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| Number | Title | Issue Date |
| 8153364 | Emulsion compositions An emulsion is useful in allowing a wide variety of gene products to be expressed via eukaryotic in vitro expression. The emulsion comprises a silicone based surfactant, a hydrophobic phase and a hydrophilic phase; wherein the hydrophilic phase comprises a plurality... | 04/10/2012 |
| 8148072 | Method of profiling gene expression in a subject having heart failure The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present inventio... | 04/03/2012 |
| 8133675 | Method of profiling gene expression in a subject having an infectious disease The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present inventio... | 03/13/2012 |
| 8133674 | Method of profiling gene expression in a subject having diabetes The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present inventio... | 03/13/2012 |
| 8133673 | Compartmentalized self tagging The present invention relates to the development of a novel method for the selection of nucleic acid processing and other enzymes. In particular the invention relates to a method for the selection of nucleic acid polymerases and other enzymes with desired properties... | 03/13/2012 |
| 8114597 | Method of profiling gene expression in a subject undergoing a treatment The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present inventio... | 02/14/2012 |
| 8110399 | Stem cells of the islets of langerhans and their use in treating diabetes mellitus Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation into a variety of pancreatic islet cells, including insulin-producing be... | 02/07/2012 |
| 8110358 | Method of profiling gene expression in a subject having prostate cancer The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present inventio... | 02/07/2012 |
| 8101358 | Method of profiling gene expression in a subject having disease The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present inventio... | 01/24/2012 |
| 8084599 | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the expression of the gene. More particularly, the invention is directed ... | 12/27/2011 |
| 8067173 | Method of profiling gene expression in a healthy subject The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present inventio... | 11/29/2011 |
| 8066066 | Borehole casing centraliser A centraliser segment (11) comprising a first collar portion(15), a second collar portion (17) and bow element (19) extending between said first collar portion and said second collar portion to maintain the collar portions in spaced relat... | 11/29/2011 |
| 8053437 | Furo[3. 2-B] pyrrol derivatives The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein: R3 is tert-butylmethyl, sec-butyl or tert-butyl; X is CH or N; and R4 is optionally substituted C1-8 alkyl or optional... | 11/08/2011 |
| 8043824 | Methods for determining the redox status of proteins A method for determining the redox status of a protein sample, the method comprising the steps of: a) contacting the sample with a first label adapted to bind to at least one reduced cysteine group therein; b) contacting the sample with a reducing agent to reduce at... | 10/25/2011 |
| 8039641 | Tetrahydrofuro[3,2-b] pyrrol-3-one intermediates The present invention relates to a process for preparing a compound of formula (Ia), (Ib), (Ic) or (Id), or a pharmaceutically acceptable salt, hydrate, solvate, complex or prodrug thereof, said process comprising the steps of: (A) (i) treating a compound of formula... | 10/18/2011 |
| 8034576 | Xanthurenic acid derivative pharmaceutical compositions and methods related thereto The present invention relates to diuretic pharmaceutical compositions and methods and in particular to certain derivatives of the formula I: or a prodrug or pharmaceutically acceptable salt thereof;... | 10/11/2011 |
| 8030453 | Methods of making an antibody that binds a chemerin polypeptide The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful f... | 10/04/2011 |
| 8008290 | Compounds A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt, hydrate, complex or pro-drug thereof, wherein: R3 is selected... | 08/30/2011 |
| 8008023 | Natural ligand of G protein coupled receptor RCC356 and uses thereof The invention relates to the identification of isovaleric acid as a natural ligand of the RCC356 G-protein coupled receptor (GPCR). The invention encompasses the use of the interaction of RCC356 polypeptides and isovaleric acid as the basis of screening assays for a... | 08/30/2011 |
| 8003347 | Nucleic acids encoding ChemerinR ligands The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful f... | 08/23/2011 |
| 7973015 | Induction of exon skipping in eukaryotic cells The present invention provides a method for at least in part decreasing the production of an aberrant protein in a cell, the cell comprising pre-mRNA comprising exons coding for the protein, by inducing so-called exon skipping in the cell. Exon-skipping results in m... | 07/05/2011 |
| 7963935 | Microprojection array having a beneficial agent containing coating The device including a plurality of stratum corneum-piercing microprojections, and a solid coating disposed upon the microprojections, wherein the solid coating includes at least one beneficial agent and a biocompatible carrier is provided. The device is applied to ... | 06/21/2011 |
| 7955845 | Modified antigen-presenting cells The invention relates to antigen-presenting cells having specificity against a selected antigen and methods for making the cells. The invention also relates to a method of selecting efficient antigen-presenting cells using reporter fusion constructs. The highly effi... | 06/07/2011 |
| 7951979 | 2,4,6-trisubstituted phenols having anesthetic properties Trisubstituted phenol compounds and methods of using the compounds, e.g., for anesthetizing a subject, are disclosed. ... | 05/31/2011 |
| 7951596 | Nucleic acid nanotube liquid crystals and use for NMR structure determination of membrane proteins Compositions and methods for preparing nucleic acid nanotubes using DNA origami techniques are described, which provide for nanotubes of predictable and uniform length. The nucleic acid nanotubes thus formed are suitable as liquid crystal preparations enabling liqui... | 05/31/2011 |
| 7947819 | B-raf polynucleotides The invention relates to mutations in B-Raf gene products. The mutations described are identified in human tumors of natural origin. These mutations are associated with cancerous phenotypes and can be used as a basis for the diagnosis of cancer, cancerous cells or a... | 05/24/2011 |
| 7927596 | Methods of antagonizing binding of CD40 to CD40L with CD40L-specific monovalent polypeptides The invention relates to antibody polypeptides that monovalently bind CD40L. Antibody polypeptides that are monovalent for binding of CD40L can inhibit CD40L activity while avoiding potential undesirable effects that can occur with antibodies capable of divalent or ... | 04/19/2011 |
| 7906278 | Diagnosis of osteoarthritis by determination of asporin RNA levels The invention relates to the identification and selection of sequences which demonstrate particular advantage in identifying individuals having osteoarthritis (OA). The invention also provides a selection of sequences particularly useful in diagnosing the degree of ... | 03/15/2011 |
| 7897341 | Optical sorting method The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their r... | 03/01/2011 |
| 7888293 | Compositions and methods relating to orthogonal ribosome mRNA pairs Orthogonal ribosome orthogonal mRNA pairs are provided, as are methods for their selection involving a novel positive-negative selection approach, and methods for their use. Also provided are cellular logic circuits involving orthogonal ribosomes. ... | 02/15/2011 |
| 7848888 | Method for identification of biologically active agents The present invention provides a method for screening for the effect of a test agent on a population of biological specimens, preferably insects, comprising the steps of providing a population of specimens, administering at least one test agent to the population, cr... | 12/07/2010 |
| 7847146 | Model for neurodegenerative disorders The present invention discloses a double transgenic fly that expresses both Tau protein and the human Aβ42 peptide of human amyloid-β precursor protein (APP). The double transgenic flies of the present invention display a synergistic altered phenotype as compared ... | 12/07/2010 |
| 7846935 | Furo[3,2-B]pyrrol-3-one derivatives and their use as cysteinyl proteinase inhibitors The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein: X is CH or N; and R4 is optionally substituted C3-8 alkyl or optio... | 12/07/2010 |
| 7858755 | Monoclonal antibodies that bind Chemerin polypeptide The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful f... | 12/28/2010 |
| 7842795 | Nucleic acids encoding a heme binding protein polypeptide The present invention relates to methods, reagents and kits for detecting of formyl peptide receptor like-2 (FPRL2) polypeptide activity in a sample and identifying agents which modulate polypeptide activity. It further relates to antibodies raised against FPRL2. It... | 11/30/2010 |
| 7842453 | Methods of identifying modulators of ChemerinR polypeptides The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful f... | 11/30/2010 |
| 7833537 | Use of parasitic biological agents for prevention and control of autoimmune diseases The invention relates to a method of treating an excessive immune response including an aberrant/enhanced Th1 response by administering a helminthic parasite preparation in an amount sufficient to reduce the excessive immune response in an individual. This invention... | 11/16/2010 |
| 7829096 | CD40L-specific monovalent polypeptides The invention relates to antibody polypeptides that monovalently bind CD40L. Antibody polypeptides that are monovalent for binding of CD40L can inhibit CD40L activity while avoiding potential undesirable effects that can occur with antibodies capable of divalent or ... | 11/09/2010 |
| 7824866 | Ligand for G-protein coupled receptor GPR72 and uses thereof The present invention relates to methods, reagents and kits for detecting of GPR72 polypeptide activity in a sample and identifying agents which modulate polypeptide activity. It further relates to antibodies raised against GPR72. It further relates to substances fo... | 11/02/2010 |
| 7803803 | Tetrahydrofuro[3,2-B] pyrrol-3-ones as cathepsin K inhibitors The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein: X is CH or N; one of R1 and R2 is H, and the other is select... | 09/28/2010 |
