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| Number | Title | Issue Date |
| 4734291 | Process for preparing shelf stable al dente cooked pasta An al dente pasta product having storage stability is produced by partially cooking freshly extruded pasta with steam or boiling water. Measured amounts of the partially cooked pasta are sealed in a container with measured amounts of water sufficient to c... | 03/29/1988 |
| 4568002 | Dispensing method and apparatus A method and apparatus for the total dispensing of the contents, e.g. insecticide, of a container, which comprises actuating a release valve by an actuator and placing at least the actuator in rotation about a vertical axis as the contents discharge.... | 02/04/1986 |
| 4568693 | N-Naphthoylglycine derivatives Herein disclosed are N-naphthoylglycine derivatives having aldose reductase inhibiting activity. The derivatives are useful for treating diabetic complications.... | 02/04/1986 |
| 4526097 | Feed mechanism for apparatus for evacuating and compacting aerosol cans An improved feeding mechanism is provided for apparatus used for evacuating and compacting filled aerosol cans. The feeding mechanism is made up of a support plate adapted to be fitted into an inclined feed chute of a compaction and evacuation apparatus. ... | 07/02/1985 |
| 4510157 | 6,7,8,9-Tetrahydro-1H-benz(g)indol-8-amine derivatives Herein is disclosed compounds of the formula ##STR1## in which R1,R2,R3,R4 and R5 each is hydrogen or lower alkyl, therapeutically acceptable acid addition salts thereof, processes for their prep... | 04/09/1985 |
| 4499310 | 5-Methyl-1-(trifluoromethyl)-2-naphthalenol, process for its preparation and ethers thereof A process and intermediates for preparing 6-(lower alkoxy)-5-(trifluoromethyl)-1-naphthalenecarboxylic acid derivatives are disclosed. The derivatives are useful for preparing aldose reductase inhibitors. With reference to the process, 1,1,1-trifluor... | 02/12/1985 |
| 4482714 | Pyrazino[2',3'-3,4]pyrido[1,2-a]indole derivatives Herein is disclosed pyrazino[2',3'-3,4]pyrido[1,2-a]indole derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions. The derivatives are useful f... | 11/13/1984 |
| 4470990 | 6,7,8,9-Tetrahydronaphtho(1,2-B)furan-8-amine derivatives and their use as dopamine receptor stimulants Herein is disclosed compounds of the formula ##STR1## in which R1 and R2 each is hydrogen or lower alkyl or R1 and R2 together form an alkylene of the formula (CH2)n wherein n is an in... | 09/11/1984 |
| 4470202 | Process and apparatus for freezing a liquid medium Spherical frozen particles, which may be subsequently freeze dried are prepared by introducing a liquid medium in the form of droplets beneath the surface of a cooling liquid. The temperature and density of the cooling liquid is chosen so that liquid drop... | 09/11/1984 |
| 4469695 | 2-(4-Hydroxyalkyl-1-piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives 2-(4-Hydroxyalkyl-1-piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions of the derivatives are disc... | 09/04/1984 |
| 4469693 | 2-(4-Substituted alkyl-1-piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives 2-(4-Substituted alkyl-1-piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions of the derivatives are... | 09/04/1984 |
| 4469694 | 2-(1-Piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives 2-(1-Piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions of the derivatives are disclosed. The deri... | 09/04/1984 |
| 4468391 | Combination of ଲ-adrenoceptor antagonists and anxiolytic agents A ଲ-adrenoceptor antagonist, which does not penetrate or penetrates poorly the brain, is combined with subtherapeutic doses of an anxiolytic agent, such as diazepam, to give a method, and pharmaceutical or veterinary composition, for treating anxiet... | 08/28/1984 |
| 4467091 | Acyl amino pyridines Novel N-(4-pyridyl)acetamide derivatives having the formula ##STR1## [where R1 and R2 are aryl or heteroarly (optionally linked together by a lower alkylene bridge) or one of R1 and R2 is aryl or heteroaryl... | 08/21/1984 |
| 4454150 | 6,7,8,9-Tetrahydro-3H-benz(e)indol-7-amines and a method of dopamine receptor stimulation therewith Herein is disclosed compounds of the formula ##STR1## in which R1, R2, R3, R4 and R5 each is hydrogen or lower alkyl, therapeutically acceptable acid addition salts thereof, processes for their p... | 06/12/1984 |
| 4447452 | N[(2-Naphthalenyl)thioxomethyl]glycine derivatives Herein disclosed are N-[(2-naphthalenyl)thioxomethyl]glycine derivatives of the formula ##STR1## wherein R1 is lower alkyl and R2 is hydrogen, lower alkyl, lower alkoxy, halo or trifluoromethyl. The derivatives have aldose reduc... | 05/08/1984 |
| 4446150 | Naphthalenylthiazole derivatives Disclosed herein are new aldose reductase inhibitors of the formula ##STR1## wherein R is ##STR2## wherein R1 is lower alkyl; R2 is halo and R3 is hydrogen, or R2 and R3 each is a substituen... | 05/01/1984 |
| 4439617 | N-Naphthoylglycine derivatives Herein disclosed are N-naphthoylglycine derivatives having aldose reductase inhibiting activity. The derivatives are useful for treating diabetic complications.... | 03/27/1984 |
| 4431657 | Analgesic compositions consisting of 2H-benzothieno[3,2-c]pyrazol-3-amine derivatives Herein is disclosed 2H-benzothieno[3,2-c]pyrazol-3-amine derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions. The derivatives are useful for... | 02/14/1984 |
| 4423232 | Tricyclic isoindole derivatives Tricyclic isoindole derivatives characterized by having a 1,2,3,4,6,10b-hexahydropyrazino]2,1-a]isoindole or 1,3,4,10b-tetrahydropyrimido[6,1-a]isoindol-6(2H)-one nucleus are disclosed. The foregoing compounds are useful antihypertensive agents. Claimed c... | 12/27/1983 |
| 4420476 | Benzofuro[3,2-c]pyrazol-3-amine derivatives Herein is disclosed benzofuro[3,2-c]pyrazol-3-amine derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions. The derivatives are useful for prod... | 12/13/1983 |
| 4409224 | Pyrimido[1,6-a]indole derivatives Pyrimido[1,6-a]indole derivatives characterized by having a substituted ethyl group at position 5 and optionally being further substituted at various positions on the pyrimido[1,6-a]indole nucleus are disclosed. The foregoing compounds are useful as antih... | 10/11/1983 |
| 4408077 | 6-(Lower alkoxy)-5-(trifluoromethyl)-1-naphthalenecarboxaldehydes A process and intermediates for preparing 6-(lower alkoxy)-5-(trifluoromethyl)-1-naphthalenecarboxylic acid derivatives are disclosed. The derivatives are useful for preparing aldose reductase inhibitors. With reference to the process, 1,1,1-trifluor... | 10/04/1983 |
| 4401656 | N-Substituted dimeric cyclopeptide derivatives The N-substituted dimeric cyclopeptide derivatives of formula ##STR1## in which A is a peptide residue having one to four amino acid residues; R1 is lower alkyl, phenyl or phenyl(lower)alkylene; R2 is lower alkyl, cyclo(lower)al... | 08/30/1983 |
| 4401653 | Combination of rapamycin and picibanil for the treatment of tumors Described is a method of using a combination of rapamycin and picibanil for the treatment of transplantable carcinogenic tumors.... | 08/30/1983 |
| 4391816 | N-(Naphthalenylthioxomethyl)aminoacid derivatives Herein disclosed are N-(naphthalenylthioxomethyl)aminoacid derivatives having aldose reductase inhibiting activity. The derivatives are useful for treating diabetic complications.... | 07/05/1983 |
| 4382088 | 4,7-Dihydro-4,7-dioxi-1H-cyclohepta[b]pyridine derivatives Aldose reductase inhibitors of the formula ##STR1## in which R1 is CH2 COOR4 wherein R4 is hydrogen or lower alkyl; R2 is COOR5 wherein R5 is hydrogen or lower alkyl; and R | 05/03/1983 |
| 4381304 | 4,9-Dihydro-4,9-dioxo-1H-cyclohepta[b]pyridine derivatives Aldose reductase inhibitors of the formula ##STR1## in which R1 is COOH and R2 is hydrogen, 8-halo or 6-hydroxy, or R1 is CON(R3)-CH2 COOH wherein R3 is lower alkyl and R2 i... | 04/26/1983 |
| 4379926 | 1,4,5,6-Tetrahydropyrimidine derivatives 1,4,5,6-Tetrahydropyrimidine derivatives characterized by having a phenyl or substituted phenyl at positions 1 and 6 in addition being further substituted at position 2. The foregoing compounds are useful as diuretic agents in a mammal. Methods for the pr... | 04/12/1983 |
| 4379780 | 17 -Dihydroequilin hapten and assay method A hapten is obtained by replacing the 3-hydroxy group of 17 -dihydroequilin with HO--CO--A--O-- wherein A is an alkylene of one to six carbon atoms. The hapten is conjugated with an immunological carrier to provide an immunogen, which in turn produ... | 04/12/1983 |
| 4379779 | Equilin hapten and assay method A hapten is obtained by replacing the 3-hydroxy group of equilin with HO--CO--A--O-- wherein A is an alkylene of one to six carbon atoms. The hapten is conjugated with an immunological carrier to provide an immunogen, which in turn produces a specific ant... | 04/12/1983 |
| 4375470 | 2(1-Piperazinyl)-cycloheptimidazole antihypertensive composition and methods 2-(1-Piperazinyl)-cycloheptimidazole derivatives are disclosed. The foregoing compounds are useful antihypertensive agents.... | 03/01/1983 |
| 4375464 | Antibiotic AY24,668 and process of preparation Antibiotic AY24,668 is producible by culturing Streptomyces hygroscopicus NRRL 5491 in an aqueous nutrient medium. AY24,668 has antifungal properties. Methods for its preparation and use are disclosed.... | 03/01/1983 |
| 4375463 | Ravidomycin and process for preparation Ravidomycin is produced by culturing Streptomyces ravidus NRRL 11,300 in an aqueous nutrient medium. Ravidomycin is useful as an antibacterial and antitumor agent. Methods for its preparation and use are disclosed.... | 03/01/1983 |
| 4371516 | Articles for carrying chemicals The invention relates to shaped articles carrying chemicals, particular to pharmaceutical dosage forms carrying pharmaceuticals, which disintegrate rapidly in water. The shaped articles comprise an open matrix network of carrier material carrying the chem... | 02/01/1983 |
| 4370341 | 6,7,8,9-Tetrahydro-3H-benz[E]indol-8-amine derivatives Herein is disclosed compounds of the formula ##STR1## in which R1,R2,R3,R4 and R5 each is hydrogen or lower alkyl, therapeutically acceptable acid addition salts thereof, processes for their prep... | 01/25/1983 |
| 4369188 | 2-Thioxobenz[cd]indole-1(2H)-acetic acid derivatives Herein are disclosed compounds of the formula ##STR1## in which R1 is hydrogen, lower alkyl or --(CH2)m --NR4 R5 wherein m is an integer from 2 to 6 and R4 and R5 each is hy... | 01/18/1983 |
| 4357333 | N-Substituted 2-(8-halo and trifluoromethyl 4-quinolylamino)benzamides and analgesic use thereof The disclosure describes new 4-aminoquinoline derivatives of general formula ##STR1## and their pharmaceutically acceptable acid addition salts, where X is trifluoromethyl or halogen, Z is hydrogen or a defined substituent and R is a group havin... | 11/02/1982 |
| 4355031 | 2,3-Dihydro-3-[4-(substituted)-1-piperazinyl]-1H-isoindol-1-ones Pyrazinoisoindolone derivatives of the formula ##STR1## wherein R1 is lower alkyl, phenyl, diphenylmethyl, pyridinyl, pyrimidinyl, pyrazinyl or pyrazinyl substituted with a lower alkyl, lower alkoxy or halo; and R2 is hydrogen, ... | 10/19/1982 |
| 4351828 | N-Substituted cyclopeptide derivatives The N-substituted cyclopeptide derivatives of formula I ##STR1## in which R1 is lower alkyl, R2 is lower alkyl or cyclo(lower)alkyl, R3 is a neutral amino acid side chain and Y is a peptide residue having three to nin... | 09/28/1982 |
