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| Number | Title | Issue Date |
| 4632939 | Anticonvulsant agents This invention provides certain benzamide derivatives of the formula: ##STR1## wherein Z is bond, --CH2 --, or CHCH3 ; A is --CH2 --, or CH2 CH2 --; and represents a single or double bond; and their... | 12/30/1986 |
| 4616078 | Process for purifying proinsulin-like materials This specification describes a process for separating impurities from an impure mixture containing proinsulin-like material with substantially complete recovery of said proinsulin-like material, which comprises: (1) applying said mixture to a reverse phase mac... | 10/07/1986 |
| 4614807 | 6,7-dihalomelatonins 6,7-Dichloromelatonin and related compounds are ovulation inhibitors of the formula ##STR1## wherein R and R1 are individually F or Cl, R2 is C1-3 alkyl, including methyl, ethyl, n-propyl and isopropyl, and R3 | 09/30/1986 |
| 4609645 | Macrolide antibiotics, pharmaceutical compositions and methods of use Macrolides PTL-448 A and B, which can be prepared by aerobic cultivation of Streptomyces ambofaciens ATCC 15154 in the presence of a macrolide intermediate selected from protylonlide, 5-O-mycaminosylprotylonolide, 20-hydroxy-5-O-mycaminosylprotylonolide a... | 09/02/1986 |
| 4609670 | Imidazolium hypoglycemic agents Imidazolium salts are effective in lowering blood glucose levels in mammals following administration.... | 09/02/1986 |
| 4604127 | Herbicidal pyridazinylimidazolidinone compounds This invention describes novel pyridazinylimidazolidinone compounds, which are useful as herbicides.... | 08/05/1986 |
| 4602025 | Aromatase inhibitors This invention provides a method of inhibiting aromatase and treating estrogen-dependent diseases in mammals by administering certain azole derivatives. Certain azole derivatives and their pharmaceutical formulations are also provided.... | 07/22/1986 |
| 4602044 | ଲ-phenethanolamine antiobesity agents ଲ-Phenethanolamines are useful as antiobesity agents.... | 07/22/1986 |
| 4600777 | Method of preparing 1-alkyl-7-oxodecahydroquinolines, and cis(&#b1;) and tran(&#b1;)isomers so prepared 1-C1-3 straight chain alkyl 7-oxodecahydroquinoline, chemical intermediates.... | 07/15/1986 |
| 4600430 | Pyridinylimidazolidinone compounds This invention discloses novel pyridinylimidazolidinone compounds, which are useful as herbicides.... | 07/15/1986 |
| 4600773 | Crystalline cephalexin hydrochloride monohydrate Crystalline cephalexin hydrochloride ethanol solvate converts to crystalline cephalexin hydrochloride monohydrate upon being exposed to moisture.... | 07/15/1986 |
| 4599339 | Use of pyrimido[4,5-g]quinolines in treating parkinsonism Trans-(&#b1;)-2-Amino or substituted amino-4-permissibly-substituted 6-lower alkyl or allyl-5,5a,-6,7,8,9,9a,10-octahydropyrimido[4,5-g]quinolines, the corresponding trans-(-)-stereoisomers and salts thereof, useful in treating anxiety, Parkinson's Syndro... | 07/08/1986 |
| 4596871 | Pyrazole-ring alkylated pyrazoloquinolines Tautomeric mixtures of trans-(&#b1;)-3,5-dialkyloctahydropyrazolo[3,4-g]quinoline, of trans-(&#b1;)-6-alkyloctahydropyrazolo[4,3-f]quinoline, and of trans-(&#b1;)-1,6-dialkyloctahydropyrazolo[4,3-f]quinoline, individual enantiomer thereof, pharmaceut... | 06/24/1986 |
| 4596827 | Alkylsulfonamidophenylalkylamine compounds used for treating arrhythmia The present invention relates to a new class of alkylsulfonamidophenylalkylamines which are potent antiarrhythmic agents having good oral bioavailability properties.... | 06/24/1986 |
| 4596676 | Bifunctional ester derivatives of 4-desacetyl indole-dihydroindole alkaloids Bifunctional ester derivatives at C-4 carbon of dimeric indole-dihydroindole alkaloids; e.g., VLB 4-hemisuccinate.... | 06/24/1986 |
| 4595754 | Process for preparing cis N-alkylperhydroquinolines A process for preparing a cis N-alkylperhydroquinoline comprising reacting a 3-chloropropyl N-alkylimine with a hydride reducing agent in a basic reaction medium at a temperature in the range of from about -20° C. to about 25° C.... | 06/17/1986 |
| 4595586 | Moisturizing lotion The present invention provides a novel moisturizing lotion which increases the rate of cell renewal on the skin without causing skin irritation and which facilitates the subsequent application of make-up.... | 06/17/1986 |
| 4595532 | N-(substituted-methyl)-azetidin-2-ones N-Mono or N-disubstituted methyl-2-azetidinones are provided via cyclization of ଲ-hydroxy or ଲ-halo substituted acid sec-amides wherein the amide nitrogen is substituted with a mono- or di-substituted methyl group having activating substituent... | 06/17/1986 |
| 4595540 | Benzonitrile and benzothiocyano intermediates There are described compounds of the formula ##STR1## in which R1 is hydrogen or C1-6 alkyl, R2 is hydrogen, C1-6 alkyl or C3-6 alkenyl, X and Y are each oxygen, sulphur, sulphinyl or sulphonyl, ... | 06/17/1986 |
| 4594417 | Crystalline antibiotic salt Crystalline cephalosporin hydrochloride salt represented by the formula ##STR1## wherein the oxime is in the syn configuration, is a useful pharmaceutical form of, and tool for purification of, the corresponding antibiotic free base; processes for it... | 06/10/1986 |
| 4594358 | Analgesic method This invention provides a method of producing analgesia in mammals which comprises administering dextropropoxyphene and fluoxetine or norfluoxetine. Pharmaceutical formulations useful in this method are also provided.... | 06/10/1986 |
| 4594338 | Thioether derivatives of tylosin 11-Thioether and certain C-20 acetal and thioacetal derivatives of tylosin and demycarosyltylosin are effective antibacterial agents. Processes for preparing, formulations containing, and methods of treating bacterial infections with these derivatives are... | 06/10/1986 |
| 4594337 | Methods of controlling mycoplasma infections Methods of controlling Mycoplasma infections which comprise administering to an infected or susceptible warm-blooded animal an effective amount of a new macrocin or lactenocin ester derivative of the formula: ##STR1## wherein R is formyl or hydroxyme... | 06/10/1986 |
| 4594247 | Synergistic antibacterial compositions and method of treatment of infections caused by multiple antibiotic-resistant organisms Antibiotic compositions comprising a 1-oxa ଲ-lactam antibiotic compound of the formula ##STR1## or pharmaceutically acceptable salts thereof and either tobramycin, amikacin or piperacillin exhibit synergistic activity against multiple-anti... | 06/10/1986 |
| 4594431 | Octahydroindolizinepropanoic acids and related compounds as enzyme inhibitors Octahydro-5-oxoindolizine-6-propanoic acids and octahydro-6-oxopyrido[1,2-A]pyridine-7-propanoic acids, the decarboxy and related ester and perhydro derivatives thereof inhibit angiotensin I converting enzyme and are hypotensive agents. Hydrogenation of A... | 06/10/1986 |
| 4591591 | Pyridazinone derivatives as inotropic agents This invention provides for the use of certain pyridazinones as positive inotropic agents.... | 05/27/1986 |
| 4590213 | Anti-anxiety method This invention provides for a method of treating anxiety which comprises the administration of fluoxetine or norfluoxetine or pharmaceutically aceptable salts thereof.... | 05/20/1986 |
| 4589905 | Herbicidal and algicidal 1-aryl-5-cyano-1H-pyrazole-4-carboxamides The present invention is directed to compounds of the formula ##STR1## wherein R1 is C1 -C6 alkyl, C5 -C6 cycloalkyl, ##STR2## each of R2 and R3 is taken separately and is i... | 05/20/1986 |
| 4588484 | Electrochemical reduction of 3-chlorobenzo[b]thiophenes The present invention relates to electrochemical reduction of a 3-chlorobenzo[b]thiophene to the corresponding 3-hydrobenzo[b]thiophene compound.... | 05/13/1986 |
| 4587348 | Process for preparing herbicidal 5-cyano-1-phenyl-N-methyl-1H-pyrazole-4-carboxamide The herbicide 5-cyano-1-phenyl-N-methyl-1H-pyrazole-4-carboxamide is prepared in high yield and high purity in a two-step process without isolation of the intermediate.... | 05/06/1986 |
| 4587344 | Isothiourea synthesis process N-methyl-S-methyl-N'-[2-(2-dimethylaminomethylthiazol-4-ylmethylthio)ethyl] isothiourea is prepared by the reaction of 2-dimethylaminomethyl-4-(2-aminoethyl)thiomethylthiazole with methylcarbonimidodithioic acid, dimethyl ester, and is a useful interm... | 05/06/1986 |
| 4587218 | Novel bioconverting microorganisms New Actinoplanes missouriensis strains CUC 014 (NRRL 15647) and CSV 558 (NRRL 15646) which operate together to cosynthesize the useful glycopeptide antibiotic CUC/CSV.... | 05/06/1986 |
| 4587053 | Preparation of oxazolines Oxazolino-azetidinones are prepared by reaction of a phosphorus compound with a 3-exomethylenecepham sulfoxide.... | 05/06/1986 |
| 4587336 | Partially hydrogenated intermediate pyrazolo, pyrimido and thiazolo[1,4]benzoxazines Intermediates useful for the preparation of pyrazolo, pyrimido and thiazolo[1,4]benzoxazines, useful as dopamine agonists.... | 05/06/1986 |
| 4587351 | Synthesis of ketones with calcium hypochlorite The present invention pertains to a process for preparing ketones employing a silica catalyzed oxidation of a secondary alcohol with calcium hypochlorite in acetonitrile.... | 05/06/1986 |
| 4585894 | Process for producing 9-carbamoyl fluorene derivatives Processes are described for preparing pharmaceutical 9-carbamoyl-9-aminoalkylfluorenes and intermediates in their preparation.... | 04/29/1986 |
| 4585861 | 1,2,4-triazine derivatives This invention relates to certain amino-5,6-diaryl-1,2,4-triazines and -pyrazines useful as activators of GABA and benzodiazepine binding.... | 04/29/1986 |
| 4584404 | Substituted phenoxyphenylproply dimethylamines Selective biogenic amine uptake inhibitors, 3-substituted phenyloxy-3-phenylpropyldimethylamines.... | 04/22/1986 |
| 4582806 | Purification of phenylethanolamine N-methyltransferase The present invention provides an efficient process for purifying the enzyme phenylethanolamine N-methyltransferase suitable for use in radioenzymatic assays of endogenous compounds.... | 04/15/1986 |
| 4582822 | Antibiotic A80190, pharmaceutical compositions containing same and method of use New polyether antibiotic A80190, its acyl and alkyl ester, acyl ester and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Methods of making A80190 by culture o... | 04/15/1986 |
