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| Number | Title | Issue Date |
| 7977311 | Methods and compositions for the prevention and treatment of anemia Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to ob... | 07/12/2011 |
| 7973009 | Methods and compositions for the prevention and treatment of anemia Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to ob... | 07/05/2011 |
| 7923008 | Methods for decreasing osteoclast formation or bone resorption using an antibody to osteoprotegerin binding protein A novel polypeptide, osteoprotegerin binding protein, involved in osteolcast maturation has been identified based upon its affinity for osteoprotegerin. Nucleic acid sequences encoding the polypeptide, or a fragment, analog or derivative thereof, vectors and host ce... | 04/12/2011 |
| 7807795 | Antibodies to osteoprotegerin binding proteins A novel polypeptide, osteoprotegerin binding protein, involved in osteoclast maturation has been identified based upon its affinity for osteoprotegerin. Nucleic acid sequences encoding the polypeptide, or a fragment, analog, or derivative thereof, vectors and host c... | 10/05/2010 |
| 7708993 | Polypeptides involved in immune response Polypeptides which comprise a receptor-ligand pair involved in T-cell activation are disclosed. Nucleic acid molecules encoding the polypeptides, and vectors and host cells for expressing the polypeptides are also disclosed. The polypeptides, or agonists and antagon... | 05/04/2010 |
| 7632922 | Osteoprotegerin The present invention discloses a novel secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin,... | 12/15/2009 |
| 7435796 | Antibodies which bind B7RP1 Novel polypeptides which comprise a receptor-ligand pair involved in T-cell activation are disclosed. Nucleic acid molecules encoding said polypeptides, and vectors and host cells for expressing same are also disclosed. The polypeptides, or agonists and antagonists ... | 10/14/2008 |
| 7304150 | Methods and compositions for the prevention and treatment of anemia Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to ob... | 12/04/2007 |
| 7097834 | Osteoprotegerin binding proteins A novel polypeptide, osteoprotegerin binding protein, involved in osteolcast maturation has been identified based upon its affinity for osteoprotegerin. Nucleic acid sequences encoding the polypeptide, or a fragment, analog or derivative thereof, vectors and host ce... | 08/29/2006 |
| 6790823 | Compositions and methods for the prevention and treatment of cardiovascular diseases Methods and compositions for the prevention and treatment of cardiovascular disease is described. Administration of osteoprotegerin (OPG) in a pharmaceutical composition prevents and treats atherosclerosis and associated cardiovascular diseases. ... | 09/14/2004 |
| 6756480 | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein The present invention concerns therapeutic agents that modulate the activity of PTH and PTHrP. In accordance with the present invention, modulators of PTH and PTHrP comprise: (a) a PTH/PTHrP modulating domain; and (b) a vehicle, such as a polymer (e.g.... | 06/29/2004 |
| 5762920 | Megakaryocyte production A method of increasing megakaryocyte production is disclosed. Such method comprises administering to a mammal a pharmaceutically effective amount of G-CSF and a pharmaceutically effective amount of IL-3 or GM-CSF, and optionally a pharmaceutically effecti... | 06/09/1998 |
| 5650504 | Nucleic acids encoding eck receptor ligands Ligands which bind to the eck receptor are disclosed. More particularly, polypeptides which bind specifically to the eck receptor (eck receptor binding proteins or EBPs) and DNA sequences encoding said polypeptides are disclosed. Methods of treatment usin... | 07/22/1997 |
| 5599690 | Control of norleucine incorporation into recombinant proteins Norleucine incorporation into recombinant gene products may be inhibited by culturing the cells expressing the gene products in media comprising a high level of leucine and/or methionine, or by expressing the gene products in a leu mutant. Norleucine inco... | 02/04/1997 |
| 5580754 | Nucleic acid encoding the progenitor B cell stimulating factor A progenitor B cell stimulating factor which promotes the formation of pre-B cells is described. DNA sequences encoding same and methods of production and purification of the factor are also disclosed. The factor is used in the treatment of hematopoietic ... | 12/03/1996 |
| 5278062 | Proteolytic enzymes This disclosure relates to a novel class of serine proteases isolated from a culture medium of fungus Tritirachium album. The serine proteases disclosed have a high degree of stability in detergent formulations. In addition, this disclosure relates to a proces... | 01/11/1994 |
