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| Number | Title | Issue Date |
| 7723068 | Gene cluster involved in safracin biosynthesis and its uses for genetic engineering A gene cluster is disclosed having open reading frames which encode polypeptides sufficient to direct the synthesis of a safracin molecule. In addition, the present disclosure is directed to a nucleic acid sequence, suitably an isolated nucleic acid sequence, which ... | 05/25/2010 |
| 7683028 | Kahalalide compositions The present invention is directed to new kahalalide antitumoral compounds, in particular to analogs of kahalalide F, useful as antitumoral, antiviral, and antifungal agents. ... | 03/23/2010 |
| 7678765 | Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them The invention relates to aplidine derivatives of the general formula: which are useful for the treatment of tumors. ... | 03/16/2010 |
| 7622458 | Combination of ET-743 and a 5-fluorouracil pro-drug for cancer treatment Methods of treating a human body for cancer are provided. In one aspect, a therapeutic amount of capecitabine is administered in combination with ET-743 in a dose range between 0.75 and 1.4 mg/m2 for Et-743. In a related aspect, an effective therapeutic a... | 11/24/2009 |
| 7576188 | Antitumoral treatments Aplidine and aplidine analogues are of use for the treatment of cancer, in particular in the treatment of leukemias and lymphomas, especially in combination therapies. ... | 08/18/2009 |
| 7572800 | Combination therapy to treat hepatitis B virus The present invention is directed to a method for treating hepatitis B virus infection in humans comprising administering a synergistically effective amount of agents having known anti-hepatitis B virus activity in combination or alternation. Specifically, the inven... | 08/11/2009 |
| 7556831 | Method for treatment of constipation-predominant irritable bowel syndrome Methods for treating constipation-predominant irritable bowel syndrome comprise administering to a patient in need thereof a polymeric proanthocyanidin composition from a Croton species or Calophyllum species in an amount sufficient to treat constipati... | 07/07/2009 |
| 7531561 | GSK-3 inhibitors Provided are thiadiazolidine compounds of formula I wherein R1 is an organic group having at least 8 atoms selected from C or O, which is not linked directly to the N through a —C(O)— and comprising at least ... | 05/12/2009 |
| 7521478 | Total synthesis of myriaporones Compounds of the general formula (I) or a pharmaceutically acceptable salt, derivative, prodrug or stereoisomer thereof are provided: wherein the substituent groups defined by R are each independently selected from the group consisting of H, SiR′3, SORâ... | 04/21/2009 |
| 7507872 | Transgenic toll-like receptor 9 (TLR9) mice The present invention provides a receptor protein specifically recognizing bacterial DNA having an unmethylated CpG sequence, a genomic DNA encoding it, an experimental animal model useful for examining responsiveness of a host immune cell against a bacterial infect... | 03/24/2009 |
| 7507708 | Antitumoral compounds The present invention is directed to new kahalalide antitumoral compounds, in particular to analogues of kahalalide F, useful as antitumoral, antiviral, antifungal agents and in the treatment of psoriasis. ... | 03/24/2009 |
| 7482429 | Kahalalide F and related compounds A process is provided for preparing kahalalide F and which leads to other kahalalide mimic compounds having useful biological activity. ... | 01/27/2009 |
| 7396837 | Antitumoral analogs of lamellarins New lamellarins are provided of the general formula III or a pharmaceutically acceptable salt, derivative, prodrug or stereoisomer thereof ... | 07/08/2008 |
| 7348311 | Derivatives of dehydrodidemnin B Dehydrodidemnin B with useful biological activity has formula (1). It can be isolated from natural sources or synthesized, and it forms active derivatives ... | 03/25/2008 |
| 7323444 | Use of kahalalide compounds for the manufacture of a medicament for the treatment of psoriasis Kahalalide compounds, in particular kahalalide F, are of use in a method to treat a mammal suffering from skin disease with avoiding toxicity and leading to clinical improvement. ... | 01/29/2008 |
| 7309601 | Sequences from an endosymbiont and their uses rDNA corresponding to an endosymbiotic bacteria associated with Ecteinascidia turbinata has been identified. The bacterium appears to be responsible for the biosynthesis of ecteinascidin compounds. The 16S rDNA sequence corresponding to Candidatus Endo... | 12/18/2007 |
| RE39887 | Dehydrodidemnin B Dehydrodidemnin B with useful biological activity has formula (1). It can be isolated from natural sources or synthesized, and it forms active derivatives. ... | 10/16/2007 |
| RE39496 | Kahalalide F and compositions and uses thereof Kalahide Kahalalide F, of formula I below, may be isolated from a sacoglossan. The compound may be used in the manufacture of pharmaceutical compositions or in the treatment of tumors or viral conditions ... | 02/27/2007 |
| 7109244 | Compositions and methods comprising long-chain, straight-chain 2-amino-3-hydroxyalkanes Investigation of the activity of extracts of the clam Spisula polynyma has led to antitumor long-chain, straight-chain alkane or alkene compounds which have a 2-amino group and a 3-hydroxy group. The present invention is directed to compositions and methods c... | 09/19/2006 |
| 7105717 | Model rat with the onset of prostatic cancer To provide a rat model with the onset of prostate cancer in which the prostate cancer including an invasive cancer can be developed and can be bred for generations stably. A rat model with the onset of prostate cancer which can develop prostate cancer including inva... | 09/12/2006 |
| 7084331 | Rice containing endophytic bacteria and method of producing it The present invention provides a rice plant that shows enhanced growth and increased seed production, which also enables reduction of the use of chemical fertilizers. In the present invention, a nitrogen-fixing endophytic bacterium is isolated from bacteria s... | 08/01/2006 |
| 7083050 | Method and apparatus for clarifying a slurry The invention relates to a method of clarifying and/or thickening a solution containing solids i.e. a slurry, and the apparatus for accomplishing this. Using the method and apparatus of the present invention, the flocculant to be fed into the clarification and thick... | 08/01/2006 |
| 7074614 | Clock gene BMAL2 The present invention provides novel clock proteins BMAL2 (Brain-Muscle-Arnt-Like protein2), which is crucial for the clock oscillation mechanism including photic-input pathway and output pathway, novel clock genes encoding the proteins, a screening method using the... | 07/11/2006 |
| 7037879 | Pest control method for grass family plants using endophytic bacteria, pest control material, and seed bound to the pest control material The objective of the present invention is to confer pest resistance to plants of Poaceae without using any chemically synthesized pesticides. The pest resistance can be conferred to plants of Poaceae by isolating from a natural plant an endophytic bacterium capable ... | 05/02/2006 |
| 7036554 | Method and system for casting metal and metal alloys The invention is relating to a system for casting metal, the system comprising a holding furnace (3) containing a base metal melt (2), at least one casting crucible (1) mounted inside the holding furnace (3) and situated at least partly i... | 05/02/2006 |
| 7026409 | Polymer-supported arylbis(perfluoroalkylsulfonyl)-methane The present invention provides a solid acid catalyst that is excellent from the point of toxicity, environment and others, wherein reaction can be progressed effectively with Bronsted acid or Lewis acid catalyst. For example, the benzoylation reaction of alcohol can... | 04/11/2006 |
| RE38793 | Spisulosine compounds The present invention is directed to the isolation and bioactive characterization of compounds isolated from the clam Spisula polynyma. These compounds include three sphingoid-type bases, spisulosines 285, 299 and 313 (1-3), each of which shows unique cytotoxicity a... | 09/06/2005 |
