Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 4939288 | Method of preparing (R)-succinic acid derivatives Method for preparing a biologically active 2-substituted succinic acid derivative involving asymmetrically catalytically hydrogenating the corresponding 2(E)-alkylidene succinate derivative in the presence of a rhodium complexed (R,R)-bisphosphine compoun... | 07/03/1990 |
| 4870208 | Asymmetric hydrogenolysis of epoxides A process of preparing chiral alcohols by the asymmetric catalytic hydrogenolysis of epoxides using rhodium or ruthenium catalysts containing chiral phosphine ligands.... | 09/26/1989 |
| 4861865 | Novel antithrombin peptide A novel synthetic peptide with potent antithrombin activity is provided which has the following amino acid sequence: ##STR1##... | 08/29/1989 |
| 4861892 | Method for synthesis of deoxymannojirimycin A method is disclosed for the chemical synthesis of 1,5-dideoxy-1,5-imino-D-mannitol or 1,5-dideoxy-1,5-imino-L-mannitol from, respectively, 2,3-O-isopropylidene-L-gulono-γ-lactone or 2,3-O-isopropylidene-D-gulono-γ-lactone which comprises carrying out ... | 08/29/1989 |
| 4857508 | Novel platelet-aggregation inhibitor peptide derivatives Novel tetrapeptide derivatives are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the sequence X-Gly-Asp-Y wherein X is illustrated by arginine and Y is illustrated by O-methyltyrosine amide.... | 08/15/1989 |
| 4857320 | Method of enhancing the solubility of tissue plasminogen activator The solubility of tissue plasminogen activator in aqueous solution is enhanced by incorporating therein arginine or a non-toxic salt of arginine in an amount effective to increase the solubility of the t-PA without substantially inhibiting its potential b... | 08/15/1989 |
| 4855241 | Tumor diagnostic method An in vitro diagnostic method for determining the presence of nerve growth factor receptor bearing tumors is disclosed which comprises determining the presence of an elevated level of a truncated nerve growth factor receptor in a sample of a body fluid fr... | 08/08/1989 |
| 4851517 | Tissue plasminogen activator oligosaccharide from normal human colon cells Glycosylated plasminogen activator (t-PA) having a glycosylation pattern significantly different than exhibited by t-PA from Bowes melanoma cells is obtained from cultured normal human colon fibroblast cells (CCD-18Co).... | 07/25/1989 |
| 4849430 | Method of inhibiting virus A method of inhibiting human immunodeficiency virus is disclosed which comprises administering to a patient infected with said virus a virally inhibitory effective amount of the N-butyl derivative of deoxynojirimycin or a pharmaceutically acceptable salt ... | 07/18/1989 |
| 4833085 | Monoclonal antibody specific for human colon fibroblast-derived t-PA A monoclonal antibody is disclosed which is specific for human colon fibroblast-derived tissue plasminogen activator (t-PA), and which is useful for immunoaffinity chromatography purification of t-PA and determination of t-PA in a biological sample.... | 05/23/1989 |
| 4818365 | Solid state indicator electrode and method of making same A junction-type metal/metal oxide solid state indicator electrode wherein the sensing portion of the electrode is coated with a perfluorocarbon copolymer, and a pH sensor made of the indicator electrode and a reference electrode.... | 04/04/1989 |
| 4814489 | Process for the preparation of substituted olefins from unsaturated organic chlorides and olefins A process to prepare a substituted olefin involving reacting an unsaturated organic chloride with bromide and/or iodide ions to form a mixture of unsaturated organic chloride, bromide and/or iodide, and reacting the mixture with an olefin in the presence ... | 03/21/1989 |
| 4806687 | Catalytic hydrodesulfurization of ortho-aminobenzylsulfides Ortho-alkylanilines are prepared by catalytic hydrodesulfurization of ortho-aminobenzyl sulfides using a cobalt-molybdenum oxide catalyst. For example, 2-methyl-6-trifluoromethylaniline is prepared by catalytic hydrodesulfurization of 3-trifluoromethyl-2-... | 02/21/1989 |
| 4801665 | Resin method for making sulfoxide for solid phase peptide synthesis A resin for solid phase peptide synthesis and a method for synthesizing the resin wherein the resin has a sulfoxide linkage which is stable to strong acid deprotecting conditions. The linkage can be reduced to a sulfide linkage which allows cleavage of th... | 01/31/1989 |
| 4794002 | Modified polymeric surfaces and process for preparing same A process for surface modifying a variety of polymeric support surfaces is disclosed in which a predetermined modifying polymer is irreversibly absorbed onto essentially all the surfaces of the support polymer accessible to the modifying polymer. The modi... | 12/27/1988 |
| 4778878 | Novel inhibitor peptides I An octapeptide inhibitor of myristoylating enzymes is disclosed having an amino acid sequence as follows or a physiologically acceptable amide or salt derivative thereof: ##STR1##... | 10/18/1988 |
| 4778877 | Novel inhibitor peptides II An octapeptide inhibitor of myristoylating enzymes is disclosed having an amino acid sequence as follows or a physiologically acceptable amide or salt derivative thereof: ##STR1##... | 10/18/1988 |
| 4772557 | DNA clone of human skin fibroblast collagenase enzyme A cDNA having a base sequence for human skin fibroblast collagenase has been cloned and characterized and the amino acid sequence of the human skin fibroblast protein has been determined.... | 09/20/1988 |
| 4771125 | Human soluble immune response suppressor Human soluble immune response suppressor (SIRS) having a molecular weight of about 10,000 to 15,000, an isoelectric point of about 7 and a defined amino acid composition distinctly different from murine SIRS is produced from a culture of MOLT-4 cells.... | 09/13/1988 |
| 4764594 | Resin support for solid phase peptide synthesis A resin and method for preparing the resin for solid phase peptide synthesis. The resin has a sulfoxide linkage, which is stable to strong acid conditions. The sulfoxide linkage can be reduced to a sulfide linkage, which allows cleavage of the peptide fro... | 08/16/1988 |
| 4764595 | Resin support for solid phase peptide synthesis A resin and method for using the resin for solid phase peptide synthesis. The resin has a sulfoxide linkage, which is stable to strong acid conditions. The sulfoxide linkage can be reduced to a sulfide linkage, which allows cleavage of the peptide from th... | 08/16/1988 |
| 4760186 | Preparation of substituted aromatic amines A process for the preparation of substituted aromatic amines comprising (1) contacting a primary aromatic amine with an oxidizing agent in a homogeneous solution containing water, an oxidizable water-miscible organic solvent and a base, and (2) reducing t... | 07/26/1988 |
| 4755382 | Immunostimulating method A method is disclosed for stimulating the immune system of a warm-blooded animal by the production of antibodies by administering an effective amount of Cytophaga allerginae lipopolysaccharide endotoxin.... | 07/05/1988 |
| 4753876 | Marker genes in pseudomonad bacteria This invention discloses the use of marker genes which do not involve antibiotics for environmental tracking of microorganisms. Such marker genes include chromogenic marker genes, and marker genes that allow a cell to proliferate on media containing a sol... | 06/28/1988 |
| 4752578 | Collagenase inducing factor A method for the production of collagenase inducing factor is disclosed which comprises growing the human liver adenocarcinoma cell line SK-HEP-1 in nutrient culture medium at 35°-38° C. and recovering the resulting collagenase inducing factor from the ... | 06/21/1988 |
| 4751084 | Tissue plasminogen activator from normal human colon cells Glycosylated plasminogen activator (t-PA) having a glycosylation pattern significantly different than exhibited by t-PA from Bowes melanoma cells is obtained from cultured normal human colon fibroblast cells (CCD-18Co).... | 06/14/1988 |
| 4740617 | Sorbic acid process with crystallization Preparation of sorbic acid from precursors by contact with acid catalysts is improved by utilizing crystallization to separate sorbic acid during the preparation.... | 04/26/1988 |
| 4740588 | Novel substrate peptides A peptide substrate for myristoylating enzymes is disclosed having an amino acid sequence selected from the group consisting of the following sequences or a physiologically acceptable amide or salt derivative thereof: ##STR1## wherein R=Ala, Asn... | 04/26/1988 |
| 4740499 | Method of enhancing the bioactivity of atrial peptides A method of prolonging or enhancing the bioactivity of atrial peptides is disclosed in which thiorphan or kelatorphan is administered contemporaneously with the administration of the atrial peptide.... | 04/26/1988 |
| 4736063 | Sorbic acid process Butadiene and acetic acid are reacted with metal ion oxidant to prepare acetoxyhexenoic acids which are then converted to sorbic acid.... | 04/05/1988 |
| 4736022 | Isolation of unreduced oligosaccharides A preparative scale method for the isolation of unreduced oligosaccharides of glycoproteins and glycohormone having a N-linked oligosaccharide structure is disclosed. The method employs hydrazinolysis of the glycoprotein or glycohormone under reaction con... | 04/05/1988 |
| 4720486 | Method of inhibiting vertebrate collagenase activity using peptide hydroxamic acid derivatives Novel peptide hydroxamic acid derivatives having useful collagenase inhibitory activity and capable of forming affinity resins for the purification of vertebrate collagenase are defined by the following structural formula: wherein R=H or N-protecting grou... | 01/19/1988 |
| 4719294 | Isolation of unreduced oligosaccharides A preparative scale method for the isolation of unreduced oligosaccharides of glycoproteins and glycohormones having an N-linked oligosaccharide structure is disclosed. The method employs hydrazinolysis of the glycoprotein or glycohormone under reaction c... | 01/12/1988 |
| 4716147 | Synthetic airial peptides Novel synthetic atrial peptides are provided with enhanced natriuretic properties by substituting one or two arginine residues for the N-terminal ser-ser in atriopeptins I, II and III and their physiologically acceptable salts, esters and amides.... | 12/29/1987 |
| 4709012 | Novel inhibitor peptides An octapeptide inhibitor of myristoylating enzymes is disclosed having an amino acid sequence selected from the group consisting of the following sequences or a physiologically acceptable amide or salt derivative thereof: ##STR1## wherein R=Leu,... | 11/24/1987 |
| 4707491 | Anticonvulsant γ-thiobutyrolactone derivatives γ-Thiobutyrolactone derivatives having short chain - and/or γ-alkyl or alkenyl substituents have useful anticonvulsant properties.... | 11/17/1987 |
| 4704380 | Method of stimulating the growth of macrophage-like cells utilizing mitogenic peptides Novel tetradecapeptides having the following sequence were found to have potent mitogenic activity for machropage-like cells: wherein X=Trp or Tyr, or the physiologically acceptable salts, esters or amides thereof.... | 11/03/1987 |
| 4704451 | Mitogenic peptides Novel tetradecapeptides having the following sequence were found to have potent mitogenic activity for machropage-like cells: wherein X=Trp or Tyr, or the physiologically acceptable salts, esters or amides thereof.... | 11/03/1987 |
| 4687841 | Peptide hydroxamic acid derivatives Novel peptide hydroxamic acid derivatives having useful collagenase inhibitory activity and capable of forming affinity resins for the purification of vertebrate collagenase are defined by the following structural formula: wherein R=H or N-protecting grou... | 08/18/1987 |
| 4677220 | Process for the preparation of -L-aspartyl-L-phenylalanine methyl ester A regioselective process for the preparation of -L-aspartyl-L-phenylalanine methyl ester is disclosed. A controlled aqueous coupling reaction between ଲ-methyl-L-aspartate-N-carboxyanhydride and L-phenylalanine produces the aspartyl methy... | 06/30/1987 |
