Did You Know...
...Chester Carlson was a patent agent who tired of having to make multiple copies of patent applications using the only duplication method available at the time: carbon paper. In 1959 he came up with a new copying system and took it to IBM for evaluation. The "experts" at IBM determined potential sales to be only 5,000 units because people wouldn't want to use a bulky machine when they had carbon paper. Carlson's invention was the xerography process, the company founded on the system is Xerox.
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| Number | Title | Issue Date |
| 7879870 | Treatment of inflammatory and ulcerative diseases of the bowel with opioid antagonists Methods for the treatment of inflammatory and ulcerative diseases of the bowel (e.g., Crohn's disease and ulcerative colitis) with a therapeutically effective dose less than 50 mg. of opioid antagonists (e.g., naltrexone, nalmefene or naloxone) are disclosed. An emb... | 02/01/2011 |
| 7860657 | Forward synthetic synthon generation and its useto identify molecules similar in 3 dimensional shape to pharmaceutical lead compounds A forward synthetic method is described that utilizes recursive application of established organic chemical reactions to derive more complex synthons from available reagents than are available from the reagent synthons themselves. The product of each reaction serves... | 12/28/2010 |
| 7580799 | Method for characterizing and analyzing 3-D shapes of molecules utilizing steric multiplets Steric features inherent in the three dimensional disposition of atoms in molecules can be represented as multiplets using a defined set of steric descriptors. The resulting multiplets can be encoded in a compressed form of bitstring known as a bitmap. Such bitmaps ... | 08/25/2009 |
| 7516018 | Structural unit analysis A computer implemented method is disclosed for analyzing a large data set of chemical compounds for which there is a measured activity in the same assay for each compound to determine the structural units which are responsible for the observed activity of the compou... | 04/07/2009 |
| 7330793 | Method for searching heterogeneous compound databases using topomeric shape descriptors and pharmacophoric features Heterogeneous compound databases can be searched for compounds which are likely to have the same biological activity as a known (query) molecule. Query molecules and the molecules in the database are split into fragments according to common fragmentation rules. Frag... | 02/12/2008 |
| 7329222 | Comparative field analysis (CoMFA) utilizing topomeric alignment of molecular fragments The static and electrostatic interaction energy fields between probe atoms and the atoms of a topomerically aligned fragment placed in a three-dimensional grid may be used to derive a CoMFA model. The topomeric CoMFA model coefficients may be used to predict partial... | 02/12/2008 |
| 7249460 | Fuel injection system for a turbine engine To improve the burning efficiency of fuel supplied to a turbine engine by electronic fuel injectors under control of a fuel injection control system, a nebulizer of unique design is employed with the fuel injectors to further reduce the individual fuel cell size fro... | 07/31/2007 |
| 7212951 | Method for characterizing and analyzing 3-D shapes of molecules utilizing steric multiplets Steric features inherent in the three dimensional disposition of atoms in molecules can be represented as multiplets using a defined set of steric descriptors. The resulting multiplets can be encoded in a compressed form of bitstring known as a bitmap. Such bitmaps ... | 05/01/2007 |
| 7185316 | Visually oriented computer implemented application development system utilizing standardized objects and multiple views A computer implemented application development (authoring) system permits objects (such as VBX custom controls) to be graphically inserted into the program under development by dragging and dropping associated icons into one of four views. The properties associated ... | 02/27/2007 |
| 7184893 | Method for selecting an optimally diverse library of small molecules based on validated molecular structural descriptors The use for biological screening purposes of a subset (library) of a large combinatorially accessible chemical universe increases the efficiency of the screening process only if the subset contains members representative of the total diversity of the universe. In or... | 02/27/2007 |
| 7136758 | Virtual library searchable for possible combinatorially derived product molecules having desired properties without the necessity of generating product structures The problem of how to select out of a large chemically accessible universe molecules representative of the diversity of that universe is resolved by the discovery of a method to validate molecular structural descriptors. Using the validated descriptors, optimally di... | 11/14/2006 |
| 7096162 | Computer-implemented method of merging libraries of molecules using validated molecular structural descriptors and neighborhood distances to maximize diversity and minimize redundancy The use for biological screening purposes of a subset (library) of a large combinatorially accessible chemical universe increases the efficiency of the screening process only if the subset contains members representative of the total diversity of the universe. In or... | 08/22/2006 |
| 6962267 | Automated shopping system A vending machine for the sale of both food and non-food products has a plurality of adjustable shelves and adjustable product dividers. Products are dispensed from the shelves by the action of a computer controlled transporter mounted on carriages permitting moveme... | 11/08/2005 |
| 6535819 | Optimal dissimilarity method for choosing distinctive items of information from a large body of information The method of this invention identifies distinctive items of information from a larger body of information on the basis of similarities or dissimilarities among the items and achieves a significant increase in speed as well as the ability to balance the r... | 03/18/2003 |
| 6240374 | Further method of creating and rapidly searching a virtual library of potential molecules using validated molecular structural descriptors The problem of how to select out of a large chemically accessible universe molecules representative of the diversity of that universe is resolved by the discovery of a method to validate molecular structural descriptors. Using the validated descriptors, o... | 05/29/2001 |
| 6221002 | Method to reduce hexavalent chromium in soils, sediments, industrial wastes and other contaminated materials using ascorbic acid The concentration of potentially toxic hexavalent chromium, {Cr(VI)}, in chromium-bearing soils/materials existing in the form of soils, sludges, sediments, fill, industrial wastes, or other materials is decreased by applying and mixing a single reducing ... | 04/24/2001 |
| 5951457 | Method to reduce hexavelant chromium in soils, sediments, industrial waste and other contaminated materials using ascorbic acid The concentration of potentially toxic hexavalent chromium, {Cr(VI)}, in chromium-bearing soils/materials existing in the form of soils, sludges, sediments, fill, industrial wastes, or other materials is decreased by applying and mixing a single reducing ... | 09/14/1999 |
| 5816118 | Chain saw sharpening bench A chain saw stabilizing bench is disclosed which permits the sharpening of chain saw cutting teeth under field conditions. The bench consists of an extended planar platform for holding the weight of the saw and an upright holder for securing the saw bar a... | 10/06/1998 |
| 5099920 | Small diameter dual pump pollutant recovery system A groundwater pollutant recovery system using the cone of depression approach, in which a sensing probe having liquid level sensors responsive to both water and pollutant levels and having attached to it the pollutant intake is deployed in a recovery well... | 03/31/1992 |
| 4930752 | Highway fencing The screening or security fence structure of this invention includes a plurality of spaced I-beam vertical support posts with standardized fence panels placed between them. While each fence panel is securely mounted to the I-beam posts, it is also firmly ... | 06/05/1990 |
