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| Number | Title | Issue Date |
| 5349128 | Cucumber mosaic virus coat protein gene The coat protein gene of cucumber mosaic virus strain WL (CMV-WL), the method of preparing it, its use to prepare transgenic plants and transgenic plants containing it are provided.... | 09/20/1994 |
| 5268284 | Ribosome binding site Provided are ribosome binding sites having an increased number of adenine (A) and thymidine (T) residues as compared to the naturally occurring ribosome binding sites from which they are derived or to which they are related, which allow high level express... | 12/07/1993 |
| 5250711 | Amine salts of alkane-1,n-dicarboxylic acid mono-(2-sulfato-ethyl) amides Amine salts of alkane-1,n-dicarboxylic acid mono-(2-sulfatoethyl)amides of the Formula I HOC(O)--(CH2)n --C(O)--N(R1)--CH2 CH2 SO3--+ HN(R2)3 ... | 10/05/1993 |
| 5245046 | -amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents Provided are novel -aminoindole-3-acetic acid derivatives having the formula ##STR1## wherein R through R9 are as defined in the specification, and pharmacologically acceptable salts of compounds wherein R9 is not OM, which are... | 09/14/1993 |
| 5220034 | Protected derivatives of the enone of spectinomycin Process for alkylating protected spectinomycin enone derivatives in the gamma position in order to produce intermediates useful in the synthesis of 6'alkylspectinomycins. The intermediate have the formula ##STR1## which comprises reacting a compound ... | 06/15/1993 |
| 5087639 | Preventing CNS toxicity of acivicin when used with four large neutral amino acids A method for the prevention of central nervous system toxicity of acivicin which comprises the concomitant administration of acivicin and an amino acid solution consisting essentially of large neutral amino acids.... | 02/11/1992 |
| 5079007 | Controlled release of antibiotic salts from an implant An controlled release implant antibiotic formulation comprising (a) a crystalline salt of the antibiotic; (b) an amorphous salt of the antibiotic; and (c) excipients; whereas the excipients comprise from 0% to 10% of the tablet by weight. A particularly e... | 01/07/1992 |
| 4978753 | 7-phenylpyrimido[1,2-alpha][1,4]benzodiazepin-3(5H)-ones A 7-phenylpyrimido[1,2-a][1,4]benzodiazepin-3(5H)-ones of the formula II: ##STR1## wherein Ro is selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms, inclusive, --COOR in which R is alkyl defined as above, ##S... | 12/18/1990 |
| 4891382 | Method of preventing pancreatitis utilizing 2-amino-cycloaliphatic amides A method for the prevention of pancreatitis utilizing cis- and trans-N-(3-aminocycloaliphatic)-2-arylacetamide derivative compounds of the formula ##STR1## e.g., N-[2-(n',N'-dimethylamino)cyclohexyl]-N-methyl-2-(4-bromophenyl)acetamide and ... | 01/02/1990 |
| 4810700 | Compositions inhibiting estrogen sulfotransferase activity An estrogen sulfotransferase inhibitor composition comprises a compound of the formula ##STR1## wherein R1 is F, Br, NO2, or H; R2 is F, Br, NO2, NH2, or H; R is H or alkyl of 1-4 carbon atoms; R... | 03/07/1989 |
| 4767847 | Nobamycin its analogs and process therefore The invention concerns a novel nogamycin having a heretofore unknown configuration and novel analogs which are active against various microorganisms. The invention also includes novel methods of making substituted and unsubstituted nogamycin having an ess... | 08/30/1988 |
| 4711960 | Isochromans Isochromans, isothiochromans, 2-benzoxepins and 2-benzothiepins are described. The compounds possess hypotensive and anti-psychotic properties; methods and compositions using them are described.... | 12/08/1987 |
| 4710565 | Thesis of 7-halo-7-deoxylincomycins Process for preparing clindamycin and analogs thereof by reacting lincomycin or an analog thereof with a dimethylformamide and an excess of thionyl halide.... | 12/01/1987 |
| 4595770 | Antibiotic compound and process for recovery thereof from a fermentation broth Novel antibiotic U-56,407 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces hagronensis strain 360, NRRL 15064. This antibiotic is active against various Gram-positive bacteria, fo... | 06/17/1986 |
| 4588817 | Antibiotic nodusmicins Novel antibacterially-active esters of antibiotic nodusmicin. Activity is demonstrated against Staphylococcus aureus, Streptococcus pyogenes, and Sarcina lutea. Thus, these esters can be used in various known environments, using well-known procedures, to ... | 05/13/1986 |
| 4568741 | Synthesis of 7-halo-7-deoxylincomycins An improved process for preparing 7-halo-7-deoxylincomycins and analogs thereof. The compounds prepared have anti-bacterial activity.... | 02/04/1986 |
| 4532336 | 6'-Alkylspectinomycins Process for preparing 6'-alkylspectinomycin and analogs thereof. Also provided are novel intermediates utilized in the process.... | 07/30/1985 |
| 4531006 | N-[(phosphinyl) amino]thio- and N-[(phosphinothioyl)amino]-thio-methylcarbamates New phosphinic acid derivatives of aminothio methylcarbamates. The new compounds are active against insects, mites and nematodes.... | 07/23/1985 |
| 4518799 | Processes for the preparation of hydratropic acids Novel processes for making arylpropionic acids are described. One process comprises carboxylating particular Grignard compounds which are the products of a catalyzed reaction between corresponding arylmagnesium bromides and ethylene. Furthermore, the reac... | 05/21/1985 |
| 4474968 | Cyclopentene derivatives Racemic mixtures and optically active isomers of (S-5S)--amino-3-chloro--isoxazoline-5-acetic acid (AT-125). Provides process for preparing AT-125 and its analogs and intermediates used in the process.... | 10/02/1984 |
| 4458083 | Cyclo pentene derivatives Racemic mixtures and optically active isomers of (S-5S)--amino-3-chloro--isoxazoline-5-acetic acid (AT-125). Provides process for preparing AT-125 and its analogs and intermediates used in the process. This case is a continuation of S... | 07/03/1984 |
| 4458084 | Cyclopentene derivatives Racemic mixtures and optically active isomers of (S-5S)--amino-3-chloro--isoxazoline-5-acetic acid (AT-125). Provides process for preparing AT-125 and its analogs and intermediates used in the process. This case is a continuation of S... | 07/03/1984 |
| 4458089 | Cyclopentene derivatives Racemic mixtures and optically active isomers of (S-5S)--amino-3-chloro--isoxazoline-5-acetic acid (AT-125). Provides process for preparing AT-125 and its analogs and intermediates used in the process. This case is a continuation of S... | 07/03/1984 |
| 4439602 | Nogalamycin derivatives Novel N-demethyl derivatives of nogalamycin and process for preparing the same. The compounds of this invention are active against various microorganisms.... | 03/27/1984 |
| 4424368 | Process for making phosphorus derivatives of aminothiomethylcarbamates This invention pertains to novel processes for preparing phosphorus derivatives of aminothiomethylcarbamates using as intermediates corresponding phosphorus derivatives of aminothiocarbamic halides. The carbamates are useful as pesticides against insects,... | 01/03/1984 |
| 4420623 | Process and intermediates for preparing 6'-methylspectinomycin and analogs thereof A method for the preparation of 6'-methylspectinomycin and analogs thereof. Additionally provides novel intermediates utilized in said method.... | 12/13/1983 |
| 4412993 | Method of treating pseudopregnancy, galactorrhea and mastitis in mammals Prophylactic and therapeutic methods of treating pseudopregnancy and galactorrhea in mammals with 7-methyltestosterones. Also, use of 7-methyltestosterones in adjunct treatment of mastitis in mammals.... | 11/01/1983 |
| 4413013 | Sulfonamide compounds, compositions and methods for combatting insects Novel pesticidal N-[[[arylformimidoyl]methylamino]thio]-N-substituted sulfonamides are disclosed with novel compositions thereof and methods for their use in controlling invertebrate arthropod pests, particularly insects, mites, and ticks.... | 11/01/1983 |
| 4405796 | Processes for making phosphorus derivatives of aminothiomethylcarbamates This invention pertains to novel processes for preparing phosphorus derivatives of aminothiomethylcarbamates using as intermediates corresponding phosphorus derivatives of aminothiocarbamic halides. The carbamates are useful as pesticides against insects,... | 09/20/1983 |
| 4400524 | Grignard reagents prepared from 5-halopentan-2-one propylene ketals A process for preparing 19-norandrostenedione. Also provides key intermediates of 19-norandrostenedione and methods for preparing them in high yields.... | 08/23/1983 |
| 4398035 | Malonic acids and esters thereof The invention concerns the novel compounds dialkyl 2-(3-fluoro-4-nitrophenyl)-2-methylmalonate IIIa and dialkyl 2-(3-fluoro-4-aminophenyl)-2-methylmalonate IVa useful as intermediates in an improved process for making 2-(2-fluoro-4-biphenylyl)propionic ac... | 08/09/1983 |
| 4380652 | Enamines of 6'-methylspectinomycin and process for preparing the same A method for the preparation of 6'-methylspectinomycin and analogs thereof. Additionally provides novel intermediates utilized in said method.... | 04/19/1983 |
| 4380651 | Process for preparing 6'-methylspectinomycin and analogs thereof A method for the preparation of 6'-methylspectinomycin and analogs thereof. Additionally provides novel intermediates utilized in said method.... | 04/19/1983 |
| 4361701 | Novel compounds, compositions and processes Anomers and asteric mixtures of novel analogs of spectinomycin. Additionally provides novel intermediates and process for preparing spectinomycin analogs.... | 11/30/1982 |
| 4354975 | Processes for making phosphorus derivatives of aminothiomethylcarbamates This invention pertains to novel processes for preparing phosphorus derivatives of aminothiomethylcarbamates using as intermediates corresponding phosphorus derivatives of aminothiocarbamic halides. The carbamates are useful as pesticides against insects,... | 10/19/1982 |
| 4352929 | 1,3-Thiazin-4-one Novel cyclized ω-carboxyethyl mono- or dithiocarbanilic acids are disclosed as immunoregulatory agents, useful in the treatment of organ transplant reject phenomenon and autoimmune diseases particularly where a delayed hypersensitivity component has been... | 10/05/1982 |
| 4352805 | Methods of treating psychosis Isochromans, isothiochromans, 2-benzoxepins and 2-benzothiepins are described. The compounds possess hypotensive and antipsychotic properties; methods and compositions using them are described.... | 10/05/1982 |
| 4351771 | Spectinomycin analogs and methods for the preparation thereof Anomers and asteric mixtures of novel analogs of spectinomycin. Additionally provides novel intermediates and process for preparing spectinomycin and analogs thereof.... | 09/28/1982 |
| 4344882 | Intermediate compounds in the preparation of spectinomycin Process for preparing intermediates of spectinomycin and analogs thereof. Also provides novel intermediates for making spectinomycin and analogs thereof.... | 08/17/1982 |
| 4345086 | Intermediate compounds in the preparation of spectinomycin Process for preparing intermediates of spectinomycin and analogs thereof. Also provides novel intermediates for making spectinomycin and analogs thereof.... | 08/17/1982 |
