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| Number | Title | Issue Date |
| 8093006 | Antibodies against human tweak and uses thereof An antibody binding to TWEAK comprising as heavy chain variable domain a CDR3H selected from the group consisting of SEQ ID NO: 8, 16 or 24. ... | 01/10/2012 |
| 8080552 | Pyrimidyl derivatives as protein kinase inhibitors Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the ... | 12/20/2011 |
| 8067599 | Imidazo [4,5-B] pyridine and pyrrolo [2,3-B] pyridine protein kinase inhibitors Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments cont... | 11/29/2011 |
| 8063085 | Substituted hydantoins The present invention relates to compounds of the formula methods for the preparation thereof, and methods for their use. The compounds are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly ... | 11/22/2011 |
| 8044213 | Thiazolyl-benzimidazoles The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof. ... | 10/25/2011 |
| 7999000 | N-(2-amino-phenyl)-acrylamides The present invention is directed to the compounds of formula wherein R1 to R4 have the significances given herein, to processes for the manufacture of said compounds as well as medicaments containing ... | 08/16/2011 |
| 7977372 | Ortho aminoamides for the treatment of cancer Compounds of formula are HDAC inhibitors. These compounds are useful for the treatment of diseases such as cancer in humans or animals. ... | 07/12/2011 |
| 7956190 | Benzimidazole amido derivatives as kinase inhibitors Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as wel... | 06/07/2011 |
| 7939532 | Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents Objects of the present invention are the compounds of formula I, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the us... | 05/10/2011 |
| 7923028 | High dose oral formulation of bisphosphonate and a process for making thereof The invention relates to a high dose oral formulation of bisphosphonates and to a process for the preparation of such formulations. ... | 04/12/2011 |
| 7846724 | Method for selecting CHO cell for production of glycosylated antibodies The invention provides an antibody comprising human IgG1 or IgG3 heavy chain constant domains that are glycosylated with a sugar chain at Asn297, said antibody being characterized in that the amount of fucose within said sugar chain is at least 99%, and in addition ... | 12/07/2010 |
| 7879884 | Aryl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the u... | 02/01/2011 |
| 7718634 | Method of treatment using bisphosphonic acid The present invention refers to a pharmaceutical composition of a bisphosphonic acid or salt thereof, and an excipient thereof, and a method of treating disorder characterized by pathologically increased bone resorption comprising orally administering at least 150% ... | 05/18/2010 |
| 7714158 | Ibandronate polymorph The present invention relates to a new polymorph crystal form of 3-(N-methyl-N-pentyl) amino-1-hydroxypropane-1 1-diphosphonic acid monosodium salt monohydrate (Ibandronate) with the following formula. ... | 05/11/2010 |
| 7662990 | Process for preparing ibandronate The invention relates to a novel multi step synthesis of 3-(N-methyl-N-pentyl)amino-1-hydroxypropane-1,1-diphosphonic acid, monosodium salt, monohydrate, of the formula ... | 02/16/2010 |
| 7625999 | Method for testing the ability of an agent to inhibit fibroblast growth factor binding with labeled heparan sulfate The present invention provides a method for testing an agent for its ability to inhibit binding between fibroblast growth factor (FGF) and heparan sulfate, comprising the steps of: interacting in solution immobilized FGF on a solid support with the agent and labeled... | 12/01/2009 |
| 7612212 | Substituted hydantoins The present invention relates to compounds of the formula methods for the preparation thereof, and methods for their use. The compounds are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly ... | 11/03/2009 |
| 7582789 | Ibandronate polymorph The present invention relates to a new crystalline polymorph of 3-(N-methyl-N-pentyl) amino-1-hydroxypropane-1,1-diphosphonic acid monosodium salt monohydrate (Ibandronate) with the following formula ... | 09/01/2009 |
| 7579157 | Antibody selection method against IGF-IR Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing the antibodies, and uses for the antibodies are disclosed. Antibodies against IGF-IR are implicated in antitumor therapy. ... | 08/25/2009 |
| 7572897 | Antibodies against insulin-like growth factor I receptor and uses thereof Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing said antibodies, and uses for such antibodies are disclosed. Antibodies against IGF-IR are implicated in antitumor therapy. ... | 08/11/2009 |
| 7557221 | Substituted hydantoins This invention relates to compounds of formula I: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, and R6 are described in this application. These compounds inhibit the enzymes MEK 1 and M... | 07/07/2009 |
| 7544833 | Methods for producing N-(8-[2-hydroxybenzoyl]-amino) caprylic acid Disclosed are improved methods for the synthesis of N-(8-[2-hydroxybenzoyl]-amino)caprylic acid. Certain compounds have been found useful for preventing the formation of a colored impurity when included in an ester hydrolysis reaction. Conducting ester hydrolysis in... | 06/09/2009 |
| 7517873 | Substituted pyrimidodiazepines The present invention provides PLK1 inhibitor compounds of formula I: Useful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such ... | 04/14/2009 |
| 7504513 | Thiazolyl-benzimidazoles The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof. ... | 03/17/2009 |
| 7501428 | Quinazoline thiazolinones Quinazoline thiazolinone derivatives which demonstrate CDK1 antiproliferative activity and are useful as anti-cancer agents. ... | 03/10/2009 |
| 7425638 | Cis-imidazolines The present invention provides compounds according to formula I having the designations provided herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit the interaction of MDM2 protein with... | 09/16/2008 |
| 7410957 | Method of treatment using bisphosphonic acid The present invention refers to a pharmaceutical composition of a bisphosphonic acid or salt thereof, and an excipient thereof, and a method of treating disorder characterized by pathologically increased bone resorption comprising orally administering at least 150% ... | 08/12/2008 |
| 7396940 | Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid Combinatorial libraries that contains various different 4, 5 fused 3-substituted-2-pyrrolocarboxylic acids for screening pharmacological activity and methods of synthesizing said libraries. ... | 07/08/2008 |
| 7378503 | Antibodies against insulin-like growth factor 1 receptor and uses thereof Antibodies which bind to IGF-IR and inhibit the binding of IGF-I and IGF-II to IGF-IR are characterized. These antibodies are implicated in anti-tumor therapy. ... | 05/27/2008 |
| 7348165 | Methods for detecting cancer cells by using nucleic acid encoding for IGF-1 receptor interacting proteins The invention relates generally to a method for the detection of the proliferation of a tumor cell and more specifically wherein said method comprises nucleic acids (SEQ ID NO:1) encoding IIP-1. ... | 03/25/2008 |
| 7329734 | IGF-1 receptor interacting proteins The invention comprises a nucleic acid molecule with the sequence SEQ ID NO:5 and the complementary sequence, and its use in diagnosis and therapy. This nucleic acid molecule (IIP-10) is a gene which encodes an IGF-1 receptor binding polypeptide. ... | 02/12/2008 |
| 7326786 | Thiazolinone unsubstituted quinolines Thiazolinone quinoline derivatives having no substitution on the quinoline ring active as CDK1 inhibitors which are useful as anti-proliferation agents such as for treating solid tumors. ... | 02/05/2008 |
| 7268231 | 1,5-Naphthyridine azolinone 1,5-Naphthyridine azolinone derivatives are disclosed. These compounds are inhibitors of CDK1 and are useful as antiproliferative agents, such as anti-cancer agents. ... | 09/11/2007 |
| 7253285 | Thiazolinone 4-monosubstituted quinolines Thiazolinone monosubstituted quinoline derivatives where the quinoline ring is mono-substituted at the 4 positions which derivatives demonstrates CDK1 antiproliferative activity and are useful as anti-cancer agents. ... | 08/07/2007 |
| 7250515 | Thiazolinone 3,4-disubstituted quinolines Thiazolinone disubstituted quinoline derivatives where the quinoline ring is disubstituted at the 3, 4 positions which derivatives demonstrate CDK1 antiproliferative activity and are useful as anti-cancer agents. ... | 07/31/2007 |
| 7247727 | Azaindole thiazolinones Azaindole thiazolinone derivatives which demonstrate CDK1 and CDK2 antiproliferative activities and are useful as anti-cancer agents. ... | 07/24/2007 |
| 7241893 | Thiazolinone 2-substituted quinolines Thiazolinone substituted quinoline derivatives where the quinoline ring is substituted at the 2 position which derivatives demonstrates CDK1 antiproliferative activity and are useful as anti-cancer agents. ... | 07/10/2007 |
| 7214818 | Method for synthesizing bisphosphonate The invention relates to a novel multi step synthesis of 3-(N-methyl-N-pentyl) amino-1-hydroxypropane-1,1-diphosphonic acid, monosodium salt, monohydrate, of the formula ... | 05/08/2007 |
| 7202058 | IGF-1 receptor interacting proteins The invention comprises a method of screening compound(s) that inhibit the interaction between IGF-1R and IIP-10. ... | 04/10/2007 |
| 7192938 | Method of treatment using bisphosphonic acid The present invention refers to a pharmaceutical composition of a bisphosphonic acid or salt thereof, and an excipient thereof, and a method of treating disorder characterized by pathologically increased bone resorption comprising orally administering at least 150% ... | 03/20/2007 |
