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| Number | Title | Issue Date |
| 7102013 | Methods of making amidino compounds useful as nitric oxide synthase inhibitors Method of making an alpha-amino acid compound having the structure of Formula 32: comprising treating under hydrolyzing conditions a hydantoin compound having the structure of Formula 33: | 09/05/2006 |
| 7012143 | Cycloalkyl-[4-(difluorophenyl)-oxazol-5-yl]-triazolo-pyridines The present invention relates to novel cycloalkyl-[4-(difluorophenyl)-oxazol-5-yl]-triazolo-pyridines, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the present invention are poten... | 03/14/2006 |
| 6951949 | Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: wherein R2 is s... | 10/04/2005 |
| 6914158 | Amidino compounds useful as nitric oxide synthase inhibitors The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the prese... | 07/05/2005 |
| 6861521 | Stereoselective transacetalization of steroidal C-22 acetonide The present invention is a process for the preparation of rofleponide of formula (II) where the 22R/22S ratio is 90/10 or greater which comprises contacting an acetonide of formula (I) | 03/01/2005 |
| 6858598 | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia A method of using an MMP inhibitor and optionally radiation therapy, and one or more antineoplastic agents of the topoisomerase class selected from the group consisting of irinotecan and topotecan, as a combination therapy for the treatment of neoplasia is disclosed... | 02/22/2005 |
| 6833373 | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of an integrin antagonist and an antineoplastic agent. ... | 12/21/2004 |
| 6822102 | Dihydrobenzopyrans, dihydrobenzothiopyrans, and tetrahydroquinolines for the treatment of COX-2 mediated disorders A class of dihydrobenzopyrans, dihydrobenzothiopyrans, tetrahydroquinolines, tetrahydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula (I) wherein X, A | 11/23/2004 |
| 6806288 | Substituted benzopyran derivatives for the treatment A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A3 | 10/19/2004 |
| 6716991 | Process for preparing a substituted pyrazolyl benzenesulfonamide for the treatment of inflammation A class of pyrazolyl benzenesulfonamide compounds is descrbed for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: wherein R2 is sele... | 04/06/2004 |
| 6664395 | Benzotriazoles anti-inflammatory compounds The present invention relates to novel benzotriazoles of the formula I ##STR1## wherein Het is an optionally substituted 5-membered heterocycle containing one to two heteroatoms selected from nitrogen, sulfur and oxygen wherein at least one of said hetero... | 12/16/2003 |
| 6649645 | Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of radiation therapy and a cyclooxygenase-2 inhibitor.... | 11/18/2003 |
| 6492411 | Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ##STR1## wherein R2 is selected from hydrido, alkyl,... | 12/10/2002 |
| 6413960 | Substituted pyrazolyl benzenesulfonamides for the treatment of asthma A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ##STR1## wherein R2 is selected from hydrido, alkyl,... | 07/02/2002 |
| 6274590 | Method of treating skin related conditions A class of 3,4-diaryl substituted thiophene, derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defined by F... | 08/14/2001 |
| 6172096 | Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor and a leukotriene B4 receptor antagonist Treatment with a cyclooxygenase-2 inhibitor and a leukotriene B4 receptor antagonist is described as being useful in reducing recipient rejection of transplanted organs and for treatment of autoimmune diseases.... | 01/09/2001 |
| 6040476 | Carbon dioxide assisted hydrolysis of aminophosphonates The invention provides a process for preparing aminophosphonic acids comprising contacting an aminophosphonate ester with a base in the presence of a hydrolysis facilitator selected from the group consisting of CO2, CS2 and COS. In o... | 03/21/2000 |
| 5986128 | Use of monosodium iminodiacetic acid solutions in the preparation of N-phosphonomethyliminodiacetic acid A method is described for making solution stable salts of iminodiacetic acid (IDA), useful as precursors in the manufacture of N-phosphonomethylglycine. Concentrated dialkali salts of IDA which are insoluble at temperatures below about 55° C., such as th... | 11/16/1999 |
| 5861525 | Method for preparing cyanophosphonate derivatives from phosphate esters and cyanide A process for preparing cyanophosphonate derivatives involves contacting a phosphate ester and cyanide in a reaction mixture under conditions sufficient to produce a cyanophosphonate derivative. That cyanophosphonate derivative product can subsequently be... | 01/19/1999 |
| 5858317 | Method for preparing cyanophosphonate derivatives from phosphoric anhydride and cyanide A process for preparing cyanophosphonate derivatives involves contacting phosphoric anhydride (P4 O10) and a cyanide, preferably in the presence of a Lewis base, in a reaction mixture under sufficient conditions to produce a cyanopho... | 01/12/1999 |
| 5859278 | Method for preparing cyanophosphonate derivatives from pyrophosphate or polyphosphate esters and cyanide A process for preparing cyanophosphonate derivatives involves contacting a pyrophosphate ester or a polyphosphate ester and cyanide in a reaction mixture under conditions sufficient to produce the cyanophosphonate derivative. The cyanophosphonate derivati... | 01/12/1999 |
| 5859290 | Hydrogenation of cyanophosphonate derivatives in the presence of a glycine derivative A process for preparing N-phosphonomethylglycine or an N-phosphonomethylglycine derivative involves the hydrogenation of cyanophosphonate derivatives in the presence of a glycine derivative and a catalyst to produce N-phosphonomethylglycine.... | 01/12/1999 |
| 5739390 | Process to prepare amino carboxylic acid salts An improved process is discloses to prepare an amino carboxylic acid salt. According to the process an aqueous solution of an amino alcohol is contacted with an alkali metal hydroxide in the presence of an effective amount of Raney copper catalyst that ha... | 04/14/1998 |
