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| Number | Title | Issue Date |
| 6369027 | Osteoprotegerin The present invention discloses a novel secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteo... | 04/09/2002 |
| 6288032 | Osteoprotegerin The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor super family and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Oste... | 09/11/2001 |
| 6284728 | Osteoprotegerin The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteo... | 09/04/2001 |
| 6284740 | Osteoprotegerin The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteo... | 09/04/2001 |
| 6284485 | Nucleic acids encoding osteoprotegerin The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteo... | 09/04/2001 |
| 6169167 | Antibodies to ligands for HEK4 receptors Polypeptides which bind to one or more EPH-like receptors, particularly the HEK4 receptor, are described. The polypeptides are designated HEK4 binding proteins. Nucleic acids encoding HEK4 binding proteins, and expression vectors, host cells and processes... | 01/02/2001 |
| 6150098 | Methods for identifying novel secreted mammalian polypeptides Methods for identifying novel secreted mammalian proteins in mammalian host cells are described. Reporter polypeptides which allow detection of signal sequences by growth selection or by enzymatic activity are also described.... | 11/21/2000 |
| 6103472 | Methods and compositions for identifying novel secreted mammalian polypeptides in yeast Method for identifying novel secreted mammalian proteins in yeast are described. Reporter polypeptides which allow detection of signal sequences by growth selection are also described.... | 08/15/2000 |
| 6087555 | Mice lacking expression of osteoprotegerin Disclosed is a mouse in which expression of the gene encoding Osteoprotegerin is suppressed. Also disclosed is a nucleic acid construct useful in preparing such a mouse, and a cell line containing such construct.... | 07/11/2000 |
| 6087167 | Eck receptor ligands Ligands which bind to the eck receptor are disclosed. More particularly, polypeptides which bind specifically to the eck receptor (eck receptor binding proteins or EBPs) and DNA sequences encoding said polypeptides are disclosed. Methods of treatment usin... | 07/11/2000 |
| 5981246 | Nucleic acids encoding EPH-like receptor protein tyrosine kinases Four novel members of the EPH sub-family of receptor protein tyrosine kinases are disclosed. Nucleic acid sequences encoding receptor proteins, recombinant plasmids and host cells for expression, and methods of producing and using such receptors are also ... | 11/09/1999 |
| 5948892 | Analogs of macrophage stimulating protein MSP analogs which have increased heterodimer formation and enhanced biological activity compared recombinant MSP are provided. The analogs are constructed by substituting unpaired cysteine residues which may interfere with interchain disulfide bonding. DN... | 09/07/1999 |
| 5874399 | Progenitor B cell stimulating factor A progenitor B cell stimulating factor which promotes the formation of pre-B cells is described. DNA sequences encoding same and methods of production and purification of the factor are also disclosed. The factor is used in the treatment of hematopoietic ... | 02/23/1999 |
| 5856298 | Erythropoietin isoforms Erythropoietin isoforms having a specific number of sialic acids per erythropoietin molecule are disclosed. Also disclosed are mixtures of such isoforms, pharmaceutical compositions containing such isoforms or mixtures thereof and methods of obtaining the... | 01/05/1999 |
| 5843678 | Osteoprotegerin binding proteins A novel polypeptide, osteoprotegerin binding protein, involved in osteolcast maturation has been identified based upon its affinity for osteoprotegerin. Nucleic acid sequences encoding the polypeptide, or a fragment, analog or derivative thereof, vectors ... | 12/01/1998 |
| 5783404 | Methods and compositions for determining HER-2/neu expression using monoclonal antibodies Anti-p185HER-2/neu antibodies which are useful in the detection of HER-2/neu oncogene overexpression in biological samples are described. The antibodies are accurate and reliable in immunocytochemical or immunohistochemical assays of cell and t... | 07/21/1998 |
| 5783186 | Antibody-induced apoptosis Anti-Her2 antibodies which induce apoptosis in Her2 expressing cells are disclosed. The antibodies are used to "tag" Her2 overexpressing tumors for elimination by the host immune system. Also disclosed are hybridoma cell lines producing the antibodies, me... | 07/21/1998 |
