile to a base wherein said pro... | 10/17/2006 |
| 7094753 | Somatostatin analog and uses thereof Claimed is a somatostatin agonist according to formula (I), D-Phe-c(Cys-Tyr(I)-D-Trp-Lys-Val-Cys)-Thr-NH2, (I) or a pharmaceutically acceptable salt thereof, and uses thereof. ... | 08/22/2006 |
| 7084117 | Pharmaceutical compositions which inhibit vascular proliferation and method of use thereof The present invention relates to a method of treating vascular proliferation in a patient in need thereof. The method includes the step of administering a therapeutically effective amount of a type-1 somatostatin agonist to said patient. ... | 08/01/2006 |
| 7078434 | Use of Ginkgo extract The present invention is directed to the use of the extract of Ginkgo biloba leaves or isolated Ginkgolide B (GKB), a component of the extract of Ginkgo biloba leaves in a method for decreasing the expression of peripheral-type benzodiazepine receptor ... | 07/18/2006 |
| 6893645 | Process to make a sustained release formulation This invention pertains to a process for making a sustained release complex. Compound (I), which comprises Compound (A), having formula (A), and a copolymer comprising poly (l)-lactic-glycolic-tartaric acid (P(I)LGT), wherein the amino group of Compound (A) is ionic... | 05/17/2005 |
| 6866847 | Method of delivering a protein to poultry A method of delivering a protein to domestic poultry by administering to the poultry by whole body spray an effective amount of a live avirulent derivative of an enteropathogenic bacterium that contains a recombinant gene encoding the protein. ... | 03/15/2005 |
| 6864100 | Automated protein purification the multiwell format by vacuum filtration The invention relates to a process and a reagent kit for obtaining clear solutions containing cell contents from biological samples in a high throughput process, comprising the steps of preparing a plurality of protein-containing solutions which contain insoluble in... | 03/08/2005 |
| 6846808 | Plasmid-based vaccine for treating atherosclerosis A plasmid-based vaccine is provided herein based on the combination of DNA segments coding for one or more B cell epitopes of CETP and one or more broad range helper T cell epitopes. Administration of the plasmids as a vaccine to a vertebrate subject provides an imm... | 01/25/2005 |
| 6841373 | Herpes virus complementing cell line The present invention is directed to a cell line capable of supporting replication of a growth-defective Herpes Simplex Virus strain; specifically a replication-defective HSV-2 double mutant. Particularly disclosed is a cell line that expresses the ICP8 protein and ... | 01/11/2005 |
| 6780405 | Regulated antigen delivery system (RADS) We describe a regulated antigen delivery system (RADS) that has (a) a vector that includes (1) a gene encoding a desired gene product operably linked to a control sequence, (2) an origin of replication conferring vector replication using DNA polymerase III, and (3) ... | 08/24/2004 |
| 6777420 | Heterocyclic antibacterial compounds The invention provides heterocyclic organic compounds that inhibit bacterial DNA polymerase IIIC and type II bacterial topoisomerase. The invention further provides compounds that are useful as intermediates in the synthesis of such heterocyclic organic compounds. S... | 08/17/2004 |
| 6723510 | Methods for separating particulate substrates from solution while minimizing particle loss The present invention provides a method for separation of a particulate matrix from a solution while reducing loss of particles during separation steps. Methods are also disclosed for isolation of molecules of interest using affinity particles or beads, wherein at l... | 04/20/2004 |
| 6713073 | Method of vaccination of newly hatched poultry A method of vaccinating poultry by spraying the poultry with an effective amount of a live avirulent derivative of an enteropathogenic enterobacteria is disclosed. ... | 03/30/2004 |
| 6706858 | Use of alkanes for contamination-free purification or separation of biopolymers The present invention relates to the use of alkanes for the contamination-free purification or separation of biopolymers. ... | 03/16/2004 |
