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"The abolishment of pain in surgery is a chimera. It is absurd to go on seeking it...knife and pain are two words in surgery that must forever be associated in the consciousness of the patient."
Dr. Alfred Velpeau, French surgeon ; 1839
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| Number | Title | Issue Date |
| 8071563 | Glutamic acid decarboxylase (GAD) chimera and methods of use The invention relates to a novel Glutamic Acid Decarboxylase (GAD). More specifically, novel DNA and protein sequences relating to GAD. Additionally, the invention discloses a novel composition and related methods for treating neurodegenerative diseases such as Park... | 12/06/2011 |
| 8017385 | Use of apotosis inhibiting compounds in degenerative neurological disorders The invention provides methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain associated with a neurodegenerative diseases that is characterized by an excess buildup of buildup of intracellular pr... | 09/13/2011 |
| 7968320 | Stabilized liquid yeast preparation, a method for producing the same, and the use thereof The present invention relates to a novel stabilized liquid yeast preparation which contains a polyhydroxy compound, preferably glycerol, and a gum, comprising carob, guar, tragacanth, arabic or xanthan gum, preferably xanthan gum. The invention also relates to a met... | 06/28/2011 |
| 7955595 | Glutamic acid decarboxylase (GAD) based delivery system The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions us... | 06/07/2011 |
| 7749371 | Method and apparatus for rapid electrochemical analysis Methods and apparatus for electrochemically determining an analyte concentration value in a physiological sample are disclosed. The methods include using a test strip in which two time-current transients are measured by a meter electrically connected to an electroch... | 07/06/2010 |
| 7723288 | Methods and compositions for the treatment of neurological disease The present invention relates to a method for delivering a nucleic acid sequence encoding neuropeptide Y, or a derivative or functional fragment thereof, to a mammalian nervous system target cell. The expression of exogenous NPY, or a derivative or a functional frag... | 05/25/2010 |
| 7713981 | Method and compounds for inhibition of cell death The invention is directed to methods and compositions for inhibiting caspase-independent apoptosis. In particular, methods and compositions for inhibiting Omi/HtrA2 activity, as well as method for identifying other inhibitors of Omi/HtrA2. Also disclosed are Omi/Htr... | 05/11/2010 |
| 7695959 | Glutamic acid decarboxylase (GAD) based delivery systems The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions us... | 04/13/2010 |
| 7645446 | Glutamic acid decarboxylase (GAD) based delivery system The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions us... | 01/12/2010 |
| 7638120 | High transgene expression of a pseudotyped adeno-associated virus type The present invention related to methods and compositions comprising recombinant vectors comprising chimeric capsids and recombinant pseudotyped vectors with non-native capsid protein(s). The recombinant vectors of the invention confer an altered tropism that permit... | 12/29/2009 |
| 7527785 | Glutamic acid decarboxylase (GAD) chimera and methods of use The invention relates to a novel Glutamic Acid Decarboxylase (GAD). More specifically, novel DNA and protein sequences relating to GAD. Additionally, the invention discloses a novel composition and related methods for treating neurodegenerative diseases such as Park... | 05/05/2009 |
| 7288546 | Method and compound for inhibition of cell death This invention relates to a chemical compound that inhibits the apoptotic activity of the protease Omi/HtrA2 and homologous proteins. This protease Omi/HtrA2 is present in all mammalian cells so that inhibition of apoptosis in this fashion results enhanced cellular ... | 10/30/2007 |
| 7131342 | Method of preventing short sampling of a capillary or wicking fill device The current invention provides a device, and a method for using the device, for ensuring that a capillary or wicking fill device is fully filled. In particular this invention is directed to, but not limited to, use with capillary or wicking action filled electrochem... | 11/07/2006 |
