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| Number | Title | Issue Date |
| 6555341 | Human theta subunit of the GABAa receptor This invention concerns the cloning of a novel cDNA sequence encoding a particular subunit of the human GABAA receptor. In addition, the invention relates to a stable cell line capable of expressing said cDNA and to the use of the cell line in ... | 04/29/2003 |
| 6514709 | High throughput screening by measurement of intracellular calcium levels The present invention provides assays in which intracellular chelators are used to alter the kinetics of signal generation triggered by divalent cations, particularly calcium influx into the cell. The use of an intracellular chelator in the assay can dela... | 02/04/2003 |
| 6452065 | Transgenic mouse expressing non-native wild-type and familial Alzheimer's Disease mutant presenilin 1 protein on native presenilin 1 null background The present invention relates to a transgenic non-human animal embryo lacking native presenilin 1 and a transgenic non-human animal having only a non-native presenilin 1. The transgenic animals and cells derived therefrom can be used in the study of the e... | 09/17/2002 |
| 6384018 | Polynucleotide tuberculosis vaccine Genes encoding Mycobacterium tuberculosis (M.tb) proteins were cloned into eukaryotic expression vectors to express the encoded proteins in mammalian muscle cells in vivo. Animals were immunized by injection of these DNA constructs, termed polynucleotide ... | 05/07/2002 |
| 6232111 | Method for improving culture medium for recombinant yeast Yields in yeast recombinant expression systems are improved by identifying bad lots and supplementing them with the appropriate combination of adenine, trehalose and/or lactate.... | 05/15/2001 |
| 6211428 | Transgenic mouse expressing a familial form of human amyloid precursor protein Transgenic non-human mammals which express in their brains a nucleic acid construct comprising a DNA sequence encoding a human amyloid precursor protein FAD variant where at amino acid position 717 valine is substituted by isoleucine. These transgenic non... | 04/03/2001 |
| 6187992 | Transgenic mouse having a disrupted amyloid precursor protein gene The present invention relates to a transgenic nonhuman animal lacking native amyloid precursor protein. The transgenic mouse of the invention may be used in the study of Alzheimer's Disease and disorders involving the central nervous system.... | 02/13/2001 |
| 6174706 | DNA encoding triol polyketide synthase DNA encoding triol polyketide synthase (TPKS) has been isolated, purified and sequenced. Expression vectors comprising TPKS, cells transformed with the expression vectors, and processes employing the transformed cells are provided.... | 01/16/2001 |
| 6130058 | Human NMDA R2A receptor subunit and isoforms of the human NMDA-R1 receptor subunit and encoding cDNAs The present invention relates to a stably co-transfected eukaryotic cell line that expresses an N-methyl-D-aspartate (NMDA) receptor, particularly a human NMDA receptor, which receptor comprises at least one R1 subunit isoform, or at least one R1 subunit ... | 10/10/2000 |
| 6124107 | Assay for marker of human polymorphonuclear leukocyte elastase activity A immunoassay based on the detection of leukocyte-elastase produced fibrinogen cleavage peptides which allows the evaluation of the potency of compounds that inhibit formation of cleavage peptides in a variety of in vitro cell biological situations is pro... | 09/26/2000 |
| 6100028 | DNA polymerase extension assay The present invention provides rapid accurate sensitive assays specific for the detection of at least one a single stranded oligonucleotide produced by the action of an enzyme on a substrate. The assays are useful to detect the presence in a sample of an ... | 08/08/2000 |
| 5958743 | Stereospecific bioconversion of benzyl acetoacetate to benzyl-(s)-(+)-hydroxybutyrate A bioconversion process where benzyl acetoacetate is converted to benzyl-(S)-(+)-3-hydroxybutyrate.... | 09/28/1999 |
| 5959172 | Gender-specific fading down turkey breed The present invention relates to a method of rapidly determining the gender of fowl. The present invention further relates to a new breed of turkey.... | 09/28/1999 |
| 5932223 | Rotavirus vaccine formulations The present invention provides novel liquid and lyophilized formulations of vaccines against rotavirus infection and methods of their preparation. The formulations include buffering agents appropriate for oral administration of rotavirus vaccines. The for... | 08/03/1999 |
| 5889167 | Synthetic glucagon binding proteins A synthetic human glucagon (hGlu) binding protein designated hGluƊ252-259 binding protein is cloned, expressed and used in an in vitro assay to screen for compounds that bind to the synthetic binding protein, including compounds that specifically stimula... | 03/30/1999 |
| 5849541 | DNA encoding triol polyketide synthase DNA encoding triol polyketide synthase (TPKS) from Aspergillus terreus has been isolated, purified and sequenced. Expression vectors comprising said DNA, cells transformed with the expression vectors, and processes employing the transformed cells are prov... | 12/15/1998 |
| 5824656 | Recombinant and native group B eimeria tenella immunogens useful as coccidiosis vaccines Genes coding for novel Group B Eimeria tenella protein immunogens have been isolated and inserted into a novel expression vector which in turn has been used to transform appropriate hosts. The transformed host cells produce recombinant Group B E. tenella ... | 10/20/1998 |
| 5795771 | Culture medium for Saccharomyces cerevisiae A synthetic culture medium for the growth of recombinant yeast and the production of recombinant proteins. The medium is useful for the growth of Saccharomyces cerevisiae which comprises per liter about 10 g ammonium sulfate, about 10 g potassium phosphat... | 08/18/1998 |
| 5780291 | Wnt-x growth factor polypeptide, DNA encoding same, and Wnt-x antibody A novel member of the Wnt-family of growth factors, termed Wnt-x, has been identified and DNA encoding the growth factor has been isolated, purified, sequenced and expressed in host cells. This DNA encoding the novel Wnt-x protein and host cells expressin... | 07/14/1998 |
| 5766909 | DNA encoding inducible nitric oxide synthase Complementary DNAs (cDNAs) encoding inducible nitric oxide synthase are isolated and purified from a cDNA library prepared from macrophage-like cells activated with interferon gamma and bacterial lipopolysaccharide. The full length cDNAs of at least two i... | 06/16/1998 |
| 5756326 | Method of transformation of nocardia lactamdurans A method is disclosed for the high efficiency transformation of species of the genus Nocardia with DNA molecules. DNA vectors for the transformation of genes into Nocardia as well as recombinant Nocardia host cells expressing recombinant genes are disclos... | 05/26/1998 |
| 5750826 | Bradykinin B2 receptor modified transgenic non-human animals A transgenic non-human animal with alterations in a bradykinin B2 receptor gene is prepared by introduction of a gene encoding an altered bradykinin B2 receptor into a host non-human animal.... | 05/12/1998 |
| 5744350 | DNA encoding triol polyketide synthase DNA encoding triol polyketide synthase (TPKS) has been isolated, purified and sequenced. Expression vectors comprising TPKS, cells transformed with the expression vectors, and processes employing the transformed cells are provided.... | 04/28/1998 |
| 5736524 | Polynucleotide tuberculosis vaccine Genes encoding Mycobacterium tuberculosis (M.tb) proteins were cloned into eukaryotic expression vectors to express the encoded proteins in mammalian muscle cells in vivo. Animals were immunized by injection of these DNA constructs, termed polynucleotide ... | 04/07/1998 |
