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| Number | Title | Issue Date |
| 7977459 | Adiponectin receptor and gene encoding the same The object is to isolate and identify human and mouse adiponectin receptors, to provide a novel protein having adiponectin binding ability, and to provide a screening method and screening kit for a ligand, agonist and antagonist to an adiponectin receptor using such... | 07/12/2011 |
| 7799902 | Receptor coupling agents and compositions thereof Receptor coupling agents, including multivalent constructs comprising anti-TNF receptor binding moieties, for treating cancer and inhibiting tumor volume in a subject are disclosed. ... | 09/21/2010 |
| 7736647 | Anti-CD71 monoclonal antibodies and uses thereof for treating malignant tumor cells The present invention provides novel anti-CD71 monoclonal antibodies, in particular mouse-human chimeric anti-CD71 monoclonal antibodies, advantageously associated to effector cells for triggering ADCC mechanisms. Anti-CD71 antibodies, as well as pharmaceutical comp... | 06/15/2010 |
| 7674462 | Cripto blocking antibodies and uses thereof The invention provides Cripto blocking antibodies, or biologically functional fragments thereof, and uses thereof. Antibodies which bind Cripto and modulate Cripto signaling are provided. Antibodies which bind Cripto and block the interaction between Cripto and ALK4... | 03/09/2010 |
| 7615380 | Methods for modulating an immune response by modulating KRC activity This invention demonstrates that KRC molecules have multiple important functions as modulating agents in regulating a wide variety of cellular processes including: inhibiting NFkB transactivation, increasing TNF-alpha induced apoptosis, inhibiting JNK activation, in... | 11/10/2009 |
| 7511122 | Humanized and chimeric antibodies specific for lipoteichoic acid of GRAM positive bacteria The present invention encompasses monoclonal and chimeric antibodies that bind to lipoteichoic acid of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro and enhance protection from lethal... | 03/31/2009 |
| 7468269 | Reagents for recombinogenic engineering and uses thereof The present invention features homologous recombination methods and systems. The methods and systems promote highly efficient homologous recombination in cells (e.g., in prokaryotic cells). The methods and systems are useful, for example, in pharmaceutical drug deve... | 12/23/2008 |
| 7427403 | Methods for inhibiting lymphotoxin β receptor signalling This invention relates to compositions and methods comprising “lymphotoxin-β receptor blocking agents”, which block lymphotoxin-β receptor signalling. Lymphotoxin-β receptor blocking agents are useful for treating lymphocyte-mediated immunological diseases, a... | 09/23/2008 |
| 7169903 | Multifunctional monoclonal antibodies directed to peptidoglycan of gram-positive bacteria The present invention encompasses protective monoclonal antibodies that bind to peptidoglycan of Gram-positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro and block nasal colonization by Gram-pos... | 01/30/2007 |
| 6967077 | Methods and compositions for regulating T cell subsets by modulating transcription factor activity Methods for modulating production of a T helper type 2 (Th2)-associated cytokine, in particular interleukin-4, by modulating the activity of a transcription factor, in particular the proto-oncoprotein c-Maf, that regulates expression of the Th2-associated cytokine g... | 11/22/2005 |
| 6936704 | Nucleic acids encoding costimulatory molecule B7-4 The invention provides isolated nucleic acids molecules, designated B7-4 nucleic acid molecules, which encode novel B7-4 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing B7-4 nucleic acid molecules... | 08/30/2005 |
| 6821779 | Methods for storing neural cells The instant methods pertain to improved methods for storing neural cells, preferably dissociated neural cells, prior to their use in transplantation and to the cells obtained using such methods. One embodiment pertains to methods for storing the neural cells in medi... | 11/23/2004 |
| 6808710 | Downmodulating an immune response with multivalent antibodies to PD-1 The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents for modulating PD-1, B7-4, and the interaction between B7-4 and PD-1 in... | 10/26/2004 |
| 6750334 | CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor CTLA4-immunoglobulin fusion proteins having modified immunoglobulin constant region-mediated effector functions, and nucleic acids encoding the fusion proteins, are described. The CTLA4-immunoglobulin fusion proteins comprise two components: a first peptide having a... | 06/15/2004 |
| 6713245 | Methods for storing neural cells such that they are suitable for transplantation The instant methods pertain to an improved methods for storing neural cells, preferably dissociated neural cells, prior to their use in transplantation and to the cells obtained using such methods. One embodiment pertains to methods for storing the neural cells in m... | 03/30/2004 |
| 6645766 | Shuttle vectors The invention provides shuttle vectors, and methods of using shuttle vectors, capable of expression in, at least, a mammalian cell. Furthermore, the shuttle vectors are capable of replication in at least yeast, and optionally, bacterial cells. Also provid... | 11/11/2003 |
| 6632608 | Methods and compositions relating to modulation of hepatocyte growth, plasma cell differentiation or T cell subset activity by modulation of XBP-1 activity The invention demonstrates that the transcription factor XBP-1 is a regulator of hepatocyte growth, plasma cell differentiation and T cell subset activity. Methods for identifying modulators of hepatocyte growth, plasma cell differentiation and/or T cell ... | 10/14/2003 |
| 6610288 | Porcine hepatocytes for use in treatment of disorders characterized by insufficient liver function Isolated porcine hepatocytes, isolated populations of such hepatocytes and methods for using the hepatocytes to treat subjects with disorders characterized by insufficient liver function are described. The porcine hepatocytes can be either hepatocytes iso... | 08/26/2003 |
