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| Number | Title | Issue Date |
| RE43003 | Epothilone derivatives The present invention relates to compounds of the formula in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1–R7 are as defined herein, methods fo... | 12/06/2011 |
| RE42191 | Methods for the preparation, isolation and purification of epothilone B, and X-ray crystal structures of epothilone B The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent pur... | 03/01/2011 |
| 7858639 | Bicyclic heterocycles as cannabinoid-1 receptor modulators The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to... | 12/28/2010 |
| 7816357 | Azabicyclic heterocycles as cannabinoid receptor modulators The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to... | 10/19/2010 |
| 7776859 | Hexahydroimidazopyrazin-3-one compounds useful as modulators of androgen receptor function The present invention is directed to compounds having the formula (I), and/or pharmaceutically-acceptable salts thereof, useful in the treatment of androgen-receptor associated conditions, wherein Ar is aryl, substituted ar... | 08/17/2010 |
| 7767432 | Methods for the preparation, isolation and purification of epothilone B, and x-ray crystal structures of epothilone B The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent pur... | 08/03/2010 |
| RE41393 | Treatment of refractory tumors using epothilone derivatives Methods of treating tumors in a mammal, especially a human that has demonstrated resistance to other chemotherapeutic agents, is disclosed. Specifically, methods of the present invention are effective in tumors that have initially been unresponsive to taxane therapy... | 06/22/2010 |
| 7655689 | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds. ... | 02/02/2010 |
| 7595300 | 7-quinolyl ketolide antibacterial agents 15-fluoroketolides of the formula having improved activity and safety, compositions comprising them, and methods for their preparation and use in the treatment of bacterial infections. ... | 09/29/2009 |
| 7517904 | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds. ... | 04/14/2009 |
| 7501416 | Quinoxaline compounds and methods of using them The present invention generally relates to quinoxaline compounds having Formula 1 or Formula 2 wherein the variables are as defined herein, and methods of using them. ... | 03/10/2009 |
| 7470797 | Fused heterocyclic imido and amido compounds Disclosed are fused cyclic compounds, method of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds of formula | 12/30/2008 |
| 7459294 | Method of producing a compound by fermentation During the production of a product compound by fermentation, the concentration of a precursor compound is maintained within a pre-selected concentration range by having an adsorbent resin in contact with the culture medium. The adsorbent resin reversibly adsorbs pre... | 12/02/2008 |
| 7432267 | Fused cyclic modulators of nuclear hormone receptor function Disclosed are compounds having the formula (I): including compounds of formulae (Ia) and (Ib): wherein G is an optionally substituted aryl or heterocyclo, L is an optional linker,... | 10/07/2008 |
| 7414056 | Pyrazole-amide compounds useful as kinase inhibitors The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where G, X, R1, R2, R3, R4, R5, R6 | 08/19/2008 |
| 7390810 | Pyrazole-amine compounds useful as kinase inhibitors The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where G, X, R1, R2, R3, R4, R5, R6 | 06/24/2008 |
| RE40387 | Pharmaceutical compositions, dosage forms and methods for oral administration of epothilones The invention relates to methods of increasing the bioavailability of orally administered epothilones. Epothilones administered by the methods of the invention are sufficiently bioavailable to have a pharmacological effect. The invention further relates to pharmaceu... | 06/17/2008 |
| 7388009 | Heteroaryl-substituted pyrrolo-triazine compounds useful as kinase inhibitors Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R1, R2, R3, R4, R5, R | 06/17/2008 |
| 7342034 | Fused heterocyclic compounds and analogs thereof, modulators of nuclear hormone receptor function Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds. ... | 03/11/2008 |
| 7314876 | Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are surprisingly advantageous as p38 kinase inhibitors, wherein R3 is hydrogen, methyl, perfluor... | 01/01/2008 |
| 7312237 | Combination of epothilone analogs and chemotherapeutic agents for the treatment of prolilferative diseases Compositions and methods are disclosed which are useful of the treatment and prevention of proliferative disorders. ... | 12/25/2007 |
| 7291637 | Fused heterocyclic compounds and analogs thereof, modulators of nuclear hormone receptor function Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds. ... | 11/06/2007 |
| 7244594 | Microbial transformation method for the preparation of an epothilone A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said al... | 07/17/2007 |
| 7241755 | Epothilone derivatives The present invention relates to compounds of the formula in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1–R7 are as defined herein,... | 07/10/2007 |
| 7235669 | Epothilone side components The invention concerns compounds which can be obtained by fermenting DSM 6773, especially epothilones A1, A2, A8, A9, B10, C1, C2, C3, C4, C5, C6, C7, C8, C9, D1, D2, D5, G1, G2, H1, H2, I1, I2, I3, I4, I5, I6 and K and trans-epothilones C1 and C2. ... | 06/26/2007 |
| 7235563 | Spirocyclic compounds useful as modulators of nuclear hormone receptor function Spirocyclic compounds, methods of using such spirocyclic compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds are disclosed. ... | 06/26/2007 |
| 7211593 | C12-cyano epothilone derivatives The present invention relates to compounds useful in the treatment of cancer or other proliferative diseases represented by the formula wherein: R1, R2 | 05/01/2007 |
| 7172884 | Methods for the preparation, isolation and purification of epothilone B, and x-ray crystal structures of epothilone B The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent pur... | 02/06/2007 |
| 7169771 | Thiazolyl-based compounds useful as kinase inhibitors The present invention provides thiazolyl-based compounds of formula (I), useful for treating p38 kinase-associated conditions, wherein ring A is phenyl or pyridyl, and X, Y, B, R2, R3, Z | 01/30/2007 |
| 7160883 | Pyrrolo-triazine aniline compounds useful as kinase inhibitors Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R1, R2, R3, R4, R... | 01/09/2007 |
| 7157595 | Degradation of epothilones According to one embodiment the invention concerns a process for a degradation of an epothilone C or a epothilone D, wherein an epothilone C or epothilone D is subjected to an olefin metathesis in the presence of ethylene and subsequently an optional ester hydrolysi... | 01/02/2007 |
| 7151113 | Pyrazole-amine compounds useful as kinase inhibitors The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where W, X, R1, R2, R3, R4, R5... | 12/19/2006 |
| 7141578 | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds. ... | 11/28/2006 |
| 7125899 | Epothilone derivatives The present invention relates to epothilone derivatives, having the following formula: in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1–R7... | 10/24/2006 |
| RE39356 | Process for the preparation of epothilone analogs The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction ... | 10/17/2006 |
| RE39251 | Polymorphs of an epothilone analog There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula Also provided are... | 08/29/2006 |
| 7053069 | Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives Pharmaceutical compositions containing C-21 modified epothilone derivatives, methods for their preparation and dosing regimen for administration of these epothilone compounds are provided. The compositions are stable and readily prepared for administration by dissol... | 05/30/2006 |
| 7041692 | Methods of treating factor VIIa-associated conditions with compounds having an amine nucleus Methods of treating Factor VIIa-associated conditions in a mammal are described, comprising administering to the mammal in need of treatment thereof an effective amount of at least one compound having the formula (I), ... | 05/09/2006 |
| 7022330 | Parenteral formulation for epothilone analogs A process for formulating certain epothilone analogs for parenteral administration is disclosed wherein the analog is dissolved in a mixture of at least 50% by volume tertiary-butanol in water, the mixture is lyophilized, the resulting lyophilized product is package... | 04/04/2006 |
| 7008936 | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases Compositions and methods are disclosed which are useful of the treatment and prevention of proliferative diseases. ... | 03/07/2006 |
