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| Number | Title | Issue Date |
| 5843941 | Ras farnesyl transferase inhibitors Benzodiazepine derivatives represented by the structure below are disclosed that act as potent inhibitors of ras farnesyl:protein transferase. Pharmaceutical compositions containing these benzodiazepines are provided for treatment of diseases foe which in... | 12/01/1998 |
| 5830647 | Hybridization and amplification of nucleic acids encoding mpl ligand Isolated mpl ligand, isolated DNA encoding mpl ligand, and recombinant methods of preparing mpl ligand are disclosed. These mpl ligands are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocyte progenit... | 11/03/1998 |
| 5756452 | Platelet aggregation inhibitors having high specificity for GP IIb IIIa A peptide containing the tripeptide recognition sequences RGD or KGD in a cycle and an exocyclic group bearing a positive charge is provided. The compound is provided in therapeutic form for administration to a mammal and exhibits high specificity and pot... | 05/26/1998 |
| 5716951 | Tricyclic inhibitors of the vitronectin receptor A tricylic benzodiazepine derivative that acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIb IIIa receptor and is provided in therapeutic compositions fo... | 02/10/1998 |
| 5705890 | Tricyclic inhibitors of the GPIIb IIIa receptor A tricylic benzodiazepine derivative that acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIb IIIa receptor and is provided in therapeutic compositions fo... | 01/06/1998 |
| 5674865 | Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIb IIIa receptor and is provided in therapeutic compositions for t... | 10/07/1997 |
| 5674863 | Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIb IIIa receptor and is provided in therapeutic compositions for t... | 10/07/1997 |
| 5663166 | Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIb IIIa receptor and is provided in therapeutic compositions for t... | 09/02/1997 |
| 5565449 | Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIb IIIa receptor and is provided in therapeutic compositions for t... | 10/15/1996 |
| 5532359 | Ras farnesyl transferase inhibitors Benzodiazepine derivatives are disclosed that act as potent inhibitors of ras farnesyl:protein transferase. Pharmaceutical compositions containing these benzodiazepines are provided for treatment of diseases for which inhibition of the ras farnesyl:protei... | 07/02/1996 |
| 5493020 | Tricyclic inhibitors of the GPIIb IIIa receptor A trycylic benzodiazepine derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIb IIIa receptor and is provided in therapeutic compositions f... | 02/20/1996 |
| 5493007 | Platelet aggregation inhibitors having high specificity for GPIIBIIIA A peptide containing the tripeptide recognition sequences RGD or KGD in a cycle and an exocyclic group bearing a positive charge is provided. The compound is provided in therapeutic form for administration to a mammal and exhibits high specificity and pot... | 02/20/1996 |
| 5403836 | Benzazepine platelet aggregation inhibitors having specificity for the GPIIb IIIa receptor A benzazepine derivative that acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIb IIIa receptor and is provided in therapeutic compositions for the treatm... | 04/04/1995 |
| 5384331 | Ketamine analogues for treatment of thrombocytopenia 5,6-Dehydronorketamine and derivatives retaining the ,ଲ-unsaturated carbonyl are disclosed. These end other Michael or Michael-type acceptors and adducts are shown to influence the replication, differentiation or maturation of blood cells, es... | 01/24/1995 |
| 5384309 | Cyclized peptides and their use as platelet aggregation inhibitors The invention in its broad aspects relates to peptide derivatives which are useful as inhibitors platelet function mediated by the GP llbllla receptor and for the prevention of thrombus formation. The compounds of this invention are shown by the following... | 01/24/1995 |
| 5346991 | Tissue factor mutants useful for the treatment of myocardial infarction and coagulopathic disorders A tissue factor protein mutant capable of neutralizing the ability of endogenous tissue factor to induce coagulation is provided. A representative tissue factor mutant designated K165A, K166A TF is useful in a method for inhibiting thrombin-induced platel... | 09/13/1994 |
| 5250732 | Ketamine analogues for treatment of thrombocytopenia 5,6-Dehydronorketamine and derivatives retaining the ,ଲ-unsaturated carbonyl are disclosed. These and other Michael or Michael-type acceptors and adducts are shown to influence the replication, differentiation or maturation of blood cells, es... | 10/05/1993 |
| 5250679 | Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIb IIIa receptor and is provided in therapeutic compositions for t... | 10/05/1993 |
| 5227469 | Platelet aggregation inhibitors from the leech A composition of matter derived from hematophagous leech comprising specified purified amino acid sequences represented by the general formula: CXXXRGDXXXXC(Seq. ID No. 11) and capable of functioning as an antithrombotic by inhibiting the binding of fibri... | 07/13/1993 |
| 5223408 | Method for making variant secreted proteins with altered properties A screening method for the selection of mutagenized proteins that are normally secreted by cells is described. The method includes the development of a cloning vector for the expression of secretory proteins as fusion proteins on the cell surface of trans... | 06/29/1993 |
| 5120859 | Chimeric amino acid analogues A chimeric amino acid analogue is provided suitable for incorporating into peptides which compound is represented by Formula 1: ##STR1## where P1 is preferably an amine protecting agent, and P2 and P3 are preferably a... | 06/09/1992 |
