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| Number | Title | Issue Date |
| 7862799 | Antibody production method A method of inducing the sustained release of antibodies in milk comprising the step of: a) implanting at least one antigen releasing device adjacent to, within close proximity of or within at least one supramammary lymph node, wherein in use the antigen releasing d... | 01/04/2011 |
| 7544510 | Stem cells of the islets of Langerhans and their use in treating diabetes mellitus Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation into a variety of pancreatic islet cells, including insulin-producing be... | 06/09/2009 |
| 7537756 | Stem cells and their use in transplantation Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation into a variety of pancreatic islet cells, including insulin-producing be... | 05/26/2009 |
| 7438902 | Stem cells and their use in transplantation Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation into a variety of pancreatic islet cells, including insulin-producing be... | 10/21/2008 |
| 7422846 | Natural ligand for orphan G protein coupled receptor GPR86 and methods of use The present invention is related to a method of detecting the dysregulation of GPR86 activity. ... | 09/09/2008 |
| 7419481 | Apparatus and method for piercing skin with microprotrusions A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent de... | 09/02/2008 |
| 7407802 | Vectors and cells for preparing immunoprotective compositions derived from transgenic plants The inventions is drawn towards vectors and methods useful for preparing genetically transformed plant cells that express immunogens from pathogenic organisms which are used to produce immunoprotective particles useful in vaccine preparations. The invention includes... | 08/05/2008 |
| 7312250 | Fluorine-substituted alkyl phenol compounds and their uses The present invention relates to the synthesis of fluorinated forms of alkyl phenol compounds and their subsequent use as pharmaceutical agents. More specifically, alkyl phenol compounds are fluorinated to increase compound volatility such that the compound may be a... | 12/25/2007 |
| 7288631 | G-coupled receptor showing selective affinity for ATP The present invention relates to an isolated G-protein coupled receptor, nucleic acid sequence encoding the receptor, and host cells capable of expressing the receptor. The invention further comprises methods for detecting the expression of a G-protein coupled recep... | 10/30/2007 |
| 7264940 | G-coupled receptor showing selective affinity for ATP The present invention relates to an isolated G-protein coupled receptor, nucleic acid sequence encoding the receptor, and host cells capable of expressing the receptor. The invention further comprises methods for detecting the expression of a G-protein coupled recep... | 09/04/2007 |
| 7258993 | Matrix screening method The invention concerns a method which can be used to screen two or more repertoires of molecules against one another and/or to create combinatorial repertoires by combining two or more repertoires. In particular, the invention relates to a method whereby two reperto... | 08/21/2007 |
| 7252946 | Nucleic acid detection The invention relates to methods for the detection of the amount of a nucleic acid in a sample. The described methods exploit the ability to physically pair nucleic acid molecules in a sample that have a reference sequence with nucleic acid molecules in the sample t... | 08/07/2007 |
| 7252943 | In Vitro sorting method The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: compartmentalizing genetic elements into microcapsules; expressing the genetic elements to produce their respec... | 08/07/2007 |
| 7247622 | Pharmaceutical compositions containing oxapenem-3-carboxylic acids An oxapenem compound which is, or is capable of forming, a zwitterion of formula wherein R is a C1-C8 branched or straight chain alkyl group which is substituted by ... | 07/24/2007 |
| 7238478 | Compositions and methods for protein isolation The invention provides for polynucleotides and vectors comprising at least two tag sequences. The invention also provides for polynucleotides and vectors comprising a streptavidin binding peptide sequence and a calmodulin binding peptide sequence. The invention also... | 07/03/2007 |
| 7235362 | Compositions and methods for protein isolation The invention provides for polynucleotides and vectors comprising at least two tag sequences. In particular, preferred vectors are viral vectors. The invention also provides for polynucleotides and vectors comprising a streptavidin binding peptide sequence and a cal... | 06/26/2007 |
| 7214509 | Methods and compositions for degradation of nitroaromatic and nitramine pollutants The invention relates to novel Methylobacterium species that are capable of degrading nitroaromatic and nitramine compounds. Compositions, kits and methods of using the Methylobacterium species for the degradation of nitroaromatic and nitramine polluta... | 05/08/2007 |
| 7189508 | Methods for detection of a target nucleic acid by capture using multi-subunit probes The invention relates to generating a signal indicative of a target nucleic acid sequence, comprising forming a complex by incubating a sample comprising a target nucleic acid sequence with a probe comprising a first and second subunit, and a binding moiety, and dis... | 03/13/2007 |
| 7186713 | Farnesyl dibenzodiazepinones and methods of treating cancer using same This invention relates to methods of inhibiting growth of a cancer cell and methods of treating cancer using a novel farnesylated dibenzodiazepinone. ... | 03/06/2007 |
| 7183052 | Methods for detection of a target nucleic acid using multi-subunit probes The invention relates to a method of generating a signal indicative of the presence of a target nucleic acid sequence in a sample, comprising forming a complex by incubating a sample comprising a target nucleic acid sequence with a probe comprising a first and secon... | 02/27/2007 |
| 7166612 | Methods for reducing platelet activation platelet aggregaton or thrombosis The invention provides methods and compositions for reducing platelet activation, platelet aggregation and thrombosis. The invention further provides compositions and methods for treating or preventing diseases or disorders in which the pathology of the disease or d... | 01/23/2007 |
| 7166475 | Compositions and methods for monitoring the modification state of a pair of polypeptides This invention relates to a method for analyzing a sample comprising: immobilising a polypeptide to a physical support; contacting the immobilised polypeptide with a test sample which may contain an agent capable of modifying the immobilised polypeptide; contacting ... | 01/23/2007 |
| 7148339 | Temperature sensitive mutant of bacteriophage T4 endonuclease VII The subject invention provides for a method of selectively cloning homoduplex nucleic acid molecules, in particular, by using a strain of host cells that contains a conditionally expressed and/or conditionally active mismatch-recognizing enzyme, e.g., a temperature ... | 12/12/2006 |
| 7138233 | IN vitro sorting method The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce thei... | 11/21/2006 |
| 7135281 | Screening for papilloma viruses The invention relates to a method of screening for precursor lesions which can lead to cervical malignancy, methods of detecting and typing human papilloma virus infections, and reagents of use in these methods. ... | 11/14/2006 |
| 7132586 | Protein production system The invention relates to a method for producing a protein of interest comprising transforming a target insect with a non-viral expression system that expresses the protein in the insect larvae, breeding the insect to produce larvae, culturing the larvae and isolatin... | 11/07/2006 |
| 7132291 | Vectors and cells for preparing immunoprotective compositions derived from transgenic plants The inventions is drawn towards vectors and methods useful for preparing genetically transformed plant cells that express immunogens from pathogenic organisms which are used to produce immunoprotective particles useful in vaccine preparations. The invention includes... | 11/07/2006 |
| 7132449 | Inhibitors of cruzipain and other cysteine proteases Compounds of general formula (I): wherein R1, R2, Y, (X)o, (W)n, (V)m, Z and U are as defined in the specification, are inhibitors of cruzipain and other cys... | 11/07/2006 |
| 7122339 | Method for generating diversity The invention relates to a method for preparing an antibody-producing cell line capable of directed constitutive hypermutation of a specific nucleic acid region, comprising the steps of: a) screening a clonal cell population for V gene diversity; b) isolating one or... | 10/17/2006 |
| 7118860 | Methods for detection of a target nucleic acid by capture The invention relates to a method of generating a signal indicative of the presence of a target nucleic acid in a sample, as well as a method of detecting or measuring a target nucleic acid in a sample. The invention comprises forming a cleavage structure by incubat... | 10/10/2006 |
| 7109178 | Method for ligating nucleic acids and molecular cloning The invention provides methods of covalently joining nucleic acid molecules and methods of molecular cloning. The methods provide either sequential or simultaneous ligation of flanking or vector nucleic acid molecules to nucleic acid insert molecules by topoisomeras... | 09/19/2006 |
| 7105307 | Compositions and methods for screening for modulators of enzymatic activity The invention provides a method to screen for a modulator of enzymatic activity comprising the step of monitoring the association or dissociation of a pair of polypeptides which can associate as a dimer. The polypeptide pair comprises a first polypeptide comprising ... | 09/12/2006 |
| 7101872 | Farnesyl dibenzodiazepinone, and processes for its production This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by cultivation of a novel strain... | 09/05/2006 |
| 7101969 | Compositions and methods involving an essential gene and its encoded protein This invention relates to newly identified polynucleotides and polypeptides, and their production and uses, as well as their variants, agonists and antagonists, and their uses. In particular, the invention relates to polynucleotides and polypeptides of a Staphylo... | 09/05/2006 |
| 7094546 | Inhibitors of the inositol polyphosphate 5-phosphatase SHIP2 molecule The present invention is related to an inhibitor of the inositol polyphosphate 5-phosphatase SHIP2 protein or its encoding nucleotide sequence identified by SEQ ID NO. 1 or of SHIP2 mRNA expression. The present invention is also related to a pharmaceutical compositi... | 08/22/2006 |
| 7083932 | Nucleic acid molecules encoding peptides having pronociceptive properties The present invention is related to nucleic acid molecules, the peptides encoded by said nucleic acid moleucles and the inhibitors direacted against said nucleic acid molecules or said peptides. The present invention concerns also the pharmaceutical composition, the... | 08/01/2006 |
| 7081600 | Method and apparatus for cover assembly for thermal cycling of samples A flexible heating cover assembly for an apparatus for heating samples of biological material with substantial temperature uniformity includes a housing having a plurality of engageable enclosure components; a resistive heater having a plurality of heater element ar... | 07/25/2006 |
| 7081339 | Methods for variation detection The invention relates to methods of monitoring the amplification of one or more nucleic acid sequences of interest. More particularly, the invention relates to methods of monitoring the amplification of sequences of interest in real time. The methods disclosed herei... | 07/25/2006 |
| 7078043 | Malaria vaccine A non-naturally occurring variant of a C-terminal fragment of a Plasmodium merozoite surface protein-1 (MSP-1) wherein said variant has (i) a reduced affinity, compared with a naturally occurring Plasmodium MSP-119, for at least one first an... | 07/18/2006 |
| 7076282 | Bioadhesive compositions and biomedical electrodes containing them Bioadhesive Compositions which comprise a hydrophobic polymer wherein the concentration of the polymer at the surface of the adhesive is greater than its concentration in the bulk of the adhesive are described; and biomedical electrodes, fixation products and wound ... | 07/11/2006 |
