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| Number | Title | Issue Date |
| 8007830 | Granule formation The present invention relates to oral granules of montelukast sodium. ... | 08/30/2011 |
| 7960409 | Pharmaceutical phenylquinoline and chromen-2-one triazole compounds The instant invention provides compounds of Formula I which are leukotriene biosynthesis inhibitors. Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotec... | 06/14/2011 |
| 7915298 | Compounds and methods for leukotriene biosynthesis inhibition This invention provides novel salt and crystalline forms thereof of (−)4-(4-fluorophenyl)-7-[({5-[1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl}amino)-methyl]-2H-chromen-2-one. The compounds are 5-LO inhibitors and are useful for treatment of condition... | 03/29/2011 |
| 7816380 | 1-hydroxycycloalkanecarboxamide derivatives α-Hydroxycycloalkanecarboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, wherein formula (a) is a single or double bond; R1, R2 and R3 are each independently selected from H, halogen and OH; or R | 10/19/2010 |
| 7790754 | Alpha-hydroxy amides as bradykinin antagonists or inverse agonists α-Hydroxy amide derivatives of the general formula (I) are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. R2a is selected from (1) a... | 09/07/2010 |
| 7776891 | VLA-4 antagonists Compounds of Formula (I) are antagonists of VLA-4, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the trea... | 08/17/2010 |
| 7696222 | Indole derivatives as CRTH2 receptor antagonists Compounds according to formula (I) wherein the radicals R1, R2 and R3 are as herein defined, and wherein Ar represents an aryl group or heteroaryl group, preferably phenyl, n is 1 or 2, and the radical X represents a group selected f... | 04/13/2010 |
| 7629467 | Diphenyl substituted cycloalkanes, compositions containing such compounds and methods of use The instant invention provides compounds of formula: (I) which are 5-lipoxygenase activating protein inhibitors: formula (I). Compounds of formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cyto-protective agents. | 12/08/2009 |
| 7560559 | Polymorphic form of montelukast sodium The invention provides novel polymorphic form of montelukast sodium, as well as methods of using and pharmaceutical compositions containing saud novel form. Also provided are montelukast sodium: acetonitrile solvates, which are intermediates in the formation of crys... | 07/14/2009 |
| 7553973 | Pharmaceutical compounds The instant invention provides compounds of Formula Ia which are leukotriene biosynthesis inhibitors. Compounds of Formula Ia are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprot... | 06/30/2009 |
| 7514409 | VLA-4 antagonists Compounds of Formula I are antagonists of VLA-4, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatm... | 04/07/2009 |
| 7511152 | Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 03/31/2009 |
| 7439260 | 7-(1,3-thiazol-2-YL)thio-coumarin derivatives and their use as leukotriene biosynthesis inhibitors The instant invention provides compounds of Formula (I) which are leukotriene biosynthesis inhibitors. Compounds of formula (I) are useful as anti-asthmatic, anti-allergic, anti-inflammatory, cytoprotective and anti-artherosclerotic agents. | 10/21/2008 |
| 7393873 | Arylsulfonamide derivatives N-aryl arylsulfonamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. ... | 07/01/2008 |
| 7332499 | Sulfonyl substituted n-(biarylmethyl) aminocyclopropanecarboxamides N-(Sulfonyloxybiarylmethyl) aminocyclopropanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. ... | 02/19/2008 |
| 7317036 | Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment Fluoro substituted cycloalkanoindole derivatives are antagonists of prostaglandins, and as such are useful for the treatment of prostaglandin mediated diseases. ... | 01/08/2008 |
| 7259157 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain. ... | 08/21/2007 |
| 7217716 | N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists Compounds represented by Formula (I): (I) or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain ... | 05/15/2007 |
| 7163951 | N-biarylmethyl aminocycloalkanecarboxamide derivatives N-Biarylmethylaminocycloalkanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. ... | 01/16/2007 |
| 7091380 | N-biphenylmethyl aminocycloalkanecarboxamide derivatives N-Biphenyl(substituted methyl) aminocycloalkanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. ... | 08/15/2006 |
| 7019022 | Substituted tetrahydrocarbazole and cyclopentanoindole derivatives The present invention provides substituted tetrahydrocarbazole and cyclopentanoindole derivatives as antagonists of DP receptor, and as such are useful for the treatment of prostaglandin D2 mediated diseases such as rhinitis, asthma and nasal congestion. ... | 03/28/2006 |
| 6960646 | Cyclic peptides as potent and selective melanocortin-4 receptors agonists Cyclic peptides of formula I are potent and selective agonists of melanocortin-4 receptors, and as such are useful research tool for the determination of the physiological roles of the MC-4 receptor, as well as for the diagnoses, treatment or prevention of disorders... | 11/01/2005 |
| 6943180 | Substituted N-arylsulfonyl-proline derivatives as potent cell adhesion inhibitors Compounds of formula (I) are antagonists of VLA-4 and/or alpha4/beta7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable... | 09/13/2005 |
| 6919343 | N-biphenyl(substituted methyl) aminocycloalkane-carboxamide derivatives N-Biphenyl(substituted methyl)aminocycloalkanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. ... | 07/19/2005 |
| 6908921 | Quinoxalinone derivatives as bradykinin B1 antagonists 2-Quinoxalinone derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. ... | 06/21/2005 |
| 6903075 | Heterocyclic amide compounds as cell adhesion inhibitors Compounds of Formula I are antagonists of VLA-4 and/or α4β7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions an... | 06/07/2005 |
| 6855708 | N-arylsulfonyl aza-bicyclic derivatives as potent cell adhesion inhibitors Compounds of Formula I are antagonists of VLA-4 and/or alpha4/beta7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable f... | 02/15/2005 |
| 6852727 | Benzimisazo[4,5-f]isoquinolinone derivatives Benzimidazo[4,5-f]isoquinolinone derivatives are inhibitors of Janus protein tyrosine kinases (Jak), and as such are useful as immunosuppressants, and in the treatment of diseases including asthma, allergies, autoimmune diseases. ... | 02/08/2005 |
| 6734311 | Substituted amidine derivatives as inhibitors of cell adhesion Compounds of Formula I are antagonists of VLA-4 and/or α4β7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions an... | 05/11/2004 |
| 5270186 | Antitumor antibiotic BMY-42448 An antibiotic designated BMY-42448 is produced by fermentation of Micromonospora narashinoensis strain C39217-R109-7 (ATCC-53791). BMY-42448 exhibits both in vitro and in vivo antitumor activity.... | 12/14/1993 |
| 5270196 | Arylsulfatase from streptomyces The present invention relates to an arylsulfatase of microbial origin. The enzyme may be linked to an antibody against a tumor-associated antigen and the resulting conjugate used in conjuction with a sulfated prodrug of a 4'-demethylepipodophyllotoxin glu... | 12/14/1993 |
| 5248796 | Taxol derivatives The present invention relates to 10-desacetoxy-11,12-dihydrotaxol-10,12(18)-diene derivatives which are useful as antitumor agents and as intermediates for the preparation of 10-desacetoxytaxol. Also disclosed is a novel process for the preparation o... | 09/28/1993 |
| 5245027 | 3-fluorosulfonyloxyceph-3-em compounds 3-Fluorosulfonyloxyceph-3-ems having a protected amino or acylamino group in the 7-position are subject to carbon-carbon bond formation at the 3-position by means of a palladium catalyzed coupling reaction with substituted organostannanes. A process for p... | 09/14/1993 |
| 5227370 | Pradimicin derivatives The present invention provides pradimicin analogs which exhibit improved water solubility relative to parent compounds. These novel agents are useful in treatment of fungal infections.... | 07/13/1993 |
| 5217877 | Process for the preparation of -glucosidase inhibitor, pradimicin Q The present invention relates to a novel -glucosidase inhibitor, pradimicin Q, having the following formula ##STR1## and its pharmaceutically acceptable base salts.... | 06/08/1993 |
| 5198560 | Cytotoxic bicyclo[7.3.1]tridec-4-ene-2,6-diyne compounds and process for the preparation thereof The present invention relates to a novel and efficient process for the preparation of 8-hydroxybicyclo[7.3.1]tridec-4-ene-2,6-diyne ring system which is part of the aglycone of esperemicin and to novel cytotoxic antitumor agents having said bicyclic ring ... | 03/30/1993 |
| 5194371 | Production of pradimicin antibiotics The present invention relates to a fermentation process for producing BMY-28960 and desxylosyl BMY-28960, and to a novel BMY-28960-producing organism belonging to the genus Actinomadura and designated as strain AB 1236 (ATCC 55208).... | 03/16/1993 |
| 5183808 | Method for treating fungal infections with serine analogs of BU-3608 antibiotics Disclosed are antibiotics BU-3608 FA-1 and FA-2 and alkyl derivatives thereof. These compounds are useful as antifungal agents. BU-3608 FA-1 and FA-2 are produced from Actinomadura hibisca in a medium containing a source of D-serine.... | 02/02/1993 |
| 5114857 | Actinomadura hibisca microorganism useful for preparing serine analogs of BU-3608 antibiotics Disclosed are antibiotics BU-3608 FA-1 and FA-2 and alkyl derivatives thereof. These compounds are useful as antifungal agents. BU-3608 FA-1 and FA-2 are produced from Actinomadura hibisca in a medium containing a source of D-serine.... | 05/19/1992 |
| 5110960 | Antifungal antibiotics Novel antibiotic herein designated as BU-3608, BU-3608 B, and BU-3608 C are produced by fermentation of Actinomadura hibisca Strain No. P157-2, ATCC 53557, and Strain No. Q278-4, ATCC 53646. The antibiotics possess antifungal and antiviral activities.... | 05/05/1992 |
