Did You Know...
...that a workman who left the soap mixing machine on too long was responsible for making Ivory Soap? He was so embarrassed by his mistake that he threw the mess in a stream. Imagine his dismay when the evidence of his error floated to the surface! Result: Ivory soap, the soap that floats.
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| Number | Title | Issue Date |
| 6586452 | C1 to C4 side chain modified nodulisporic acid analogs The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.... | 07/01/2003 |
| 6579889 | Substituted isonipecotyl derivatives as inhibitors of cell adhesion Compounds of Formula I are antagonists of VLA-4 and/or 댔ଲ.sub.7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical ... | 06/17/2003 |
| 6559174 | N-arylsulfonyl aryl aza-bicyclic derivatives as potent cell adhesion inhibitors Compounds of Formula I are antagonists of VLA-4 and/or alpha4/beta7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are... | 05/06/2003 |
| 6528531 | Aliphatic hydroxy substituted piperidyl diaryl pyrrole derivatives as antiprotozoal agents Trisubstituted pyrroles are antiprotozoal agents useful in the treatment and prevention of protozoal diseases in human and animals, including the control of coccidiosis in poultry.... | 03/04/2003 |
| 6482840 | Substituted cyclic amidine derivatives as inhibitors of cell adhesion Compounds of Formula I are antagonists of VLA-4 and/or 댔ଲ.sub.7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical ... | 11/19/2002 |
| 6479672 | Diastereoselective preparation of Michael adducts Michael addition conducted in the presence of a zinc-amine complex and additional amounts of the amine component results in product with high diastereomeric excess.... | 11/12/2002 |
| 6469172 | Process for the preparation of chemical compounds An improved and efficient synthesis for the preparation of 2-amino-6-[(4-aminopiperidin-1-yl]methyl]pyridine, an intermediate compound in the preparation of muscarinic M3 receptor antagonists, includes as a final step the removal of trimethylacetyl and an... | 10/22/2002 |
| 6432980 | Aliphatic amine substituted piperidyl diaryl pyrrole derivatives as antiprotozoal agents Trisubstituted pyrroles are antiprotozoal agents useful in the treatment and prevention of protozoal diseases in human and animals, including the control of coccidiosis in poultry.... | 08/13/2002 |
| 6420418 | Heterocycle amides as cell adhesion inhibitors Compounds of Formula I are antagonists of VLA-4 and/or 댔댧, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and... | 07/16/2002 |
| 6410583 | Cyclopentanoindoles, compositions containing such compounds and methods of treatment Substituted cyclopentanoindole derivatives are antagonists of prostaglandins, and as such are useful for the treatment of prostaglandin mediated diseases.... | 06/25/2002 |
| 6403584 | Substituted nipecotyl derivatives as inhibitors of cell adhesion Compounds of Formula I are antagonists of VLA-4 and/or 댔ଲ.sub.7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical ... | 06/11/2002 |
| 6384052 | Anticoccidial compounds Trisubstituted pyrroles are useful in the control of coccidiosis in poultry.... | 05/07/2002 |
| 6353099 | Substituted ureas as cell adhesion inhibitors Compounds of Formula I are antagonists of VLA-4 and/or 댔ଲ.sub.7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical ... | 03/05/2002 |
| 6320052 | Process for the preparation of leukotriene antagonists The present invention relates to a process for the preparation of a compound of formula (I) or a sodium salt thereof ##STR1## wherein HET is 7-chloroquinolin-2-yl or 6,7-difluoroquinolin-2-yl, which comprises: reacting the dilithium dianion of 1-(mer... | 11/20/2001 |
| 6291511 | Biarylalkanoic acids as cell adhesion inhibitors Compounds of Formula I are antagonists of VLA-4 and/or 댔ଲ.sub.7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical ... | 09/18/2001 |
| 6291491 | Amide derivatives as ଲ 3 agonists Amide derivatives are selective 댣 adrenergic receptor agonists with very little 댡 and 댢 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure... | 09/18/2001 |
| 6291480 | Diaryl piperidyl pyrrole derivatives as antiprotozoal agents Trisubstituted pyrroles are antiprotozoal agents useful in the treatment and prevention of protozoal diseases in human and animals, including the control of coccidiosis in poultry.... | 09/18/2001 |
| 6271252 | Cyclic amino acid derivatives as cell adhesion inhibitors Cyclic amino acid derivatives of Formula I are antagonists of VLA-4 and/or 댔ଲ.sub.7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated ... | 08/07/2001 |
| 6221888 | Sulfonamides as cell adhesion inhibitors Compounds of Formula I are antagonists of VLA-4 and/or 댔ଲ.sub.7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical ... | 04/24/2001 |
| 6204034 | Leukotriene C4 synthase Leukotriene C4 synthase polypeptide identified by photoaffinity labelling, and purification of leukotriene C4 synthase to homogeneity is described.... | 03/20/2001 |
| 6191171 | Para-aminomethylaryl carboxamide derivatives para-Aminomethylaryl carboxamides of Formula I are antagonists of VLA-4 and/or 댔ଲ.sub.7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formula... | 02/20/2001 |
| 6090841 | Substituted pyrrole derivatives as cell adhesion inhibitors Substituted pyrrole derivatives of Formula I are antagonists of VLA-4 and/or 댔 댧, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be fo... | 07/18/2000 |
| 6069163 | Azapeptide acids as cell adhesion inhibitors Azapeptide acids of Formula I are antagonists of VLA-4 and/or 댔 댧, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into p... | 05/30/2000 |
| 6043253 | Fused piperidine substituted arylsulfonamides as 댣-agonists Fused piperidine substituted arylsulfonamides are 댣 adrenergic receptor agonists with very little 댡 and 댢 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and ... | 03/28/2000 |
| 6034106 | Oxadiazole benzenesulfonamides as selective ଲ3 Agonist for the treatment of Diabetes and Obesity Oxadiazole substituted benzenesulfonamides are selective 댣 adrenergic receptor agonists with very little 댡 and 댢 adrenergic receptor activity and as such the compounds are capable of increasing lipolys... | 03/07/2000 |
| 6020347 | 4-substituted-4-piperidine carboxamide derivatives 4-Substituted-4-piperidinecarboxamides of Formula I are antagonists of VLA-4 and/or 댔 댧, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds ma... | 02/01/2000 |
| 6011048 | Thiazole benzenesulfonamides as 댣 agonists for treatment of diabetes and obesity Thiazole substituted benzenesulfonamides are 댣 adrenergic receptor agonists with very little 댡 and 댢 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energ... | 01/04/2000 |
| 5972996 | 4-cyano-4-deformylsordarin derivatives 4-Cyano-4-deformylsordarin derivatives are antifungal agents useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops.... | 10/26/1999 |
| 5962499 | Nodulisporic acid derivatives The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.... | 10/05/1999 |
| 5955480 | Triaryl substituted imidazoles, compositions containing such compounds and methods of use 2,4-Diaryl-5-pyridylimidazoles are glucagon antagonists and inhibitors of the biosynthesis and/or action of TNF- and IL-1. The compounds block the action of glucagon at its receptor and thereby decrease the levels of plasma glucose. The instant imi... | 09/21/1999 |
| 5952347 | Quinoline leukotriene antagonists Compounds of Formula I: ##STR1## are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, ... | 09/14/1999 |
| 5945317 | Antiparasitic agents Novel compounds isolated from the fermentation of producing cultures of Nodulisporium sp. are antiparasitic and insecticidal agents.... | 08/31/1999 |
| 5922837 | Antiprotozoal cyclic tetrapeptides The present invention provides novel cyclic tetrapeptides useful in the treatment or prevention of protozoal diseases; in particular, the novel compounds are active against the causative pathogens in malaria, toxoplasmosis, and coccidiosis. The invention ... | 07/13/1999 |
| 5880139 | Triaryl substituted imidazoles as glucagon antagonists 2,4-Diaryl-5-pyridylimidazoles are glucagon antagonists. The compounds block the action of glucagon at its receptor. Thus, the compounds can be used in the prophylaxis or treatment of disease states in mammals mediated by elevated levels of glucagon. Exam... | 03/09/1999 |
| 5880280 | Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity Aryl, alkyl, alkenyl and alkynyl macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by modification at C-30, C-33, and/or C-34 of the cyclohexyl ring. These macrolide immunosuppressants are usefu... | 03/09/1999 |
| 5877184 | Macrolides having immunosuppressive activity Macrolides of the general structural Formula I: ##STR1## are immunosuppressants useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants and/or related af... | 03/02/1999 |
| 5869673 | Process for 3-(2-(7-chloro-2-quinolinyl)ethenyl) - benzaldehyde The yield of monoaldehyde ##STR1## from 7-chloroquinaldine and isophthalaldehyde is increased to about 82% by using a 2 molar excess of isophthalaldehyde, conditions favoring precipitation of product during the reaction and recycling unreacted i... | 02/09/1999 |
| 5861375 | Antiprotozoal cyclic tetrapeptides The present invention provides novel cyclic tetrapeptides useful in the treatment or prevention of protozoal diseases; in particular, the novel compounds are active against the causative pathogens in malaria, toxoplasmosis, and coccidiosis.... | 01/19/1999 |
| 5856322 | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists Compounds having the formula I: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in t... | 01/05/1999 |
| 5846791 | N-(R)-(2-hydroxy-2-pyridine-3-yl-ethyl)-2-(4-nitro-phenyl)-acetamide Asymmetric bioreduction of a ketone substrate with yeast produces the corresponding (R)-alcohol of structure: ##STR1## a key intermediate in the synthesis of a 댣 -agonist of structure ##STR2##... | 12/08/1998 |
