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| Number | Title | Issue Date |
| 8114878 | 6,7-dihydrothieno[3,2-d]pyrimidine for the treatment of inflammatory diseases The invention relates to new dihydrothienopyrimidine of formula 1, as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein X is SO or SO2, but p... | 02/14/2012 |
| 8106060 | 8-(3-amino-piperidin-1-yl)-xanthines, their preparation, and their use as pharmaceuticals The invention relates to 8-[3-amino-piperidin-1-yl]-xanthines and the physiologically acceptable salts thereof, particularly the hydrochlorides thereof. ... | 01/31/2012 |
| 8034809 | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments Enantiomerically pure compounds of general formula 1 wherein the groups R1, R2, R3, R4, and X− may have the meanings given in the claims and in the specification, pro... | 10/11/2011 |
| 7988001 | Container provided with a pressure equalization opening A process for producing a container comprising an outer container, an inner bag disposed therein and a pressure equalisation opening disposed in the outer container, and a container produced according to this process, is described, wherein a pre-moulding, comprising... | 08/02/2011 |
| 7932392 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof Compounds of Formula (IA) wherein R1, R2, R3, R4 and R5 are as defined herein for Formula (IA), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical composi... | 04/26/2011 |
| 7923449 | Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders The invention relates to the use of benzimidazolone derivatives of formula (I) for the preparation of a medicament for the treatment of premenstrual and other female sexual disorders. ... | 04/12/2011 |
| 7919312 | Self-replicating RNA molecule from hepatitis C virus A unique HCV RNA molecule is provided having an enhanced efficiency of establishing cell culture replication. Novel adaptive mutations have been identified within the HCV non-structural region that improves the efficiency of establishing persistently replicating HCV... | 04/05/2011 |
| 7795272 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof Compounds of Formula (IA) and Formula (IB) where in R1 stands for the following group (the dashed line indicates the point of attachment) and R2, R3 | 09/14/2010 |
| 7741361 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, and R7 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceu... | 06/22/2010 |
| 7723360 | Alkyl-and piperidine-substituted benzimidazole derivatives A compound of general formula 1a wherein R1, R5, R6, A, B, Y, i, j and m are defined as in the description and claims. It is another object of the present invention to provide pharma... | 05/25/2010 |
| 7635711 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, and R7 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceu... | 12/22/2009 |
| 7632834 | Long acting beta-2-agonists and their use as medicaments A compound of formula 1′″ wherein: V is —CH2—, —NH—, or —O—; Ra and Rb are each independently hydrogen, C1-4-alkyl, or halogen-C1-4 | 12/15/2009 |
| 7622594 | Glucocortioid mimetics, methods of making them, pharmaceutical compositions, and uses thereof Compounds of Formula (IA) and (IB) wherein R1, R2, R3, A, B, C, D, and E are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such ... | 11/24/2009 |
| 7608722 | Preparation of 1,7,′-dimethyl-2′-propyl-2,5′-bi-1-benzimidazole A process for preparing 1,7′-dimethyl-2′-propyl-2,5′-bi-1H-benzimidazole of formula (I) reacting N-methyl-o-phenylenediamine of formula (II) or the salts thereof with 2-prop... | 10/27/2009 |
| 7592373 | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds Compounds of formula (I) wherein A, B, b, W, X, Y, Z, R1, R2, and R3 have the meanings given in claim 1, pharmaceutical compositions these compounds, and methods of preventing or trea... | 09/22/2009 |
| 7592358 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds Alkyne compounds having MCH-receptor antagonistic activity, which are useful for preparing pharmaceutical compositions for the treatment of metabolic disorders and/or eating disorders, particularly obesity and diabetes. ... | 09/22/2009 |
| 7579469 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, and X are as defined herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or s... | 08/25/2009 |
| 7575760 | Chewable tablet containing lysine A tablet with enhanced compliance by humans, in particular children and/or juveniles, comprising: (a) a vitamin; (b) lysine or a pharmaceutically acceptable salt thereof; (c) a sweetener; and ... | 08/18/2009 |
| 7563806 | Substituted cycloalkyl derivatives, process for the manufacture thereof and use thereof as medicament The present invention relates to compounds of formula 1 wherein the groups R1, R2, R3, R4, R5, R6, R7, R8, n, m and X may have the mean... | 07/21/2009 |
| 7553966 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof Compounds of Formula (IA) and Formula (IB) wherein R1, R2, R3, R4, R5, and R6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug,... | 06/30/2009 |
| 7524862 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds Alkyne compounds of formula I wherein A, B, W, X, Y, Z, R1, and R2 have the meanings given herein, which have MCH-receptor antagonistic activity and are useful for preparing pharmaceutical compositions... | 04/28/2009 |
| 7514468 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions The present invention relates to indolinone derivatives substituted in the 6 position of general formula wherein R1 to R6 and X are defined as in claim 1, the tautomers, enantiomers... | 04/07/2009 |
| 7511045 | Compounds for the treatment of inflammatory diseases Dihydrothienopyrimidines of formula 1 and the pharmacologically acceptable salts, enantiomers, racemates, hydrates, or solvates thereof, which are suitable for the treatment of respiratory or gastrointestinal complaints or ... | 03/31/2009 |
| 7507843 | Stereoselective synthesis of certain trifluoromethyl-substituted alcohols A process for stereoselective synthesis of compounds of Formula X wherein: R1 is an aryl or heteroaryl group, each optionally independently substituted with one to three substit... | 03/24/2009 |
| 7507745 | Pharmaceutical compositions based on fluorenecarboxylic acid esters and soluble TNF receptor fusion proteins The present invention relates to novel pharmaceutical compositions based on fluorene carboxylic acid ester derived anticholinergics of formula 1 and soluble TNF receptor fusion proteins, processes for preparing them and the... | 03/24/2009 |
| 7491719 | Enantiomerically pure beta agonists, process for the manufacture thereof, and use thereof as medicaments Enantiomerically pure compounds of general formula 1 wherein the groups R1, R2, R3, R4, and X− may have the meanings given in the claims and in the specification, pro... | 02/17/2009 |
| 7470422 | Method for the production of propellant gas-free aerosols from aqueous medicament preparations The present invention relates to pharmaceutical preparations in the form of aqueous solutions for the production of propellant-free aerosols. ... | 12/30/2008 |
| 7451884 | Container provided with a pressure equalization opening A process for the production of a container (1) comprising an outer container (2), an inner bag (3) disposed therein and a pressure equalisation opening (10) disposed in the outer container (2), and also a container (1) prod... | 11/18/2008 |
| 7452911 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds The present invention relates to alkyne compounds of general formula I wherein the groups and residues A, B, W, X, Y, Z, R1 and R2 have the meanings given in claim 1. The invention further relat... | 11/18/2008 |
| 7429602 | Treating conjunctivitis by topically administering an epinastine solution to the conjunctiva Treating allergic conjunctivitis by administered aqueous solutions containing epinastine, optionally in the form of its racemate or its enantiomers and optionally, in the form of the pharmacologically acceptable acid addition salts thereof, to the conjunctiva. ... | 09/30/2008 |
| 7425629 | Stereoselective synthesis of certain trifluoromethyl-substituted alcohols A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein. ... | 09/16/2008 |
| 7423146 | Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones A process for making a compound of formula 1 or a salt thereof, wherein: R1 and R2 are each independently H, halogen, or C1-4-alkyl, or R1 and R2 together ... | 09/09/2008 |
| 7375104 | Long acting beta-2-agonists and their use as medicaments A compound of formula 1′ wherein: V is —CH2—, —NH—, or —O—; Ra and Rb are each independently hydrogen, C1-4-alkyl, or halogen-C1-4 | 05/20/2008 |
| 7351719 | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds The present invention relates to amide compounds of general formula I wherein the groups and residues A, B, b, W, X, Y, Z, R1, R2 and R3 have the meanings given in claim 1. Moreover t... | 04/01/2008 |
| 7326791 | Carboxylic acid amides, the preparation thereof, and their use as pharmaceutical compositions Substituted carboxylic acid amides of general formula wherein A, B, and R1 to R5 are as defined herein, and the tautomers and the salts thereof, particularly the physiologically acceptable s... | 02/05/2008 |
| 7307076 | Beta agonists for the treatment of respiratory diseases The present invention relates to compounds of general formula 1 wherein the groups n, A, B, R1, R2 and R3 may have the meanings given in the claims and in the specification, processes for pr... | 12/11/2007 |
| 7268152 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof Compounds of Formula (IA) and Formula (IB) wherein R1, R2, R3, R4, R5, and R6 are as defined herein for Formula (IA) or Formula (IB), or a tautome... | 09/11/2007 |
| RE39820 | Esters of thienyl carboxylic acids and amino alcohols and their quaternization products Compounds of the formula of which, in exemplary compounds, the thienyl group is attached via the 2-position and; (a) A is 3α-(6β, 7β-epoxy)-tropanyl methobromide and R1 is 2-thieny... | 09/04/2007 |
| 7256300 | Stereoselective synthesis of certain trifluoromethyl-substituted alcohols A process for stereoselective synthesis of a compound of Formula (X) or Formula (X′) wherein R1, R2, and R3 are as defined herein, the process comprising: (a) react... | 08/14/2007 |
| 7244728 | Long acting betamimetics for the treatment of respiratory diseases The present invention relates to the compounds of general formula 1 wherein the groups R, R1, R2, R3 and A may have the meanings given in the claims and specification, processes for preparing them and their use a... | 07/17/2007 |
