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| Number | Title | Issue Date |
| 8110560 | Spinal muscular atrophy (SMA) treatment via targeting of splice site inhibitory sequences The present invention is directed to methods and compositions capable of blocking the inhibitory effect of a newly-identified intronic inhibitory sequence element, named ISS-N1 (for “intronic splicing silencer”), located in the SMN2 gene. The compositions and me... | 02/07/2012 |
| 8097585 | Methods of treating inflammation by administration of heme oxygenase-1 and products of heme degradation The present invention relates to the treatment of disorders using heme oxygenase-1 and heme degradation products. ... | 01/17/2012 |
| 8093360 | Antibodies that bind exotoxin, formulations thereof, and methods of use The present invention provides an antibody which binds to B. anthracis with toxin, formulations for administration of such antibodies intramuscularly, and methods of administering such antibodies prophylactically or therapeutically. ... | 01/10/2012 |
| 8084026 | Multispecific binding molecules comprising connecting peptides The instant invention describes novel multispecific binding molecules comprising synthetic connecting peptides. The synthetic connecting peptides result in the preferential synthesis of multispecific binding molecules comprising polypeptide chains that are linked vi... | 12/27/2011 |
| 8067375 | Treatment of demyelinating disorders with soluble lymphotoxin-β-receptor Methods of treating a demyelinating disorder using inhibitors of the lymphotoxin pathway. ... | 11/29/2011 |
| 8048672 | T-bet compositions and methods of use thereof Isolated nucleic acid molecules encoding T-bet, and isolated T-bet polypeptides, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which ... | 11/01/2011 |
| 7951371 | Soluble lymphotoxin-β receptor fusion protein and methods for inhibiting lymphotoxin β-receptor signaling This invention relates to compositions and methods comprising “lymphotoxin-β-receptor blocking agents”, which block lymphotoxin-β receptor signalling. Lymphotoxin-β receptor blocking agents are useful for treating lymphocyte-mediated immunological diseases, a... | 05/31/2011 |
| 7947271 | Methods of decreasing tumor volume and reducing tumor burden using TNF-receptor-coupling agents Receptor coupling agents, including multivalent constructs comprising anti-TNF receptor binding moieties, for treating cancer and inhibiting tumor volume in a subject are disclosed. ... | 05/24/2011 |
| 7935338 | Antibodies to treat cancer Compositions and methods for the treatment of cancer, particularly melanoma, myeloma, small cell lung cancer, thymic lymphoma, T-cell lymphoma, B-cell lymphoma, osteosarcoma, and acute T-cell leukemia, are disclosed. Illustrative compositions include one or more ant... | 05/03/2011 |
| 7902339 | Antitumor antibodies, proteins, and uses thereof Antibodies that bind to a 40 kDa protein which is expressed on tumors, but is not expressed on normal adult hemopoietic cells are disclosed. Also disclosed are methods for production and the use of such antibodies. ... | 03/08/2011 |
| 7863419 | Antibodies having altered effector function and methods for making the same The invention provides a method of producing aglycosylated Fc-containing polypeptides, such as antibodies, having desired effector function. The invention also provides aglycosylated antibodies produced according to the method as well as methods of using such antibo... | 01/04/2011 |
| 7838657 | Spinal muscular atrophy (SMA) treatment via targeting of splice site inhibitory sequences The present invention is directed to methods and compositions capable of blocking the inhibitory effect of a newly-identified intronic inhibitory sequence element, named ISS-N1 (for “intronic splicing silencer”), located in the SMN2 gene. The compositions and me... | 11/23/2010 |
| 7785598 | Alternate reading frame hepatitis C virus peptides and uses thereof Novel hepatitis C virus (HCV) polypeptides are provided which are not encoded by the standard HCV open reading frame. These alternate reading frame polypeptides are useful, inter alia, in vaccine compositions, in diagnosing HCV infection, and as therapeutic targets.... | 08/31/2010 |
| 7781569 | Antibodies to treat cancer Compositions and methods for the treatment of cancer, particularly melanoma, myeloma, small cell lung cancer, thymic lymphoma, T-cell lymphoma, B-cell lymphoma, osteosarcoma, and acute T-cell leukemia, are disclosed. Illustrative compositions include one or more ant... | 08/24/2010 |
| 7781212 | Antitumor antibodies, proteins, and uses thereof Antibodies that bind to a 40 kDa protein which is expressed on tumors, but is not expressed on normal adult hemopoietic cells are disclosed. Also disclosed are methods for production and the use of such antibodies. ... | 08/24/2010 |
| 7745581 | T-bet compositions and methods of use thereof Isolated nucleic acid molecules encoding T-bet, and isolated T-bet proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the ... | 06/29/2010 |
| 7744891 | Soluble lymphotoxin-beta receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological diseases Compositions and methods comprising “lymphotoxin-β receptor blocking agents” which block lymphotoxin-β receptor signaling and are useful for altering immunological diseases, and particularly antibody mediated immune responses. ... | 06/29/2010 |
| 7741044 | Libraries of oligomers labeled with different tags A method of making a set of labelled compounds by the use of a preferably particulate support, comprises dividing the support into lots, performing a different chemical reaction on each lot of the support, e.g. to couple a chemical moiety to that lot of the support,... | 06/22/2010 |
| 7700097 | Purification and preferential synthesis of binding molecules The instant invention describes methods of separating or preferentially synthesizing dimers which are linked via at least one interchain disulfide linkage from dimers which are not linked via at least one interchain disulfide linkage from a mixture comprising the tw... | 04/20/2010 |
| 7678371 | Methods of humanizing immunoglobulin variable regions through rational modification of complementarity determining residues The present invention is based, at least in part, on the discovery that strategic modifications of non-human donor antibody CDR residue(s) can be used to humanize antibodies. Such modifications modulate the 3D structural fit between donor antibody CDRs and human acc... | 03/16/2010 |
| 7618933 | Treatment of follicular lymphomas using inhibitors of the LT pathway Therapeutic uses of inhibitors of the Lymphotoxin Pathway to treat tumors, specifically to treat follicular lymphomas. ... | 11/17/2009 |
| 7604931 | Cripto mutant and uses thereof The present invention is based on the discovery that CRIPTO mutants each comprising at least one amino acid substitution from a CRIPTO polypeptide demonstrate tumor blocking activity. ... | 10/20/2009 |
| 7592147 | Modulation of IL-2 production by T-bet The instant invention is based, at least in part, on the dentification of a mechanism by which T-bet modulates IL2 production. The present invention pertains to methods of identifying agents that modulate the kinase-mediated interaction of T-bet with RelA, as well a... | 09/22/2009 |
| 7585946 | Active lymphotoxin-β receptor immunoglobulin chimeric protein compositions Methods for high level expression of active lymphotoxin-β receptor immunoglobulin chimeric proteins and their purification. ... | 09/08/2009 |
| 7582299 | Cripto-specific antibodies The invention provides Cripto-specific antibodies, or biologically functional fragments thereof, and uses thereof. Antibodies which bind Cripto and inhibit Cripto activity are provided. Antibodies which bind Cripto and inhibit the interaction between Cripto and ALK4... | 09/01/2009 |
| 7531174 | Cripto blocking antibodies and uses thereof The invention provides Cripto blocking antibodies, or biologically functional fragments thereof, and uses thereof. Antibodies which bind Cripto and modulate Cripto signaling are provided. Antibodies which bind Cripto and block the interaction between Cripto and ALK4... | 05/12/2009 |
| 7501490 | Adiponectin receptor and gene encoding the same The object is to isolate and identify human and mouse adiponectin receptors, to provide a novel protein having adiponectin binding ability, and to provide a screening method and screening kit for a ligand, agonist and antagonist to an adiponectin receptor using such... | 03/10/2009 |
| 7485698 | Pharmaceutical composition for preventing or treating malignant glioma An object of the present invention is to provide a novel malignant glioma antitumor agent and malignant glioma antitumor agent for animals, and in order to achieve this object, in the present invention a polypeptide indicated by the following (a) or (b), or a mixtur... | 02/03/2009 |
| 7423138 | Compositions and methods for treating papillomavirus-infected cells By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and compositions of this invention may be used to treat any mammal, includin... | 09/09/2008 |
| 7405342 | Transgenic mice expressing heterologous complement receptor type 1 (CR1) molecules on erythrocytes and uses therefor The present invention is directed, at least in part, to mice which express exogenous complement receptor type 1 (CR1) on red blood cells. The invention also pertains to genetic constructs encoding heterologous CR1 for expression on red blood cells. Methods of using ... | 07/29/2008 |
| 7405276 | Method of producing bispecific molecules by protein trans-splicing The invention provides methods of using protein trans-splicing for the production of bispecific molecule which has a first antigen recognition portion that binds a C3b-like receptor and a second antigen recognition portion that binds an antigenic molecule present in... | 07/29/2008 |
| 7399846 | Libraries of oligomers labeled with different tags A method of making a set of labelled compounds by the use of a preferably particulate support, comprises dividing the support into lots, performing a different chemical reaction on each lot of the support, e.g. to couple a chemical moiety to that lot of the support,... | 07/15/2008 |
| 7393944 | T-bet compositions and methods of use thereof Isolated nucleic acid molecules encoding T-bet, and isolated T-bet proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the ... | 07/01/2008 |
| 7365169 | T-bet antibodies Isolated nucleic acid molecules encoding T-bet, and isolated T-bet proteins, are provided. The invention further provides, e.g., anti-T-bet antibodies. Methods of using the T-bet compositions of the invention are also disclosed, including, e.g., methods for detectin... | 04/29/2008 |
| 7279162 | Isolated broadly reactive opsonic immunoglobulin for treating a pathogenic coagulase-negative staphylococcus infection The invention describes the identification, making, and isolation of immunoglobulin and antigen useful for preventing, diagnosing, and treating staphylococcal infections. The invention further describes an in vivo animal model useful for testing the efficacy of phar... | 10/09/2007 |
| 7052830 | Hepatitis C virus peptides and uses thereof Novel hepatitis C virus (HCV) polypetides are provided which are not encoded by the standard HCV open reading frame. These alternate reading frame polypeptides are useful, inter alia, in vaccine compositions, in diagnosing HCV infection, and as therapeutic targets. | 05/30/2006 |
| 7026136 | Methods of reducing microbial resistance to drugs The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, methods of sc... | 04/11/2006 |
| 6946247 | RNAse probe protection assays in screening for modulators of immunoglobulin germline transcription The present invention relates to the field of immunology, and more particularly to the regulation of antibody idiotypes. Provided are compositions and methods for determining and quantitating immunoglobulin germline transcript expression. As disclosed herein, these ... | 09/20/2005 |
| 6933125 | Human c-Maf compositions and methods of use thereof Isolated nucleic acid molecules encoding human c-Maf, and isolated c-Maf proteins, are provided. The invention further provides antisense nucleic acid molecules. recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into whic... | 08/23/2005 |
| 6824779 | Methods for inhibiting the interaction of B7-2 with its natural ligand The present invention relates to, inter alia, methods for inhibiting the interaction of the B-lymphocyte antigen, B7-2, with its natural ligand on the surface of an immune cell are disclosed. The methods comprise contacting the immune cell with an agent which inhibi... | 11/30/2004 |
