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| Number | Title | Issue Date |
| 8183003 | Polymer end group detection Provided herein are processes of detecting and quantifying the number of polymer end groups in a sample. In particular instances provided herein are processes of detecting. ... | 05/22/2012 |
| 8176004 | Systems and methods for intelligent paperless document management Provided are systems and methods for Web-based intelligent paperless document management where users can collect, store, and share all document from various locations. The system requires security sign-up for the user account and it automatically classifies the inco... | 05/08/2012 |
| 8173708 | Method and composition for administering an NMDA receptor antagonist to a subject The invention provides methods and compositions for administering an NMDA receptor antagonist (e.g., memantine) to a subject. ... | 05/08/2012 |
| 8168678 | -disubstituted aminoalkylbiphenyl antagonists of prostaglandin Dreceptors Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination ... | 05/01/2012 |
| 8168655 | Compositions and methods for treatment of eye disorders The present invention provides compounds and methods for the treatment of LFA-1 mediated diseases. In particular, LFA-1 antagonists are described herein and these antagonists are used in the treatment of LFA-1 mediated diseases. One aspect of the invention provides ... | 05/01/2012 |
| 8168209 | Method and composition for administering an NMDA receptor antagonist to a subject The invention provides methods and compositions for administering an NMDA receptor antagonist (e.g., memantine) to a subject. ... | 05/01/2012 |
| 8167130 | Rapid deployment first aid kit and system for refilling A first aid kit organized with pockets containing first aid and emergency preparedness supplies and equipment and a system for refilling. Each pocket in the kit contains supplies and equipment useful in providing initial care for a particular illness or injury and i... | 05/01/2012 |
| 8163795 | Chroman derivatives, medicaments and use in therapy Novel chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described. ... | 04/24/2012 |
| 8158647 | Substituted pyrrolopyridines and pyrazolopyridines as kinase modulators Provided herein are substituted pyrrolopyridine heterocycles and substituted pyrazolopyridine heterocycles, pharmaceutical compositions comprising said heterocycles and methods of using said heterocycles in the treatment of disease. The heterocycles disclosed herein... | 04/17/2012 |
| 8156695 | Anchor post Provided herein are methods, devices and systems comprising an anchor post that has a shaft, at least one stabilizing element attached to the anchor post configured to resist movement of the anchor post, and at least one alignment element. ... | 04/17/2012 |
| 8153758 | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can includ... | 04/10/2012 |
| 8153162 | Purified amniotic membrane compositions and methods of use Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in ... | 04/10/2012 |
| 8153139 | Treatment of rosacea with clostridia neurotoxins Methods of using clostridial toxins and other biological agents to treat rosacea in humans is provided. The disclosed methods provide beneficial effects in humans. ... | 04/10/2012 |
| 8148509 | Transgene delivering retrovirus targeting collagen exposed at site of tissue injury A viral or non-viral vector particle having a modified viral surface protein wherein the viral surface protein is modified to include a targeting polypeptide including a binding region which binds to an extracellular matrix component. Such vector particles are usefu... | 04/03/2012 |
| 8143269 | Inhibitors of store operated calcium release Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with othe... | 03/27/2012 |
| 8143226 | Tyrosine kinase receptor antagonists and methods of treatment for breast cancer A method of treatment is disclosed whereby cancer cells are brought into contact with a formulation comprising an inhibitor of tyrosine kinase receptors. The formulation may be comprised of an injectable carrier and two or more tyrosine kinase receptor inhibitors wh... | 03/27/2012 |
| 8142781 | Fusion proteins for blood-brain barrier delivery The invention provides compositions, methods, and kits for increasing transport of agents across the blood brain barrier while allowing their activity once across the barrier to remain substantially intact. The agents are transported across the blood brain barrier v... | 03/27/2012 |
| 8142775 | Crystallized oxalate decarboxylase and methods of use Oxalate decarboxylase crystals, including stabilized crystals, such as cross-linked crystals of oxalate decarboxylase, are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using oxalate decarboxylase crystals are also disclosed. ... | 03/27/2012 |
| 8138147 | Conditioned cell culture medium compositions and methods of use Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic c... | 03/20/2012 |
| 8133737 | Systems and methods for breast cancer detection and risk assessment The invention relates to a simple screening test for neoplasia, a precancerous condition, or cancer of the breast. A method is described whereby a breast cancer marker is detected in breast fluid. In a particular embodiment, the method involves treating samples of b... | 03/13/2012 |
| 8133471 | CLK-peptide and SLK-peptide The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured collagen type-IV with substantially greater affinity than to the native triple helical form of collagen type-... | 03/13/2012 |
| 8128968 | Compositions and methods for treating infestations Compositions containing about 0.6% to about 20% of tea tree oil are described. Some compositions are in the form of solutions, suspensions, spray, lotions, gels, pastes, medicated sticks, balms, cleansers (including shampoos and soaps), creams, or ointments. Also de... | 03/06/2012 |
| 8119170 | Herbal compositions and methods for enhancing vital energy and athletic performance Compositions, kits and methods are provided for enhancing vital energy and athletic performance, improving or restoring blood circulation, promoting mental acuity, reducing fatigue, and improving aerobic performance. In one embodiment, the composition comprises the ... | 02/21/2012 |
| 8114871 | 3-amido-pyrrolo[3,4-C]pyrazole-5(1H,4H,6H) carbaldehyde derivatives The present invention relates to compounds and pharmaceutically acceptable salts of Formula (I): wherein X, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined above. The invention... | 02/14/2012 |
| 8110552 | Antagonists against interaction of PF4 and RANTES The invention relates to polypeptides of amino acid sequence SEQ ID NO: 1 according to formula (1), the use thereof for producing a medicament, and medicaments for the treatment of diseases related to monocyte recruitment. ... | 02/07/2012 |
| 8110228 | Composition for treatment of menopause A method of using an herbal extract of the a mixture of: Herba Scutellaria barbata, Radix Sophora subprostratae, Radix Anemarrhena, Semen Glycine sojae, Radix Glycyrrhiza, Rhizoma Rhei, Fructus Tritici levis, Radix | 02/07/2012 |
| 8108040 | Method and apparatus for delivery of therapeutic agents Method and apparatus for the reproducible, consistent and efficacious delivery of a therapeutic agent to a patient. The invention comprises means for the controlled administration of the therapeutic agent (30) through an orifice to the patient, a plurality of... | 01/31/2012 |
| 8106205 | N[S(4-aryl-triazol-3-yl)α-mercaptoacetyl]-amino benzoic acids as HIV reverse transcriptase inhibitors A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives. are provided, where Q is CO2H, or a salt or ester thereof, or a C(O) N-linked amino acid. The compoun... | 01/31/2012 |
| 8097593 | Lipid A and other carbohydrate ligand analogs The core structure of pentaerythritol has been used as a replacement for one or both sugars in lipid A, leading to the generation of a series of lipid A analogs. These lipid A analogs may further differ from lipid A with respect to, e.g., the number, nature and loca... | 01/17/2012 |
| 8095404 | Decision making and implementation system A system and method for generating recommendations of analyses of circumstances in business, accounting, science, medicine and other fields. An algorithm is generated using an interactive generation process based on decision tree type inquiries. The algorithm is tra... | 01/10/2012 |
| 8092841 | Estrogenic extracts of ait. of the oleaceae family and uses thereof Extracts of various species of the Moraceae family have estrogenic properties. For example, aqueous and ethanolic extracts of Ligustrum lucidum Ait. of the Oleaceae Family possess estrogenic properties in both ERα+ and ERβ+ cells. These estrogenic effects i... | 01/10/2012 |
| 8088781 | Inhibitors of brutons tyrosine kinase Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include th... | 01/03/2012 |
| 8084628 | Substituted chroman derivatives, medicaments and use in therapy Novel substituted chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described. ... | 12/27/2011 |
| 8084483 | Compounds and compositions and methods of use Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant le... | 12/27/2011 |
| 8084465 | Derivatives of pryidone and use thereof The present invention provides N-substituted-2(1H) pyridones or the pharmaceutical acceptable salts thereof, and the pharmaceutical preparations containing the compounds. The compounds of the present invention can be used to treat various fibrotic diseases effective... | 12/27/2011 |
| 8084425 | Dopaminergic neuronal survival-promoting factors and uses thereof In general, the invention features substantially purified MANF and substantially purified nucleic acids encoding the same. The invention also features a pharmaceutical composition that includes MANF and a pharmaceutically-acceptable excipient, methods for treatment ... | 12/27/2011 |
| 8076516 | Amine derivative compounds for treating ophthalmic diseases and disorders Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions. ... | 12/13/2011 |
| 8071809 | Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides Disclosed herein are accelerants for the formation of oxime-containing compounds from the reaction of a carbonyl-containing compound and a hydroxylamine-containing compound. The oxime-containing compound, the carbonyl-containing compound and the hydroxylamine-contai... | 12/06/2011 |
| 8071617 | Modulators of cellular adhesion The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in... | 12/06/2011 |
| 8071582 | Substituted aniline derivatives The present invention relates to novel aniline derivatives and their use in therapy, in particular their use in the treatment of fungal infections. ... | 12/06/2011 |
